OpenClinica

OpenClinica is a clinical-trial electronic data capture (EDC) and clinical data management platform used to build studies, capture case report form (CRF) data, schedule study events, and manage participants across sites. It ships as a free, open-source Community Edition (LGPL) and as a fully supported, hosted Enterprise Edition. OpenClinica exposes a documented REST web services API - authenticated with OAuth 2.0 bearer tokens - for programmatically adding and updating participants (single and bulk), scheduling and updating study events, and importing and retrieving clinical data. Data is interchanged using the CDISC ODM (Operational Data Model) standard as XML or JSON, so studies remain portable and standards-based.

OpenClinica publishes 6 APIs on the APIs.io network, including Authentication API, Bulk Operations API, Clinical Data API, and 3 more. Tagged areas include Clinical Trials, Electronic Data Capture, EDC, Clinical Data Management, and CDISC ODM.

OpenClinica’s developer surface includes authentication, documentation, and 9 more developer resources.

🌐 Visit website 📡 Source on GitHub

27.4/100 thin ▼ -10.5 Agent 22/100 agent aware Full breakdown ↓
scored 2026-08-25 · rubric v0.14.0

AccessFreemiumSelf serve⚡ Free to try

6 APIs

Clinical Trials Electronic Data Capture EDC Clinical Data ManagementCDISC ODMHealthcare Open-Source

Kin Score

Kin Score How this is scored →
scored 2026-08-25 · rubric v0.14.0

Composite quality — 27.4/100 · thin

Contract Quality 3.0 / 21

Developer Ergonomics 3.6 / 17

Access Clarity 6.3 / 17

Operational Transparency 3.8 / 11

Contract Governance 0.0 / 10

Discoverability 6.3 / 9

Regulatory Posture 3.2 / 15

Agent readiness — 22/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 10 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 7 / 7

Rate-Limit Signaling 7 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Surface 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. This rating is computed from github.com/api-evangelist/openclinica: open an issue to ask a question, or submit a pull request to add artifacts. Want it done for you? Prioritized profiling — $2,500 →

APIs 6

Individual APIs this provider publishes, each with its own machine-readable definition.

Rate Limits 1

Documented rate limits and quota policies.

Openclinica Rate Limits

4 limits

RATE LIMITS

FinOps 1

Cost, billing, and metering signals for API financial operations.

Documentation 1

Reference material describing how the API behaves

Documentation

Documentation

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

AgenticAccess

AgenticAccess

Build 1

SDKs, sample code, and the tooling you integrate with

GitHubOrganization

GitHubOrganization

Access & Security 3

Authentication, authorization, and security posture

TrustCenter

TrustCenter

DomainSecurity

DomainSecurity

Authentication

Authentication

Operate 1

Status, limits, changes, and where to get help

RateLimits

RateLimits

Commercial 2

Pricing, plans, and the legal terms of use

Plans

Plans

FinOps

FinOps

Company 2

The organization behind the API

LinkedIn

Website

Website

Source (apis.yml)

aid: openclinica
url: https://raw.githubusercontent.com/api-evangelist/openclinica/refs/heads/main/apis.yml
name: OpenClinica
kind: company
description: OpenClinica is a clinical-trial electronic data capture (EDC) and clinical data management platform used to build
  studies, capture case report form (CRF) data, schedule study events, and manage participants across sites. It ships as a
  free, open-source Community Edition (LGPL) and as a fully supported, hosted Enterprise Edition. OpenClinica exposes a documented
  REST web services API - authenticated with OAuth 2.0 bearer tokens - for programmatically adding and updating participants
  (single and bulk), scheduling and updating study events, and importing and retrieving clinical data. Data is interchanged
  using the CDISC ODM (Operational Data Model) standard as XML or JSON, so studies remain portable and standards-based.
accessModel:
  pricing: freemium
  onboarding: self-serve
  trial: false
  try_now: true
  public: false
  label: Freemium · Self-serve signup
  confidence: high
  source:
  - plans
  - authentication
  generated: '2026-07-22'
  method: derived
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/openclinica.png
tags:
- Clinical Trials
- Electronic Data Capture
- EDC
- Clinical Data Management
- CDISC ODM
- Healthcare
- Open-Source
tags_raw:
- Clinical Trials
- Electronic Data Capture
- EDC
- Clinical Data Management
- CDISC ODM
- Healthcare
- Open Source
created: '2026-07-05'
modified: '2026-07-05'
specificationVersion: '0.23'
apis:
- aid: openclinica:openclinica-authentication-api
  name: OpenClinica Authentication API
  description: OAuth 2.0 token acquisition.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Authentication
  properties:
  - type: OpenAPI
    url: openapi/openclinica-authentication-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-bulk-operations-api
  name: OpenClinica Bulk Operations API
  description: Bulk participant and event operations plus the bulk actions log.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Bulk Operations
  properties:
  - type: OpenAPI
    url: openapi/openclinica-bulk-operations-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-clinical-data-api
  name: OpenClinica Clinical Data API
  description: Import and retrieve CRF data using CDISC ODM.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Clinical Data
  properties:
  - type: OpenAPI
    url: openapi/openclinica-clinical-data-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-metadata-api
  name: OpenClinica Metadata API
  description: Read ODM study design metadata.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Metadata
  properties:
  - type: OpenAPI
    url: openapi/openclinica-metadata-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-participants-api
  name: OpenClinica Participants API
  description: Study participants (subjects) - add, update, list, and extract contact info.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Participants
  properties:
  - type: OpenAPI
    url: openapi/openclinica-participants-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
- aid: openclinica:openclinica-study-events-api
  name: OpenClinica Study Events API
  description: Scheduling and updating study events (visits) for participants.
  humanURL: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  baseURL: https://{subdomain}.build.openclinica.io/user-service/api
  tags:
  - Study Events
  properties:
  - type: OpenAPI
    url: openapi/openclinica-study-events-api-openapi.yml
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-oauth-and-openclinica/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-add/
  - type: APIReference
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-participants-get-participants-study-level-or-site-level/
  - type: PostmanCollection
    url: collections/openclinica.postman_collection.json
  - type: OpenCollection
    url: collections/openclinica.opencollection.json
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-openclinica-4-technical-documentation-events-create-and-update-single-study-event/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-clinicaldata-import-crf-data/
  - type: Documentation
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/rest-api-specifications-read-openclinica-odm-metadata-rest-service/
  - type: APIReference
    url: https://docs.openclinica.com/3-1-technical-documents/rest-api-specifications/openclinica-restful-urls/
  - type: Documentation
    url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/oc4-participantsbulk-add-bulk-list-participant-ids/
common:
- type: AgenticAccess
  url: agentic-access/openclinica-agentic-access.yml
- type: TrustCenter
  url: security/openclinica-trust-center.yml
- type: DomainSecurity
  url: security/openclinica-domain-security.yml
- type: Authentication
  url: authentication/openclinica-authentication.yml
- type: GitHubOrganization
  url: https://github.com/OpenClinica
- type: LinkedIn
  url: https://www.linkedin.com/company/openclinica
- type: Website
  url: https://www.openclinica.com
- type: Documentation
  url: https://docs.openclinica.com/oc4/how-and-when-to-use-apis/
- type: Plans
  url: plans/openclinica-plans-pricing.yml
- type: RateLimits
  url: rate-limits/openclinica-rate-limits.yml
- type: FinOps
  url: finops/openclinica-finops.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com

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