Orionis Biosciences

Orionis Biosciences is a privately held biotechnology company headquartered at 950 Winter Street in Waltham, Massachusetts, with a research site in Ghent, Belgium, co-founded by Niko Kley and Jan Tavernier. It develops precision medicines across three modalities — small molecule molecular glues built on its Allo-Glue platform, conditional and cis-targeted cytokines built on its A-Kine platform, and multi-specific cell engagers built on its MCE platform — combining disease biology, immunology, chemistry, protein engineering, computational science and machine learning at genome scale. Its lead A-Kine program ORB-011, an attenuated cis-targeted interferon immunotherapy, has entered Phase 1. Orionis has run multi-year molecular-glue discovery collaborations with Genentech (2023, and a 2025 expansion with $105M upfront and more than $2B in potential milestones) and Novartis (from 2020, expanded in 2026 with $40M upfront and up to $1.4B in milestones). Orionis Biosciences publishes no developer program, no product API and no OpenAPI of its own; the only machine-readable surface on orionisbio.com is the WordPress REST API (wp/v2) that serves the company newsroom, corporate and platform pages, leadership and scientific-team profiles and the media library as anonymously readable JSON, alongside a WordPress Abilities API (wp-abilities/v1) registry that is present but authentication-gated.

Orionis Biosciences publishes 11 APIs on the APIs.io network, including Abilities API, Comments API, Discovery API, and 8 more. Tagged areas include Company, Biotechnology, Life Sciences, Drug Discovery, and Pharmaceuticals.

Orionis Biosciences’ developer surface includes engineering blog, product news, support, authentication, and 23 more developer resources.

🌐 Visit website 📡 Source on GitHub

23.0/100 emerging ▬ flat Agent 39/100 agent ready Full breakdown ↓
scored 2026-08-17 · rubric v0.11.0

11 APIs 1 MCP Servers

CompanyBiotechnologyLife SciencesDrug DiscoveryPharmaceuticalsOncologyImmunotherapyProtein EngineeringMolecular GluesComputational BiologyMachine LearningClinical TrialsContent

Kin Score

Kin Score How this is scored →
scored 2026-08-17 · rubric v0.11.0

Composite quality — 23.0/100 · emerging

Contract Quality 3.1 / 21

Developer Ergonomics 3.6 / 17

Commercial Clarity 3.6 / 17

Operational Transparency 0.0 / 11

Governance 1.2 / 10

Discoverability 6.9 / 9

Regulatory Posture 4.7 / 15

Agent readiness — 39/100 · agent ready

Machine-Readable Contract 18 / 18

Agentic Access Contract 10 / 10

MCP Server 12 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. This rating is computed from github.com/api-evangelist/orionis-biosciences: open an issue to ask a question, or submit a pull request to add artifacts. Want it done for you? Prioritized profiling — $2,500 →

APIs 11

Individual APIs this provider publishes, each with its own machine-readable definition.

Open Collections 12

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

MCP Servers 1

Model Context Protocol servers that expose these APIs to AI agents.

Agent Surfaces 5

MCP servers, agent skills, and machine-readable catalogs

MCPServer

LLMsTxt

WellKnown

AgenticAccess

AgentSkill

Design & Contract 3

Pagination, idempotency, versioning, errors, and events

Conventions

Conventions

Conformance

Conformance

Lifecycle

Lifecycle

Build 1

SDKs, sample code, and the tooling you integrate with

Packages

Packages

Access & Security 2

Authentication, authorization, and security posture

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 1

Status, limits, changes, and where to get help

Support

Support

Commercial 2

Pricing, plans, and the legal terms of use

TermsOfService

TermsOfService

PrivacyPolicy

PrivacyPolicy

Company 7

The organization behind the API

Website

About

Blog

BlogRSS

News

LinkedIn

Twitter

Twitter

Scroll for all 7

Other 6

Properties that don't map to a standard resource type

Overlay

Team

Technology

Pipeline

CookiePolicy

SecondaryMarket

Source (apis.yml)

aid: orionis-biosciences
name: Orionis Biosciences
description: Orionis Biosciences is a privately held biotechnology company headquartered at 950 Winter Street in Waltham,
  Massachusetts, with a research site in Ghent, Belgium, co-founded by Niko Kley and Jan Tavernier. It develops precision
  medicines across three modalities — small molecule molecular glues built on its Allo-Glue platform, conditional and cis-targeted
  cytokines built on its A-Kine platform, and multi-specific cell engagers built on its MCE platform — combining disease biology,
  immunology, chemistry, protein engineering, computational science and machine learning at genome scale. Its lead A-Kine
  program ORB-011, an attenuated cis-targeted interferon immunotherapy, has entered Phase 1. Orionis has run multi-year molecular-glue
  discovery collaborations with Genentech (2023, and a 2025 expansion with $105M upfront and more than $2B in potential milestones)
  and Novartis (from 2020, expanded in 2026 with $40M upfront and up to $1.4B in milestones). Orionis Biosciences publishes
  no developer program, no product API and no OpenAPI of its own; the only machine-readable surface on orionisbio.com is the
  WordPress REST API (wp/v2) that serves the company newsroom, corporate and platform pages, leadership and scientific-team
  profiles and the media library as anonymously readable JSON, alongside a WordPress Abilities API (wp-abilities/v1) registry
  that is present but authentication-gated.
url: https://raw.githubusercontent.com/api-evangelist/orionis-biosciences/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enrichment-pipeline
image: https://orionisbio.com/wp-content/uploads/2020/02/cropped-favicon-coast-192x192.png
specificationVersion: '0.20'
created: '2026-08-04'
modified: '2026-08-04'
tags:
- Company
- Biotechnology
- Life Sciences
- Drug Discovery
- Pharmaceuticals
- Oncology
- Immunotherapy
- Protein Engineering
- Molecular Glues
- Computational Biology
- Machine Learning
- Clinical Trials
- Content
apis:
- aid: orionis-biosciences:orionis-biosciences-abilities-api
  name: Orionis Biosciences Abilities API
  description: The Abilities API from Orionis Biosciences — 6 operation(s) for abilities.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Abilities
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-abilities-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-comments-api
  name: Orionis Biosciences Comments API
  description: The Comments API from Orionis Biosciences — 2 operation(s) for comments.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Comments
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-comments-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-discovery-api
  name: Orionis Biosciences Discovery API
  description: The Discovery API from Orionis Biosciences — 8 operation(s) for discovery.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Discovery
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-discovery-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-media-api
  name: Orionis Biosciences Media API
  description: The Media API from Orionis Biosciences — 4 operation(s) for media.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Media
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-media-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-news-api
  name: Orionis Biosciences News API
  description: The News API from Orionis Biosciences — 2 operation(s) for news.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - News
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-news-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-oembed-api
  name: Orionis Biosciences O Embed API
  description: The oEmbed API from Orionis Biosciences — 3 operation(s) for oembed.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - oEmbed
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-oembed-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-pages-api
  name: Orionis Biosciences Pages API
  description: The Pages API from Orionis Biosciences — 2 operation(s) for pages.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Pages
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-pages-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-search-api
  name: Orionis Biosciences Search API
  description: The Search API from Orionis Biosciences — 1 operation(s) for search.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Search
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-search-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-taxonomy-api
  name: Orionis Biosciences Taxonomy API
  description: The Taxonomy API from Orionis Biosciences — 4 operation(s) for taxonomy.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Taxonomy
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-taxonomy-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-team-api
  name: Orionis Biosciences Team API
  description: The Team API from Orionis Biosciences — 2 operation(s) for team.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Team
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-team-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
- aid: orionis-biosciences:orionis-biosciences-users-api
  name: Orionis Biosciences Users API
  description: The Users API from Orionis Biosciences — 3 operation(s) for users.
  humanURL: https://orionisbio.com/news/
  baseURL: https://orionisbio.com/wp-json/wp/v2
  tags:
  - Users
  properties:
  - type: OpenAPI
    url: openapi/orionis-biosciences-users-api-openapi.yml
  - type: DataModel
    url: data-model/orionis-biosciences-data-model.yml
  - type: ErrorCatalog
    url: errors/orionis-biosciences-problem-types.yml
  - type: Examples
    url: examples/orionis-biosciences-examples.yml
x-enrichment:
  date: '2026-08-04'
  status: enriched
  artifacts_added: 20
  pass: local-v1
x-coverage:
  state: covered
  reason: covered
  detail: Orionis Biosciences runs no developer program, but contract discovery found a real provider-served machine-readable
    surface — the WordPress REST route index at https://orionisbio.com/wp-json/ (HTTP 200), whose wp/v2 namespace returns
    the newsroom, platform pages, the orionis_team profiles and the media library anonymously. That index was saved verbatim
    and the OpenAPI, data model, error catalog, conventions and skills were derived from it.
  evidence:
  - url: https://orionisbio.com/wp-json/
    status: 200
  - url: https://orionisbio.com/wp-json/wp/v2/posts
    status: 200
  - url: https://orionisbio.com/.well-known/agent-card.json
    status: 404
  - url: https://orionisbio.com/llms.txt
    status: 404
  checked: '2026-08-04'
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: MCPServer
  url: mcp/orionis-biosciences-mcp.yml
- type: Overlay
  url: overlays/orionis-biosciences-content-overlay.yaml
- type: Website
  url: https://orionisbio.com/
- type: About
  url: https://orionisbio.com/about-us/
- type: Blog
  url: https://orionisbio.com/news/
- type: BlogRSS
  url: https://orionisbio.com/feed/
- type: News
  url: https://orionisbio.com/news/
- type: Support
  url: https://orionisbio.com/contact/
- type: Team
  url: https://orionisbio.com/about-us/executive-team/
- type: Technology
  url: https://orionisbio.com/platforms/
- type: Pipeline
  url: https://orionisbio.com/pipeline/
- type: TermsOfService
  url: https://orionisbio.com/terms-of-use/
- type: PrivacyPolicy
  url: https://orionisbio.com/privacy-policy/
- type: CookiePolicy
  url: https://orionisbio.com/cookie-policy/
- type: LinkedIn
  url: https://www.linkedin.com/company/orionis-biosciences/
- type: Twitter
  url: https://twitter.com/orionisbio
- type: SecondaryMarket
  url: https://forgeglobal.com/orionis-biosciences_stock/
- type: Packages
  url: packages/orionis-biosciences-packages.yml
- type: LLMsTxt
  url: llms/orionis-biosciences-llms.txt
- type: WellKnown
  url: well-known/orionis-biosciences-well-known.yml
- type: Authentication
  url: authentication/orionis-biosciences-authentication.yml
- type: Conventions
  url: conventions/orionis-biosciences-conventions.yml
- type: Conformance
  url: conformance/orionis-biosciences-conformance.yml
- type: Lifecycle
  url: lifecycle/orionis-biosciences-lifecycle.yml
- type: DomainSecurity
  url: security/orionis-biosciences-domain-security.yml
- type: AgenticAccess
  url: agentic-access/orionis-biosciences-agentic-access.yml
- type: AgentSkill
  url: skills/_index.yml