Cradle is a Dutch–Swiss biotechnology software company founded in 2021 with headquarters in Amsterdam and an office in Zurich, building an AI-powered protein engineering platform for industrial biotech and biopharma R&D teams. The platform combines proprietary generative AI models — trained on billions of natural protein sequences and on data produced in Cradle's own Amsterdam wet lab — with a web application and REST API/Python SDK so that scientists can design, simulate, and co-optimize amino-acid sequence variants across multiple measurable properties such as activity, binding affinity, stability, expression, and developability. Core platform capabilities include AI candidate generation, multi-property co-optimization, virtual plate design, experimental data management with full versioning and audit trails, task orchestration (analyze data, diversify, engineer, select, search, train) across modalities including antibodies/mAbs, enzymes, vaccines, therapeutic peptides, and food ingredients, plus a Custom Predictors framework letting customers plug in their own ML models. Cradle is sold as enterprise SaaS to R&D organizations — disclosed customers and partners include Johnson & Johnson Janssen, Bayer, Novozymes/Novonesis, and Twist Bioscience, with the platform serving six of the top 25 global pharma companies and over 50 active R&D programs. The company has raised approximately $115M to date across a seed round (Index Ventures, 2022), a $24M Series A (Index Ventures, 2023), and a $73M Series B (IVP, 2024). Co-founders are Stef van Grieken (CEO), Jelle Prins, Elise de Reus, Eli Bixby, and Harmen van Rossum.
Cradle is listed with 1 API on the APIs.io network. Tagged areas include Protein Engineering, Generative Biology, Generative AI, Foundation Models, and Machine Learning.
Cradle’s developer surface includes documentation, API reference, engineering blog, and 17 more developer resources.
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The Cradle Platform API is an enterprise REST API for programmatic access to Cradle's AI-driven protein engineering platform. It is organized under per-workspace v2 endpoints an...
aid: cradle-bio
name: Cradle
description: Cradle is a Dutch–Swiss biotechnology software company founded in 2021 with headquarters in Amsterdam and an
office in Zurich, building an AI-powered protein engineering platform for industrial biotech and biopharma R&D teams. The
platform combines proprietary generative AI models — trained on billions of natural protein sequences and on data produced
in Cradle's own Amsterdam wet lab — with a web application and REST API/Python SDK so that scientists can design, simulate,
and co-optimize amino-acid sequence variants across multiple measurable properties such as activity, binding affinity, stability,
expression, and developability. Core platform capabilities include AI candidate generation, multi-property co-optimization,
virtual plate design, experimental data management with full versioning and audit trails, task orchestration (analyze data,
diversify, engineer, select, search, train) across modalities including antibodies/mAbs, enzymes, vaccines, therapeutic
peptides, and food ingredients, plus a Custom Predictors framework letting customers plug in their own ML models. Cradle
is sold as enterprise SaaS to R&D organizations — disclosed customers and partners include Johnson & Johnson Janssen, Bayer,
Novozymes/Novonesis, and Twist Bioscience, with the platform serving six of the top 25 global pharma companies and over
50 active R&D programs. The company has raised approximately $115M to date across a seed round (Index Ventures, 2022), a
$24M Series A (Index Ventures, 2023), and a $73M Series B (IVP, 2024). Co-founders are Stef van Grieken (CEO), Jelle Prins,
Elise de Reus, Eli Bixby, and Harmen van Rossum.
type: Index
deliveryModel:
model: saas
open_source: false
commercial: true
callable_host: false
label: Hosted service · you call their endpoint
confidence: medium
source:
- pricing
generated: '2026-08-28'
method: derived
accessModel:
pricing: unknown
onboarding: unknown
trial: false
try_now: false
public: false
label: Unknown
confidence: low
source:
- security
generated: '2026-11-13'
method: derived
position: Producing
access: 3rd-Party
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/cradle-bio.png
tags:
- Protein Engineering
- Generative Biology
- Generative AI
- Foundation Models
- Machine Learning
- Biotechnology
- Biopharma
- Drug Discovery
- Antibody Discovery
- Enzyme Engineering
- Vaccines
- Therapeutic Peptides
- Industrial Biotech
- Synthetic Biology
- Computational Biology
- Wet Lab
- Life Sciences
- Custom Predictors
tags_raw:
- Protein Engineering
- Generative Biology
- Generative AI
- Foundation Models
- Machine Learning
- Biotechnology
- Biopharma
- Drug Discovery
- Antibody Discovery
- Enzyme Engineering
- Vaccines
- Therapeutic Peptides
- Industrial Biotech
- Synthetic Biology
- Computational Biology
- Wet Lab
- Life Sciences
- Custom Predictors
- Machine-Learning
url: https://raw.githubusercontent.com/api-evangelist/cradle-bio/refs/heads/main/apis.yml
created: '2026-05-25'
modified: '2026-05-25'
specificationVersion: '0.23'
apis:
- aid: cradle-bio:cradle-platform-api
name: Cradle Platform API
tags:
- Protein Engineering
- Workspace
- Project
- Rounds
- Data Management
- Tables
- Data Loads
- Artifacts
- Task
- Audit Logs
- Custom Predictors
tags_raw:
- Protein Engineering
- Workspaces
- Projects
- Rounds
- Data Management
- Tables
- Data Loads
- Artifacts
- Tasks
- Audit Logs
- Custom Predictors
humanURL: https://docs.cradle.bio/api/
baseURL: https://app.cradle.bio/v2
properties:
- type: Documentation
url: https://docs.cradle.bio/api/
- type: GettingStarted
url: https://docs.cradle.bio/docs/getting-started/overview/
- type: SDKs
url: https://docs.cradle.bio/sdk/cradle/sdk/
- type: PythonSDKPackage
url: https://pypi.org/project/cradle-sdk/
- type: CustomPredictorTemplate
url: https://github.com/cradlebio/custom-predictor-template
- type: Login
url: https://app.cradle.bio
description: The Cradle Platform API is an enterprise REST API for programmatic access to Cradle's AI-driven protein engineering
platform. It is organized under per-workspace v2 endpoints and exposes resource groups for Workspaces, Projects, Rounds,
Data Management, Tables, Data Loads (file upload/download with finalize, undo, and redo), Artifacts, Tasks, Audit Logs,
and Custom Predictors. Task creation endpoints (analyze-data/v2, diversify/v2, engineer/v2, select/v2, search/v2, train/v2)
drive Cradle's core generative protein workflows — sequence diversification, multi-property co-optimization, candidate
selection, similarity search, and model fine-tuning — and return artifacts that can be inspected, pulled into custom pipelines,
or chained into downstream lab automation. The API is paired with an official Python SDK (`cradle-sdk` on PyPI) and a
Custom Predictor framework that lets customers register internally developed models against the same orchestration surface
used by the Cradle web application. Access is enterprise-gated (no public self-serve tier); authentication and SSO are
handled at the workspace level with SOC 2 controls, and the spec is rendered as ReDoc-based reference rather than published
as a downloadable OpenAPI file.
common:
- type: DomainSecurity
url: security/cradle-bio-domain-security.yml
- type: Website
url: https://www.cradle.bio
- type: Platform
url: https://www.cradle.bio/platform
- type: Application
url: https://app.cradle.bio
- type: Documentation
url: https://docs.cradle.bio
- type: APIReference
url: https://docs.cradle.bio/api/
- type: SDKs
url: https://docs.cradle.bio/sdk/cradle/sdk/
- type: Blog
url: https://www.cradle.bio/blog
- type: Careers
url: https://www.cradle.bio/careers
- type: Security
url: https://www.cradle.bio/security
- type: PyPIPackage
url: https://pypi.org/project/cradle-sdk/
- type: GitHubOrganization
url: https://github.com/cradlebio
- type: BoltzModel
url: https://github.com/cradlebio/boltz
- type: CustomPredictorTemplate
url: https://github.com/cradlebio/custom-predictor-template
- type: Bioutils
url: https://github.com/cradlebio/bioutils
- type: LinkedIn
url: https://www.linkedin.com/company/cradlebio
- type: Twitter
url: https://twitter.com/cradlebio
- type: GoogleCloudCaseStudy
url: https://cloud.google.com/customers/cradlebio
- type: BayerPartnership
url: https://www.bayer.com/en/us/news-stories/ai-enabled-antibody-discovery-and-optimization
- type: Wikipedia
url: https://en.wikipedia.org/wiki/Cradle_(company)
maintainers:
- FN: Kin Lane
email: kin@apievangelist.com
Cradle API — frequently asked questions
Does Cradle have an API?
Yes. APIs.io lists 1 API from Cradle, including Cradle Platform API.
Is the Cradle API ready for AI agents?
Cradle has a Kin Score of 11.3 out of 100 (emerging) and an Agent Readiness score of 0.0 (human-only), scored by API Evangelist on 2026-11-13.
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