OrsoBio

OrsoBio is a privately held, clinical-stage biopharmaceutical company founded in 2021 and headquartered in Palo Alto, California, developing first-in-class oral therapies that restore energy homeostasis in patients living with severe metabolic disorders — obesity, type 2 diabetes, severe dyslipidemias, lipodystrophies and MASH. The name is drawn from the metabolic adaptability of bears ("orso" in Italian). Its pipeline is led by three mitochondrial protonophores — TLC-6740, TLC-1180 and TLC-1235 — intended to increase energy expenditure and improve metabolic and cardiovascular health, alongside an LXR inverse agonist (TLC-2716) for severe hypertriglyceridemia and MASH, an ACC2 inhibitor (TLC-3595) for insulin sensitivity in type 2 diabetes, and an ACMSD inhibitor to augment NAD+ biosynthesis in metabolic and inflammatory liver and kidney disorders. The company closed an oversubscribed $67 million Series B in September 2024, co-led by Ascenta Capital and Woodline Partners with participation from Samsara BioCapital, Enavate Sciences and Longitude Capital. OrsoBio publishes a corporate site covering its science, pipeline, team, board, publications, events and press releases, but runs no developer program: no API documentation, no SDKs, no developer portal, no GitHub organisation and no machine-readable API contract of any kind. The only machine-readable surface on orsobio.com is the site's own WordPress CMS route index, which the site's robots.txt explicitly disallows at /wp-json/ and which is therefore not harvested or catalogued here.

OrsoBio is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Life Sciences, and Metabolic Disease.

OrsoBio’s developer surface includes product news, engineering blog, and 14 more developer resources.

🌐 Visit website 📡 Source on GitHub

4.1/100 minimal ▬ flat Agent 3/100 human only Full breakdown ↓
scored 2026-09-08 · rubric v0.20.0

0 APIs

Company Biotechnology Pharmaceuticals Life Sciences Metabolic Disease Obesity Clinical Trials Drug Development Healthcare

Kin Score

Kin Score How this is scored →
scored 2026-09-08 · rubric v0.20.0

Composite quality — 4.1/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.0 / 17

Access Clarity 0.0 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.0 / 10

Discoverability 4.9 / 9

Regulatory Posture 1.1 / 15

Agent readiness — 3/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 4 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/orsobio: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Orsobio Domain Security

TLSv1.3 · DNSSEC

SECURITY

Resources

Agent Surfaces 2

MCP servers, agent skills, and machine-readable catalogs

WellKnown

WellKnown

LLMsTxt

LLMsTxt

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Commercial 1

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

Company 8

The organization behind the API

Website

About

News

Blog

BlogRSS

LinkedIn

Twitter

Twitter

Instagram

Instagram

Scroll for all 8

Other 4

Properties that don't map to a standard resource type

Science

Pipeline

Team

SecondaryMarket

Source (apis.yml)

aid: orsobio
name: OrsoBio
deliveryModel:
  model: unknown
  open_source: false
  commercial: false
  callable_host: false
  label: Delivery model not determined — needs a product licence on record
  confidence: low
  source:
  - none
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - security
  generated: '2026-09-02'
  method: derived
image: https://orsobio.com/wp-content/uploads/2022/10/orso-bio.png
description: 'OrsoBio is a privately held, clinical-stage biopharmaceutical company founded in 2021 and headquartered in Palo
  Alto, California, developing first-in-class oral therapies that restore energy homeostasis in patients living with severe
  metabolic disorders — obesity, type 2 diabetes, severe dyslipidemias, lipodystrophies and MASH. The name is drawn from the
  metabolic adaptability of bears ("orso" in Italian). Its pipeline is led by three mitochondrial protonophores — TLC-6740,
  TLC-1180 and TLC-1235 — intended to increase energy expenditure and improve metabolic and cardiovascular health, alongside
  an LXR inverse agonist (TLC-2716) for severe hypertriglyceridemia and MASH, an ACC2 inhibitor (TLC-3595) for insulin sensitivity
  in type 2 diabetes, and an ACMSD inhibitor to augment NAD+ biosynthesis in metabolic and inflammatory liver and kidney disorders.
  The company closed an oversubscribed $67 million Series B in September 2024, co-led by Ascenta Capital and Woodline Partners
  with participation from Samsara BioCapital, Enavate Sciences and Longitude Capital. OrsoBio publishes a corporate site covering
  its science, pipeline, team, board, publications, events and press releases, but runs no developer program: no API documentation,
  no SDKs, no developer portal, no GitHub organisation and no machine-readable API contract of any kind. The only machine-readable
  surface on orsobio.com is the site''s own WordPress CMS route index, which the site''s robots.txt explicitly disallows at
  /wp-json/ and which is therefore not harvested or catalogued here.'
url: https://raw.githubusercontent.com/api-evangelist/orsobio/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: harvest
specificationVersion: '0.23'
created: '2026-08-04'
modified: '2026-08-04'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Life Sciences
- Metabolic Disease
- Obesity
- Clinical Trials
- Drug Development
- Healthcare
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: DomainSecurity
  url: security/orsobio-domain-security.yml
- type: Website
  url: https://orsobio.com/
- type: About
  url: https://orsobio.com/about/
- type: Science
  url: https://orsobio.com/science/
- type: Pipeline
  url: https://orsobio.com/our-pipeline/
- type: Team
  url: https://orsobio.com/team/
- type: News
  url: https://orsobio.com/news/
- type: Blog
  url: https://orsobio.com/news/
- type: BlogRSS
  url: https://orsobio.com/feed/
- type: PrivacyPolicy
  url: https://orsobio.com/privacy-policy/
- type: LinkedIn
  url: https://www.linkedin.com/company/orsobio/
- type: Twitter
  url: https://twitter.com/OrsoBio
- type: Instagram
  url: https://www.instagram.com/orsobio/
- type: SecondaryMarket
  url: https://forgeglobal.com/orsobio_stock/
- type: WellKnown
  url: well-known/orsobio-well-known.yml
- type: LLMsTxt
  url: llms/orsobio-llms.txt
x-enrichment:
  date: '2026-08-04'
  status: minimal
  artifacts_added: 3
  pass: local-v1
x-coverage:
  state: none
  reason: not-a-software-company
  detail: OrsoBio is a clinical-stage biopharmaceutical company with no developer program — no api., developer., docs., portal.
    or status. host resolves for orsobio.com, no orsobio GitHub organisation exists, and every spec path and /.well-known/
    document on the corporate site is answered by a SiteGround CAPTCHA interstitial that resolves to the site's WordPress
    404 page, leaving only the CMS routes at /wp-json/ that the site's own robots.txt disallows.
  evidence:
  - url: https://orsobio.com/openapi.json
    status: 202
  - url: https://orsobio.com/.well-known/agent-card.json
    status: 202
  - url: https://api.github.com/orgs/orsobio
    status: 404
  checked: '2026-08-04'

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