Prokarium

Prokarium is a clinical-stage biopharmaceutical company headquartered in London, UK, developing bacterial immunotherapies for solid tumors. Its foundational technology uses a proprietary attenuated strain of Salmonella enterica serovar Typhi (ZH9) as a microbial immunotherapy platform that is naturally tumor-targeting and oncolytic, designed to overcome the suppressive tumor microenvironment and generate anti-tumor immune responses while enabling diverse cargo delivery. The lead program, ZH9 for non-muscle invasive bladder cancer, is in the Phase 1/1b PARADIGM-1 trial, with a muscle-invasive bladder cancer combination arm alongside checkpoint inhibitors, an oral immune fitness agent (IO Prime), and a discovery-stage Living Cures cargo-delivery platform. Prokarium is a therapeutics developer, not a software or data company, and publishes no public API, SDK, developer portal or machine-readable interface of any kind.

Prokarium is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Life Sciences, and Immunotherapy.

Prokarium’s developer surface includes engineering blog and 3 more developer resources.

🌐 Visit website 📡 Profile data on GitHub

6.4/100 minimal ▬ flat Agent 0/100 human only Front door AI 1/6 silent Heartbeat 29/100 slowing Full breakdown ↓
scored 2026-11-06 · rubric v0.27.0 · Show this score on your site →

0 APIs

Company Biotechnology Pharmaceuticals Life Sciences Immunotherapy Oncology Synthetic Biology Clinical Trials Healthcare

Kin Score

Kin Score How this is scored →
scored 2026-11-06 · rubric v0.27.0

Composite quality — 6.4/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.4 / 17

Access Clarity 1.8 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.0 / 10

Discoverability 3.8 / 9

Regulatory Posture 1.2 / 15

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Pagination 5 / 5

Distinct Operations 3 / 3

MCP Tool Quality 6 / 6

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

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Agent readiness — checks not met, largest first (exact, from this profile):

Machine-Readable Contract +18 pts — api_specs includes an OpenAPI document
MCP Server +12 pts — deployment.mode + probe verdict on the mcp/ manifest, not the pointer; an unprobed slug falls back to authorship
Agentic Access Contract +10 pts — agentic_access artifact present (x-agentic-access), graded by author
Machine-Readable Auth +10 pts — a served openid-configuration/oauth-authorization-server carrying `issuer` (served), else the securitySchemes class in the provider OpenAPIs — bound (mutualTLS, DPoP, Signature) > negotiable (oauth2 authorizationCode/clientCredentials, openIdConnect) > bearer (http bearer, apiKey)
Idempotency +9 pts — OpenAPI mutating operations declare an idempotency key — a header, a request-body property, or a named de-duplication token whose own description says so (verified); else common[].type matches /idempoten/i (documented)
Stable Error Semantics +8 pts — OpenAPI $refs a shared error schema across 4xx/5xx responses (verified), else common[].type includes ErrorCatalog / ErrorCodes / DeclineCodes

13 more unmet checks in the Agent Readiness table above.

Kin Score — facets with the most composite points still available (weight × headroom):

Contract Quality scores 0.0 — up to +25.0 composite points
Developer Ergonomics scores 2.4 — up to +19.5 composite points
Access Clarity scores 10.5 — up to +17.9 composite points

Each check links to what satisfies it. Publish the artifact, or tell us where it already lives, and the score moves on the next scoring run.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from the provider profile at artifacts.apis.io/prokarium/apis.yml: open an issue on github.com/api-evangelist/prokarium to ask a question or point us at an artifact you publish. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Prokarium Domain Security

TLSv1.3 · HSTS

SECURITY

Resources

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Commercial 1

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

Company 2

The organization behind the API

Website

Website

Blog

Blog

Source (apis.yml)

aid: prokarium
name: Prokarium
description: Prokarium is a clinical-stage biopharmaceutical company headquartered in London, UK, developing bacterial immunotherapies
  for solid tumors. Its foundational technology uses a proprietary attenuated strain of Salmonella enterica serovar Typhi
  (ZH9) as a microbial immunotherapy platform that is naturally tumor-targeting and oncolytic, designed to overcome the suppressive
  tumor microenvironment and generate anti-tumor immune responses while enabling diverse cargo delivery. The lead program,
  ZH9 for non-muscle invasive bladder cancer, is in the Phase 1/1b PARADIGM-1 trial, with a muscle-invasive bladder cancer
  combination arm alongside checkpoint inhibitors, an oral immune fitness agent (IO Prime), and a discovery-stage Living Cures
  cargo-delivery platform. Prokarium is a therapeutics developer, not a software or data company, and publishes no public
  API, SDK, developer portal or machine-readable interface of any kind.
url: https://raw.githubusercontent.com/api-evangelist/prokarium/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
deliveryModel:
  model: unknown
  open_source: false
  commercial: false
  callable_host: false
  label: Delivery model not determined — needs a product licence on record
  confidence: low
  source:
  - none
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  probe_state: none
  source:
  - security
  generated: '2026-11-06'
  method: derived
specificationVersion: '0.20'
created: '2026-08-26'
modified: '2026-08-26'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Life Sciences
- Immunotherapy
- Oncology
- Synthetic Biology
- Clinical Trials
- Healthcare
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: DomainSecurity
  url: security/prokarium-domain-security.yml
- type: Website
  url: https://www.prokarium.com/
- type: PrivacyPolicy
  url: https://www.prokarium.com/privacy
- type: Blog
  url: https://www.prokarium.com/news
x-enrichment:
  date: '2026-08-26'
  status: minimal
  artifacts_added: 2
  pass: local-v1
x-coverage:
  state: none
  reason: not-a-software-company
  detail: Prokarium is a clinical-stage biopharmaceutical company developing the ZH9 bacterial immunotherapy for bladder cancer;
    its entire 96-URL sitemap is corporate, pipeline and press-release pages with no developer, docs, API or data section,
    and github.com/prokarium returns 404, so there is no software product for an API to sit behind.
  evidence:
  - url: https://www.prokarium.com/openapi.json
    status: 404
  - url: https://www.prokarium.com/.well-known/agent-card.json
    status: 404
  - url: https://www.prokarium.com/llms.txt
    status: 404
  - url: https://github.com/prokarium
    status: 404
  - url: https://www.prokarium.com/sitemap.xml
    status: 200
  checked: '2026-08-26'

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