OpenClinica

OpenClinica is a clinical-trial electronic data capture (EDC) and clinical data management platform used to build studies, capture case report form (CRF) data, schedule study events, and manage participants across sites. It ships as a free, open-source Community Edition (LGPL) and as a fully supported, hosted Enterprise Edition. OpenClinica exposes a documented REST web services API - authenticated with OAuth 2.0 bearer tokens - for programmatically adding and updating participants (single and bulk), scheduling and updating study events, and importing and retrieving clinical data. Data is interchanged using the CDISC ODM (Operational Data Model) standard as XML or JSON, so studies remain portable and standards-based.

OpenClinica publishes 6 APIs on the APIs.io network, including Authentication API, Bulk Operations API, Clinical Data API, and 3 more. Tagged areas include Clinical Trials, Electronic Data Capture, EDC, Clinical Data Management, and CDISC ODM.

OpenClinica’s developer surface includes authentication, documentation, and 9 more developer resources.

🌐 Visit website 📡 Source on GitHub

26.5/100 thin ▬ flat Agent 22/100 agent aware saas Full breakdown ↓
scored 2026-09-14 · rubric v0.22.0

AccessFreemiumSelf serve⚡ Free to try

1 APIs

Clinical Trials Electronic Data Capture EDC Clinical Data ManagementCDISC ODMHealthcare Open-Source

Kin Score

Kin Score How this is scored →
scored 2026-09-14 · rubric v0.22.0

Composite quality — 26.5/100 · thin

Contract Quality 0.0 / 19

Developer Ergonomics 4.5 / 15

Access Clarity 5.5 / 15

Operational Transparency 3.3 / 10

Contract Governance 0.0 / 9

Discoverability 5.1 / 8

Regulatory Posture 3.2 / 15

Create-or-Update Ergonomics 2.2 / 10

Agent readiness — 22/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 10 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 7 / 7

Rate-Limit Signaling 7 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics applies to this provider. This API accepts writes, so it carries 10 points of the composite. It is scored from the published contracts themselves: whether a caller can create-or-update in one call, whether the write accepts a key the caller already holds, and whether the response says which branch ran. Without that, every write needs a search-and-branch in front of it, and the first time that check is skipped a duplicate record is created. Scored against the observed mean rather than raw — a provider at the catalog average is unchanged by this facet, not penalised by it.

The six quality facets above are damped to 75 points between them, because the conditional facet above carries the other 25. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 75% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/openclinica: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

APIs 6

Individual APIs this provider publishes, each with its own machine-readable definition.

OpenClinica Authentication API

OAuth 2.0 token acquisition.

OpenClinica Bulk Operations API

Bulk participant and event operations plus the bulk actions log.

OpenClinica Clinical Data API

Import and retrieve CRF data using CDISC ODM.

OpenClinica Metadata API

Read ODM study design metadata.

OpenClinica Participants API

Study participants (subjects) - add, update, list, and extract contact info.

OpenClinica Study Events API

Scheduling and updating study events (visits) for participants.

Open Collections 8

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

API Collection

OPEN COLLECTION

OpenClinica REST Authentication API

OPEN COLLECTION

OpenClinica REST Authentication Bulk Operations API

OPEN COLLECTION

OpenClinica REST Authentication Clinical Data API

OPEN COLLECTION

OpenClinica REST Authentication Metadata API

OPEN COLLECTION

OpenClinica REST Authentication Participants API

OPEN COLLECTION

OpenClinica REST Authentication Study Events API

OPEN COLLECTION

OpenClinica REST API

OPEN COLLECTION

Scroll for all 8

Pricing Plans 1

Published pricing tiers and plan structures.

Openclinica Plans Pricing

2 plans

PLANS

Rate Limits 1

Documented rate limits and quota policies.

Openclinica Rate Limits

4 limits

RATE LIMITS

FinOps 1

Cost, billing, and metering signals for API financial operations.

Openclinica Finops

FINOPS

Security Posture 3

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Openclinica Authentication

http · 1 scheme

SECURITY

Openclinica Domain Security

TLSv1.3 · HSTS · DMARC

SECURITY

Openclinica Trust Center

SOC 2, ISO 27001

SECURITY

Agentic Access 1

Recommended x-agentic-access execution contracts for AI agents.

Openclinica Agentic Access

14 operations · 9 acting

AGENTIC

Resources

Documentation 1

Reference material describing how the API behaves

Documentation

Documentation

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

AgenticAccess

AgenticAccess

Build 1

SDKs, sample code, and the tooling you integrate with

GitHubOrganization

GitHubOrganization

Access & Security 3

Authentication, authorization, and security posture

TrustCenter

TrustCenter

DomainSecurity

DomainSecurity

Authentication

Authentication

Operate 1

Status, limits, changes, and where to get help

RateLimits

RateLimits

Commercial 2

Pricing, plans, and the legal terms of use

Plans

Plans

FinOps

FinOps

Company 2

The organization behind the API

LinkedIn

Website

Website

Source (apis.yml)

aid: openclinica
url: https://raw.githubusercontent.com/api-evangelist/openclinica/refs/heads/main/apis.yml
name: OpenClinica
kind: company
description: OpenClinica is a clinical-trial electronic data capture (EDC) and clinical data management platform used to build
  studies, capture case report form (CRF) data, schedule study events, and manage participants across sites. It ships as a
  free, open-source Community Edition (LGPL) and as a fully supported, hosted Enterprise Edition. OpenClinica exposes a documented
  REST web services API - authenticated with OAuth 2.0 bearer tokens - for programmatically adding and updating participants
  (single and bulk), scheduling and updating study events, and importing and retrieving clinical data. Data is interchanged
  using the CDISC ODM (Operational Data Model) standard as XML or JSON, so studies remain portable and standards-based.
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: true
  label: Hosted service · you call their endpoint
  confidence: high
  source:
  - openapi
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: freemium
  onboarding: self-serve
  trial: false
  try_now: true
  public: false
  label: Freemium · Self-serve signup
  confidence: medium
  source:
  - plans
  - authentication
  - security
  generated: '2026-09-03'
  method: derived
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/openclinica.png
tags:
- Clinical Trials
- Electronic Data Capture
- EDC
- Clinical Data Management
- CDISC ODM
- Healthcare
- Open-Source
tags_raw:
- Clinical Trials
- Electronic Data Capture
- EDC
- Clinical Data Management
- CDISC ODM
- Healthcare
- Open Source
created: '2026-07-05'
modified: '2026-07-05'
specificationVersion: '0.23'
apis:
- aid: openclinica:openclinica-authentication-api
  name: OpenClinica Authentication API
  description: OAuth 2.0 token acquisition.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Authentication
  properties:
  - type: OpenAPI
    url: openapi/openclinica-authentication-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-bulk-operations-api
  name: OpenClinica Bulk Operations API
  description: Bulk participant and event operations plus the bulk actions log.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Bulk Operations
  properties:
  - type: OpenAPI
    url: openapi/openclinica-bulk-operations-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-clinical-data-api
  name: OpenClinica Clinical Data API
  description: Import and retrieve CRF data using CDISC ODM.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Clinical Data
  properties:
  - type: OpenAPI
    url: openapi/openclinica-clinical-data-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-metadata-api
  name: OpenClinica Metadata API
  description: Read ODM study design metadata.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Metadata
  properties:
  - type: OpenAPI
    url: openapi/openclinica-metadata-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-participants-api
  name: OpenClinica Participants API
  description: Study participants (subjects) - add, update, list, and extract contact info.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Participants
  properties:
  - type: OpenAPI
    url: openapi/openclinica-participants-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-study-events-api
  name: OpenClinica Study Events API
  description: Scheduling and updating study events (visits) for participants.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Study Events
  properties:
  - type: OpenAPI
    url: openapi/openclinica-study-events-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
common:
- type: AgenticAccess
  url: agentic-access/openclinica-agentic-access.yml
- type: TrustCenter
  url: security/openclinica-trust-center.yml
- type: DomainSecurity
  url: security/openclinica-domain-security.yml
- type: Authentication
  url: authentication/openclinica-authentication.yml
- type: GitHubOrganization
  url: https://github.com/OpenClinica
- type: LinkedIn
  url: https://www.linkedin.com/company/openclinica
- type: Website
  url: https://www.openclinica.com
- type: Documentation
  url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
- type: Plans
  url: plans/openclinica-plans-pricing.yml
- type: RateLimits
  url: rate-limits/openclinica-rate-limits.yml
- type: FinOps
  url: finops/openclinica-finops.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com

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