#### Options to download assembled genome data, including the associated sequence, annotation and metadata. These genome services allow you to get genome metadata as a data report or download genome, transcript and protein sequence, annotation and metadata as a genome data package, for assembled genomes.
openapi: 3.0.3
info:
title: ClinicalTrials.gov REST BioSample Genome API
description: This API is made available to provide users meta data, statistics, and the most recent version of the clinical trials available on ClinicalTrials.gov.
version: 2.0.5
servers:
- url: https://clinicaltrials.gov/api/v2
description: This server
tags:
- name: Genome
description: '#### Options to download assembled genome data, including the associated sequence, annotation and metadata.
These genome services allow you to get genome metadata as a data report or download genome, transcript and protein sequence, annotation and metadata as a genome data package, for assembled genomes.
'
paths:
/genome/accession/{accessions}/download_summary:
get:
summary: Get a download summary (preview) of a genome data package by genome assembly accession
description: Get a download summary (preview) of a genome data package, including counts and file sizes, in JSON format.
tags:
- Genome
operationId: genome_download_summary
responses:
default:
description: An unexpected error response.
content:
text/plain:
schema:
$ref: '#/components/schemas/rpcStatus'
'200':
description: A successful response
content:
application/json:
schema:
$ref: '#/components/schemas/v2DownloadSummary'
parameters:
- name: accessions
description: One or more genome assembly accessions, limited to 100
in: path
required: true
schema:
type: array
items:
type: string
examples:
example-0:
value: GCF_000001405.40
summary: Human reference genome, GRCh38.p14
example-1:
value:
- GCF_000001405.40
- GCF_000001635.27
summary: Human and mouse reference genomes, GRCh38.p14 and GRCm39
- name: chromosomes
description: Only return genomic fasta sequence for the specified chromosomes.
in: query
required: false
schema:
type: array
items:
type: string
examples:
example-0:
value:
- '1'
- MT
summary: Chromosome 1 and mitochondrial genome sequence
example-1:
value:
- X
- Y
summary: Human sex chromosomes X and Y
- name: include_annotation_type
description: Specify which sequence, annotation, and report files to include in the data package. The assembly data report is always included, and its inclusion is not affected by this parameter.
in: query
required: false
schema:
type: array
items:
$ref: '#/components/schemas/v2AnnotationForAssemblyType'
examples:
example-0:
value: GENOME_FASTA
summary: Include the genome sequence only
example-1:
value:
- GENOME_FASTA
- PROT_FASTA
- GENOME_GFF
- SEQUENCE_REPORT
summary: Include genomic and protein sequences, a gff3 annotation file, and the sequence report
/genome/download_summary:
post:
summary: Get a download summary (preview) of a genome data package by genome assembly accession
description: Get a downlaod summary (preview) of a genome data package, including counts and file sizes, in JSON format.
tags:
- Genome
operationId: genome_download_summary_by_post
responses:
default:
description: An unexpected error response.
content:
text/plain:
schema:
$ref: '#/components/schemas/rpcStatus'
'200':
description: A successful response
content:
application/json:
schema:
$ref: '#/components/schemas/v2DownloadSummary'
requestBody:
required: true
content:
application/json:
schema:
$ref: '#/components/schemas/v2AssemblyDatasetRequest'
examples:
Single GCF accession example:
description: Tribolium castaneum reference genome, icTRiCast1.1, with genome sequence, annotation and sequence report files
value:
accessions:
- GCF_031307605.1
include_annotation_type:
- GENOME_FASTA
- GENOME_GFF
- SEQUENCE_REPORT
/genome/accession/{accessions}/dataset_report:
get:
summary: Get a genome assembly report by genome assembly accession
description: 'Get a genome assembly report by assembly accession. By default, in paged JSON format, but also available in tabular (accept: text/tab-separated-values) or JSON Lines (accept: application/x-ndjson) formats.'
tags:
- Genome
operationId: genome_dataset_report
responses:
default:
description: An unexpected error response.
content:
text/plain:
schema:
$ref: '#/components/schemas/rpcStatus'
'200':
description: A successful response
content:
application/json:
schema:
$ref: '#/components/schemas/v2reportsAssemblyDataReportPage'
application/x-ndjson:
schema:
$ref: '#/components/schemas/v2reportsAssemblyDataReportPage'
text/tab-separated-values:
schema:
type: string
parameters:
- name: accessions
description: One or more genome assembly accessions, limited to 100
in: path
required: true
schema:
type: array
items:
type: string
examples:
example-0:
value: GCF_000001405.40
summary: Human reference genome assembly, GRCh38.p14
example-1:
value:
- GCF_000001405.40
- GCF_000001635.27
summary: Human and mouse reference genomes, GRCh38.p14 and GRCm39
- name: filters.reference_only
description: If true, limit to reference genome assemblies.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: true
summary: Limit to reference genomes
example-1:
value: false
summary: Include all genomes
- name: filters.assembly_source
description: Limit to either RefSeq (GCF_) or GenBank (GCA_) genome assemblies.
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetDescriptorsFilterAssemblySource'
default: all
examples:
example-0:
value: refseq
summary: Limit to RefSeq genomes
example-1:
value: genbank
summary: Limit to GenBank genomes
example-2:
value: all
summary: Include all genomes
- name: filters.has_annotation
description: Limit to annotated genome assemblies.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: true
summary: Limit to annotated genomes
example-1:
value: false
summary: Include all genomes
- name: filters.exclude_paired_reports
description: If true, for GenBank (GCA_)/RefSeq (GCF_) pairs, returns the RefSeq copy. When no RefSeq copy exists, the GenBank assembly is returned.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes, including both members of a GenBank/RefSeq pair
example-1:
value: true
summary: Returns the RefSeq copy for GenBank/RefSeq pairs, otherwise returns the GenBank assembly
- name: filters.exclude_atypical
description: If true, exclude [atypical genome assemblies](https://www.ncbi.nlm.nih.gov/datasets/docs/v2/data-processing/policies-annotation/genome-processing/genome_notes/#atypical-assemblies), i.e., genomes that have assembly issues or are otherwise atypical.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes
example-1:
value: true
summary: Limit to genomes that are not atypical
- name: filters.assembly_version
description: Limit to the most recent (current) version of a genome assembly.
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetDescriptorsFilterAssemblyVersion'
default: current
examples:
example-0:
value: current
summary: Limit to the most recent version of a genome assembly
example-1:
value: all_assemblies
summary: Include all genome assemblies
- name: filters.assembly_level
description: Limit to genomes at the specified [assembly level](https://www.ncbi.nlm.nih.gov/datasets/docs/v2/glossary/#assembly-level)
in: query
required: false
schema:
type: array
items:
$ref: '#/components/schemas/v2reportsAssemblyLevel'
examples:
example-0:
value:
- chromosome
- complete_genome
summary: Chromosome-level and complete genomes
example-1:
value:
- scaffold
- chromosome
- complete_genome
summary: Scaffold-level genomes and higher
- name: filters.first_release_date
description: Limit to genomes released on or after the specified date
in: query
required: false
schema:
type: string
format: date-time
examples:
example-0:
value: '2024-01-10'
summary: January 10th, 2024, in ISO 8601 YYYY-MM-DD format
- name: filters.last_release_date
description: Limit to genomes released on or before the specified date
in: query
required: false
schema:
type: string
format: date-time
examples:
example-0:
value: '2025-01-10'
summary: January 10th, 2025, in ISO 8601 YYYY-MM-DD format
- name: filters.search_text
description: Limit to genomes that match the specified submitter name, assembly name, infraspecific name (or modifier), or organism name.
in: query
required: false
schema:
type: array
items:
type: string
examples:
example-0:
value: Genome Reference Consortium
summary: Limit to genomes that match this submitter name
example-1:
value: GRCh38
summary: Limit to genomes that match this assembly name
example-2:
value: C57BL/6J
summary: Limit to genomes that match this strain name, a type of infraspecific name
- name: filters.is_metagenome_derived
description: Exclude or limit to metagenome-assembled genomes (MAGs).
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetDescriptorsFilterMetagenomeDerivedFilter'
examples:
example-0:
value: metagenome_derived_exclude
summary: Exclude metagenome-assembled genomes, or MAGs
example-1:
value: metagenome_derived_only
summary: Limit to metagenome-assembled genomes, or MAGs
- name: filters.is_type_material
description: If true, limit to genomes derived from type material.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes
example-1:
value: true
summary: Limit to genomes derived from type material
- name: filters.is_ictv_exemplar
description: If true, limit to genomes derived from an ICTV exemplar (only applies to virus genomes).
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes
example-1:
value: true
summary: Limit to genomes derived from an ICTV exemplar
- name: filters.exclude_multi_isolate
description: If true, exclude genomes that were sequenced as part of large multi-isolate projects.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes
example-1:
value: true
summary: Exclude genomes that were sequenced as part of large multi-isolate projects
- name: filters.type_material_category
description: Limit to genomes derived from specific type material categories.
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetDescriptorsFilterTypeMaterialCategory'
examples:
example-0:
value: TYPE_MATERIAL_CLADE
summary: Limit to genomes designated as clade exemplar
example-1:
value: TYPE_MATERIAL_NEOTYPE
summary: Limit to genomes derived from neotype material
- name: table_fields
in: query
required: false
schema:
type: array
items:
type: string
examples:
example-0:
value: accession
summary: Genome assembly accession
example-1:
value:
- accession
- assminfo-name
summary: Genome assembly accession and name
- name: returned_content
description: Return complete genome assembly reports, or abbreviated reports with assembly accessions with or without paired assembly information.
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetReportsRequestContentType'
examples:
example-0:
value: ASSM_ACC
summary: Return abbreviated report with genome assembly accessions
example-1:
value: PAIRED_ACC
summary: Return abbreviated report with genome assembly accessions and paired assembly information
- name: page_size
description: The maximum number of genome assembly reports to return. Default is 20 and maximum is 1000. If the number of results exceeds the page size, `page_token` can be used to retrieve the remaining results.
in: query
required: false
schema:
type: integer
default: 20
- name: page_token
description: A page token is returned when the results count exceeds `page size`. Use this token along with previous request parameters to retrieve the next page of results. When `page_token` is empty, all results have been retrieved.
in: query
required: false
schema:
type: string
- name: sort.field
in: query
required: false
schema:
type: string
- name: sort.direction
in: query
required: false
schema:
$ref: '#/components/schemas/v2SortDirection'
- name: include_tabular_header
description: Specify when to include the table header when requesting a tabular report.
in: query
required: false
schema:
$ref: '#/components/schemas/v2IncludeTabularHeader'
/genome/taxon/{taxons}/dataset_report:
get:
summary: Get a genome assembly report by taxon
description: 'Get a genome assembly report by taxon. By default, in paged JSON format, but also available in tabular (accept: text/tab-separated-values) or JSON Lines (accept: application/x-ndjson) formats.'
tags:
- Genome
operationId: genome_dataset_reports_by_taxon
responses:
default:
description: An unexpected error response.
content:
text/plain:
schema:
$ref: '#/components/schemas/rpcStatus'
'200':
description: A successful response
content:
application/json:
schema:
$ref: '#/components/schemas/v2reportsAssemblyDataReportPage'
application/x-ndjson:
schema:
$ref: '#/components/schemas/v2reportsAssemblyDataReportPage'
text/tab-separated-values:
schema:
type: string
parameters:
- name: taxons
description: NCBI Taxonomy ID or name (common or scientific) at any taxonomic rank
in: path
required: true
schema:
type: array
items:
type: string
examples:
example-0:
value: '9606'
summary: NCBI Taxonomy ID for human
example-1:
value:
- chimpanzee
- eastern gorilla
summary: Common names
example-2:
value: Homo sapiens
summary: Scientific name
- name: filters.reference_only
description: If true, limit to reference genome assemblies.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: true
summary: Limit to reference genomes
example-1:
value: false
summary: Include all genomes
- name: filters.assembly_source
description: Limit to either RefSeq (GCF_) or GenBank (GCA_) genome assemblies.
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetDescriptorsFilterAssemblySource'
default: all
examples:
example-0:
value: refseq
summary: Limit to RefSeq genomes
example-1:
value: genbank
summary: Limit to GenBank genomes
example-2:
value: all
summary: Include all genomes
- name: filters.has_annotation
description: Limit to annotated genome assemblies.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: true
summary: Limit to annotated genomes
example-1:
value: false
summary: Include all genomes
- name: filters.exclude_paired_reports
description: If true, for GenBank (GCA_)/RefSeq (GCF_) pairs, returns the RefSeq copy. When no RefSeq copy exists, the GenBank assembly is returned.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes, including both members of a GenBank/RefSeq pair
example-1:
value: true
summary: Returns the RefSeq copy for GenBank/RefSeq pairs, otherwise returns the GenBank assembly
- name: filters.exclude_atypical
description: If true, exclude [atypical genome assemblies](https://www.ncbi.nlm.nih.gov/datasets/docs/v2/data-processing/policies-annotation/genome-processing/genome_notes/#atypical-assemblies), i.e., genomes that have assembly issues or are otherwise atypical.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes
example-1:
value: true
summary: Limit to genomes that are not atypical
- name: filters.assembly_version
description: Limit to the most recent (current) version of a genome assembly.
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetDescriptorsFilterAssemblyVersion'
default: current
examples:
example-0:
value: current
summary: Limit to the most recent version of a genome assembly
example-1:
value: all_assemblies
summary: Include all genome assemblies
- name: filters.assembly_level
description: Limit to genomes at the specified [assembly level](https://www.ncbi.nlm.nih.gov/datasets/docs/v2/glossary/#assembly-level)
in: query
required: false
schema:
type: array
items:
$ref: '#/components/schemas/v2reportsAssemblyLevel'
examples:
example-0:
value:
- chromosome
- complete_genome
summary: Chromosome-level and complete genomes
example-1:
value:
- scaffold
- chromosome
- complete_genome
summary: Scaffold-level genomes and higher
- name: filters.first_release_date
description: Limit to genomes released on or after the specified date
in: query
required: false
schema:
type: string
format: date-time
examples:
example-0:
value: '2024-01-10'
summary: January 10th, 2024, in ISO 8601 YYYY-MM-DD format
- name: filters.last_release_date
description: Limit to genomes released on or before the specified date
in: query
required: false
schema:
type: string
format: date-time
examples:
example-0:
value: '2025-01-10'
summary: January 10th, 2025, in ISO 8601 YYYY-MM-DD format
- name: filters.search_text
description: Limit to genomes that match the specified submitter name, assembly name, infraspecific name (or modifier), or organism name.
in: query
required: false
schema:
type: array
items:
type: string
examples:
example-0:
value: Genome Reference Consortium
summary: Limit to genomes that match this submitter name
example-1:
value: GRCh38
summary: Limit to genomes that match this assembly name
example-2:
value: C57BL/6J
summary: Limit to genomes that match this strain name, a type of infraspecific name
- name: filters.is_metagenome_derived
description: Exclude or limit to metagenome-assembled genomes (MAGs).
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetDescriptorsFilterMetagenomeDerivedFilter'
examples:
example-0:
value: metagenome_derived_exclude
summary: Exclude metagenome-assembled genomes, or MAGs
example-1:
value: metagenome_derived_only
summary: Limit to metagenome-assembled genomes, or MAGs
- name: filters.is_type_material
description: If true, limit to genomes derived from type material.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes
example-1:
value: true
summary: Limit to genomes derived from type material
- name: filters.is_ictv_exemplar
description: If true, limit to genomes derived from an ICTV exemplar (only applies to virus genomes).
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes
example-1:
value: true
summary: Limit to genomes derived from an ICTV exemplar
- name: filters.exclude_multi_isolate
description: If true, exclude genomes that were sequenced as part of large multi-isolate projects.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes
example-1:
value: true
summary: Exclude genomes that were sequenced as part of large multi-isolate projects
- name: filters.type_material_category
description: Limit to genomes derived from specific type material categories.
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetDescriptorsFilterTypeMaterialCategory'
examples:
example-0:
value: TYPE_MATERIAL_CLADE
summary: Limit to genomes designated as clade exemplar
example-1:
value: TYPE_MATERIAL_NEOTYPE
summary: Limit to genomes derived from neotype material
- name: tax_exact_match
description: If true, only return assemblies matching the specified taxon, but not child taxa. For example, if querying by "Canis lupus", return Canis lupus but not Canis lupus familiaris genomes.
in: query
required: false
schema:
type: boolean
default: false
- name: table_fields
in: query
required: false
schema:
type: array
items:
type: string
examples:
example-0:
value: accession
summary: Genome assembly accession
example-1:
value:
- accession
- assminfo-name
summary: Genome assembly accession and name
- name: returned_content
description: Return complete genome assembly reports, or abbreviated reports with assembly accessions with or without paired assembly information.
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetReportsRequestContentType'
examples:
example-0:
value: ASSM_ACC
summary: Return abbreviated report with genome assembly accessions
example-1:
value: PAIRED_ACC
summary: Return abbreviated report with genome assembly accessions and paired assembly information
- name: page_size
description: The maximum number of genome assembly reports to return. Default is 20 and maximum is 1000. If the number of results exceeds the page size, `page_token` can be used to retrieve the remaining results.
in: query
required: false
schema:
type: integer
default: 20
- name: page_token
description: A page token is returned when the results count exceeds `page size`. Use this token along with previous request parameters to retrieve the next page of results. When `page_token` is empty, all results have been retrieved.
in: query
required: false
schema:
type: string
- name: sort.field
in: query
required: false
schema:
type: string
- name: sort.direction
in: query
required: false
schema:
$ref: '#/components/schemas/v2SortDirection'
- name: include_tabular_header
description: Specify when to include the table header when requesting a tabular report.
in: query
required: false
schema:
$ref: '#/components/schemas/v2IncludeTabularHeader'
/genome/bioproject/{bioprojects}/dataset_report:
get:
summary: Get genome assembly reports by BioProject accession
description: 'Get genome assembly reports by BioProject accession. By default, in paged JSON format, but also available in tabular (accept: text/tab-separated-values) or JSON Lines (accept: application/x-ndjson) formats.'
tags:
- Genome
operationId: genome_dataset_reports_by_bioproject
responses:
default:
description: An unexpected error response.
content:
text/plain:
schema:
$ref: '#/components/schemas/rpcStatus'
'200':
description: A successful response
content:
application/json:
schema:
$ref: '#/components/schemas/v2reportsAssemblyDataReportPage'
application/x-ndjson:
schema:
$ref: '#/components/schemas/v2reportsAssemblyDataReportPage'
text/tab-separated-values:
schema:
type: string
parameters:
- name: bioprojects
in: path
required: true
schema:
type: array
items:
type: string
examples:
example-0:
value: PRJNA489243
summary: Vertebrate Genomes Project
example-1:
value: PRJNA31257
summary: Human Genome Project
- name: filters.reference_only
description: If true, limit to reference genome assemblies.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: true
summary: Limit to reference genomes
example-1:
value: false
summary: Include all genomes
- name: filters.assembly_source
description: Limit to either RefSeq (GCF_) or GenBank (GCA_) genome assemblies.
in: query
required: false
schema:
$ref: '#/components/schemas/v2AssemblyDatasetDescriptorsFilterAssemblySource'
default: all
examples:
example-0:
value: refseq
summary: Limit to RefSeq genomes
example-1:
value: genbank
summary: Limit to GenBank genomes
example-2:
value: all
summary: Include all genomes
- name: filters.has_annotation
description: Limit to annotated genome assemblies.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: true
summary: Limit to annotated genomes
example-1:
value: false
summary: Include all genomes
- name: filters.exclude_paired_reports
description: If true, for GenBank (GCA_)/RefSeq (GCF_) pairs, returns the RefSeq copy. When no RefSeq copy exists, the GenBank assembly is returned.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes, including both members of a GenBank/RefSeq pair
example-1:
value: true
summary: Returns the RefSeq copy for GenBank/RefSeq pairs, otherwise returns the GenBank assembly
- name: filters.exclude_atypical
description: If true, exclude [atypical genome assemblies](https://www.ncbi.nlm.nih.gov/datasets/docs/v2/data-processing/policies-annotation/genome-processing/genome_notes/#atypical-assemblies), i.e., genomes that have assembly issues or are otherwise atypical.
in: query
required: false
schema:
type: boolean
default: false
examples:
example-0:
value: false
summary: Include all genomes
example-1:
value: true
summary: Limit to genomes that are not atypical
- name: filters.assembly_version
description: Limit to the most recent (current) version of a genome assembly.
in: query
required: false
schema:
$ref: '#/compone
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