OpenClinica

OpenClinica is a clinical-trial electronic data capture (EDC) and clinical data management platform used to build studies, capture case report form (CRF) data, schedule study events, and manage participants across sites. It ships as a free, open-source Community Edition (LGPL) and as a fully supported, hosted Enterprise Edition. OpenClinica exposes a documented REST web services API - authenticated with OAuth 2.0 bearer tokens - for programmatically adding and updating participants (single and bulk), scheduling and updating study events, and importing and retrieving clinical data. Data is interchanged using the CDISC ODM (Operational Data Model) standard as XML or JSON, so studies remain portable and standards-based.

OpenClinica publishes 6 APIs on the APIs.io network, including Authentication API, Bulk Operations API, Clinical Data API, and 3 more. Tagged areas include Clinical Trials, Electronic Data Capture, EDC, Clinical Data Management, and CDISC ODM.

OpenClinica’s developer surface includes authentication, documentation, and 9 more developer resources.

🌐 Visit website 📡 Source on GitHub
36.8/100 thin ▬ flat Agent 34/100 agent aware Full breakdown ↓
scored 2026-08-05 · rubric v0.9.1
AccessFreemiumSelf serve⚡ Free to try
6 APIs
Clinical TrialsElectronic Data CaptureEDCClinical Data ManagementCDISC ODMHealthcareOpen Source

Kin Score

Kin Score Kin Score How this is scored →
scored 2026-08-05 · rubric v0.9.1
Composite quality — 36.8/100 · thin
Contract Quality 16.0 / 25
Developer Ergonomics 3.9 / 20
Commercial Clarity 7.4 / 20
Operational Transparency 4.8 / 13
Governance 0.0 / 12
Discoverability 7.4 / 10
Agent readiness — 34/100 · agent aware
Machine-Readable Contract 18 / 18
Agentic Access Contract 10 / 10
MCP Server 0 / 12
Machine-Readable Auth 10 / 10
Idempotency 0 / 9
Stable Error Semantics 0 / 8
Request/Response Examples 7 / 7
Rate-Limit Signaling 7 / 7
Typed Event Surface 0 / 6
Agent Skills 0 / 5
Well-Known Catalog 0 / 4
Consent & Bot Identity 0 / 3
A2A Agent Card 0 / 8
Dry-Run / Simulate Mode 0 / 4
Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. This rating is computed from github.com/api-evangelist/openclinica: open an issue to ask a question, or submit a pull request to add artifacts. Want it done for you? Prioritized profiling — $2,500 →

APIs 6

Individual APIs this provider publishes, each with its own machine-readable definition.

OpenClinica Authentication API

OAuth 2.0 token acquisition.

OpenClinica Bulk Operations API

Bulk participant and event operations plus the bulk actions log.

OpenClinica Clinical Data API

Import and retrieve CRF data using CDISC ODM.

OpenClinica Metadata API

Read ODM study design metadata.

OpenClinica Participants API

Study participants (subjects) - add, update, list, and extract contact info.

OpenClinica Study Events API

Scheduling and updating study events (visits) for participants.

Open Collections 1

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

OpenClinica REST API

OPEN COLLECTION

Pricing Plans 1

Published pricing tiers and plan structures.

Openclinica Plans Pricing

2 plans

PLANS

Rate Limits 1

Documented rate limits and quota policies.

Openclinica Rate Limits

4 limits

RATE LIMITS

FinOps 1

Cost, billing, and metering signals for API financial operations.

Openclinica Finops

FINOPS

Security Posture 3

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Openclinica Authentication

http · 1 scheme

SECURITY

Openclinica Domain Security

TLSv1.3 · HSTS · DMARC

SECURITY

Openclinica Trust Center

SOC 2, ISO 27001

SECURITY

Agentic Access 1

Recommended x-agentic-access execution contracts for AI agents.

Openclinica Agentic Access

14 operations · 9 acting

14 operations · 9 acting

AGENTIC

Resources

Documentation 1

Reference material describing how the API behaves

Documentation
Documentation

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

AgenticAccess
AgenticAccess

Build 1

SDKs, sample code, and the tooling you integrate with

GitHubOrganization
GitHubOrganization

Access & Security 3

Authentication, authorization, and security posture

TrustCenter
TrustCenter
 DomainSecurity
DomainSecurity
 Authentication
Authentication

Operate 1

Status, limits, changes, and where to get help

RateLimits
RateLimits

Commercial 2

Pricing, plans, and the legal terms of use

Plans
Plans
 FinOps
FinOps

Company 2

The organization behind the API

LinkedIn
LinkedIn
 Website
Website

Source (apis.yml)

apis.yml Raw ↑ 
aid: openclinica
url: https://raw.githubusercontent.com/api-evangelist/openclinica/refs/heads/main/apis.yml
name: OpenClinica
kind: company
description: OpenClinica is a clinical-trial electronic data capture (EDC) and clinical data management platform used to build
  studies, capture case report form (CRF) data, schedule study events, and manage participants across sites. It ships as a
  free, open-source Community Edition (LGPL) and as a fully supported, hosted Enterprise Edition. OpenClinica exposes a documented
  REST web services API - authenticated with OAuth 2.0 bearer tokens - for programmatically adding and updating participants
  (single and bulk), scheduling and updating study events, and importing and retrieving clinical data. Data is interchanged
  using the CDISC ODM (Operational Data Model) standard as XML or JSON, so studies remain portable and standards-based.
accessModel:
  pricing: freemium
  onboarding: self-serve
  trial: false
  try_now: true
  public: false
  label: Freemium · Self-serve signup
  confidence: high
  source:
  - plans
  - authentication
  generated: '2026-07-22'
  method: derived
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/openclinica.png
tags:
- Clinical Trials
- Electronic Data Capture
- EDC
- Clinical Data Management
- CDISC ODM
- Healthcare
- Open Source
created: '2026-07-05'
modified: '2026-07-05'
specificationVersion: '0.19'
apis:
- aid: openclinica:openclinica-authentication-api
  name: OpenClinica Authentication API
  description: OAuth 2.0 token acquisition.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Authentication
  properties:
  - type: OpenAPI
    url: openapi/openclinica-authentication-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-bulk-operations-api
  name: OpenClinica Bulk Operations API
  description: Bulk participant and event operations plus the bulk actions log.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Bulk Operations
  properties:
  - type: OpenAPI
    url: openapi/openclinica-bulk-operations-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-clinical-data-api
  name: OpenClinica Clinical Data API
  description: Import and retrieve CRF data using CDISC ODM.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Clinical Data
  properties:
  - type: OpenAPI
    url: openapi/openclinica-clinical-data-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-metadata-api
  name: OpenClinica Metadata API
  description: Read ODM study design metadata.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Metadata
  properties:
  - type: OpenAPI
    url: openapi/openclinica-metadata-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-participants-api
  name: OpenClinica Participants API
  description: Study participants (subjects) - add, update, list, and extract contact info.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Participants
  properties:
  - type: OpenAPI
    url: openapi/openclinica-participants-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-study-events-api
  name: OpenClinica Study Events API
  description: Scheduling and updating study events (visits) for participants.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Study Events
  properties:
  - type: OpenAPI
    url: openapi/openclinica-study-events-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
common:
- type: AgenticAccess
  url: agentic-access/openclinica-agentic-access.yml
- type: TrustCenter
  url: security/openclinica-trust-center.yml
- type: DomainSecurity
  url: security/openclinica-domain-security.yml
- type: Authentication
  url: authentication/openclinica-authentication.yml
- type: GitHubOrganization
  url: https://github.com/OpenClinica
- type: LinkedIn
  url: https://www.linkedin.com/company/openclinica
- type: Website
  url: https://www.openclinica.com
- type: Documentation
  url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
- type: Plans
  url: plans/openclinica-plans-pricing.yml
- type: RateLimits
  url: rate-limits/openclinica-rate-limits.yml
- type: FinOps
  url: finops/openclinica-finops.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com