Penn Medicine
Penn Medicine is the University of Pennsylvania Health System (UPHS) plus the Perelman School of Medicine. It is an $11.9 billion enterprise powered by nearly 49,000 faculty and staff, operating six hospitals (Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Chester County Hospital, Lancaster General Health, Princeton Health, and Pennsylvania Hospital — the first hospital in the United States, chartered in 1751) plus Penn Medicine at Home, Good Shepherd Penn Partners Rehabilitation, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health. The Perelman School of Medicine was awarded $580 million in NIH funding in fiscal year 2023. From an API perspective, Penn Medicine runs a production Epic-backed HL7 FHIR R4 endpoint at `https://ssproxy.pennhealth.com/PRD-FHIR/api/FHIR/R4` (Epic Organization ID 346, implementation description "University of Pennsylvania Health Systems FHIR Server"). The CapabilityStatement instantiates `us-core-server|6.1.0` and the HL7 Bulk Data Access IG, exposes 59 FHIR resource types covering Patient Access (clinical + claims) and Provider Directory per CMS-9115-F, and protects them with OAuth 2.0 / SMART-on-FHIR. Penn Medicine also operates the MyPennMedicine MyChart patient portal and the PhysicianLink referring-provider portal, and publishes open-source informatics work through several Perelman School of Medicine GitHub orgs (Penn-Medicine-CHCI, pennsignals, PMACS, pennbiobank).
APIs
Penn Medicine FHIR R4 API
The University of Pennsylvania Health Systems FHIR Server. Epic (November 2025) on the back end, conforming to US Core 6.1.0 and the HL7 Bulk Data Access IG. Serves Patient Acce...
MyPennMedicine Patient Portal
MyChart-based patient portal that gives Penn Medicine patients access to medical records, lab results, secure messaging with their care team, telehealth visits, medication refil...
PhysicianLink Referring Physician Portal
EpicLink-based portal for community and referring physicians that provides secure access to Penn Medicine patient records: clinical notes, lab and imaging results, medication li...
Penn Medicine Open Source Health Informatics
Penn Medicine and the Perelman School of Medicine publish open-source health-informatics software across several GitHub organizations: Penn Medicine Center for Health Care Innov...
Collections
Pricing Plans
Rate Limits
FinOps
Penn Medicine Finops
FINOPSFeatures
HL7 FHIR R4 server with US Core 6.1.0 conformance and SMART on FHIR authorization, fulfilling CMS-9115-F Patient Access requirements.
Unauthenticated FHIR resources for Practitioner, PractitionerRole, Organization, Location, and Endpoint.
Group-level $export per the HL7 Bulk Data IG; supports backend services (client_credentials) authentication.
CapabilityStatement advertises 59 resource types covering clinical, administrative, and financial data including AllergyIntolerance, Condition, Observation, MedicationRequest, Immunization, Procedure, Encounter, DiagnosticReport, DocumentReference, Coverage, ExplanationOfBenefit, and Claim.
MyChart-based portal that fronts the FHIR surface for patients and their authorized apps.
EpicLink portal for community physicians referring patients into UPHS.
Use Cases
Patients authorize third-party PHR and care-coordination apps to pull their complete clinical and claims history from Penn Medicine via SMART on FHIR.
Approved EHR-launched and standalone SMART apps surface Penn Medicine clinical data inside referring-provider, payer, and longitudinal-care tools.
Approved system-level clients run Group-level $export to extract de-identified cohorts for quality measurement, research, and risk modeling.
Payers, referral platforms, and health information exchanges consume the public Provider Directory bundle without authentication.
PhysicianLink gives credentialed community physicians read access to UPHS records for shared patients.
Integrations
UPHS's underlying EHR; the FHIR endpoint is served by Epic November 2025.
Third-party app developers register apps at fhir.epic.com and target Penn Medicine (Organization ID 346).
SMART on FHIR launch protocols for EHR-integrated and standalone apps.
Backend-services authentication and Group-level export.
CapabilityStatement instantiates us-core-server profile.
Penn Medicine participated in Apple's 2018 launch of Health Records on iPhone, allowing patients to view FHIR-formatted records.
National interoperability framework Penn Medicine participates in for record retrieval across networks.
Epic-to-Epic record exchange for connecting providers.
Solutions
CMS-mandated patient-mediated data access surface for UPHS patients.
CMS-mandated public provider directory surface.
Population-scale FHIR data extraction for approved partners.
Open-source Cobalt platform from Penn Medicine CHCI delivering employee mental health and well-being services.