HotSpot Therapeutics

aid: hotspot-therapeutics
name: HotSpot Therapeutics
description: 'HotSpot Therapeutics is a clinical-stage biopharmaceutical company headquartered in Boston, Massachusetts, pioneering
  allosteric drug discovery by targeting "natural hotspots" — the regulatory on/off switches on proteins. Its Smart Allostery
  platform combines AI-driven mining of large, diverse structural and biological data sets with a tailored pharmacology toolkit
  and bespoke medicinal chemistry to design first-in-class oral small molecules, and has been applied across E3 ligases, kinases
  and transcription factors. The company has raised roughly $190M across Series A, B and C financings and advanced its lead
  candidate HST-1011, an oral allosteric CBL-B inhibitor, into first-in-human dosing for cancer, alongside programs in autoimmune
  disease. HotSpot sells medicines and research collaborations, not software: it publishes no public developer program, API,
  SDK or machine-readable contract of any kind.'
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: false
  label: Hosted service · you call their endpoint
  confidence: medium
  source:
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  probe_state: none
  source:
  - security
  generated: '2026-11-13'
  method: derived
image: https://avatars.githubusercontent.com/u/105356575?v=4
url: https://raw.githubusercontent.com/api-evangelist/hotspot-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: harvest
specificationVersion: '0.20'
created: '2026-08-22'
modified: '2026-10-06'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Drug Discovery
- Life Sciences
- Oncology
- Immunology
- Artificial Intelligence
- Health
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- url: https://www.hotspotthera.com/news/
  type: Blog
- url: https://www.hotspotthera.com/feed/
  type: BlogRSS
- type: DomainSecurity
  url: security/hotspot-therapeutics-domain-security.yml
- type: Website
  url: https://www.hotspotthera.com/
- type: GitHubOrganization
  url: https://github.com/HotSpot-Therapeutics
- type: Blog
  url: https://www.hotspotthera.com/blog/
- type: PrivacyPolicy
  url: https://www.hotspotthera.com/privacy-policy/
- type: TermsOfService
  url: https://www.hotspotthera.com/terms-and-conditions/
- type: SecondaryMarketListing
  url: https://forgeglobal.com/hotspot-therapeutics_stock/
- type: UsageTerms
  url: terms/hotspot-therapeutics-terms-of-service.yml
- type: DataProcessing
  url: privacy/hotspot-therapeutics-privacy-policy.yml
- type: Eligibility
  url: eligibility/hotspot-therapeutics-eligibility.yml
- type: DataLicense
  url: data-license/hotspot-therapeutics-data-license.yml
x-enrichment:
  date: '2026-08-22'
  status: minimal
  artifacts_added: 2
  pass: local-v1
x-coverage:
  state: none
  reason: not-a-software-company
  detail: HotSpot Therapeutics is a clinical-stage biopharmaceutical company whose product is an oral small-molecule drug
    pipeline (HST-1011, a CBL-B allosteric inhibitor), not software — its "Smart Allostery" AI platform is an internal discovery
    engine with no external interface, no api./docs./developer. host resolves in DNS, every /.well-known/ path 404s, and its
    only public GitHub repo is a fork of the third-party SETH bioinformatics tool.
  evidence:
  - url: https://www.hotspotthera.com/.well-known/api-catalog
    status: 404
  - url: https://www.hotspotthera.com/llms.txt
    status: 404
  - url: https://hotspotthera.com/.well-known/agent-card.json
    status: 404
  - url: https://api.github.com/orgs/HotSpot-Therapeutics/repos
    status: 200
  checked: '2026-08-22'