Orionis Biosciences

Orionis Biosciences is a privately held biotechnology company headquartered at 950 Winter Street in Waltham, Massachusetts, with a research site in Ghent, Belgium, co-founded by Niko Kley and Jan Tavernier. It develops precision medicines across three modalities — small molecule molecular glues built on its Allo-Glue platform, conditional and cis-targeted cytokines built on its A-Kine platform, and multi-specific cell engagers built on its MCE platform — combining disease biology, immunology, chemistry, protein engineering, computational science and machine learning at genome scale. Its lead A-Kine program ORB-011, an attenuated cis-targeted interferon immunotherapy, has entered Phase 1. Orionis has run multi-year molecular-glue discovery collaborations with Genentech (2023, and a 2025 expansion with $105M upfront and more than $2B in potential milestones) and Novartis (from 2020, expanded in 2026 with $40M upfront and up to $1.4B in milestones). Orionis Biosciences publishes no developer program, no product API and no OpenAPI of its own; the only machine-readable surface on orionisbio.com is the WordPress REST API (wp/v2) that serves the company newsroom, corporate and platform pages, leadership and scientific-team profiles and the media library as anonymously readable JSON, alongside a WordPress Abilities API (wp-abilities/v1) registry that is present but authentication-gated.

Orionis Biosciences publishes 11 APIs on the APIs.io network, including Abilities API, Comments API, Discovery API, and 8 more. Tagged areas include Company, Biotechnology, Life Sciences, Drug Discovery, and Pharmaceuticals.

Orionis Biosciences’ developer surface includes engineering blog, product news, support, authentication, and 23 more developer resources.

🌐 Visit website 📡 Source on GitHub

21.8/100 emerging ▬ flat Agent 25/100 agent aware saas Full breakdown ↓
scored 2026-09-08 · rubric v0.20.0

1 APIs

Company Biotechnology Life Sciences Drug Discovery Pharmaceuticals Oncology Immunotherapy Protein EngineeringMolecular GluesComputational Biology Machine-Learning Clinical Trials Content

Kin Score

Kin Score How this is scored →
scored 2026-09-08 · rubric v0.20.0

Composite quality — 21.8/100 · emerging

Contract Quality 3.6 / 19

Developer Ergonomics 3.1 / 15

Access Clarity 3.2 / 15

Operational Transparency 0.0 / 10

Contract Governance 0.4 / 9

Discoverability 5.1 / 8

Regulatory Posture 4.7 / 15

Create-or-Update Ergonomics 0.0 / 10

Agent readiness — 25/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 10 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 7 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics applies to this provider. This API accepts writes, so it carries 10 points of the composite. It is scored from the published contracts themselves: whether a caller can create-or-update in one call, whether the write accepts a key the caller already holds, and whether the response says which branch ran. Without that, every write needs a search-and-branch in front of it, and the first time that check is skipped a duplicate record is created. Scored against the observed mean rather than raw — a provider at the catalog average is unchanged by this facet, not penalised by it.

The six quality facets above are damped to 75 points between them, because the conditional facet above carries the other 25. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 75% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/orionis-biosciences: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

APIs 11

Individual APIs this provider publishes, each with its own machine-readable definition.

Orionis Biosciences Abilities API

The Abilities API from Orionis Biosciences — 6 operation(s) for abilities.

Orionis Biosciences Comments API

The Comments API from Orionis Biosciences — 2 operation(s) for comments.

Orionis Biosciences Discovery API

The Discovery API from Orionis Biosciences — 8 operation(s) for discovery.

Orionis Biosciences Media API

The Media API from Orionis Biosciences — 4 operation(s) for media.

Orionis Biosciences News API

The News API from Orionis Biosciences — 2 operation(s) for news.

Orionis Biosciences O Embed API

The oEmbed API from Orionis Biosciences — 3 operation(s) for oembed.

Orionis Biosciences Pages API

The Pages API from Orionis Biosciences — 2 operation(s) for pages.

Orionis Biosciences Search API

The Search API from Orionis Biosciences — 1 operation(s) for search.

Orionis Biosciences Taxonomy API

The Taxonomy API from Orionis Biosciences — 4 operation(s) for taxonomy.

Orionis Biosciences Team API

The Team API from Orionis Biosciences — 2 operation(s) for team.

Orionis Biosciences Users API

The Users API from Orionis Biosciences — 3 operation(s) for users.

Scroll for all 11

Open Collections 12

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

API Collection

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) Abilities API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) Comments API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) Discovery API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) Media API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) News API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) O Embed API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) Pages API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) Search API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) Taxonomy API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) Team API

OPEN COLLECTION

Orionis Biosciences Website Content API (WordPress REST) Users API

OPEN COLLECTION

Scroll for all 12

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Orionis Biosciences Authentication

apiKey/http · 2 schemes

SECURITY

Orionis Biosciences Domain Security

TLSv1.3 · DMARC

SECURITY

Agentic Access 1

Recommended x-agentic-access execution contracts for AI agents.

Orionis Biosciences Agentic Access

85 operations · 50 acting

AGENTIC

Resources

Agent Surfaces 5

MCP servers, agent skills, and machine-readable catalogs

X-MCPServerCandidate

LLMsTxt

WellKnown

AgenticAccess

AgentSkill

Design & Contract 3

Pagination, idempotency, versioning, errors, and events

Conventions

Conventions

Conformance

Conformance

Lifecycle

Lifecycle

Build 1

SDKs, sample code, and the tooling you integrate with

Packages

Packages

Access & Security 2

Authentication, authorization, and security posture

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 1

Status, limits, changes, and where to get help

Support

Support

Commercial 2

Pricing, plans, and the legal terms of use

TermsOfService

TermsOfService

PrivacyPolicy

PrivacyPolicy

Company 7

The organization behind the API

Website

About

Blog

BlogRSS

News

LinkedIn

Twitter

Twitter

Scroll for all 7

Other 6

Properties that don't map to a standard resource type

Overlay

Team

Technology

Pipeline

CookiePolicy

SecondaryMarket

Source (apis.yml)

aid: orionis-biosciences
name: Orionis Biosciences
description: Orionis Biosciences is a privately held biotechnology company headquartered at 950 Winter Street in Waltham,
  Massachusetts, with a research site in Ghent, Belgium, co-founded by Niko Kley and Jan Tavernier. It develops precision
  medicines across three modalities — small molecule molecular glues built on its Allo-Glue platform, conditional and cis-targeted
  cytokines built on its A-Kine platform, and multi-specific cell engagers built on its MCE platform — combining disease biology,
  immunology, chemistry, protein engineering, computational science and machine learning at genome scale. Its lead A-Kine
  program ORB-011, an attenuated cis-targeted interferon immunotherapy, has entered Phase 1. Orionis has run multi-year molecular-glue
  discovery collaborations with Genentech (2023, and a 2025 expansion with $105M upfront and more than $2B in potential milestones)
  and Novartis (from 2020, expanded in 2026 with $40M upfront and up to $1.4B in milestones). Orionis Biosciences publishes
  no developer program, no product API and no OpenAPI of its own; the only machine-readable surface on orionisbio.com is the
  WordPress REST API (wp/v2) that serves the company newsroom, corporate and platform pages, leadership and scientific-team
  profiles and the media library as anonymously readable JSON, alongside a WordPress Abilities API (wp-abilities/v1) registry
  that is present but authentication-gated.
url: https://raw.githubusercontent.com/api-evangelist/orionis-biosciences/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enrichment-pipeline
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: true
  label: Hosted service · you call their endpoint
  confidence: high
  source:
  - openapi
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  probe_state: covered
  source:
  - authentication
  - security
  generated: '2026-09-03'
  method: derived
image: https://orionisbio.com/wp-content/uploads/2020/02/cropped-favicon-coast-192x192.png
specificationVersion: '0.23'
created: '2026-08-04'
modified: '2026-08-04'
tags:
- Company
- Biotechnology
- Life Sciences
- Drug Discovery
- Pharmaceuticals
- Oncology
- Immunotherapy
- Protein Engineering
- Molecular Glues
- Computational Biology
- Machine-Learning
- Clinical Trials
- Content
tags_raw:
- Company
- Biotechnology
- Life Sciences
- Drug Discovery
- Pharmaceuticals
- Oncology
- Immunotherapy
- Protein Engineering
- Molecular Glues
- Computational Biology
- Machine Learning
- Clinical Trials
- Content
apis:
- aid: orionis-biosciences:orionis-biosciences-abilities-api
  name: Orionis Biosciences Abilities API
  description: The Abilities API from Orionis Biosciences — 6 operation(s) for abilities.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Abilities
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-abilities-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-comments-api
  name: Orionis Biosciences Comments API
  description: The Comments API from Orionis Biosciences — 2 operation(s) for comments.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Comments
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-comments-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-discovery-api
  name: Orionis Biosciences Discovery API
  description: The Discovery API from Orionis Biosciences — 8 operation(s) for discovery.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Discovery
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-discovery-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-media-api
  name: Orionis Biosciences Media API
  description: The Media API from Orionis Biosciences — 4 operation(s) for media.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Media
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-media-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-news-api
  name: Orionis Biosciences News API
  description: The News API from Orionis Biosciences — 2 operation(s) for news.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - News
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-news-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-oembed-api
  name: Orionis Biosciences O Embed API
  description: The oEmbed API from Orionis Biosciences — 3 operation(s) for oembed.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - oEmbed
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-oembed-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-pages-api
  name: Orionis Biosciences Pages API
  description: The Pages API from Orionis Biosciences — 2 operation(s) for pages.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Pages
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-pages-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-search-api
  name: Orionis Biosciences Search API
  description: The Search API from Orionis Biosciences — 1 operation(s) for search.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Search
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-search-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-taxonomy-api
  name: Orionis Biosciences Taxonomy API
  description: The Taxonomy API from Orionis Biosciences — 4 operation(s) for taxonomy.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Taxonomy
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-taxonomy-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-team-api
  name: Orionis Biosciences Team API
  description: The Team API from Orionis Biosciences — 2 operation(s) for team.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Team
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-team-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-users-api
  name: Orionis Biosciences Users API
  description: The Users API from Orionis Biosciences — 3 operation(s) for users.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - User
  tags_raw:
  - Users
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-users-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
x-enrichment:
  date: '2026-08-04'
  status: enriched
  artifacts_added: 20
  pass: local-v1
x-coverage:
  state: covered
  reason: covered
  detail: Orionis Biosciences runs no developer program, but contract discovery found a real provider-served machine-readable
    surface — the WordPress REST route index at https://orionisbio.com/wp-json/ (HTTP 200), whose wp/v2 namespace returns
    the newsroom, platform pages, the orionis_team profiles and the media library anonymously. That index was saved verbatim
    and the OpenAPI, data model, error catalog, conventions and skills were derived from it.
  evidence:
  - url: https://orionisbio.com/wp-json/
    status: 200
  - url: https://orionisbio.com/wp-json/wp/v2/posts
    status: 200
  - url: https://orionisbio.com/.well-known/agent-card.json
    status: 404
  - url: https://orionisbio.com/llms.txt
    status: 404
  checked: '2026-08-04'
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: X-MCPServerCandidate
  url: mcp/orionis-biosciences-mcp.yml
  note: 'Renamed from MCPServer 2026-09-03 (roadmap#247): the manifest self-describes as status: candidate — a tool list derived
    from the published API contracts, not an existing server. The scorer already read the manifest and reported mcp_server
    correctly; the MCPServer type was crediting the artifact-type surfaces with a server that does not exist.'
- type: Overlay
  url: overlays/orionis-biosciences-content-overlay.yaml
- type: Website
  url: https://orionisbio.com/
- type: About
  url: https://orionisbio.com/about-us/
- type: Blog
  url: https://orionisbio.com/news/
- type: BlogRSS
  url: https://orionisbio.com/feed/
- type: News
  url: https://orionisbio.com/news/
- type: Support
  url: https://orionisbio.com/contact/
- type: Team
  url: https://orionisbio.com/about-us/executive-team/
- type: Technology
  url: https://orionisbio.com/platforms/
- type: Pipeline
  url: https://orionisbio.com/pipeline/
- type: TermsOfService
  url: https://orionisbio.com/terms-of-use/
- type: PrivacyPolicy
  url: https://orionisbio.com/privacy-policy/
- type: CookiePolicy
  url: https://orionisbio.com/cookie-policy/
- type: LinkedIn
  url: https://www.linkedin.com/company/orionis-biosciences/
- type: Twitter
  url: https://twitter.com/orionisbio
- type: SecondaryMarket
  url: https://forgeglobal.com/orionis-biosciences_stock/
- type: Packages
  url: packages/orionis-biosciences-packages.yml
- type: LLMsTxt
  url: llms/orionis-biosciences-llms.txt
- type: WellKnown
  url: well-known/orionis-biosciences-well-known.yml
- type: Authentication
  url: authentication/orionis-biosciences-authentication.yml
- type: Conventions
  url: conventions/orionis-biosciences-conventions.yml
- type: Conformance
  url: conformance/orionis-biosciences-conformance.yml
- type: Lifecycle
  url: lifecycle/orionis-biosciences-lifecycle.yml
- type: DomainSecurity
  url: security/orionis-biosciences-domain-security.yml
- type: AgenticAccess
  url: agentic-access/orionis-biosciences-agentic-access.yml
- type: AgentSkill
  url: skills/_index.yml

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