Kyoto Encyclopedia of Genes and Genomes (KEGG)

name: Kyoto Encyclopedia of Genes and Genomes (KEGG)
description: 'The Kyoto Encyclopedia of Genes and Genomes (KEGG) is an integrated database resource for understanding high-level
  functions and utilities of biological systems from molecular-level information derived from genome sequencing and other
  high-throughput experiments. The KEGG REST API at rest.kegg.jp provides programmatic access to KEGG databases covering biological
  pathways, metabolic networks, molecular interactions, drug targets, disease associations, chemical compounds, genomic sequences,
  and functional orthologs across thousands of organisms. The API exposes seven core operations — info, list, find, get, conv,
  link, and ddi — enabling identifier conversion, cross-database linking, keyword and structure searches, and full entry retrieval
  in text, KGML, and JSON formats. Academic use is free via the REST API; FTP and commercial access require subscriptions
  managed through NPO Bioinformatics Japan and Pathway Solutions.

  '
url: https://www.kegg.jp/kegg/rest/
accessModel:
  pricing: freemium
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Freemium
  confidence: medium
  source:
  - plans
  generated: '2026-07-22'
  method: derived
image: https://www.kegg.jp/favicon.ico
tags:
- Bioinformatics
- Genomics
- Life Sciences
- Pathways
- Metabolomics
- Drug Targets
- Disease
- Chemical Compounds
- Enzymes
- Orthology
created: '2026-06-13'
modified: '2026-06-13'
specificationVersion: '0.19'
apis:
- name: KEGG REST API
  description: 'The KEGG REST API provides unified programmatic access to all KEGG databases through seven operations: INFO
    (database statistics and release notes), LIST (entry identifiers and names), FIND (keyword and molecular weight/formula
    search), GET (full entry retrieval in flat-file, KGML, JSON, image, or sequence formats), CONV (identifier conversion
    between KEGG and external databases such as NCBI, UniProt, PubChem, and ChEBI), LINK (cross-reference lookup between KEGG
    databases), and DDI (adverse drug-drug interaction queries). Databases covered include PATHWAY, BRITE, MODULE, KO, GENES,
    GENOME, COMPOUND, GLYCAN, REACTION, ENZYME, DISEASE, DRUG, NETWORK, VARIANT, and DGROUP. The API is restricted to academic
    users; commercial use requires a license from Pathway Solutions. Rate limit is 3 requests per second per client.

    '
  image: https://www.kegg.jp/favicon.ico
  humanURL: https://www.kegg.jp/kegg/rest/
  baseURL: https://rest.kegg.jp
  tags:
  - Pathways
  - Metabolic Networks
  - Genomics
  - Drug Targets
  - Disease
  - Chemical Compounds
  - Enzymes
  - Identifier Conversion
  - Orthology
  properties:
  - type: Documentation
    url: https://www.kegg.jp/kegg/rest/keggapi.html
  - type: TermsOfService
    url: https://www.kegg.jp/kegg/legal.html
  - type: RateLimits
    url: https://api-evangelist.github.io/kegg/rate-limits/kegg-rest-api.yml
  - type: Plans
    url: https://api-evangelist.github.io/kegg/plans/kegg-rest-api.yml
  - type: FinOps
    url: https://api-evangelist.github.io/kegg/finops/overview.yml
  contact:
  - FN: KEGG Support
    url: https://www.kegg.jp/kegg/feedback.html
- aid: kegg:kegg-conv-api
  name: Kyoto Encyclopedia of Genes and Genomes (KEGG) conv API
  description: Convert identifiers between KEGG and external databases
  humanURL: https://www.kegg.jp/kegg/rest/
  baseURL: https://rest.kegg.jp
  tags:
  - conv
  properties:
  - type: OpenAPI
    url: openapi/kegg-conv-api-openapi.yml
- aid: kegg:kegg-ddi-api
  name: Kyoto Encyclopedia of Genes and Genomes (KEGG) ddi API
  description: Find adverse drug-drug interactions
  humanURL: https://www.kegg.jp/kegg/rest/
  baseURL: https://rest.kegg.jp
  tags:
  - ddi
  properties:
  - type: OpenAPI
    url: openapi/kegg-ddi-api-openapi.yml
- aid: kegg:kegg-find-api
  name: Kyoto Encyclopedia of Genes and Genomes (KEGG) find API
  description: Search entries by keyword or molecular property
  humanURL: https://www.kegg.jp/kegg/rest/
  baseURL: https://rest.kegg.jp
  tags:
  - find
  properties:
  - type: OpenAPI
    url: openapi/kegg-find-api-openapi.yml
- aid: kegg:kegg-get-api
  name: Kyoto Encyclopedia of Genes and Genomes (KEGG) get API
  description: Retrieve specific database entries
  humanURL: https://www.kegg.jp/kegg/rest/
  baseURL: https://rest.kegg.jp
  tags:
  - get
  properties:
  - type: OpenAPI
    url: openapi/kegg-get-api-openapi.yml
- aid: kegg:kegg-info-api
  name: Kyoto Encyclopedia of Genes and Genomes (KEGG) info API
  description: Display database release information and statistics
  humanURL: https://www.kegg.jp/kegg/rest/
  baseURL: https://rest.kegg.jp
  tags:
  - info
  properties:
  - type: OpenAPI
    url: openapi/kegg-info-api-openapi.yml
- aid: kegg:kegg-link-api
  name: Kyoto Encyclopedia of Genes and Genomes (KEGG) link API
  description: Find related entries using database cross-references
  humanURL: https://www.kegg.jp/kegg/rest/
  baseURL: https://rest.kegg.jp
  tags:
  - link
  properties:
  - type: OpenAPI
    url: openapi/kegg-link-api-openapi.yml
- aid: kegg:kegg-list-api
  name: Kyoto Encyclopedia of Genes and Genomes (KEGG) list API
  description: Obtain a list of entry identifiers and associated names
  humanURL: https://www.kegg.jp/kegg/rest/
  baseURL: https://rest.kegg.jp
  tags:
  - list
  properties:
  - type: OpenAPI
    url: openapi/kegg-list-api-openapi.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
common:
- type: AgenticAccess
  url: agentic-access/kegg-agentic-access.yml
- type: DomainSecurity
  url: security/kegg-domain-security.yml