National Institutes of Health (NIH)

aid: nih
name: National Institutes of Health (NIH)
description: The US National Institutes of Health (NIH) provides a suite of public REST APIs for biomedical research, including
  PubMed literature search via E-utilities, ClinicalTrials.gov clinical trial data, chemical compound data through PubChem,
  gene and genome databases via NCBI Datasets, BLAST sequence alignment, and NIH research funding data through RePORTER.
type: Index
accessModel:
  pricing: free
  onboarding: self-serve
  trial: false
  try_now: true
  public: false
  label: Free · Self-serve signup
  confidence: high
  source:
  - plans
  - authentication
  generated: '2026-07-22'
  method: derived
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/nih.png
url: https://raw.githubusercontent.com/api-evangelist/nih/refs/heads/main/apis.yml
created: '2026-06-13'
modified: '2026-06-13'
specificationVersion: '0.19'
tags:
- Biomedical
- Research
- PubMed
- ClinicalTrials
- PubChem
- Genomics
- Health
- Science
- Government
apis:
- name: NCBI E-utilities (Entrez Programming Utilities)
  description: The public API to the NCBI Entrez system providing programmatic access to all Entrez databases including PubMed,
    PMC, Gene, Nuccore, and Protein. Supports searching, fetching, linking, and summarizing records across 38+ databases.
  image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - PubMed
  - Literature
  - Genomics
  - Entrez
  properties:
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/books/NBK25500/
  contact:
  - FN: NCBI
    email: info@ncbi.nlm.nih.gov
- name: PubChem Power User Gateway (PUG REST)
  description: Suite of REST APIs providing programmatic access to PubChem chemical compound data, including chemical structure
    searches, compound properties, biological assay data, and chemical standardization for millions of compounds.
  image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg
  humanURL: https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access
  baseURL: https://pubchem.ncbi.nlm.nih.gov/rest/pug/
  tags:
  - Chemistry
  - Chemical Data
  - PubChem
  - Compounds
  - Bioassay
  properties:
  - type: Documentation
    url: https://pubchem.ncbi.nlm.nih.gov/docs/programmatic-access
  - type: Documentation
    url: https://pubchem.ncbi.nlm.nih.gov/pug_rest/PUG_REST.html
  contact:
  - FN: PubChem
    url: https://pubchemdocs.ncbi.nlm.nih.gov/contact
- name: NIH RePORTER API
  description: REST API providing programmatic access to NIH-funded research project data including grants, contracts, publications,
    and patents. Enables search and retrieval of funding records with extensive filtering by institute, mechanism, fiscal
    year, and keywords.
  image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg
  humanURL: https://reporter.nih.gov/
  baseURL: https://api.reporter.nih.gov/v2/
  tags:
  - Research Funding
  - Grants
  - Publications
  - NIH Projects
  properties:
  - type: Documentation
    url: https://api.reporter.nih.gov/
  contact:
  - FN: NIH RePORTER
    url: https://reporter.nih.gov/
- name: NCBI BLAST URL API
  description: API enabling developers to submit BLAST (Basic Local Alignment Search Tool) sequence searches via HTTPS for
    processing at NCBI or cloud service providers, check job status, and retrieve results in multiple formats for sequence
    similarity analysis.
  image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg
  humanURL: https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Web&PAGE_TYPE=BlastDocs&DOC_TYPE=DeveloperInfo
  baseURL: https://blast.ncbi.nlm.nih.gov/blast/Blast.cgi
  tags:
  - BLAST
  - Sequence Alignment
  - Genomics
  - Bioinformatics
  properties:
  - type: Documentation
    url: https://ncbi.github.io/blast-cloud/dev/api.html
  contact:
  - FN: NCBI
    email: info@ncbi.nlm.nih.gov
- name: PubMed Central (PMC) OA API
  description: APIs for programmatic access to PubMed Central's Open Access content, including file validation, Open Access
    service, and an ID converter for translating between PMCID, PMID, Manuscript ID, and DOI identifiers.
  image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/apis-json-logo.jpg
  humanURL: https://pmc.ncbi.nlm.nih.gov/tools/developers/
  baseURL: https://www.ncbi.nlm.nih.gov/pmc/
  tags:
  - PubMed Central
  - Open Access
  - Publications
  - Literature
  properties:
  - type: Documentation
    url: https://pmc.ncbi.nlm.nih.gov/tools/developers/
  contact:
  - FN: PMC
    url: https://pmc.ncbi.nlm.nih.gov/
- aid: nih:nih-biosample-api
  name: National Institutes of Health (NIH) BioSample API
  description: '#### Options to download BioSample data.

    This BioSample service allows you to get BioSample data as a data report.'
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - BioSample
  properties:
  - type: OpenAPI
    url: openapi/nih-biosample-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
- aid: nih:nih-gene-api
  name: National Institutes of Health (NIH) Gene API
  description: '#### Options to download gene data, including the associated sequence and metadata.

    These gene services allow you to get gene metadata as a data report or download gene, transcript and protein sequence,
    and metadata, as a gene data package, for all genes in NCBI Gene.'
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - Gene
  properties:
  - type: OpenAPI
    url: openapi/nih-gene-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
- aid: nih:nih-genome-api
  name: National Institutes of Health (NIH) Genome API
  description: '#### Options to download assembled genome data, including the associated sequence, annotation and metadata.

    These genome services allow you to get genome metadata as a data report or download genome, transcript and protein sequence,
    annotation and metadata as a genome data package, for assembled genomes.'
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - Genome
  properties:
  - type: OpenAPI
    url: openapi/nih-genome-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
- aid: nih:nih-organelle-api
  name: National Institutes of Health (NIH) Organelle API
  description: '#### Options to download RefSeq organelle genome data, including the associated sequence and metadata.

    These organelle services allow you to get RefSeq organelle genome metadata as a data report or download gene, transcript
    and protein sequence, and metadata, as an organelle data package, for RefSeq organelle genomes.'
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - Organelle
  properties:
  - type: OpenAPI
    url: openapi/nih-organelle-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
- aid: nih:nih-prokaryote-api
  name: National Institutes of Health (NIH) Prokaryote API
  description: '#### Options to download prokaryote gene data, including the associated sequence and metadata.

    These gene services allow you to download gene and protein sequence, and metadata as a prokaryote gene data package, for
    prokaryotic [RefSeq non-redundant proteins](https://www.ncbi.nlm.nih.gov/refseq/about/nonredundantproteins/).'
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - Prokaryote
  properties:
  - type: OpenAPI
    url: openapi/nih-prokaryote-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
- aid: nih:nih-stats-api
  name: National Institutes of Health (NIH) Stats API
  description: Data statistics
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - Stats
  properties:
  - type: OpenAPI
    url: openapi/nih-stats-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
- aid: nih:nih-studies-api
  name: National Institutes of Health (NIH) Studies API
  description: Related to clinical trial studies
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - Studies
  properties:
  - type: OpenAPI
    url: openapi/nih-studies-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
- aid: nih:nih-taxonomy-api
  name: National Institutes of Health (NIH) Taxonomy API
  description: '#### Options to download taxonomy data.

    These taxonomy services allow you to get taxonomy data as a data report or download taxonomy data as a taxonomy data package,
    for taxonomic nodes in NCBI Taxonomy.'
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - Taxonomy
  properties:
  - type: OpenAPI
    url: openapi/nih-taxonomy-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
- aid: nih:nih-version-api
  name: National Institutes of Health (NIH) Version API
  description: Version info
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - Version
  properties:
  - type: OpenAPI
    url: openapi/nih-version-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
- aid: nih:nih-virus-api
  name: National Institutes of Health (NIH) Virus API
  description: '#### Options to download virus genome data, including the associated sequence and metadata.

    These virus services allow you to get virus genome metadata as a data report or download genome and protein sequence,
    and metadata, as a virus data package, for virus GenBank genomes.'
  humanURL: https://www.ncbi.nlm.nih.gov/home/develop/api/
  baseURL: https://eutils.ncbi.nlm.nih.gov/entrez/eutils/
  tags:
  - Virus
  properties:
  - type: OpenAPI
    url: openapi/nih-virus-api-openapi.yml
  - type: Documentation
    url: https://www.ncbi.nlm.nih.gov/datasets/docs/v2/api/rest-api/
  - type: Documentation
    url: https://clinicaltrials.gov/data-api/api
common:
- type: AgenticAccess
  url: agentic-access/nih-agentic-access.yml
- type: DomainSecurity
  url: security/nih-domain-security.yml
- type: Authentication
  url: authentication/nih-authentication.yml
- type: Website
  url: https://www.nih.gov/
- type: Documentation
  url: https://www.ncbi.nlm.nih.gov/home/develop/api/
- type: GitHubOrg
  url: https://github.com/ncbi
- type: LinkedIn
  url: https://www.linkedin.com/company/national-institutes-of-health
- type: Blog
  url: https://ncbiinsights.ncbi.nlm.nih.gov/
- type: Pricing
  url: https://www.ncbi.nlm.nih.gov/home/develop/api/
- type: StatusPage
  url: https://www.ncbi.nlm.nih.gov/home/develop/api/
- type: X
  url: https://x.com/NIH
- type: Plans
  url: plans/nih-plans-pricing.yml
- type: RateLimits
  url: rate-limits/nih-rate-limits.yml
- type: FinOps
  url: finops/nih-finops.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com