Helical

Helical turns your data into biological intelligence for target identification and biomarker discovery. Your models and the intelligence they capture stay yours. Helical provides a virtual AI lab for drug discovery, enabling users to teach biological foundation models with proprietary data, run target and biomarker workflows, and assess cross-species translation with evidence to prioritize experiments.

Helical is listed with 1 API on the APIs.io network. Tagged areas include Company, Biotech, AI, Drug Discovery, and Bioinformatics.

Helical’s developer surface includes CLI, documentation, API reference, getting-started guide, support, engineering blog, and 9 more developer resources.

🌐 Visit website 📡 Profile data on GitHub

23.8/100 emerging Agent 18/100 agent aware Full breakdown ↓
scored 2026-10-31 · rubric v0.25.0 · Show this score on your site →

1 API

CompanyBiotechAIDrug Discovery Bioinformatics Platform

Kin Score

Kin Score How this is scored →
scored 2026-10-31 · rubric v0.25.0

Composite quality — 23.8/100 · emerging

Contract Quality 0.0 / 21

Developer Ergonomics 8.9 / 17

Access Clarity 3.6 / 17

Operational Transparency 0.6 / 11

Contract Governance 0.0 / 10

Discoverability 5.6 / 9

Regulatory Posture 4.1 / 15

Agent readiness — 18/100 · agent aware

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 7 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 6 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 6 / 6

Agentic Commerce Well-Known Document 0 / 5

Pagination 5 / 5

Distinct Operations 3 / 3

Regulatory Posture applies to this provider. Its tags matched the Horizontal (data, software, accessibility, platform) regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

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Agent readiness — checks not met, largest first (exact, from this profile):

Machine-Readable Contract +18 pts — api_specs includes an OpenAPI document
MCP Server +12 pts — deployment.mode + probe verdict on the mcp/ manifest, not the pointer; an unprobed slug falls back to authorship
Agentic Access Contract +10 pts — agentic_access artifact present (x-agentic-access), graded by author
Idempotency +9 pts — OpenAPI mutating operations declare an idempotency key — a header, a request-body property, or a named de-duplication token whose own description says so (verified); else common[].type matches /idempoten/i (documented)
A2A Agent Card +8 pts — a2a/-a2a.yml manifest, graded on conformance.grade against A2A 1.0.0
Stable Error Semantics +8 pts — OpenAPI $refs a shared error schema across 4xx/5xx responses (verified), else common[].type includes ErrorCatalog / ErrorCodes / DeclineCodes

9 more unmet checks in the Agent Readiness table above.

Kin Score — facets with the most composite points still available (weight × headroom):

Contract Quality scores 0.0 — up to +25.0 composite points
Access Clarity scores 21.1 — up to +15.8 composite points
Operational Transparency scores 5.3 — up to +12.3 composite points

Each check links to what satisfies it. Publish the artifact, or tell us where it already lives, and the score moves on the next scoring run.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from the provider profile at artifacts.apis.io/helical/apis.yml: open an issue on github.com/api-evangelist/helical to ask a question or point us at an artifact you publish. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

APIs 1

Individual APIs this provider publishes, each with its own machine-readable definition.

Helical MCP API

Helical MCP API provides endpoints for model listing, dataset upload, job execution, and more.

Pricing Plans 1

Published pricing tiers and plan structures.

Helical Plans Pricing

0 plans

PLANS

Rate Limits 1

Documented rate limits and quota policies.

Helical Rate Limits

0 limits

RATE LIMITS

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Helical Authentication

0 schemes

SECURITY

Helical Domain Security

TLSv1.3 · HSTS · DMARC

SECURITY

Scopes 1

OAuth scopes governing access to this provider's APIs.

Helical Scopes

OAuth 2.0 · no documented scopes

0 scopes

SCOPES

Resources

Get Started 2

Portal, sign-up, and the first successful call

DeveloperPortal

DeveloperPortal

GettingStarted

GettingStarted

Documentation 2

Reference material describing how the API behaves

Documentation

Documentation

APIReference

APIReference

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

WellKnown

WellKnown

Build 2

SDKs, sample code, and the tooling you integrate with

CLI

CLI

GitHubOrganization

GitHubOrganization

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Operate 1

Status, limits, changes, and where to get help

Support

Support

Commercial 2

Pricing, plans, and the legal terms of use

TermsOfService

TermsOfService

PrivacyPolicy

PrivacyPolicy

Company 2

The organization behind the API

Website

Website

Blog

Blog

Other 2

Properties that don't map to a standard resource type

Hosts

Hosts

Vendors

Vendors

Source (apis.yml)

aid: helical
name: Helical
description: Helical turns your data into biological intelligence for target identification and biomarker discovery. Your
  models and the intelligence they capture stay yours. Helical provides a virtual AI lab for drug discovery, enabling users
  to teach biological foundation models with proprietary data, run target and biomarker workflows, and assess cross-species
  translation with evidence to prioritize experiments.
url: https://artifacts.apis.io/helical/apis.yml
image: https://www.helical.bio/brand/og.jpg
x-type: company
x-source: harvest:vc-portfolio
x-tier: profiled
x-tier-reason: enrichment pass 2026-10-29 (modular-v1; was harvest)
specificationVersion: '0.20'
created: '2026-10-29'
modified: '2026-10-29'
tags:
- Company
- Biotech
- AI
- Drug Discovery
- Bioinformatics
- Platform
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: CLI
  url: cli/helical-cli.yml
- type: WellKnown
  url: well-known/helical-well-known.yml
- type: Hosts
  url: hosts/helical-hosts.yml
- type: Vendors
  url: vendors/helical-vendors.yml
- type: DomainSecurity
  url: security/helical-domain-security.yml
- type: Website
  url: https://www.helical.bio/
- type: DeveloperPortal
  url: https://www.helical.bio/plugin
- type: Documentation
  url: https://www.helical.bio/plugin/docs
- type: APIReference
  url: https://www.helical.bio/plugin/docs
- type: GettingStarted
  url: https://www.helical.bio/plugin/cookbooks/getting-started-with-helical-mcp
- type: Support
  url: https://console.helical.bio/contact
- type: Blog
  url: https://www.helical.bio/blog
- type: GitHubOrganization
  url: https://github.com/helicalAI/helical
- type: TermsOfService
  url: https://www.helical.bio/plugin/terms
- type: PrivacyPolicy
  url: https://www.helical.bio/plugin/privacy
apis:
- aid: helical:mcp-api
  name: Helical MCP API
  description: Helical MCP API provides endpoints for model listing, dataset upload, job execution, and more.
  humanURL: https://www.helical.bio/plugin/docs
  baseURL: https://api.helical.bio
  tags:
  - MCP
  - AI
  - Bioinformatics
  tags_raw:
  - mcp
  - ai
  - bioinformatics
  x-coverage:
    state: unreadable
    reason: no-machine-readable-spec
    detail: Documentation lists API endpoints but no OpenAPI/GraphQL spec is provided.
    evidence:
    - url: https://www.helical.bio/plugin/docs
      status: 200
    checked: '2026-10-29'
  properties:
  - type: Documentation
    url: https://www.helical.bio/plugin/docs
  - type: APIReference
    url: https://www.helical.bio/plugin/docs
x-backed-by:
- gradient-ventures
x-coverage:
  state: gated
  reason: partner-login
  method: derived
  generated: '2026-10-29'
  generator: derive-coverage.py (pre-flight evidence)
  detail: the company serves an API surface but requires credentials before any description of it can be read
  evidence:
  - url: https://api.helical.bio/mcp
    status: 401
  - url: https://www.helical.bio/
    status: 200
x-enrichment:
  date: '2026-10-29'
  status: enriched
  artifacts_added: 22
  pass: modular-v1
  engine: identity=oss,contract=oss,surfaces=oss,docs=oss,regulatory=oss

Helical API — frequently asked questions

Does Helical have an API?

Yes. APIs.io lists 1 API from Helical, including Helical MCP API.

How do I authenticate with the Helical API?

Helical documents its authentication (0 schemes). The details are profiled on APIs.io as Helical Authentication.

Is the Helical API ready for AI agents?

Helical has a Kin Score of 23.8 out of 100 (emerging) and an Agent Readiness score of 17.6 (agent-aware), scored by API Evangelist on 2026-10-31.

Work with this as data

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https://apis.io/mcp

Tools for providers

9 MCP tools reach this

find_providersBrowse and filter every provider in the catalog.
get_provider_artifactsEvery artifact this provider publishes, grouped by type.
get_provider_operationsEvery operation across all of their OpenAPIs — one call instead of parsing every spec.
get_provider_toolsEvery MCP tool they ship, with the operation each wraps.
get_provider_evidenceHow each part of their score was established. Free — the basis for a claim should not sit behind it.
get_provider_ratingPRO — composite, band, trend and facet scores.
apis_io_searchSTART HERE — APIs, providers and tags for one query, each with its total.
resolveTurn a domain, URL or GitHub org into the provider it belongs to.
find_cohortsEvery scored population of providers in the catalog.

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How their score was established

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