Syntis Bio

Syntis Bio is a clinical-stage biopharmaceutical company in Boston, Massachusetts developing oral therapies that use the small intestine as a delivery site. Its SYNT platform (Synthetic Tissue-lining) applies a mussel-inspired polydopamine polymer coating transiently to specific tissues in the GI tract, sustaining therapeutic activity for up to 24 hours before being naturally cleared. The platform is being applied to nutrient exclusion for obesity, gut-restricted enzyme replacement for rare metabolic disorders such as homocystinuria and maple syrup urine disease, and oral bioavailability enhancement for peptides and biologics. Lead candidate SYNT-101 is a once-daily oral pill intended to mimic aspects of gastric bypass by transiently blocking nutrient absorption in the duodenum. The company was co-founded in 2022 by MIT's Robert Langer and Giovanni Traverso with CEO Rahul Dhanda. Syntis Bio is a therapeutics developer and publishes no public API, developer program, SDK, or machine-readable specification.

Syntis Bio is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Life Sciences, and Drug Delivery.

Syntis Bio’s developer surface includes engineering blog and 10 more developer resources.

🌐 Visit website 📡 Profile data on GitHub

10.1/100 minimal ▬ flat Agent 0/100 human only Front door AI 1/6 silent Heartbeat 72/100 alive Full breakdown ↓
scored 2026-11-06 · rubric v0.27.0 · Show this score on your site →

0 APIs

Company Biotechnology Pharmaceuticals Life Sciences Drug Delivery Clinical Stage Obesity Rare Disease Health

Kin Score

Kin Score How this is scored →
scored 2026-11-06 · rubric v0.27.0

Composite quality — 10.1/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.4 / 17

Access Clarity 3.6 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.0 / 10

Discoverability 4.7 / 9

Regulatory Posture 1.6 / 15

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Pagination 5 / 5

Distinct Operations 3 / 3

MCP Tool Quality 6 / 6

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

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Agent readiness — checks not met, largest first (exact, from this profile):

Machine-Readable Contract +18 pts — api_specs includes an OpenAPI document
MCP Server +12 pts — deployment.mode + probe verdict on the mcp/ manifest, not the pointer; an unprobed slug falls back to authorship
Agentic Access Contract +10 pts — agentic_access artifact present (x-agentic-access), graded by author
Machine-Readable Auth +10 pts — a served openid-configuration/oauth-authorization-server carrying `issuer` (served), else the securitySchemes class in the provider OpenAPIs — bound (mutualTLS, DPoP, Signature) > negotiable (oauth2 authorizationCode/clientCredentials, openIdConnect) > bearer (http bearer, apiKey)
Idempotency +9 pts — OpenAPI mutating operations declare an idempotency key — a header, a request-body property, or a named de-duplication token whose own description says so (verified); else common[].type matches /idempoten/i (documented)
Stable Error Semantics +8 pts — OpenAPI $refs a shared error schema across 4xx/5xx responses (verified), else common[].type includes ErrorCatalog / ErrorCodes / DeclineCodes

13 more unmet checks in the Agent Readiness table above.

Kin Score — facets with the most composite points still available (weight × headroom):

Contract Quality scores 0.0 — up to +25.0 composite points
Developer Ergonomics scores 2.4 — up to +19.5 composite points
Access Clarity scores 21.1 — up to +15.8 composite points

Each check links to what satisfies it. Publish the artifact, or tell us where it already lives, and the score moves on the next scoring run.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from the provider profile at artifacts.apis.io/syntis-bio/apis.yml: open an issue on github.com/api-evangelist/syntis-bio to ask a question or point us at an artifact you publish. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Syntis Bio Domain Security

TLSv1.3

SECURITY

Resources

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

LLMsTxt

LLMsTxt

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Commercial 2

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

TermsOfService

TermsOfService

Company 7

The organization behind the API

Website

About

Blog

BlogRSS

Careers

LinkedIn

Twitter

Twitter

Scroll for all 7

Source (apis.yml)

aid: syntis-bio
name: Syntis Bio
description: Syntis Bio is a clinical-stage biopharmaceutical company in Boston, Massachusetts developing oral therapies that
  use the small intestine as a delivery site. Its SYNT platform (Synthetic Tissue-lining) applies a mussel-inspired polydopamine
  polymer coating transiently to specific tissues in the GI tract, sustaining therapeutic activity for up to 24 hours before
  being naturally cleared. The platform is being applied to nutrient exclusion for obesity, gut-restricted enzyme replacement
  for rare metabolic disorders such as homocystinuria and maple syrup urine disease, and oral bioavailability enhancement
  for peptides and biologics. Lead candidate SYNT-101 is a once-daily oral pill intended to mimic aspects of gastric bypass
  by transiently blocking nutrient absorption in the duodenum. The company was co-founded in 2022 by MIT's Robert Langer and
  Giovanni Traverso with CEO Rahul Dhanda. Syntis Bio is a therapeutics developer and publishes no public API, developer program,
  SDK, or machine-readable specification.
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  probe_state: none
  source:
  - security
  generated: '2026-11-06'
  method: derived
image: https://syntis.bio/wp-content/uploads/2024/06/logo-header.svg
url: https://raw.githubusercontent.com/api-evangelist/syntis-bio/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enrichment-pass-no-api-surface
specificationVersion: '0.20'
created: '2026-08-29'
modified: '2026-08-29'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Life Sciences
- Drug Delivery
- Clinical Stage
- Obesity
- Rare Disease
- Health
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Website
  url: https://syntis.bio/
- type: About
  url: https://syntis.bio/about/
- type: Blog
  url: https://syntis.bio/news/
- type: BlogRSS
  url: https://syntis.bio/feed/
- type: PrivacyPolicy
  url: https://syntis.bio/privacy-policy/
- type: TermsOfService
  url: https://syntis.bio/terms-of-use/
- type: Careers
  url: https://syntis.bio/careers/
- type: LinkedIn
  url: https://www.linkedin.com/company/syntis-bio/
- type: Twitter
  url: https://x.com/syntisbio
- type: DomainSecurity
  url: security/syntis-bio-domain-security.yml
- type: LLMsTxt
  url: llms/syntis-bio-llms.txt
x-enrichment:
  date: '2026-08-29'
  status: minimal
  artifacts_added: 3
  pass: local-v1
x-coverage:
  state: none
  reason: not-a-software-company
  detail: Syntis Bio is a clinical-stage biopharmaceutical company whose product is an oral drug-delivery polymer (SYNT /
    SYNT-101), not software; syntis.bio is a single WordPress marketing site with no api./developer./docs. subdomain resolving,
    no GitHub organization, and a 404 on every OpenAPI, GraphQL and /.well-known/ path probed.
  evidence:
  - url: https://syntis.bio/openapi.json
    status: 404
  - url: https://syntis.bio/.well-known/api-catalog
    status: 404
  - url: https://syntis.bio/.well-known/agent-card.json
    status: 404
  - url: https://syntis.bio/graphql
    status: 404
  - url: https://syntis.bio/
    status: 200
  checked: '2026-08-29'

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