iECURE

iECURE is a clinical-stage genetic medicines company developing variant-agnostic, in vivo targeted gene insertion therapies for rare, life-threatening inherited metabolic diseases, with an initial focus on urea cycle disorders and other neurometabolic conditions of the liver. The company takes its name from iecur, the Latin word for liver, and was founded on the translational gene therapy research of James M. Wilson, M.D., Ph.D., advancing its pipeline in partnership with the University of Pennsylvania Gene Therapy Program. Its lead candidate, ECUR-506, pairs a dual-AAV delivery approach with Precision BioSciences' ARCUS nuclease to insert a functional copy of the OTC gene into the genome of infants with neonatal-onset ornithine transcarbamylase deficiency; it is in the OTC-HOPE study and has received FDA Orphan Drug, Rare Pediatric Disease, Fast Track and RMAT designations plus EU orphan designation, with clinical trial clearances in the United States, United Kingdom, Australia and the EU. Discovery-stage programs target citrullinemia type 1 and phenylketonuria. iECURE has raised roughly $115 million across a $50 million Series A in 2021 and a $65 million Series A-1 in 2022 from Versant Ventures, OrbiMed, Novo Holdings, the Qatar Investment Authority, LYFE Capital and Double Point Ventures. iECURE runs no developer program and publishes no product API, developer portal or API documentation. The only machine-readable surface reachable without credentials is the WordPress REST content API behind iecure.com, catalogued here.

iECURE is listed with 1 API on the APIs.io network. Tagged areas include Company, Biotechnology, Genetic Medicine, Gene Editing, and Gene Therapy.

iECURE’s developer surface includes product news, support, authentication, and 25 more developer resources.

🌐 Visit website 📡 Source on GitHub

17.9/100 emerging ▬ flat Agent 7/100 agent aware Front door AI 1/6 silent saas Full breakdown ↓
scored 2026-10-09 · rubric v0.23.0

1 API

Company Biotechnology Genetic Medicine Gene Editing Gene Therapy Rare Disease Clinical Trials Life Sciences Pharmaceuticals content-api

Kin Score

Kin Score How this is scored →
scored 2026-10-09 · rubric v0.23.0

Composite quality — 17.9/100 · emerging

Contract Quality 0.0 / 21

Developer Ergonomics 4.8 / 17

Access Clarity 3.6 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.5 / 10

Discoverability 5.5 / 9

Regulatory Posture 2.9 / 15

Agent readiness — 7/100 · agent aware

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 7 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/iecure: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

APIs 1

Individual APIs this provider publishes, each with its own machine-readable definition.

iECURE Website (WordPress REST)

The public WordPress REST API (wp-json) of the iECURE website at iecure.com: the route index of the site's content management system, catalogued as one site surface rather than ...

Pricing Plans 1

Published pricing tiers and plan structures.

Iecure Plans Pricing

0 plans

PLANS

Rate Limits 1

Documented rate limits and quota policies.

Iecure Rate Limits

0 limits

RATE LIMITS

OpenAPI Overlays 1

Overlays applied on top of this provider's contracts. Each card says who wrote it: a document the provider publishes, or one API Evangelist derived or generated.

Iecure Content Overlay

7 actions · update

GENERATED

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Iecure Authentication

http · 1 scheme

SECURITY

Iecure Domain Security

TLSv1.3 · DMARC

SECURITY

Resources

Documentation 1

Reference material describing how the API behaves

SocialMediaGuidelines

SocialMediaGuidelines

Agent Surfaces 2

MCP servers, agent skills, and machine-readable catalogs

LLMsTxt

LLMsTxt

AgentSkill

AgentSkill

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions

Conformance

ErrorCatalog

Lifecycle

DataModel

Access & Security 2

Authentication, authorization, and security posture

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 2

Status, limits, changes, and where to get help

Support

Support

RateLimits

RateLimits

Commercial 3

Pricing, plans, and the legal terms of use

TermsOfService

TermsOfService

PrivacyPolicy

PrivacyPolicy

Plans

Plans

Company 6

The organization behind the API

Website

About

News

BlogRSS

Careers

LinkedIn

Other 7

Properties that don't map to a standard resource type

Approach

Approach

Pipeline

Pipeline

ExpandedAccessPolicy

PatientResources

CookieNotice

SecondaryMarket

Overlay

Scroll for all 7

Source (apis.yml)

aid: iecure
name: iECURE
description: iECURE is a clinical-stage genetic medicines company developing variant-agnostic, in vivo targeted gene insertion
  therapies for rare, life-threatening inherited metabolic diseases, with an initial focus on urea cycle disorders and other
  neurometabolic conditions of the liver. The company takes its name from iecur, the Latin word for liver, and was founded
  on the translational gene therapy research of James M. Wilson, M.D., Ph.D., advancing its pipeline in partnership with the
  University of Pennsylvania Gene Therapy Program. Its lead candidate, ECUR-506, pairs a dual-AAV delivery approach with Precision
  BioSciences' ARCUS nuclease to insert a functional copy of the OTC gene into the genome of infants with neonatal-onset ornithine
  transcarbamylase deficiency; it is in the OTC-HOPE study and has received FDA Orphan Drug, Rare Pediatric Disease, Fast
  Track and RMAT designations plus EU orphan designation, with clinical trial clearances in the United States, United Kingdom,
  Australia and the EU. Discovery-stage programs target citrullinemia type 1 and phenylketonuria. iECURE has raised roughly
  $115 million across a $50 million Series A in 2021 and a $65 million Series A-1 in 2022 from Versant Ventures, OrbiMed,
  Novo Holdings, the Qatar Investment Authority, LYFE Capital and Double Point Ventures. iECURE runs no developer program
  and publishes no product API, developer portal or API documentation. The only machine-readable surface reachable without
  credentials is the WordPress REST content API behind iecure.com, catalogued here.
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: true
  label: Hosted service · you call their endpoint
  confidence: high
  source:
  - openapi
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - authentication
  - rate-limits
  - security
  generated: '2026-09-03'
  method: derived
image: https://iecure.com/wp-content/uploads/iECURE_White_Logo.png
url: https://raw.githubusercontent.com/api-evangelist/iecure/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enriched
specificationVersion: '0.23'
created: '2026-08-22'
modified: '2026-08-22'
tags:
- Company
- Biotechnology
- Genetic Medicine
- Gene Editing
- Gene Therapy
- Rare Disease
- Clinical Trials
- Life Sciences
- Pharmaceuticals
- content-api
tags_raw:
- Company
- biotechnology
- genetic-medicine
- gene-editing
- gene-therapy
- rare-disease
- clinical-trials
- life-sciences
- pharmaceuticals
- content-api
apis:
- aid: iecure:iecure-com-website-wordpress-rest
  name: iECURE Website (WordPress REST)
  description: 'The public WordPress REST API (wp-json) of the iECURE website at iecure.com: the route index of the site''s
    content management system, catalogued as one site surface rather than as separate APIs.'
  baseURL: https://iecure.com/wp-json
  tags:
  - WordPress
  x-surface: platform-generated
  properties:
  - type: Documentation
    url: https://iecure.com/wp-json
  x-platform: wordpress
  x-platform-surface: rest
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Website
  url: https://iecure.com/
- type: About
  url: https://iecure.com/about/
- type: Approach
  url: https://iecure.com/approach/
- type: Pipeline
  url: https://iecure.com/programs/
- type: News
  url: https://iecure.com/news/
- type: BlogRSS
  url: https://iecure.com/feed/
- type: Careers
  url: https://iecure.com/careers/
- type: Support
  url: https://iecure.com/contact/
- type: ExpandedAccessPolicy
  url: https://iecure.com/expanded-access-policy/
- type: PatientResources
  url: https://otc-hope.com/
- type: TermsOfService
  url: https://iecure.com/terms-of-service/
- type: PrivacyPolicy
  url: https://iecure.com/privacy-notice/
- type: CookieNotice
  url: https://iecure.com/cookie-notice/
- type: SocialMediaGuidelines
  url: https://iecure.com/social-media-community-guidelines/
- type: LinkedIn
  url: https://www.linkedin.com/company/iecure
- type: SecondaryMarket
  url: https://www.nasdaqprivatemarket.com/
- type: Authentication
  url: authentication/iecure-authentication.yml
- type: Conventions
  url: conventions/iecure-conventions.yml
- type: Conformance
  url: conformance/iecure-conformance.yml
- type: ErrorCatalog
  url: errors/iecure-problem-types.yml
- type: Lifecycle
  url: lifecycle/iecure-lifecycle.yml
- type: DataModel
  url: data-model/iecure-data-model.yml
- type: DomainSecurity
  url: security/iecure-domain-security.yml
- type: Overlay
  url: overlays/iecure-content-overlay.yaml
- type: LLMsTxt
  url: llms/iecure-llms.txt
- type: RateLimits
  url: rate-limits/iecure-rate-limits.yml
- type: Plans
  url: plans/iecure-plans-pricing.yml
- type: AgentSkill
  url: skills/_index.yml
x-enrichment:
  date: '2026-08-22'
  status: enriched
  artifacts_added: 27
  pass: local-v1

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