Engrail Therapeutics

Engrail Therapeutics is a clinical-stage precision-neuroscience pharmaceutical company founded in 2019 and headquartered in San Diego, California. It applies precision chemistry and pharmacology to scientifically validated mechanisms of action, developing targeted small-molecule therapies for neuropsychiatric and neurodevelopmental diseases with significant unmet need — including generalized anxiety disorder, major depressive disorder characterized by anhedonia, post-traumatic stress disorder and rare neurodegenerative conditions. Its lead program, ENX-102, is a highly selective GABA-A alpha-2,3,5 positive allosteric modulator in Phase 2 (the ENCALM trial) for generalized anxiety disorder; ENX-104 is in clinical development for anhedonic depression. The company closed an oversubscribed $157M Series B in March 2024 co-led by F-Prime Capital, Forbion and Norwest Venture Partners, bringing total capital raised since inception past $220M. Engrail publishes no product or developer API; the machine-readable surfaces catalogued here are the public read-only content API and the OAuth-protected Model Context Protocol servers exposed by its corporate website.

Engrail Therapeutics publishes 10 APIs on the APIs.io network, including Categories API, Comments API, Media API, and 7 more. Tagged areas include Company, Biotechnology, Pharmaceuticals, Life Sciences, and Neuroscience.

Engrail Therapeutics’ developer surface includes engineering blog, support, authentication, and 20 more developer resources.

🌐 Visit website 📡 Source on GitHub

26.5/100 thin ▬ flat Agent 46/100 agent native saas Full breakdown ↓
scored 2026-09-14 · rubric v0.22.0

AccessSelf serve

11 APIs 1 MCP Servers

Company Biotechnology Pharmaceuticals Life Sciences Neuroscience Clinical Trials Drug Development Healthcare Mental Health MCP

Kin Score

Kin Score How this is scored →
scored 2026-09-14 · rubric v0.22.0

Composite quality — 26.5/100 · thin

Contract Quality 2.9 / 21

Developer Ergonomics 3.5 / 17

Access Clarity 3.6 / 17

Operational Transparency 0.0 / 11

Contract Governance 1.9 / 10

Discoverability 6.3 / 9

Regulatory Posture 7.9 / 15

Agent readiness — 46/100 · agent native

Machine-Readable Contract 18 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 6 / 6

MCP Server 12 / 12

Machine-Readable Auth 10 / 10

Idempotency 9 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 4 / 4

Delegated User Identity 6 / 6

Protected Resource Metadata 5 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics does not apply to this provider. The published contracts declare no write operations, and a read-only API cannot create-or-update. The facet is excluded from this provider's denominator entirely — not scored zero. A reference or data API is not deficient for being unable to upsert.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/engrail-therapeutics: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

APIs 11

Individual APIs this provider publishes, each with its own machine-readable definition.

Engrail Therapeutics MCP Servers

Two live Model Context Protocol servers registered under the `mcp` REST namespace on engrail.com, fronted by RFC 8414 and RFC 9728 OAuth discovery documents at the apex. Both ar...

Engrail Therapeutics Categories API

The Categories API from Engrail Therapeutics — 2 operation(s) for categories.

Engrail Therapeutics Comments API

The Comments API from Engrail Therapeutics — 2 operation(s) for comments.

Engrail Therapeutics Media API

The Media API from Engrail Therapeutics — 2 operation(s) for media.

Engrail Therapeutics Pages API

The Pages API from Engrail Therapeutics — 2 operation(s) for pages.

Engrail Therapeutics Posts API

The Posts API from Engrail Therapeutics — 2 operation(s) for posts.

Engrail Therapeutics Search API

The Search API from Engrail Therapeutics — 1 operation(s) for search.

Engrail Therapeutics Statuses API

The Statuses API from Engrail Therapeutics — 1 operation(s) for statuses.

Engrail Therapeutics Tags API

The Tags API from Engrail Therapeutics — 2 operation(s) for tags.

Engrail Therapeutics Taxonomies API

The Taxonomies API from Engrail Therapeutics — 1 operation(s) for taxonomies.

Engrail Therapeutics Types API

The Types API from Engrail Therapeutics — 1 operation(s) for types.

Scroll for all 11

Open Collections 1

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

Engrail Therapeutics Site Content API (WordPress REST)

OPEN COLLECTION

MCP Servers 1

Model Context Protocol servers that expose these APIs to AI agents.

Engrail Therapeutics MCP Server

MCP SERVER

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Engrail Therapeutics Authentication

http/oauth2 · 2 schemes

SECURITY

Engrail Therapeutics Domain Security

TLSv1.3 · HSTS · DMARC

SECURITY

Scopes 1

OAuth scopes governing access to this provider's APIs.

Engrail Therapeutics Scopes

1 scope · authorizationCode

1 scopes

SCOPES

Resources

Agent Surfaces 3

MCP servers, agent skills, and machine-readable catalogs

WellKnown

WellKnown

LLMsTxt

LLMsTxt

AgentSkill

AgentSkill

Design & Contract 3

Pagination, idempotency, versioning, errors, and events

Conventions

Conventions

Conformance

Conformance

Lifecycle

Lifecycle

Access & Security 3

Authentication, authorization, and security posture

Authentication

Authentication

OAuthScopes

OAuthScopes

DomainSecurity

DomainSecurity

Operate 1

Status, limits, changes, and where to get help

Support

Support

Commercial 3

Pricing, plans, and the legal terms of use

TermsOfService

TermsOfService

PrivacyPolicy

PrivacyPolicy

LegalDisclaimer

LegalDisclaimer

Company 7

The organization behind the API

Website

About

Blog

BlogRSS

Careers

Partners

LinkedIn

Scroll for all 7

Other 3

Properties that don't map to a standard resource type

Overlay

Overlay

SecondaryMarket

SecondaryMarket

Pipeline

Pipeline

Source (apis.yml)

aid: engrail-therapeutics
name: Engrail Therapeutics
description: Engrail Therapeutics is a clinical-stage precision-neuroscience pharmaceutical company founded in 2019 and headquartered
  in San Diego, California. It applies precision chemistry and pharmacology to scientifically validated mechanisms of action,
  developing targeted small-molecule therapies for neuropsychiatric and neurodevelopmental diseases with significant unmet
  need — including generalized anxiety disorder, major depressive disorder characterized by anhedonia, post-traumatic stress
  disorder and rare neurodegenerative conditions. Its lead program, ENX-102, is a highly selective GABA-A alpha-2,3,5 positive
  allosteric modulator in Phase 2 (the ENCALM trial) for generalized anxiety disorder; ENX-104 is in clinical development
  for anhedonic depression. The company closed an oversubscribed $157M Series B in March 2024 co-led by F-Prime Capital, Forbion
  and Norwest Venture Partners, bringing total capital raised since inception past $220M. Engrail publishes no product or
  developer API; the machine-readable surfaces catalogued here are the public read-only content API and the OAuth-protected
  Model Context Protocol servers exposed by its corporate website.
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: true
  label: Hosted service · you call their endpoint
  confidence: high
  source:
  - openapi
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: self-serve
  trial: false
  try_now: false
  public: false
  label: Self-serve signup
  confidence: medium
  source:
  - authentication
  - scopes
  - security
  generated: '2026-09-02'
  method: derived
image: https://www.engrail.com/wp-content/uploads/2022/05/logo.png
url: https://raw.githubusercontent.com/api-evangelist/engrail-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enrichment-pipeline
specificationVersion: '0.23'
created: '2026-08-01'
modified: '2026-08-01'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Life Sciences
- Neuroscience
- Clinical Trials
- Drug Development
- Healthcare
- Mental Health
- MCP
tags_raw:
- Company
- Biotechnology
- Pharmaceuticals
- Life Sciences
- Neuroscience
- Clinical Trials
- Drug Development
- Healthcare
- Mental Health
- Model Context Protocol
apis:
- aid: engrail-therapeutics:mcp
  name: Engrail Therapeutics MCP Servers
  description: Two live Model Context Protocol servers registered under the `mcp` REST namespace on engrail.com, fronted by
    RFC 8414 and RFC 9728 OAuth discovery documents at the apex. Both are OAuth-protected — anonymous tools/list returns HTTP
    401 — so the live tool manifest is not readable and no tool list is recorded.
  humanURL: https://www.engrail.com/
  baseURL: https://www.engrail.com/wp-json/mcp/mcp-oauth-server
  tags:
  - MCP
  - Agents
  tags_raw:
  - Model Context Protocol
  - Agents
  properties:
  - type: MCPServer
    url: mcp/engrail-therapeutics-mcp.yml
  - type: ToolCrosswalk
    url: mcp/engrail-therapeutics-tool-crosswalk.yml
- aid: engrail-therapeutics:engrail-therapeutics-categories-api
  name: Engrail Therapeutics Categories API
  description: The Categories API from Engrail Therapeutics — 2 operation(s) for categories.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - Categories
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-categories-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
- aid: engrail-therapeutics:engrail-therapeutics-comments-api
  name: Engrail Therapeutics Comments API
  description: The Comments API from Engrail Therapeutics — 2 operation(s) for comments.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - Comments
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-comments-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
- aid: engrail-therapeutics:engrail-therapeutics-media-api
  name: Engrail Therapeutics Media API
  description: The Media API from Engrail Therapeutics — 2 operation(s) for media.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - Media
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-media-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
- aid: engrail-therapeutics:engrail-therapeutics-pages-api
  name: Engrail Therapeutics Pages API
  description: The Pages API from Engrail Therapeutics — 2 operation(s) for pages.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - Pages
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-pages-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
- aid: engrail-therapeutics:engrail-therapeutics-posts-api
  name: Engrail Therapeutics Posts API
  description: The Posts API from Engrail Therapeutics — 2 operation(s) for posts.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - Posts
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-posts-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
- aid: engrail-therapeutics:engrail-therapeutics-search-api
  name: Engrail Therapeutics Search API
  description: The Search API from Engrail Therapeutics — 1 operation(s) for search.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - Search
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-search-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
- aid: engrail-therapeutics:engrail-therapeutics-statuses-api
  name: Engrail Therapeutics Statuses API
  description: The Statuses API from Engrail Therapeutics — 1 operation(s) for statuses.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - Status
  tags_raw:
  - Statuses
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-statuses-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
- aid: engrail-therapeutics:engrail-therapeutics-tags-api
  name: Engrail Therapeutics Tags API
  description: The Tags API from Engrail Therapeutics — 2 operation(s) for tags.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - Tags
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-tags-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
- aid: engrail-therapeutics:engrail-therapeutics-taxonomies-api
  name: Engrail Therapeutics Taxonomies API
  description: The Taxonomies API from Engrail Therapeutics — 1 operation(s) for taxonomies.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - taxonomies
  tags_raw:
  - Taxonomies
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-taxonomies-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
- aid: engrail-therapeutics:engrail-therapeutics-types-api
  name: Engrail Therapeutics Types API
  description: The Types API from Engrail Therapeutics — 1 operation(s) for types.
  humanURL: https://www.engrail.com/investors-media/
  baseURL: https://www.engrail.com/wp-json
  tags:
  - Types
  properties:
  - type: OpenAPI
    url: openapi/engrail-therapeutics-types-api-openapi.yml
  - type: ErrorCatalog
    url: errors/engrail-therapeutics-problem-types.yml
  - type: DataModel
    url: data-model/engrail-therapeutics-data-model.yml
  - type: Blog
    url: https://www.engrail.com/investors-media/
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Overlay
  url: overlays/engrail-therapeutics-content-overlay.yaml
- type: Website
  url: https://www.engrail.com/
- type: SecondaryMarket
  url: https://forgeglobal.com/engrail-therapeutics_stock/
- type: About
  url: https://www.engrail.com/about-us/
- type: Blog
  url: https://www.engrail.com/investors-media/
- type: BlogRSS
  url: https://www.engrail.com/feed/
- type: Support
  url: https://www.engrail.com/contact-us/
- type: TermsOfService
  url: https://www.engrail.com/terms-of-use/
- type: PrivacyPolicy
  url: https://www.engrail.com/privacy-policy/
- type: LegalDisclaimer
  url: https://www.engrail.com/legal-disclaimer/
- type: Careers
  url: https://www.engrail.com/careers/
- type: Partners
  url: https://www.engrail.com/partners/
- type: Pipeline
  url: https://www.engrail.com/pipeline/
- type: LinkedIn
  url: https://www.linkedin.com/company/engrail-therapeutics
- type: WellKnown
  url: well-known/engrail-therapeutics-well-known.yml
- type: Authentication
  url: authentication/engrail-therapeutics-authentication.yml
- type: OAuthScopes
  url: scopes/engrail-therapeutics-scopes.yml
- type: Conventions
  url: conventions/engrail-therapeutics-conventions.yml
- type: Conformance
  url: conformance/engrail-therapeutics-conformance.yml
- type: Lifecycle
  url: lifecycle/engrail-therapeutics-lifecycle.yml
- type: DomainSecurity
  url: security/engrail-therapeutics-domain-security.yml
- type: LLMsTxt
  url: llms/engrail-therapeutics-llms.txt
- type: AgentSkill
  url: skills/_index.yml
x-enrichment:
  date: '2026-08-01'
  status: enriched
  artifacts_added: 20
  pass: local-v1

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