Reactome

Reactome is a free, open-source, curated, and peer-reviewed biological pathway database. It provides comprehensive pathway data covering human biology and orthologous reactions for over 14 non-human species including mouse, rat, yeast, and fruit fly. The platform exposes two primary REST APIs — the Content Service for querying pathway data, molecular interactions, species comparisons, and reaction network visualization, and the Analysis Service for pathway enrichment analysis of gene and protein identifier lists. Both APIs are freely accessible without authentication, fully documented with OpenAPI (Swagger), and cross-referenced with major biological databases including NCBI, Ensembl, UniProt, KEGG, ChEBI, PubMed, and Gene Ontology. Data is authored by expert biologist researchers and maintained by Reactome editorial staff.

Reactome publishes 23 APIs on the APIs.io network, including database API, discover API, diseases API, and 20 more. Tagged areas include Biological Pathways, Bioinformatics, Life Sciences, Pathway Analysis, and Gene Enrichment.

The Reactome catalog on APIs.io includes 1 JSON-LD context and 1 Spectral governance ruleset.

Reactome’s developer surface includes documentation, FAQ, GitHub presence, engineering blog, and 8 more developer resources.

🌐 Visit website 📡 Source on GitHub

29.6/100 thin ▼ -5.9 Agent 32/100 agent aware Full breakdown ↓
scored 2026-07-28 · rubric v0.6

23 APIs

Biological PathwaysBioinformaticsLife SciencesPathway AnalysisGene EnrichmentMolecular InteractionsSystems BiologyOpen Science

Kin Score

Kin Score How this is scored →
scored 2026-07-28 · rubric v0.6

Composite quality — 29.6/100 · thin

Contract Quality 13.4 / 25

Developer Ergonomics 3.9 / 20

Commercial Clarity 0.0 / 20

Operational Transparency 0.7 / 13

Governance 7.0 / 12

Discoverability 7.4 / 10

Agent readiness — 32/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 10 / 10

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 7 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. This rating is computed from github.com/api-evangelist/reactome: open an issue to ask a question, or submit a pull request to add artifacts. Want it done for you? Prioritized profiling — $2,500 →

APIs 23

Individual APIs this provider publishes, each with its own machine-readable definition.

JSON Schema 71

Standalone JSON Schema definitions for this provider's data models.

Scroll for all 71

Get Started 1

Portal, sign-up, and the first successful call

DeveloperPortal

DeveloperPortal

Documentation 1

Reference material describing how the API behaves

Documentation

Documentation

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

AgenticAccess

AgenticAccess

Design & Contract 1

Pagination, idempotency, versioning, errors, and events

DataModel

DataModel

Build 1

SDKs, sample code, and the tooling you integrate with

GitHub

GitHub

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Operate 2

Status, limits, changes, and where to get help

FAQ

FAQ

Contact

Contact

Commercial 1

Pricing, plans, and the legal terms of use

License

License

Company 3

The organization behind the API

Website

Website

Blog

Blog

About

About

Source (apis.yml)

aid: reactome
name: Reactome
description: Reactome is a free, open-source, curated, and peer-reviewed biological pathway database. It provides comprehensive
  pathway data covering human biology and orthologous reactions for over 14 non-human species including mouse, rat, yeast,
  and fruit fly. The platform exposes two primary REST APIs — the Content Service for querying pathway data, molecular interactions,
  species comparisons, and reaction network visualization, and the Analysis Service for pathway enrichment analysis of gene
  and protein identifier lists. Both APIs are freely accessible without authentication, fully documented with OpenAPI (Swagger),
  and cross-referenced with major biological databases including NCBI, Ensembl, UniProt, KEGG, ChEBI, PubMed, and Gene Ontology.
  Data is authored by expert biologist researchers and maintained by Reactome editorial staff.
type: Index
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source: []
  generated: '2026-07-22'
  method: derived
position: Provider
access: Public
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/reactome.png
tags:
- Biological Pathways
- Bioinformatics
- Life Sciences
- Pathway Analysis
- Gene Enrichment
- Molecular Interactions
- Systems Biology
- Open Science
url: https://raw.githubusercontent.com/api-evangelist/reactome/refs/heads/main/apis.yml
created: '2026-06-13'
modified: '2026-06-13'
specificationVersion: '0.19'
apis:
- aid: reactome:reactome-database-api
  name: Reactome database API
  description: Database info queries
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - database
  properties:
  - type: OpenAPI
    url: openapi/reactome-database-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-discover-api
  name: Reactome discover API
  description: 'Reactome Data: Search engines discovery schema'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - discover
  properties:
  - type: OpenAPI
    url: openapi/reactome-discover-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-diseases-api
  name: Reactome diseases API
  description: 'Reactome Data: Disease related queries'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - diseases
  properties:
  - type: OpenAPI
    url: openapi/reactome-diseases-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-download-api
  name: Reactome download API
  description: Methods to download different views of a result
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - download
  properties:
  - type: OpenAPI
    url: openapi/reactome-download-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-entities-api
  name: Reactome entities API
  description: 'Reactome Data: PhysicalEntity queries'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - entities
  properties:
  - type: OpenAPI
    url: openapi/reactome-entities-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-events-api
  name: Reactome events API
  description: 'Reactome Data: Queries related to events'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - events
  properties:
  - type: OpenAPI
    url: openapi/reactome-events-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-exporter-api
  name: Reactome exporter API
  description: 'Reactome Data: Format Exporter'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - exporter
  properties:
  - type: OpenAPI
    url: openapi/reactome-exporter-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-identifier-api
  name: Reactome identifier API
  description: Queries for only one identifier
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - identifier
  properties:
  - type: OpenAPI
    url: openapi/reactome-identifier-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-identifiers-api
  name: Reactome identifiers API
  description: Queries for multiple identifiers
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - identifiers
  properties:
  - type: OpenAPI
    url: openapi/reactome-identifiers-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-import-api
  name: Reactome import API
  description: Imports an external result
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - import
  properties:
  - type: OpenAPI
    url: openapi/reactome-import-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-interactors-api
  name: Reactome interactors API
  description: Molecule interactors
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - interactors
  properties:
  - type: OpenAPI
    url: openapi/reactome-interactors-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-mapping-api
  name: Reactome mapping API
  description: Identifiers mapping methods
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - mapping
  properties:
  - type: OpenAPI
    url: openapi/reactome-mapping-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-orthology-api
  name: Reactome orthology API
  description: 'Reactome Data: Orthology related queries'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - orthology
  properties:
  - type: OpenAPI
    url: openapi/reactome-orthology-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-participants-api
  name: Reactome participants API
  description: 'Reactome Data: Queries related to participants'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - participants
  properties:
  - type: OpenAPI
    url: openapi/reactome-participants-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-pathways-api
  name: Reactome pathways API
  description: 'Reactome Data: Pathway related queries'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - pathways
  properties:
  - type: OpenAPI
    url: openapi/reactome-pathways-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-person-api
  name: Reactome person API
  description: 'Reactome Data: Person queries'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - person
  properties:
  - type: OpenAPI
    url: openapi/reactome-person-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-query-api
  name: Reactome query API
  description: 'Reactome Data: Common data retrieval'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - query
  properties:
  - type: OpenAPI
    url: openapi/reactome-query-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-references-api
  name: Reactome references API
  description: 'Reactome xRefs: ReferenceEntity queries'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - references
  properties:
  - type: OpenAPI
    url: openapi/reactome-references-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-report-api
  name: Reactome report API
  description: Retrieves report files in PDF format
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - report
  properties:
  - type: OpenAPI
    url: openapi/reactome-report-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-schema-api
  name: Reactome schema API
  description: 'Reactome Data: Schema class queries'
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - schema
  properties:
  - type: OpenAPI
    url: openapi/reactome-schema-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-search-api
  name: Reactome search API
  description: Reactome Search
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - search
  properties:
  - type: OpenAPI
    url: openapi/reactome-search-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-species-api
  name: Reactome species API
  description: Species comparison
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - species
  properties:
  - type: OpenAPI
    url: openapi/reactome-species-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
- aid: reactome:reactome-token-api
  name: Reactome token API
  description: Previous queries filter
  humanURL: https://reactome.org/dev/content-service
  baseURL: https://reactome.org/ContentService
  tags:
  - token
  properties:
  - type: OpenAPI
    url: openapi/reactome-token-api-openapi.yml
  - type: Documentation
    url: https://reactome.org/dev/content-service
  - type: SwaggerUI
    url: https://reactome.org/ContentService/
  - type: Documentation
    url: https://reactome.org/dev/analysis
  - type: SwaggerUI
    url: https://reactome.org/AnalysisService/
common:
- type: AgenticAccess
  url: agentic-access/reactome-agentic-access.yml
- type: DomainSecurity
  url: security/reactome-domain-security.yml
- type: Website
  url: https://reactome.org/
- type: Documentation
  url: https://reactome.org/documentation
- type: DeveloperPortal
  url: https://reactome.org/dev
- type: DataModel
  url: https://reactome.org/documentation/data-model
- type: FAQ
  url: https://reactome.org/documentation/faq
- type: GitHub
  url: https://github.com/reactome
- type: Blog
  url: https://reactome.org/about/news
- type: License
  url: https://reactome.org/license
- type: Contact
  url: https://reactome.org/about/contact-us
- type: About
  url: https://reactome.org/about
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com