Dyno

aid: dyno
accessModel:
  pricing: unknown
  onboarding: self-service
  trial: true
  try_now: true
  public: true
  label: Self-service signup, API key from dashboard
  confidence: medium
  source:
  - https://design.dynotx.com/
  - https://design.dynotx.com/cli
  generated: '2026-08-10'
  method: searched
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/dyno.png
name: Dyno
description: 'Dyno Therapeutics is an AI and biotechnology company building high-performance gene delivery technologies to
  unlock the potential of next-generation genetic medicine. Using its CapsidMap platform, which combines machine learning
  with high-throughput in vivo measurement, Dyno designs novel adeno-associated virus (AAV) capsids with improved tissue targeting,
  immune evasion, manufacturability, and payload capacity. Alongside its capsid partnerships, Dyno operates a public developer
  platform — Dyno Psi-Phi at design.dynotx.com — that exposes a REST API for agentic protein design: submit structure-prediction,
  inverse-folding and binder-scoring jobs against GPU-backed open models (AlphaFold2, ESMFold, ProteinMPNN, Boltz, ESM-2,
  RFDiffusion3, BoltzGen, OpenFold3), track job status, and retrieve scored results. The platform ships a first-party Python
  CLI (dyno-phi), an MIT-licensed open-source repository, and a provider-published Claude Code Agent Skill. Founded on research
  from George Church''s lab at Harvard, Dyno is headquartered in Watertown, Massachusetts, and is an a16z Bio+Health portfolio
  company.'
url: https://raw.githubusercontent.com/api-evangelist/dyno/refs/heads/main/apis.yml
x-type: company
x-source: vc-portfolio
x-backed-by:
- a16z
x-tier: profile
x-tier-reason: public-api-discovered
x-industry: biotechnology
specificationVersion: '0.23'
created: '2026-07-17'
modified: '2026-08-10'
tags:
- Company
- Biotechnology
- Gene Therapy
- Genetic Medicine
- Gene Delivery
- AAV Capsid
- Artificial Intelligence
- Machine-Learning
- Drug Discovery
- Healthcare
- Protein Design
- Protein Structure Prediction
- Bioinformatics
- Computational Biology
- Agentic AI
- Life Sciences
tags_raw:
- Company
- Biotechnology
- Gene Therapy
- Genetic Medicine
- Gene Delivery
- AAV Capsid
- Artificial Intelligence
- Machine Learning
- Drug Discovery
- Healthcare
- Protein Design
- Protein Structure Prediction
- Bioinformatics
- Computational Biology
- Agentic AI
- Life Sciences
apis:
- name: Dyno Phi — Protein Design API
  description: Phi is a biomodal computation platform for protein design. The REST API lets a caller create datasets from
    PDB/CIF structures, submit structure-prediction and sequence-design jobs across twenty biomodal job types (ESMFold, AlphaFold2
    multimer, ProteinMPNN, Boltz, Chai-1, ESM-2, RFDiffusion3, BoltzGen, OpenFold3, BindCraft, AF2Rank, TM-score and more),
    compose and execute multi-step workflows and protocols, register agents and tools, poll job status, stream job logs, and
    download scored results and artifacts. Authentication is a static API key; per-user and per-organization job quotas are
    exposed through the API itself.
  humanURL: https://design.dynotx.com/docs
  baseURL: https://api.dyno-agents.app
  tags:
  - Protein Design
  - Structure Prediction
  - Machine-Learning
  - Job
  - Workflows
  tags_raw:
  - Protein Design
  - Structure Prediction
  - Machine Learning
  - Jobs
  - Workflows
  properties:
  - type: OpenAPI
    url: openapi/dyno-phi-openapi.yml
  - type: Documentation
    url: https://design.dynotx.com/docs
  - type: APIReference
    url: https://api.dyno-agents.app/
  - type: Authentication
    url: authentication/dyno-authentication.yml
  - type: Conventions
    url: conventions/dyno-conventions.yml
  - type: ErrorCatalog
    url: errors/dyno-problem-types.yml
  - type: DataModel
    url: data-model/dyno-data-model.yml
  - type: RateLimits
    url: rate-limits/dyno-rate-limits.yml
  - type: Overlay
    url: overlays/dyno-phi-overlay.yaml
  - type: Sandbox
    url: sandbox/dyno-sandbox.yml
  - type: CLI
    url: cli/dyno-cli.yml
  - type: AgentSkill
    url: skills/_index.yml
  - type: SDKs
    url: packages/dyno-packages.yml
common:
- type: MCPServer
  url: mcp/dyno-mcp.yml
- type: License
  name: MIT
  url: https://github.com/dynotx/phi-cli/blob/main/LICENSE
- type: Website
  url: https://www.dynotx.com
- type: DeveloperPortal
  url: https://design.dynotx.com/
- type: Documentation
  url: https://design.dynotx.com/docs
- type: APIReference
  url: https://api.dyno-agents.app/
- type: GettingStarted
  url: https://design.dynotx.com/cli
- type: Blog
  url: https://dynotx.substack.com/
- type: GitHubOrganization
  url: https://github.com/dynotx
- type: Support
  url: https://github.com/dynotx/phi-cli/issues
- type: SignUp
  url: https://design.dynotx.com/
- type: TermsOfService
  url: https://www.dynotx.com/legal/terms-and-conditions
- type: PrivacyPolicy
  url: https://www.dynotx.com/legal/privacy-policy
- type: AcceptableUsePolicy
  url: https://design.dynotx.com/acceptable-use
- type: OpenSourceNotice
  url: https://design.dynotx.com/open-source
- type: SourceCode
  url: https://github.com/dynotx/phi-cli
- type: Packages
  url: packages/dyno-packages.yml
- type: SDKs
  url: packages/dyno-packages.yml
- type: CLI
  url: cli/dyno-cli.yml
- type: AgentSkill
  url: skills/_index.yml
- type: Authentication
  url: authentication/dyno-authentication.yml
- type: Conventions
  url: conventions/dyno-conventions.yml
- type: ErrorCatalog
  url: errors/dyno-problem-types.yml
- type: RateLimits
  url: rate-limits/dyno-rate-limits.yml
- type: Plans
  url: plans/dyno-plans-pricing.yml
- type: DataModel
  url: data-model/dyno-data-model.yml
- type: Lifecycle
  url: lifecycle/dyno-lifecycle.yml
- type: ChangeLog
  url: changelog/dyno-changelog.yml
- type: Conformance
  url: conformance/dyno-conformance.yml
- type: Sandbox
  url: sandbox/dyno-sandbox.yml
- type: LLMsTxt
  url: llms/dyno-llms.txt
- type: DomainSecurity
  url: security/dyno-domain-security.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
x-enrichment:
  date: '2026-08-10'
  status: enriched
  artifacts_added: 21
  pass: local-v1
  note: STEP 0b contract discovery overturned the prior "no public developer API" profile. A live OpenAPI 3.1.0 (64 paths,
    80 operations, 62 schemas) is served at https://api.dyno-agents.app/v1/phi/openapi.json with ReDoc at the API root — neither
    the docs host nor the API host answers /openapi.json, so only probing the versioned path prefix found it.