Kartos Therapeutics

Kartos Therapeutics, Inc. is a privately held, clinical-stage biopharmaceutical company headquartered at 275 Shoreline Drive, Redwood City, California, developing navtemadlin (KRT-232), an orally administered, potent and selective small-molecule inhibitor of MDM2. The company was founded in 2016 by Wayne Rothbaum, president of Quogue Capital and co-founder of Acerta Pharma, around an MDM2 inhibitor in-licensed from Amgen. Navtemadlin blocks the MDM2 protein that suppresses p53, restoring p53 function in tumours that retain wild-type TP53 and driving cell-cycle arrest through p21 and apoptosis through pro-apoptotic Bcl-2 family proteins. The clinical programme is centred on myelofibrosis and includes the enrolling global Phase 3 POIESIS trial of navtemadlin added to ruxolitinib (NCT06479135), the Phase 1b/2 KRT-232-109 combination study (NCT04485260), and the completed Phase 3 BOREAS study of navtemadlin versus best available therapy in JAK-inhibitor relapsed or refractory myelofibrosis (NCT03662126), with reported activity also in acute myeloid leukaemia and Merkel cell carcinoma. Kartos is led by CEO Jesse McGreivy, MD, with Srdan Verstovsek, MD, PhD as chief medical officer, and is backed by Quogue Capital, OrbiMed Advisors, Amgen, SR One, Fidelity, BlackRock, T. Rowe Price, Invus and Soleus Capital. Kartos Therapeutics runs no developer program and publishes no product API, no developer portal and no API documentation; the only machine-readable surface reachable without credentials is the WordPress REST content API behind kartosthera.com, catalogued here.

Kartos Therapeutics publishes 1 API on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Oncology, and Hematology.

Kartos Therapeutics’ developer surface includes support, authentication, and 20 more developer resources.

🌐 Visit website 📡 Source on GitHub

15.0/100 emerging ▬ flat Agent 4/100 human only Front door AI 1/6 silent Full breakdown ↓
scored 2026-09-25 · rubric v0.23.0

1 APIs

Company Biotechnology Pharmaceuticals Oncology Hematology Rare Disease Precision Medicine Clinical Trials Life Sciences content-api

Kin Score

Kin Score How this is scored →
scored 2026-09-25 · rubric v0.23.0

Composite quality — 15.0/100 · emerging

Contract Quality 0.4 / 21

Developer Ergonomics 4.8 / 17

Access Clarity 1.8 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.5 / 10

Discoverability 4.9 / 9

Regulatory Posture 2.5 / 15

Agent readiness — 4/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/kartos-therapeutics: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

APIs 1

Individual APIs this provider publishes, each with its own machine-readable definition.

Kartos Therapeutics Website (WordPress REST)

The public WordPress REST API (wp-json) of the Kartos Therapeutics website at kartosthera.com: the route index of the site's content management system, catalogued as one site su...

Open Collections 1

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

API Collection

OPEN COLLECTION

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Kartos Therapeutics Authentication

http · 1 scheme

SECURITY

Kartos Therapeutics Domain Security

TLSv1.3 · HSTS · DMARC

SECURITY

Resources

Agent Surfaces 3

MCP servers, agent skills, and machine-readable catalogs

WellKnown

WellKnown

LLMsTxt

LLMsTxt

AgentSkill

AgentSkill

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions

Conformance

ErrorCatalog

Lifecycle

DataModel

Access & Security 2

Authentication, authorization, and security posture

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 2

Status, limits, changes, and where to get help

Contact

Contact

Support

Support

Commercial 1

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

Company 3

The organization behind the API

Website

Website

About

About

LinkedIn

Other 6

Properties that don't map to a standard resource type

Overlay

Science

Research

Presentations

PatientResources

SecondaryMarket

Source (apis.yml)

aid: kartos-therapeutics
name: Kartos Therapeutics
description: Kartos Therapeutics, Inc. is a privately held, clinical-stage biopharmaceutical company headquartered at 275
  Shoreline Drive, Redwood City, California, developing navtemadlin (KRT-232), an orally administered, potent and selective
  small-molecule inhibitor of MDM2. The company was founded in 2016 by Wayne Rothbaum, president of Quogue Capital and co-founder
  of Acerta Pharma, around an MDM2 inhibitor in-licensed from Amgen. Navtemadlin blocks the MDM2 protein that suppresses p53,
  restoring p53 function in tumours that retain wild-type TP53 and driving cell-cycle arrest through p21 and apoptosis through
  pro-apoptotic Bcl-2 family proteins. The clinical programme is centred on myelofibrosis and includes the enrolling global
  Phase 3 POIESIS trial of navtemadlin added to ruxolitinib (NCT06479135), the Phase 1b/2 KRT-232-109 combination study (NCT04485260),
  and the completed Phase 3 BOREAS study of navtemadlin versus best available therapy in JAK-inhibitor relapsed or refractory
  myelofibrosis (NCT03662126), with reported activity also in acute myeloid leukaemia and Merkel cell carcinoma. Kartos is
  led by CEO Jesse McGreivy, MD, with Srdan Verstovsek, MD, PhD as chief medical officer, and is backed by Quogue Capital,
  OrbiMed Advisors, Amgen, SR One, Fidelity, BlackRock, T. Rowe Price, Invus and Soleus Capital. Kartos Therapeutics runs
  no developer program and publishes no product API, no developer portal and no API documentation; the only machine-readable
  surface reachable without credentials is the WordPress REST content API behind kartosthera.com, catalogued here.
deliveryModel:
  model: unknown
  open_source: false
  commercial: false
  callable_host: true
  label: Delivery model not determined — needs a product licence on record
  confidence: low
  source:
  - openapi
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - authentication
  - security
  generated: '2026-09-03'
  method: derived
image: https://kartosthera.com/wp-content/uploads/2025/10/og_kartos-therapeutics.jpg
url: https://raw.githubusercontent.com/api-evangelist/kartos-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enriched
specificationVersion: '0.23'
created: '2026-08-04'
modified: '2026-08-04'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Oncology
- Hematology
- Rare Disease
- Precision Medicine
- Clinical Trials
- Life Sciences
- content-api
tags_raw:
- Company
- biotechnology
- pharmaceuticals
- oncology
- hematology
- rare-disease
- precision-medicine
- clinical-trials
- life-sciences
- content-api
apis:
- aid: kartos-therapeutics:kartosthera-com-website-wordpress-rest
  name: Kartos Therapeutics Website (WordPress REST)
  description: 'The public WordPress REST API (wp-json) of the Kartos Therapeutics website at kartosthera.com: the route index
    of the site''s content management system, catalogued as one site surface rather than as separate APIs.'
  baseURL: https://kartosthera.com/wp-json
  tags:
  - WordPress
  x-surface: platform-generated
  properties:
  - type: Documentation
    url: https://kartosthera.com/wp-json
  x-platform: wordpress
  x-platform-surface: rest
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Overlay
  url: overlays/kartos-therapeutics-content-overlay.yaml
- type: Website
  url: https://kartosthera.com/
- type: About
  url: https://kartosthera.com/about/
- type: Science
  url: https://kartosthera.com/science/
- type: Research
  url: https://kartosthera.com/research/
- type: Presentations
  url: https://kartosthera.com/presentations/
- type: PatientResources
  url: https://kartosthera.com/advocacy/
- type: Contact
  url: https://kartosthera.com/contact/
- type: Support
  url: https://kartosthera.com/contact/
- type: PrivacyPolicy
  url: https://kartosthera.com/privacy-policy/
- type: LinkedIn
  url: https://www.linkedin.com/company/kartos-therapeutics
- type: SecondaryMarket
  url: https://forgeglobal.com/kartos-therapeutics_stock/
- type: Authentication
  url: authentication/kartos-therapeutics-authentication.yml
- type: Conventions
  url: conventions/kartos-therapeutics-conventions.yml
- type: Conformance
  url: conformance/kartos-therapeutics-conformance.yml
- type: ErrorCatalog
  url: errors/kartos-therapeutics-problem-types.yml
- type: Lifecycle
  url: lifecycle/kartos-therapeutics-lifecycle.yml
- type: DataModel
  url: data-model/kartos-therapeutics-data-model.yml
- type: WellKnown
  url: well-known/kartos-therapeutics-well-known.yml
- type: DomainSecurity
  url: security/kartos-therapeutics-domain-security.yml
- type: LLMsTxt
  url: llms/kartos-therapeutics-llms.txt
- type: AgentSkill
  url: skills/_index.yml
x-enrichment:
  date: '2026-08-04'
  status: enriched
  artifacts_added: 15
  pass: local-v1

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