National Institutes of Health (NIH) BioSample API

openapi: 3.0.3
info:
  title: ClinicalTrials.gov REST BioSample API
  description: This API is made available to provide users meta data, statistics, and the most recent version of the clinical trials available on ClinicalTrials.gov.
  version: 2.0.5
servers:
- url: https://clinicaltrials.gov/api/v2
  description: This server
tags:
- name: BioSample
  description: '#### Options to download BioSample data.

    This BioSample service allows you to get BioSample data as a data report.

    '
paths:
  /biosample/accession/{accessions}/biosample_report:
    get:
      summary: Get BioSample dataset reports by accession(s)
      description: 'Get BioSample dataset reports by accession(s). By default, in paged JSON format, but also available as tabular (accept: text/tab-separated-values) or json-lines (accept: application/x-ndjson)'
      tags:
      - BioSample
      operationId: BioSample_dataset_report
      responses:
        default:
          description: An unexpected error response.
          content:
            text/plain:
              schema:
                $ref: '#/components/schemas/rpcStatus'
        '200':
          description: A successful response
          content:
            application/json:
              schema:
                $ref: '#/components/schemas/v2reportsBioSampleDataReportPage'
            application/x-ndjson:
              schema:
                $ref: '#/components/schemas/v2reportsBioSampleDataReportPage'
            text/tab-separated-values:
              schema:
                type: string
      parameters:
      - name: accessions
        in: path
        required: true
        schema:
          type: array
          items:
            type: string
        examples:
          example-0:
            value: SAMN15960293
            summary: Animal sample from Gallus gallus, bGalGal3
          example-1:
            value: SAMN12629504
            summary: Animal sample from Carcharodon carcharias
components:
  schemas:
    v2reportsErrorOrganelleErrorCode:
      type: string
      enum:
      - UNKNOWN_ORGANELLE_ERROR_CODE
      - INVALID_ORGANELLE_TAXON
      - NO_ORGANELLES_FOR_ACCESSION
      default: UNKNOWN_ORGANELLE_ERROR_CODE
    v2reportsBioSampleAttribute:
      type: object
      properties:
        name:
          type: string
        value:
          type: string
    v2reportsErrorAssemblyErrorCode:
      type: string
      enum:
      - UNKNOWN_ASSEMBLY_ERROR_CODE
      - INVALID_BIOPROJECT_IDS
      - NO_ASSEMBLIES_FOR_BIOPROJECTS
      - INVALID_TAXON
      - MISSING_SEARCH_FIELD
      - INVALID_BIOSAMPLE_IDS
      - NO_ASSEMBLIES_FOR_BIOSAMPLE_IDS
      - NO_ASSEMBLIES_FOR_ASSEMBLY_NAMES
      - INVALID_WGS_ACCESSIONS
      - NO_ASSEMBLIES_FOR_WGS_ACCESSIONS
      default: UNKNOWN_ASSEMBLY_ERROR_CODE
    v2reportsBioSampleContact:
      type: object
      properties:
        lab:
          type: string
          title: Submitter lab name.
    v2reportsError:
      type: object
      properties:
        assembly_error_code:
          $ref: '#/components/schemas/v2reportsErrorAssemblyErrorCode'
        gene_error_code:
          $ref: '#/components/schemas/v2reportsErrorGeneErrorCode'
        organelle_error_code:
          $ref: '#/components/schemas/v2reportsErrorOrganelleErrorCode'
        virus_error_code:
          $ref: '#/components/schemas/v2reportsErrorVirusErrorCode'
        taxonomy_error_code:
          $ref: '#/components/schemas/v2reportsErrorTaxonomyErrorCode'
        reason:
          type: string
        message:
          type: string
        invalid_identifiers:
          type: array
          items:
            type: string
    v2reportsBioSampleOwner:
      type: object
      properties:
        name:
          type: string
        contacts:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsBioSampleContact'
    v2reportsBioSampleDataReportPage:
      type: object
      properties:
        reports:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsBioSampleDataReport'
        total_count:
          type: integer
          title: The total count of available datasets (ignoring the page_size parameter).
        next_page_token:
          type: string
          title: A token that can be sent as `page_token` to retrieve the next page. If this field is omitted, there are no subsequent pages.
        messages:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsMessage'
    v2reportsInfraspecificNames:
      type: object
      properties:
        breed:
          type: string
          title: A homogenous group of animals within a domesticated species
        cultivar:
          type: string
          title: A variety of plant within a species produced and maintained by cultivation
        ecotype:
          type: string
          title: A population or subspecies occupying a distinct habitat
        isolate:
          type: string
          title: The individual isolate from which the sequences in the genome assembly were derived
        sex:
          type: string
          title: Physical sex of sampled organism
        strain:
          type: string
          title: A genetic variant, subtype or culture within a species
    v2reportsWarningReplacedId:
      type: object
      properties:
        requested:
          type: string
        returned:
          type: string
    v2reportsErrorVirusErrorCode:
      type: string
      enum:
      - UNKNOWN_VIRUS_ERROR_CODE
      default: UNKNOWN_VIRUS_ERROR_CODE
    v2reportsBioProject:
      type: object
      properties:
        accession:
          type: string
          title: BioProject accession
        title:
          type: string
          title: Title of the BioProject provided by the submitter
        parent_accession:
          type: string
        parent_accessions:
          type: array
          items:
            type: string
    v2reportsBioSampleDescription:
      type: object
      properties:
        title:
          type: string
        organism:
          $ref: '#/components/schemas/v2reportsOrganism'
        comment:
          type: string
    v2reportsBioSampleId:
      type: object
      properties:
        db:
          type: string
        label:
          type: string
        value:
          type: string
    v2reportsBioSampleStatus:
      type: object
      properties:
        status:
          type: string
        when:
          type: string
    v2reportsLineageOrganism:
      type: object
      properties:
        tax_id:
          type: integer
          title: NCBI Taxonomy identifier
        name:
          type: string
          title: Scientific name
    v2reportsErrorTaxonomyErrorCode:
      type: string
      enum:
      - UNKNOWN_TAXONOMY_ERROR_CODE
      - INVALID_TAXONOMY_TAXON
      default: UNKNOWN_TAXONOMY_ERROR_CODE
    protobufAny:
      type: object
      properties:
        type_url:
          type: string
        value:
          type: string
          format: byte
    v2reportsMessage:
      type: object
      properties:
        error:
          $ref: '#/components/schemas/v2reportsError'
        warning:
          $ref: '#/components/schemas/v2reportsWarning'
    v2reportsErrorGeneErrorCode:
      type: string
      enum:
      - UNKNOWN_GENE_ERROR_CODE
      - INCOMPLETE_LOOKUP_SYMBOL
      - INVALID_TAXON_GENE_ARGUMENT
      default: UNKNOWN_GENE_ERROR_CODE
    v2reportsBioSampleDataReport:
      type: object
      properties:
        accession:
          type: string
          title: BioSample Accession identifier
        last_updated:
          type: string
          title: When the biosample object was last updated.
        publication_date:
          type: string
          title: BioSample object publication date.
        submission_date:
          type: string
          title: BioSample object submission date.
        sample_ids:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsBioSampleId'
        description:
          $ref: '#/components/schemas/v2reportsBioSampleDescription'
          title: BioSample description.
        owner:
          $ref: '#/components/schemas/v2reportsBioSampleOwner'
          title: BioSample owner.
        models:
          type: array
          items:
            type: string
        bioprojects:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsBioProject'
        package:
          type: string
          title: Package identifier.
        attributes:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsBioSampleAttribute'
        status:
          $ref: '#/components/schemas/v2reportsBioSampleStatus'
          title: Current status of the object.
        age:
          type: string
          title: Age at the time of sampling
        biomaterial_provider:
          type: string
          title: Name and address of the lab or PI
        breed:
          type: string
          title: Breed name
        collected_by:
          type: string
          title: Name of persons or institute who collected the sample
        collection_date:
          type: string
          title: Date on which the sample was collected
        cultivar:
          type: string
          title: Cultivated variety of plant
        dev_stage:
          type: string
          title: Developmental stage at the time of sampling
        ecotype:
          type: string
          title: Population within a given species adapted to a local habitat
        geo_loc_name:
          type: string
          title: Geographical origin of the sample
        host:
          type: string
          title: The natural host to the organism
        host_disease:
          type: string
          title: Name of relevant disease
        identified_by:
          type: string
          title: Name of the taxonomist who identified the specimen
        ifsac_category:
          type: string
          title: Interagency Food Safety Analytics Collaboration (IFSAC) category
        isolate:
          type: string
          title: Description of the specific individual from which the sample was derived
        isolate_name_alias:
          type: string
          title: Other IDs associated with this isolate
        isolation_source:
          type: string
          title: Source of the sample
        lat_lon:
          type: string
          title: Geogrpahic coordinates of the location where the sample was collected
        project_name:
          type: string
          title: Name of the project
        sample_name:
          type: string
          title: Sample name in source database
        serovar:
          type: string
          title: Taxonomic name below subspecies. Same as serotype.
        sex:
          type: string
          title: Physical sex of sampled organism
        source_type:
          type: string
          title: Controlled vocabulary describing the isolation source
        strain:
          type: string
          title: Strain name
        sub_species:
          type: string
          title: Sub-species taxonomic name
        tissue:
          type: string
          title: Type of tissue from which the sample was derived
        serotype:
          type: string
          title: Taxonomic name below subspecies. Same as serovar
    v2reportsOrganism:
      type: object
      properties:
        tax_id:
          type: integer
          title: NCBI Taxonomy identifier
        sci_name:
          type: string
          title: Scientific name
        organism_name:
          type: string
          title: Scientific name
        common_name:
          type: string
          title: Common name
        lineage:
          type: array
          items:
            $ref: '#/components/schemas/v2reportsLineageOrganism'
        strain:
          type: string
        pangolin_classification:
          type: string
        infraspecific_names:
          $ref: '#/components/schemas/v2reportsInfraspecificNames'
    rpcStatus:
      type: object
      properties:
        code:
          type: integer
          format: int32
        message:
          type: string
        details:
          type: array
          items:
            $ref: '#/components/schemas/protobufAny'
    v2reportsWarningGeneWarningCode:
      type: string
      enum:
      - UNKNOWN_GENE_WARNING_CODE
      - ACCESSION_VERSION_MISMATCH
      - REPLACED_GENE_ID
      - DISCONTINUED_GENE_ID
      - UNRECOGNIZED_GENE_ID
      - UNRECOGNIZED_GENE_SYMBOL
      - UNRECOGNIZED_ACCESSION
      - UNRECOGNIZED_TAX_TOKEN
      - NO_GENE_ANNOTATION_FOUND
      - ABOVE_SPECIES_TAXON
      default: UNKNOWN_GENE_WARNING_CODE
    v2reportsWarning:
      type: object
      properties:
        gene_warning_code:
          $ref: '#/components/schemas/v2reportsWarningGeneWarningCode'
        reason:
          type: string
        message:
          type: string
        replaced_id:
          $ref: '#/components/schemas/v2reportsWarningReplacedId'
        unrecognized_identifier:
          type: string
externalDocs:
  description: Introduction on clinicaltrials.gov
  url: https://clinicaltrials.gov/data-about-studies/learn-about-api