Reactome · Agentic Access
Reactome Agentic Access

x-agentic-access generated
Reactome exposes 122 API operations that an AI agent could call, of which 31 are state-changing ‘acting’ operations. This is a recommended x-agentic-access execution contract — the scope, audience, consequence tier, short-lived token constraints, and escalation each action should carry before it is handed to an autonomous agent.
By consequence: 91 read, 30 write, and 1 physical.
Contracts are classified heuristically from the provider’s OpenAPI and refresh on every APIs.io network build; audience is bound per deployment. The model follows Curity’s Access Intelligence (apidays Munich 2026). Browse every provider’s agent contracts at agentic-access.apis.io.
Biological PathwaysBioinformaticsLife SciencesPathway AnalysisGene EnrichmentMolecular InteractionsSystems BiologyOpen Science
Operations: 122 Acting: 31 Human-in-the-loop: 0 Method: generated
By consequence

read 91 write 30 physical 1
Highest-consequence actions

The physical and safety-critical operations an agent could invoke — the ones that most warrant scoped tokens, tight TTLs, and escalation. Full per-operation contracts are in the source below.
Method	Path	Consequence	Human-in-loop
POST	/interactors/upload/tuple/url	physical	conditional
Source

Agentic Access

generated: '2026-07-15'
method: generated
source: openapi/analysis-service.json, openapi/content-service.json
description: Recommended x-agentic-access execution contracts, classified heuristically from
  the OpenAPI. A governance starting point for exposing this API to AI agents — review and bind
  audience per deployment. See research/curity/agentic-governance/.
summary:
  operations: 122
  by_action_class:
    connected: 91
    acting: 31
  by_consequence:
    read: 91
    write: 30
    physical: 1
  human_in_the_loop_required: 0
operations:
- path: /database/name
  method: get
  operationId: getDBName
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /database/version
  method: get
  operationId: getDBVersion
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /download/{token}/entities/found/{resource}/{filename}.csv
  method: get
  operationId: downloadMappingResult
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /download/{token}/entities/notfound/{filename}.csv
  method: get
  operationId: downloadNotFound
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /download/{token}/pathways/{resource}/{filename}.csv
  method: get
  operationId: downloadResultCSV
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /download/{token}/result.json
  method: get
  operationId: downloadResultJSON
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /download/{token}/result.json.gz
  method: get
  operationId: downloadResultGZIP
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /identifier/{id}
  method: get
  operationId: getIdentifier
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /identifier/{id}/projection
  method: get
  operationId: getIdentifierToHuman
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /identifiers/
  method: post
  operationId: getPostText_1
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /identifiers/form
  method: post
  operationId: getPostFile_1
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /identifiers/form/projection
  method: post
  operationId: getPostFileToHuman
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /identifiers/projection
  method: post
  operationId: getPostTextToHuman
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /identifiers/url
  method: post
  operationId: getPostURL_1
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /identifiers/url/projection
  method: post
  operationId: getPostURLToHuman
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /import/
  method: post
  operationId: getPostText
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /import/form
  method: post
  operationId: getPostFile
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /import/url
  method: post
  operationId: getPostURL
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /mapping/
  method: post
  operationId: getMapping
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /mapping/form
  method: post
  operationId: getMappingPostFile
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /mapping/form/projection
  method: post
  operationId: getMappingPostFileToHuman
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /mapping/projection
  method: post
  operationId: getMappingToHuman
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /mapping/url
  method: post
  operationId: getMappingPostURL
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /mapping/url/projection
  method: post
  operationId: getMappingPostURLToHuman
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /report/{token}/{species}/{filename}.pdf
  method: get
  operationId: generatePdfReport
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /species/homoSapiens/{species}
  method: get
  operationId: compareHomoSapiensTo
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}
  method: get
  operationId: getToken
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}/filter/pathways
  method: post
  operationId: getTokenFilterPathways
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /token/{token}/filter/species/{species}
  method: get
  operationId: filterBySpecies
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}/found/all
  method: post
  operationId: getTokenHitEntitiesPathways
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /token/{token}/found/all/{pathway}
  method: get
  operationId: getTokenHitEntitiesPathway
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}/found/entities/{pathway}
  method: get
  operationId: getTokenIdentifiersPathway
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}/found/interactors/{pathway}
  method: get
  operationId: getTokenInteractorsPathway
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}/notFound
  method: get
  operationId: getNotFoundIdentifiers
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}/page/{pathway}
  method: get
  operationId: getPageOfPathway
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}/pathways/binned
  method: get
  operationId: getPathwaysBinnedBySize
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}/reactions/pathways
  method: post
  operationId: getTokenFilterPathwaysReactions
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /token/{token}/reactions/{pathway}
  method: get
  operationId: getTokenFilterPathwayReactions
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /token/{token}/resources
  method: get
  operationId: getResources
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/complex/{id}/subunits
  method: get
  operationId: getComplexSubunits
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/complexes/{resource}/{identifier}
  method: get
  operationId: getComplexesFor
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/database/name
  method: get
  operationId: getDBName
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/database/version
  method: get
  operationId: getDBVersion
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/discover/{identifier}
  method: get
  operationId: eventDiscovery
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/diseases
  method: get
  operationId: getDiseases
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/diseases/doid
  method: get
  operationId: getDiseasesSummary
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/entity/{id}/componentOf
  method: get
  operationId: getComponentsOf
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/entity/{id}/in-depth
  method: get
  operationId: getPhysicalEntityInDepth
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/entity/{id}/otherForms
  method: get
  operationId: getOtherFormsOf
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/event/{id}/ancestors
  method: get
  operationId: getEventAncestors
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/event/{id}/in-depth
  method: get
  operationId: getEventInDepth
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/eventsHierarchy/{species}
  method: get
  operationId: getEventHierarchy
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/mapping/{resource}/{identifier}/pathways
  method: get
  operationId: getPathways
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/mapping/{resource}/{identifier}/reactions
  method: get
  operationId: getReactionsLikeEvent
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/orthologies/ids/species/{speciesId}
  method: post
  operationId: getOrthologies
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /data/orthology/{id}/species/{speciesId}
  method: get
  operationId: getOrthology
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/participants/{id}
  method: get
  operationId: getParticipants
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/participants/{id}/participatingPhysicalEntities
  method: get
  operationId: getParticipatingPhysicalEntities
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/participants/{id}/referenceEntities
  method: get
  operationId: getParticipatingReferenceEntities
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/pathway/{id}/containedEvents
  method: get
  operationId: getContainedEvents
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/pathway/{id}/containedEvents/{attributeName}
  method: get
  operationId: getContainedEvents_1
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/pathways/low/diagram/entity/{id}
  method: get
  operationId: getPathwaysWithDiagramFor
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/pathways/low/diagram/entity/{id}/allForms
  method: get
  operationId: getPathwaysWithDiagramForAllFormsOf
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/pathways/low/entity/{id}
  method: get
  operationId: getPathwaysFor
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/pathways/low/entity/{id}/allForms
  method: get
  operationId: getPathwaysForAllFormsOf
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/pathways/top/{species}
  method: get
  operationId: getTopLevelPathways
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/people/name/{name}
  method: get
  operationId: queryPersonByName
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/people/name/{name}/exact
  method: get
  operationId: findPersonByName
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/person/{id}
  method: get
  operationId: findPerson
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/person/{id}/authoredPathways
  method: get
  operationId: getAuthoredPathways
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/person/{id}/publications
  method: get
  operationId: getPublicationsOfPerson
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/person/{id}/{attributeName}
  method: get
  operationId: findPerson_1
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/query/enhanced/v2/{id}
  method: get
  operationId: findEnhancedObjectById
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/query/enhanced/{id}
  method: get
  operationId: findOldEnhancedObjectById
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/query/ids
  method: post
  operationId: findByIds
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /data/query/ids/map
  method: post
  operationId: findByIdsMap
  x-agentic-access:
    action-class: acting
    consequence: write
    subject: required
    audience: null
    token:
      max-ttl: 900
    escalation:
      human-in-the-loop: conditional
      triggers:
      - abnormal
      - high-value
    audit: required
- path: /data/query/{id}
  method: get
  operationId: findById
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/query/{id}/{attributeName}
  method: get
  operationId: findById_1
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/schema/model
  method: get
  operationId: getSchemaModel
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/schema/{className}
  method: get
  operationId: getDatabaseObjectsForClassName
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/schema/{className}/count
  method: get
  operationId: countEntries
  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none
- path: /data/schema/{className}/min
  method: get
  operationId: getSimpleDatabaseObjectByClassName
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- path: /data/schema/{className}/reference
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- path: /data/species/all
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- path: /data/species/main
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- path: /exporter/diagram/{identifier}.{ext}
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- path: /exporter/document/event/{identifier}.pdf
  method: get
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    subject: optional
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- path: /exporter/event/{identifier}.sbgn
  method: get
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- path: /exporter/event/{identifier}.sbml
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- path: /exporter/fireworks/{species}.{ext}
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- path: /exporter/reaction/{identifier}.{ext}
  method: get
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    action-class: connected
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- path: /interactors/psicquic/molecule/{resource}/{acc}/details
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- path: /interactors/psicquic/molecule/{resource}/{acc}/summary
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  operationId: getProteinSummaryByResource
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- path: /interactors/psicquic/molecules/{resource}/details
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- path: /interactors/psicquic/resources
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- path: /interactors/static/molecule/enhanced/{acc}/details
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- path: /interactors/static/molecule/{acc}/details
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- path: /interactors/static/molecule/{acc}/pathways
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- path: /interactors/static/molecule/{acc}/summary
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- path: /interactors/static/molecules/details
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- path: /interactors/upload/tuple/content
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  method: get
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- path: /search/diagram/{pathwayId}/flag
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- path: /search/facet
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- path: /search/fireworks/flag
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- path: /search/pathways/of/{dbId}
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    action-class: connected
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    audit: none
- path: /search/query
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    action-class: connected
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- path: /search/query/paginated
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    action-class: connected
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    token:
      max-ttl: 3600
    audit: none
- path: /search/spellcheck
  method: get
  operationId: spellcheckerSuggestions
  x-agentic-access:
    action-class: connected
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    token:
      max-ttl: 3600
    audit: none
- path: /search/suggest
  method: get
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  x-agentic-access:
    action-class: connected
    consequence: read
    subject: optional
    token:
      max-ttl: 3600
    audit: none