Sionna Therapeutics

Sionna Therapeutics, Inc. (Nasdaq: SION) is a clinical-stage biopharmaceutical company headquartered at 21 Hickory Drive, Waltham, Massachusetts, working to revolutionize the treatment paradigm for cystic fibrosis (CF) by developing novel small molecules that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Building on more than a decade of its co-founders' research, the company advances a pipeline of first-in-class stabilizers of CFTR's nucleotide-binding domain 1 (NBD1) — the domain that carries F508del, the most common CF-causing mutation — including SION-719 and SION-451, alongside a portfolio of complementary CFTR modulators such as SION-2222 (galicaftor) and SION-109 designed to work synergistically with the NBD1 stabilizers. Sionna operates purely as a drug-development organization: its public web presence is a nine-page WordPress marketing site covering science, pipeline, careers, contact and legal material, plus a hosted investor-relations portal. It publishes no developer program, public API, SDK, webhook surface, or machine-readable specification of any kind.

Sionna Therapeutics is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Life Sciences, and Clinical Trials.

🌐 Visit website 📡 Source on GitHub

9.0/100 minimal ▬ flat Agent 0/100 human only saas Full breakdown ↓
scored 2026-09-02 · rubric v0.18.0

0 APIs

Company Biotechnology Pharmaceuticals Life Sciences Clinical Trials Drug Development Rare DiseaseCystic FibrosisSmall Molecule

Kin Score

Kin Score How this is scored →
scored 2026-09-02 · rubric v0.18.0

Composite quality — 9.0/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.0 / 17

Access Clarity 3.6 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.0 / 10

Discoverability 4.3 / 9

Regulatory Posture 2.6 / 15

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Surface 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/sionna-therapeutics: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

LLMsTxt

LLMsTxt

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Operate 1

Status, limits, changes, and where to get help

Contact

Contact

Commercial 2

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

TermsOfService

TermsOfService

Company 4

The organization behind the API

Website

Website

About

About

Careers

Careers

InvestorRelations

InvestorRelations

Other 3

Properties that don't map to a standard resource type

Science

Science

Pipeline

Pipeline

SecondaryMarket

SecondaryMarket

Source (apis.yml)

aid: sionna-therapeutics
name: Sionna Therapeutics
description: 'Sionna Therapeutics, Inc. (Nasdaq: SION) is a clinical-stage biopharmaceutical company headquartered at 21 Hickory
  Drive, Waltham, Massachusetts, working to revolutionize the treatment paradigm for cystic fibrosis (CF) by developing novel
  small molecules that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Building
  on more than a decade of its co-founders'' research, the company advances a pipeline of first-in-class stabilizers of CFTR''s
  nucleotide-binding domain 1 (NBD1) — the domain that carries F508del, the most common CF-causing mutation — including SION-719
  and SION-451, alongside a portfolio of complementary CFTR modulators such as SION-2222 (galicaftor) and SION-109 designed
  to work synergistically with the NBD1 stabilizers. Sionna operates purely as a drug-development organization: its public
  web presence is a nine-page WordPress marketing site covering science, pipeline, careers, contact and legal material, plus
  a hosted investor-relations portal. It publishes no developer program, public API, SDK, webhook surface, or machine-readable
  specification of any kind.'
url: https://raw.githubusercontent.com/api-evangelist/sionna-therapeutics/refs/heads/main/apis.yml
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: false
  label: Hosted service · you call their endpoint
  confidence: medium
  source:
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - security
  generated: '2026-09-02'
  method: derived
image: https://www.sionnatx.com/wp-content/uploads/share_news-from-sionna.jpg
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: harvest
specificationVersion: '0.23'
created: '2026-08-27'
modified: '2026-08-27'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Life Sciences
- Clinical Trials
- Drug Development
- Rare Disease
- Cystic Fibrosis
- Small Molecule
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
x-coverage:
  state: none
  reason: not-a-software-company
  detail: Sionna Therapeutics is a clinical-stage biopharmaceutical company whose product is a small-molecule CFTR modulator,
    not software — its entire public surface is a nine-page WordPress marketing site (home, about, science, pipeline, careers,
    contact, legal) whose Yoast sitemap lists no developer, API or documentation page, and the only machine-readable endpoint
    on the host is the default WordPress /wp-json/ CMS route table (343 core/plugin routes, no product API).
  evidence:
  - url: https://www.sionnatx.com/openapi.json
    status: 404
  - url: https://www.sionnatx.com/developers
    status: 404
  - url: https://www.sionnatx.com/.well-known/agent-card.json
    status: 404
  - url: https://www.sionnatx.com/.well-known/security.txt
    status: 404
  - url: https://www.sionnatx.com/page-sitemap.xml
    status: 200
  - url: https://api.github.com/orgs/sionna-therapeutics
    status: 404
  - url: https://investors.sionnatx.com/
    status: 0
  checked: '2026-08-27'
common:
- type: DomainSecurity
  url: security/sionna-therapeutics-domain-security.yml
- type: LLMsTxt
  url: llms/sionna-therapeutics-llms.txt
- type: Website
  url: https://www.sionnatx.com/
- type: About
  url: https://www.sionnatx.com/about-us/
- type: Science
  url: https://www.sionnatx.com/our-science/
- type: Pipeline
  url: https://www.sionnatx.com/pipeline/
- type: Careers
  url: https://www.sionnatx.com/join-us/
- type: Contact
  url: https://www.sionnatx.com/contact-us/
- type: PrivacyPolicy
  url: https://www.sionnatx.com/privacy-policy/
- type: TermsOfService
  url: https://www.sionnatx.com/terms-of-use/
- type: InvestorRelations
  url: https://investors.sionnatx.com/
- type: SecondaryMarket
  url: https://forgeglobal.com/sionna-therapeutics_stock/
x-enrichment:
  date: '2026-08-27'
  status: minimal
  artifacts_added: 3
  pass: local-v1

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