Synthego

Synthego is a genome-engineering company that manufactures synthetic guide RNA (sgRNA, crRNA, trRNA), CRISPR kits, and engineered cells for research and cell/gene-therapy development. Its public Synthego Order API is a third-party integration API that lets partners retrieve current product pricing, generate a priced order preview from a list of guide-RNA sequences, and track an order through to checkout on Synthego's eCommerce site. Authentication is by an API key passed in the SYNTHEGOAPIKEY header. Synthego was surfaced as a portfolio company of SoftBank Vision Fund.

Synthego publishes 1 API contract indexed on the APIs.io network: Order API. Tagged areas include Company, Health Tech, Genomics, CRISPR, and Biotechnology.

The Synthego catalog on APIs.io includes 1 Spectral governance ruleset.

Synthego’s developer surface includes engineering blog, documentation, API reference, support, authentication, and 20 more developer resources.

🌐 Visit website 📡 Profile data on GitHub

34.1/100 thin ▬ flat Agent 26/100 agent aware Front door AI 1/6 silent Heartbeat 57/100 alive saas Full breakdown ↓
scored 2026-11-06 · rubric v0.27.0 · Show this score on your site →

1 published contract 1 Agent Skills

Company Health Tech Genomics CRISPR Biotechnology Life Sciences Synthetic Biology Ordering

What this lets a business do 1

Business capabilities this provider's published APIs can perform, derived from its own contracts. Browse all capabilities →

Supply Chain Management

BC-520

Order

POST /order/ GET /order/{order_request_id}

Kin Score

Kin Score How this is scored →
scored 2026-11-06 · rubric v0.27.0

Composite quality — 34.1/100 · thin

Contract Quality 7.9 / 19

Developer Ergonomics 5.6 / 15

Access Clarity 4.3 / 15

Operational Transparency 0.3 / 10

Contract Governance 1.2 / 9

Discoverability 5.5 / 8

Regulatory Posture 3.5 / 15

Create-or-Update Ergonomics 0.0 / 10

Agent readiness — 26/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 10 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Pagination 5 / 5

Distinct Operations 3 / 3

MCP Tool Quality 6 / 6

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics applies to this provider. This API accepts writes, so it carries 10 points of the composite. It is scored from the published contracts themselves: whether a caller can create-or-update in one call, whether the write accepts a key the caller already holds, and whether the response says which branch ran. Without that, every write needs a search-and-branch in front of it, and the first time that check is skipped a duplicate record is created. Scored against the observed mean rather than raw — a provider at the catalog average is unchanged by this facet, not penalised by it.

The six quality facets above are damped to 75 points between them, because the conditional facet above carries the other 25. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 75% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

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Agent readiness — checks not met, largest first (exact, from this profile):

MCP Server +12 pts — deployment.mode + probe verdict on the mcp/ manifest, not the pointer; an unprobed slug falls back to authorship
Idempotency +9 pts — OpenAPI mutating operations declare an idempotency key — a header, a request-body property, or a named de-duplication token whose own description says so (verified); else common[].type matches /idempoten/i (documented)
A2A Agent Card +8 pts — a2a/-a2a.yml manifest, graded on conformance.grade against A2A 1.0.0
Rate-Limit Signaling +7 pts — OpenAPI responses document X-RateLimit-* / RateLimit headers (verified), else a rate_limits artifact or RateLimits link (documented)
Request/Response Examples +7 pts — share of operations carrying request/response examples; else an Examples / Code Samples link
Registration Without a Human +6 pts — a `registration_endpoint` in the served RFC 8414 / OIDC discovery document

8 more unmet checks in the Agent Readiness table above.

Kin Score — facets with the most composite points still available (weight × headroom):

Contract Quality scores 42.2 — up to +14.5 composite points
Access Clarity scores 28.9 — up to +14.2 composite points
Operational Transparency scores 2.6 — up to +12.7 composite points

Each check links to what satisfies it. Publish the artifact, or tell us where it already lives, and the score moves on the next scoring run.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from the provider profile at artifacts.apis.io/synthego/apis.yml: open an issue on github.com/api-evangelist/synthego to ask a question or point us at an artifact you publish. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Markets this provider is in provisional

The Kin Score Market layer reads a provider inside its market: its position, and how deep its integrations go. Depth is only comparable within a position. Provisional and unweighted: not part of the Kin Score or agent readiness.

Market	Position	Depth	Registered MCP server	Declares compatibility
Chemistry and Materials (chemical data depositors, materials-data APIs)	undeclared	-	-	-
Cell & Gene Therapy	undeclared	-	-	-
GA4GH Genomics Standards (htsget, DRS, TES, WES, Beacon, Passports)	undeclared	-	-	-

Registered MCP server and declares compatibility are report only — not weighted. Undeclared means we found nothing we can read, so there is no number: we never infer integrations.

Standards implemented 1

Standards this provider implements or carries. De facto ones are profiled and measured by the API Commons; formal ones come from the standards directory and are linked by the provider's own tags. The evidence column says how each claim was established — not that it was made.

OpenAPI

measured — observed by APIs.io (published)

APIs 1

Individual APIs this provider publishes, each with its own machine-readable definition.

Synthego Order API

The Order API from Synthego — 3 operation(s) for order.

Open Collections 1

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

Synthego Order API

OPEN COLLECTION

Agent Skills 1

Packaged agent skills for driving this provider's APIs from an AI assistant.

Place a Synthego guide-RNA order

AGENT SKILL

Spectral Rules 1

Spectral governance rulesets for linting and validating these APIs.

Synthego API Rules

50 rules · 48 errors 1 warnings 1 info

SPECTRAL

OpenAPI Overlays 1

Overlays applied on top of this provider's contracts. Each card says who wrote it: a document the provider publishes, or one API Evangelist derived or generated.

Synthego Order Overlay

4 actions · documentation · synthego-order-openapi.json

DERIVED

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Synthego Authentication

apiKey · 1 scheme

SECURITY

Synthego Domain Security

TLSv1.2 · DMARC

SECURITY

Agentic Access 1

Recommended x-agentic-access execution contracts for AI agents.

Synthego Agentic Access

3 operations · 1 acting

AGENTIC

Resources

Documentation 2

Reference material describing how the API behaves

Documentation

Documentation

APIReference

APIReference

Agent Surfaces 5

MCP servers, agent skills, and machine-readable catalogs

AgenticAccess

AgenticAccess

WellKnown

WellKnown

X-MCPServerCandidate

X-MCPServerCandidate

LLMsTxt

LLMsTxt

AgentSkill

AgentSkill

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions

ErrorCatalog

DataModel

Lifecycle

Conformance

Build 1

SDKs, sample code, and the tooling you integrate with

GitHubOrganization

GitHubOrganization

Access & Security 3

Authentication, authorization, and security posture

Compliance

Compliance

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 1

Status, limits, changes, and where to get help

Support

Support

Commercial 2

Pricing, plans, and the legal terms of use

TermsOfService

TermsOfService

PrivacyPolicy

PrivacyPolicy

Company 4

The organization behind the API

Blog

BlogRSS

Website

Blog

Other 2

Properties that don't map to a standard resource type

CapabilityMap

CapabilityMap

Overlay

Overlay

Source (apis.yml)

aid: synthego
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: true
  label: Hosted service · you call their endpoint
  confidence: high
  source:
  - openapi
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - authentication
  - security
  generated: '2026-11-06'
  method: derived
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/synthego.png
name: Synthego
description: Synthego is a genome-engineering company that manufactures synthetic guide RNA (sgRNA, crRNA, trRNA), CRISPR
  kits, and engineered cells for research and cell/gene-therapy development. Its public Synthego Order API is a third-party
  integration API that lets partners retrieve current product pricing, generate a priced order preview from a list of guide-RNA
  sequences, and track an order through to checkout on Synthego's eCommerce site. Authentication is by an API key passed in
  the SYNTHEGOAPIKEY header. Synthego was surfaced as a portfolio company of SoftBank Vision Fund.
url: https://raw.githubusercontent.com/api-evangelist/synthego/refs/heads/main/apis.yml
x-type: company
x-source: vc-portfolio
x-backed-by:
- softbank-vision-fund
x-tier: stub
x-tier-reason: portfolio-lead
specificationVersion: '0.23'
created: '2026-07-17'
modified: '2026-10-06'
x-docs-platform: swagger-ui
x-docs-platform-confidence: medium
x-docs-platform-checked: 2026-10-17
tags:
- Company
- Health Tech
- Genomics
- CRISPR
- Biotechnology
- Life Sciences
- Synthetic Biology
- Ordering
apis:
- aid: synthego:synthego-order-api
  name: Synthego Order API
  description: The Order API from Synthego — 3 operation(s) for order.
  humanURL: https://api.synthego.com/
  baseURL: https://api.synthego.com/
  tags:
  - Order
  properties:
  - type: OpenAPI
    url: openapi/synthego-order-api-openapi.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- url: https://www.synthego.com/press/
  type: Blog
- url: https://www.synthego.com/feed/
  type: BlogRSS
- type: CapabilityMap
  url: capabilities/synthego-capability-edges.yml
  name: Synthego Business Capability Map
- type: Overlay
  url: overlays/synthego-order-overlay.yaml
- type: AgenticAccess
  url: agentic-access/synthego-agentic-access.yml
- type: Website
  url: https://www.synthego.com/
- type: Documentation
  url: https://api.synthego.com/
- type: APIReference
  url: https://api.synthego.com/
- type: Blog
  url: https://www.synthego.com/blog
- type: Support
  url: https://www.synthego.com/contact
- type: GitHubOrganization
  url: https://github.com/synthego
- type: TermsOfService
  url: https://www.synthego.com/legal/terms-of-use/
- type: PrivacyPolicy
  url: https://www.synthego.com/legal/privacy-policy/
- type: Compliance
  url: https://www.synthego.com/legal/iso-certification/
- type: Authentication
  url: authentication/synthego-authentication.yml
- type: DomainSecurity
  url: security/synthego-domain-security.yml
- type: Conventions
  url: conventions/synthego-conventions.yml
- type: ErrorCatalog
  url: errors/synthego-problem-types.yml
- type: DataModel
  url: data-model/synthego-data-model.yml
- type: Lifecycle
  url: lifecycle/synthego-lifecycle.yml
- type: Conformance
  url: conformance/synthego-conformance.yml
- type: WellKnown
  url: well-known/synthego-well-known.yml
- type: X-MCPServerCandidate
  url: mcp/synthego-mcp.yml
  note: 'Renamed from MCPServer 2026-09-03 (roadmap#247): the manifest self-describes as status: candidate — a tool list derived
    from the published API contracts, not an existing server. The scorer already read the manifest and reported mcp_server
    correctly; the MCPServer type was crediting the artifact-type surfaces with a server that does not exist.'
- type: LLMsTxt
  url: llms/synthego-llms.txt
- type: AgentSkill
  url: skills/synthego-place-order.md
x-enrichment:
  date: '2026-07-21'
  status: enriched
  artifacts_added: 16
  pass: local-v1

Synthego API — frequently asked questions

Does Synthego have an API?

Yes. APIs.io lists 1 API from Synthego, including Synthego Order API.

Is there an OpenAPI specification for the Synthego API?

Yes. APIs.io indexes 1 OpenAPI specification for Synthego, each linked for download from this page.

How do I authenticate with the Synthego API?

Synthego uses bearer-token authentication (apiKey · 1 scheme). The details are profiled on APIs.io as Synthego Authentication.

Is the Synthego API ready for AI agents?

Synthego has a Kin Score of 34.1 out of 100 (thin) and an Agent Readiness score of 25.5 (agent-aware), scored by API Evangelist on 2026-11-06.

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