Mana.bio

Mana.bio is an AI-driven drug-delivery biotechnology company specializing in programmable lipid nanoparticles (LNPs) for nucleic-acid therapeutics and vaccines, including mRNA, DNA, and CRISPR-based gene therapy. The company runs a closed-loop design-build-test-learn platform that uses machine-learning models to design novel LNP candidates, synthesizes dozens of formulations weekly via high-throughput automation, screens them with comprehensive assays, and feeds results back to continuously improve its models — targeting precise, optimized extrahepatic delivery. Mana.bio also operates Mina (ChatLNP), an AI agent that helps scientists explore curated literature, predict LNP properties, and optimize formulations, plus an LNP patents / freedom-to-operate map. The company is backed by a16z. Mana.bio publishes no first-party developer or product API; its only public agent surface is a Wix Site MCP endpoint and an llms.txt on its site.

Mana.bio is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Drug Delivery, Lipid Nanoparticles, and Gene Therapy.

Mana.bio’s developer surface includes engineering blog and 6 more developer resources.

🌐 Visit website 📡 Profile data on GitHub

4.9/100 minimal ▬ flat Agent 2/100 human only Front door AI 4/6 moderate Heartbeat 40/100 slowing Full breakdown ↓
scored 2026-11-06 · rubric v0.27.0 · Show this score on your site →

0 APIs 1 MCP Servers

Company Biotechnology Drug Delivery Lipid Nanoparticles Gene Therapy Artificial Intelligence Machine Learning Genetic Medicine mRNA

Kin Score

Kin Score How this is scored →
scored 2026-11-06 · rubric v0.27.0

Composite quality — 4.9/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.4 / 17

Access Clarity 0.0 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.0 / 10

Discoverability 5.0 / 9

Regulatory Posture 0.8 / 15

Agent readiness — 2/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 12 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Pagination 5 / 5

Distinct Operations 3 / 3

MCP Tool Quality 6 / 6

Regulatory Posture applies to this provider. Its tags matched the Horizontal (data, software, accessibility, platform) regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

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Agent readiness — checks not met, largest first (exact, from this profile):

Machine-Readable Contract +18 pts — api_specs includes an OpenAPI document
Agentic Access Contract +10 pts — agentic_access artifact present (x-agentic-access), graded by author
Machine-Readable Auth +10 pts — a served openid-configuration/oauth-authorization-server carrying `issuer` (served), else the securitySchemes class in the provider OpenAPIs — bound (mutualTLS, DPoP, Signature) > negotiable (oauth2 authorizationCode/clientCredentials, openIdConnect) > bearer (http bearer, apiKey)
Idempotency +9 pts — OpenAPI mutating operations declare an idempotency key — a header, a request-body property, or a named de-duplication token whose own description says so (verified); else common[].type matches /idempoten/i (documented)
Stable Error Semantics +8 pts — OpenAPI $refs a shared error schema across 4xx/5xx responses (verified), else common[].type includes ErrorCatalog / ErrorCodes / DeclineCodes
A2A Agent Card +8 pts — a2a/-a2a.yml manifest, graded on conformance.grade against A2A 1.0.0

12 more unmet checks in the Agent Readiness table above.

Kin Score — facets with the most composite points still available (weight × headroom):

Contract Quality scores 0.0 — up to +25.0 composite points
Access Clarity scores 0.0 — up to +20.0 composite points
Developer Ergonomics scores 2.4 — up to +19.5 composite points

Each check links to what satisfies it. Publish the artifact, or tell us where it already lives, and the score moves on the next scoring run.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from the provider profile at artifacts.apis.io/manabio/apis.yml: open an issue on github.com/api-evangelist/manabio to ask a question or point us at an artifact you publish. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Standards implemented 2

Standards this provider implements or carries. De facto ones are profiled and measured by the API Commons; formal ones come from the standards directory and are linked by the provider's own tags. The evidence column says how each claim was established — not that it was made.

Model Context Protocol (MCP)

measured — observed by APIs.io (platform)

Universal Commerce Protocol (UCP)

measured — observed by APIs.io (wix)

MCP Servers 1

Model Context Protocol servers that expose these APIs to AI agents.

Mana.bio Site MCP

Remote MCP server at www.mana.bio over HTTP; 10 tools listed.

MCP SERVER

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Manabio Domain Security

TLSv1.3 · HSTS

SECURITY

Resources

Agent Surfaces 2

MCP servers, agent skills, and machine-readable catalogs

MCPServer

MCPServer

LLMsTxt

LLMsTxt

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Company 3

The organization behind the API

Website

Website

Blog

Blog

Jobs

Jobs

Other 1

Properties that don't map to a standard resource type

Publications

Publications

Source (apis.yml)

aid: manabio
name: Mana.bio
description: Mana.bio is an AI-driven drug-delivery biotechnology company specializing in programmable lipid nanoparticles
  (LNPs) for nucleic-acid therapeutics and vaccines, including mRNA, DNA, and CRISPR-based gene therapy. The company runs
  a closed-loop design-build-test-learn platform that uses machine-learning models to design novel LNP candidates, synthesizes
  dozens of formulations weekly via high-throughput automation, screens them with comprehensive assays, and feeds results
  back to continuously improve its models — targeting precise, optimized extrahepatic delivery. Mana.bio also operates Mina
  (ChatLNP), an AI agent that helps scientists explore curated literature, predict LNP properties, and optimize formulations,
  plus an LNP patents / freedom-to-operate map. The company is backed by a16z. Mana.bio publishes no first-party developer
  or product API; its only public agent surface is a Wix Site MCP endpoint and an llms.txt on its site.
url: https://raw.githubusercontent.com/api-evangelist/manabio/refs/heads/main/apis.yml
x-type: company
x-source: vc-portfolio
x-backed-by:
- a16z
x-tier: stub
x-tier-reason: portfolio-lead
deliveryModel:
  model: unknown
  open_source: false
  commercial: false
  callable_host: false
  label: Delivery model not determined — needs a product licence on record
  confidence: low
  source:
  - none
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - security
  generated: '2026-11-06'
  method: derived
specificationVersion: '0.23'
created: '2026-07-17'
modified: '2026-07-20'
tags:
- Company
- Biotechnology
- Drug Delivery
- Lipid Nanoparticles
- Gene Therapy
- Artificial Intelligence
- Machine Learning
- Genetic Medicine
- mRNA
tags_raw:
- Company
- Biotechnology
- Drug Delivery
- Lipid Nanoparticles
- Gene Therapy
- Artificial Intelligence
- Machine Learning
- Genetic Medicine
- mRNA
- Machine-Learning
image: https://static.wixstatic.com/media/d7e63b_1d6eb702d51a4cdaad0396e94610de66~mv2.jpg/v1/fit/w_2500,h_1330,al_c/d7e63b_1d6eb702d51a4cdaad0396e94610de66~mv2.jpg
apis: []
x-enrichment:
  date: '2026-07-20'
  status: enriched
  artifacts_added: 3
  pass: local-v1
common:
- type: Website
  url: https://www.mana.bio/
- type: Blog
  url: https://www.mana.bio/news
- type: Publications
  url: https://www.mana.bio/publications
- type: Jobs
  url: https://www.mana.bio/jobs
- type: MCPServer
  name: Mana.bio Site MCP
  url: mcp/manabio-mcp.yml
- type: LLMsTxt
  url: llms/manabio-llms.txt
- type: DomainSecurity
  url: security/manabio-domain-security.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io

Mana.bio API — frequently asked questions

Does Mana.bio have an MCP server?

Yes. APIs.io lists 1 MCP server for Mana.bio: Remote MCP server at www.mana.bio over HTTP; 10 tools listed.

Is the Mana.bio API ready for AI agents?

Mana.bio has a Kin Score of 4.9 out of 100 (minimal) and an Agent Readiness score of 2.2 (human-only), scored by API Evangelist on 2026-11-06.

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