Reactome mapping API

openapi: 3.0.1
info:
  title: Pathway Analysis Service database mapping API
  description: Provides an API for pathway over-representation and expression analysis as well as species comparison tool.
  termsOfService: /license
  contact:
    name: Reactome
    url: https://reactome.org
    email: help@reactome.org
  license:
    name: Creative Commons Attribution 3.0 Unsupported License
    url: https://creativecommons.org/licenses/by/3.0/legalcode
  version: '2.0'
servers:
- url: /AnalysisService
tags:
- name: mapping
  description: Identifiers mapping methods
paths:
  /mapping/:
    post:
      tags:
      - mapping
      description: Maps the post identifiers over the different species
      operationId: getMapping
      parameters:
      - name: interactors
        in: query
        description: Include interactors
        required: false
        schema:
          type: boolean
          default: false
        example: false
      - name: importableOnly
        in: query
        description: Only include resources which can be later imported
        required: false
        schema:
          type: boolean
          default: false
        example: false
      requestBody:
        description: <b>input</b> Identifiers to be mapped (if expression values åre submitted these will be omitted in the result)
        content:
          text/plain:
            schema:
              type: string
        required: true
      responses:
        ' 400':
          description: Bad request
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
  /mapping/form:
    post:
      tags:
      - mapping
      description: Maps the identifiers in the file over the different species
      operationId: getMappingPostFile
      parameters:
      - name: interactors
        in: query
        description: Include interactors
        required: false
        schema:
          type: boolean
          default: false
        example: false
      - name: importableOnly
        in: query
        description: Only include resources which can be later imported
        required: false
        schema:
          type: boolean
          default: false
        example: false
      requestBody:
        content:
          multipart/form-data:
            schema:
              type: object
              properties:
                file:
                  type: string
                  format: binary
                  description: A file with the data to be mapped
              required:
              - file
      responses:
        '400':
          description: Bad request
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '413':
          description: The file size is larger than the maximum configured size (50MB)
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '415':
          description: Unsupported Media Type (only 'text/plain')
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
  /mapping/form/projection:
    post:
      tags:
      - mapping
      summary: Maps the identifiers in the file over the different species and projects the result to Homo Sapiens
      description: The projection is calculated by the orthologous slot in the Reactome database.
      operationId: getMappingPostFileToHuman
      parameters:
      - name: interactors
        in: query
        description: Include interactors
        required: false
        schema:
          type: boolean
          default: false
        example: false
      - name: importableOnly
        in: query
        description: Only include resources which can be later imported
        required: false
        schema:
          type: boolean
          default: false
        example: false
      requestBody:
        content:
          multipart/form-data:
            schema:
              type: object
              properties:
                file:
                  type: string
                  format: binary
                  description: A file with the data to be mapped
              required:
              - file
      responses:
        '400':
          description: Bad request
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '413':
          description: The file size is larger than the maximum configured size (50MB)
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '415':
          description: Unsupported Media Type (only 'text/plain')
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
  /mapping/projection:
    post:
      tags:
      - mapping
      summary: Maps the post identifiers over the different species and projects the result to Homo Sapiens
      description: The projection is calculated by the orthologous slot in the Reactome database.
      operationId: getMappingToHuman
      parameters:
      - name: interactors
        in: query
        description: Include interactors
        required: false
        schema:
          type: boolean
          default: false
        example: false
      - name: importableOnly
        in: query
        description: Only include resources which can be later imported
        required: false
        schema:
          type: boolean
          default: false
        example: false
      requestBody:
        description: <b>input</b> Identifiers to be mapped (if expression values are submitted these will be omitted in the result)
        content:
          text/plain:
            schema:
              type: string
        required: true
      responses:
        '400':
          description: Bad request
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
  /mapping/url:
    post:
      tags:
      - mapping
      summary: Maps the identifiers contained in the provided url over the different species
      operationId: getMappingPostURL
      parameters:
      - name: interactors
        in: query
        description: Include interactors
        required: false
        schema:
          type: boolean
          default: false
        example: false
      - name: importableOnly
        in: query
        description: Only include resources which can be later imported
        required: false
        schema:
          type: boolean
          default: false
        example: false
      requestBody:
        description: <b>url</b> A URL pointing to the data to be mapped
        content:
          text/plain:
            schema:
              type: string
              description: A URL pointing to the data to be mapped
        required: true
      responses:
        '400':
          description: Bad request
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '413':
          description: The file size is larger than the maximum configured size (50MB)
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '415':
          description: Unsupported Media Type (only 'text/plain')
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '422':
          description: The provided URL is not processable
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
  /mapping/url/projection:
    post:
      tags:
      - mapping
      summary: Maps the identifiers contained in the provided url over the different species and projects the result to Homo Sapiens
      description: The projection is calculated by the orthologous slot in the Reactome database.
      operationId: getMappingPostURLToHuman
      parameters:
      - name: interactors
        in: query
        description: Include interactors
        required: false
        schema:
          type: boolean
          default: false
        example: false
      - name: importableOnly
        in: query
        description: Only include resources which can be later imported
        required: false
        schema:
          type: boolean
          default: false
        example: false
      requestBody:
        description: <b>url</b> A URL pointing to the data to be analysed
        content:
          text/plain:
            schema:
              type: string
        required: true
      responses:
        '400':
          description: Bad request
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '413':
          description: The file size is larger than the maximum configured size (50MB)
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '415':
          description: Unsupported Media Type (only 'text/plain')
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
        '422':
          description: The provided URL is not processable
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/MappedEntity'
  /data/mapping/{resource}/{identifier}/pathways:
    get:
      tags:
      - mapping
      summary: The lower level pathways where an identifier can be mapped to
      description: Entities play different roles in reactions, and reactions are events that conform a pathway. This method retrieves the pathways for which an identifier plays a role within one or more of their events.
      operationId: getPathways
      parameters:
      - name: resource
        in: path
        description: The <a href='/content/schema/objects/ReferenceDatabase'>resource</a> <b>name</b> for which the identifier is submitted
        required: true
        schema:
          type: string
        example: UniProt
      - name: identifier
        in: path
        description: The identifier to be mapped
        required: true
        schema:
          type: string
        example: PTEN
      - name: species
        in: query
        description: 'Species for which the result is filtered. Accepts <b>taxonomy id</b>, <b>species name</b> and <b>dbId</b>. Important: when identifier points to chemical, this becomes mandatory and if not provided, the default is ''Homo sapiens'''
        required: false
        schema:
          type: string
        example: 9606
      - name: view
        in: query
        description: Global parameter - Customise the view to be more concise and/or aggregate relationships
        required: false
        schema:
          type: string
          default: flatten
          enum:
          - flatten
          - nested
          - nested-aggregated
          example: null
      - name: includeRef
        in: query
        description: Global parameter - If true, replace element ref to dbId by standard JSOG object {@ref}
        required: false
        schema:
          type: boolean
          default: false
          example: null
      responses:
        '404':
          description: No pathways found for the submitted identifier/resource
          content:
            application/json:
              schema:
                type: array
                items:
                  type: object
        '500':
          description: Internal Server Error
          content:
            application/json:
              schema:
                type: array
                items:
                  type: object
  /data/mapping/{resource}/{identifier}/reactions:
    get:
      tags:
      - mapping
      summary: The reactions where an identifier can be mapped to
      description: Entities play different roles in reactions. This method retrieves the reactions for which an identifier plays a role .
      operationId: getReactionsLikeEvent
      parameters:
      - name: resource
        in: path
        description: The <a href='/content/schema/objects/ReferenceDatabase'>resource</a> <b>name</b> for which the identifier is submitted
        required: true
        schema:
          type: string
        example: UniProt
      - name: identifier
        in: path
        description: The identifier to be mapped
        required: true
        schema:
          type: string
        example: PTEN
      - name: species
        in: query
        description: 'Species for which the result is filtered. Accepts <b>taxonomy id</b>, <b>species name</b> and <b>dbId</b>. Important: when identifier points to chemical, this becomes mandatory and if not provided, the default is ''Homo sapiens'''
        required: false
        schema:
          type: string
        example: 9606
      - name: view
        in: query
        description: Global parameter - Customise the view to be more concise and/or aggregate relationships
        required: false
        schema:
          type: string
          default: flatten
          enum:
          - flatten
          - nested
          - nested-aggregated
          example: null
      - name: includeRef
        in: query
        description: Global parameter - If true, replace element ref to dbId by standard JSOG object {@ref}
        required: false
        schema:
          type: boolean
          default: false
          example: null
      responses:
        '404':
          description: No reactions found for the submitted identifier/resource
          content:
            application/json:
              schema:
                type: array
                items:
                  type: object
        '500':
          description: Internal Server Error
          content:
            application/json:
              schema:
                type: array
                items:
                  type: object
components:
  schemas:
    MappedIdentifier:
      type: object
      properties:
        identifier:
          type: string
        interactsWith:
          type: array
          items:
            $ref: '#/components/schemas/MappedIdentifier'
        resource:
          type: string
    MappedEntity:
      type: object
      properties:
        identifier:
          type: string
        mapsTo:
          uniqueItems: true
          type: array
          items:
            $ref: '#/components/schemas/MappedIdentifier'