Cradle

Cradle Platform API

The Cradle Platform API is an enterprise REST API for programmatic access to Cradle's AI-driven protein engineering platform. It is organized under per-workspace v2 endpoints and exposes resource groups for Workspaces, Projects, Rounds, Data Management, Tables, Data Loads (file upload/download with finalize, undo, and redo), Artifacts, Tasks, Audit Logs, and Custom Predictors. Task creation endpoints (analyze-data/v2, diversify/v2, engineer/v2, select/v2, search/v2, train/v2) drive Cradle's core generative protein workflows — sequence diversification, multi-property co-optimization, candidate selection, similarity search, and model fine-tuning — and return artifacts that can be inspected, pulled into custom pipelines, or chained into downstream lab automation. The API is paired with an official Python SDK (`cradle-sdk` on PyPI) and a Custom Predictor framework that lets customers register internally developed models against the same orchestration surface used by the Cradle web application. Access is enterprise-gated (no public self-serve tier); authentication and SSO are handled at the workspace level with SOC 2 controls, and the spec is rendered as ReDoc-based reference rather than published as a downloadable OpenAPI file.

GitHub

Documentation

📖
Documentation
https://docs.cradle.bio/api/
📖
GettingStarted
https://docs.cradle.bio/docs/getting-started/overview/

Other Resources

🔗
SDKs
https://docs.cradle.bio/sdk/cradle/sdk/
🔗
PythonSDKPackage
https://pypi.org/project/cradle-sdk/
🔗
CustomPredictorTemplate
https://github.com/cradlebio/custom-predictor-template
🔗
Login
https://app.cradle.bio
🔗
APIsJSON
https://raw.githubusercontent.com/api-evangelist/cradle-bio/refs/heads/main/apis.yml

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API entry from apis.yml

apis.yml Raw ↑ 
aid: cradle-bio:cradle-platform-api
name: Cradle Platform API
tags:
- Protein Engineering
- Workspaces
- Project
- Rounds
- Data Management
- Tables
- Data Loads
- Artifacts
- Task
- Audit Logs
- Custom Predictors
tags_raw:
- Protein Engineering
- Workspaces
- Projects
- Rounds
- Data Management
- Tables
- Data Loads
- Artifacts
- Tasks
- Audit Logs
- Custom Predictors
humanURL: https://docs.cradle.bio/api/
baseURL: https://app.cradle.bio/v2
properties:
- type: Documentation
  url: https://docs.cradle.bio/api/
- type: GettingStarted
  url: https://docs.cradle.bio/docs/getting-started/overview/
- type: SDKs
  url: https://docs.cradle.bio/sdk/cradle/sdk/
- type: PythonSDKPackage
  url: https://pypi.org/project/cradle-sdk/
- type: CustomPredictorTemplate
  url: https://github.com/cradlebio/custom-predictor-template
- type: Login
  url: https://app.cradle.bio
description: The Cradle Platform API is an enterprise REST API for programmatic access to Cradle's AI-driven
  protein engineering platform. It is organized under per-workspace v2 endpoints and exposes resource
  groups for Workspaces, Projects, Rounds, Data Management, Tables, Data Loads (file upload/download with
  finalize, undo, and redo), Artifacts, Tasks, Audit Logs, and Custom Predictors. Task creation endpoints
  (analyze-data/v2, diversify/v2, engineer/v2, select/v2, search/v2, train/v2) drive Cradle's core generative
  protein workflows — sequence diversification, multi-property co-optimization, candidate selection, similarity
  search, and model fine-tuning — and return artifacts that can be inspected, pulled into custom pipelines,
  or chained into downstream lab automation. The API is paired with an official Python SDK (`cradle-sdk`
  on PyPI) and a Custom Predictor framework that lets customers register internally developed models against
  the same orchestration surface used by the Cradle web application. Access is enterprise-gated (no public
  self-serve tier); authentication and SSO are handled at the workspace level with SOC 2 controls, and
  the spec is rendered as ReDoc-based reference rather than published as a downloadable OpenAPI file.