HotSpot Therapeutics

HotSpot Therapeutics is a clinical-stage biopharmaceutical company headquartered in Boston, Massachusetts, pioneering allosteric drug discovery by targeting "natural hotspots" — the regulatory on/off switches on proteins. Its Smart Allostery platform combines AI-driven mining of large, diverse structural and biological data sets with a tailored pharmacology toolkit and bespoke medicinal chemistry to design first-in-class oral small molecules, and has been applied across E3 ligases, kinases and transcription factors. The company has raised roughly $190M across Series A, B and C financings and advanced its lead candidate HST-1011, an oral allosteric CBL-B inhibitor, into first-in-human dosing for cancer, alongside programs in autoimmune disease. HotSpot sells medicines and research collaborations, not software: it publishes no public developer program, API, SDK or machine-readable contract of any kind.

HotSpot Therapeutics is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Drug Discovery, and Life Sciences.

HotSpot Therapeutics’ developer surface includes engineering blog and 6 more developer resources.

🌐 Visit website 📡 Source on GitHub

9.4/100 minimal ▬ flat Agent 0/100 human only saas Full breakdown ↓
scored 2026-09-14 · rubric v0.22.0

0 APIs

Company Biotechnology Pharmaceuticals Drug Discovery Life Sciences Oncology Immunology Artificial Intelligence Health

Kin Score

Kin Score How this is scored →
scored 2026-09-14 · rubric v0.22.0

Composite quality — 9.4/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.0 / 17

Access Clarity 3.6 / 17

Operational Transparency 0.3 / 11

Contract Governance 0.0 / 10

Discoverability 4.3 / 9

Regulatory Posture 2.6 / 15

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/hotspot-therapeutics: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Hotspot Therapeutics Domain Security

TLSv1.3 · DMARC

SECURITY

Resources

Build 1

SDKs, sample code, and the tooling you integrate with

GitHubOrganization

GitHubOrganization

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Commercial 2

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

TermsOfService

TermsOfService

Company 2

The organization behind the API

Website

Website

Blog

Blog

Other 1

Properties that don't map to a standard resource type

SecondaryMarketListing

SecondaryMarketListing

Source (apis.yml)

aid: hotspot-therapeutics
name: HotSpot Therapeutics
description: 'HotSpot Therapeutics is a clinical-stage biopharmaceutical company headquartered in Boston, Massachusetts, pioneering
  allosteric drug discovery by targeting "natural hotspots" — the regulatory on/off switches on proteins. Its Smart Allostery
  platform combines AI-driven mining of large, diverse structural and biological data sets with a tailored pharmacology toolkit
  and bespoke medicinal chemistry to design first-in-class oral small molecules, and has been applied across E3 ligases, kinases
  and transcription factors. The company has raised roughly $190M across Series A, B and C financings and advanced its lead
  candidate HST-1011, an oral allosteric CBL-B inhibitor, into first-in-human dosing for cancer, alongside programs in autoimmune
  disease. HotSpot sells medicines and research collaborations, not software: it publishes no public developer program, API,
  SDK or machine-readable contract of any kind.'
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: false
  label: Hosted service · you call their endpoint
  confidence: medium
  source:
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - security
  generated: '2026-09-02'
  method: derived
image: https://avatars.githubusercontent.com/u/105356575?v=4
url: https://raw.githubusercontent.com/api-evangelist/hotspot-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: harvest
specificationVersion: '0.20'
created: '2026-08-22'
modified: '2026-08-22'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Drug Discovery
- Life Sciences
- Oncology
- Immunology
- Artificial Intelligence
- Health
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: DomainSecurity
  url: security/hotspot-therapeutics-domain-security.yml
- type: Website
  url: https://www.hotspotthera.com/
- type: GitHubOrganization
  url: https://github.com/HotSpot-Therapeutics
- type: Blog
  url: https://www.hotspotthera.com/blog/
- type: PrivacyPolicy
  url: https://www.hotspotthera.com/privacy-policy/
- type: TermsOfService
  url: https://www.hotspotthera.com/terms-and-conditions/
- type: SecondaryMarketListing
  url: https://forgeglobal.com/hotspot-therapeutics_stock/
x-enrichment:
  date: '2026-08-22'
  status: minimal
  artifacts_added: 2
  pass: local-v1
x-coverage:
  state: none
  reason: not-a-software-company
  detail: HotSpot Therapeutics is a clinical-stage biopharmaceutical company whose product is an oral small-molecule drug
    pipeline (HST-1011, a CBL-B allosteric inhibitor), not software — its "Smart Allostery" AI platform is an internal discovery
    engine with no external interface, no api./docs./developer. host resolves in DNS, every /.well-known/ path 404s, and its
    only public GitHub repo is a fork of the third-party SETH bioinformatics tool.
  evidence:
  - url: https://www.hotspotthera.com/.well-known/api-catalog
    status: 404
  - url: https://www.hotspotthera.com/llms.txt
    status: 404
  - url: https://hotspotthera.com/.well-known/agent-card.json
    status: 404
  - url: https://api.github.com/orgs/HotSpot-Therapeutics/repos
    status: 200
  checked: '2026-08-22'

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