GRIN Therapeutics

GRIN Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to the research and development of precision therapeutics for pediatric neurodevelopmental disorders caused by NMDA receptor dysfunction. It is an affiliate of Neurvati Neurosciences, a Blackstone Life Sciences portfolio company, and traces its founding to Dr. Pierandrea Muglia's attendance at the 2019 CFERV Conference on GRIN Variants at Emory University. Its lead investigational asset is radiprodil, an orally bioavailable selective negative allosteric modulator of the GluN2B subunit of the NMDA receptor, designed to fine-tune dysregulated receptor activity rather than fully block the channel. Radiprodil is in development for GRIN-related neurodevelopmental disorder (GRIN-NDD) arising from gain-of-function variants in GRIN1, GRIN2A, GRIN2B and GRIN2D, and for tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) type II. The clinical programme comprises the completed Phase 1b/2a Honeycomb trial, the enrolling global Phase 3 Beeline registrational trial, the Phase 1b/2a Astroscape trial in TSC and FCD type II, and a GRIN-NDD natural history study; radiprodil carries FDA Breakthrough Therapy, Orphan Drug and Rare Pediatric Disease designations and EMA PRIME and Orphan Drug designations. In May 2025 GRIN Therapeutics entered an exclusive collaboration with Angelini Pharma to develop and commercialise radiprodil outside North America. GRIN Therapeutics runs no developer program and publishes no product API, no developer portal and no API documentation; the only machine-readable surface reachable without credentials is the WordPress REST content API behind grintherapeutics.com, catalogued here.

GRIN Therapeutics publishes 1 API contract indexed on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Neuroscience, and Rare Disease.

GRIN Therapeutics’ developer surface includes product news, support, authentication, and 24 more developer resources.

🌐 Visit website 📡 Source on GitHub

14.6/100 emerging ▬ flat Agent 6/100 agent aware Front door AI 1/6 silent Full breakdown ↓
scored 2026-10-09 · rubric v0.23.0

1 published contract

Company Biotechnology Pharmaceuticals Neuroscience Rare Disease Precision Medicine Clinical Trials Pediatrics Epilepsy Life Sciences content-api

Kin Score

Kin Score How this is scored →
scored 2026-10-09 · rubric v0.23.0

Composite quality — 14.6/100 · emerging

Contract Quality 0.0 / 21

Developer Ergonomics 4.8 / 17

Access Clarity 1.8 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.5 / 10

Discoverability 4.9 / 9

Regulatory Posture 2.5 / 15

Agent readiness — 6/100 · agent aware

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics does not apply to this provider. The published contracts declare no write operations, and a read-only API cannot create-or-update. The facet is excluded from this provider's denominator entirely — not scored zero. A reference or data API is not deficient for being unable to upsert.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/grin-therapeutics: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

APIs 1

Individual APIs this provider publishes, each with its own machine-readable definition.

GRIN Therapeutics Website (WordPress REST)

The public WordPress REST API (wp-json) of the GRIN Therapeutics website at grintherapeutics.com: the route index of the site's content management system, catalogued as one site...

Open Collections 1

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

API Collection

OPEN COLLECTION

OpenAPI Overlays 1

Overlays applied on top of this provider's contracts. Each card says who wrote it: a document the provider publishes, or one API Evangelist derived or generated.

Grin Therapeutics Content Overlay

7 actions · update · grin-therapeutics-content-openapi.yml

UNRECORDED

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Grin Therapeutics Authentication

none/http · 3 schemes

SECURITY

Grin Therapeutics Domain Security

TLSv1.3 · HSTS · DMARC

SECURITY

Resources

Agent Surfaces 3

MCP servers, agent skills, and machine-readable catalogs

WellKnown

WellKnown

LLMsTxt

LLMsTxt

AgentSkill

AgentSkill

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions

Conformance

ErrorCatalog

Lifecycle

DataModel

Access & Security 2

Authentication, authorization, and security posture

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 2

Status, limits, changes, and where to get help

Contact

Contact

Support

Support

Commercial 1

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

Company 7

The organization behind the API

Website

About

News

BlogRSS

Careers

LinkedIn

Twitter

Twitter

Scroll for all 7

Other 7

Properties that don't map to a standard resource type

Overlay

Science

DiseaseState

PatientResources

CookiePolicy

ParentCompany

SecondaryMarket

Scroll for all 7

Source (apis.yml)

aid: grin-therapeutics
name: GRIN Therapeutics
description: GRIN Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to the research and development of
  precision therapeutics for pediatric neurodevelopmental disorders caused by NMDA receptor dysfunction. It is an affiliate
  of Neurvati Neurosciences, a Blackstone Life Sciences portfolio company, and traces its founding to Dr. Pierandrea Muglia's
  attendance at the 2019 CFERV Conference on GRIN Variants at Emory University. Its lead investigational asset is radiprodil,
  an orally bioavailable selective negative allosteric modulator of the GluN2B subunit of the NMDA receptor, designed to fine-tune
  dysregulated receptor activity rather than fully block the channel. Radiprodil is in development for GRIN-related neurodevelopmental
  disorder (GRIN-NDD) arising from gain-of-function variants in GRIN1, GRIN2A, GRIN2B and GRIN2D, and for tuberous sclerosis
  complex (TSC) and focal cortical dysplasia (FCD) type II. The clinical programme comprises the completed Phase 1b/2a Honeycomb
  trial, the enrolling global Phase 3 Beeline registrational trial, the Phase 1b/2a Astroscape trial in TSC and FCD type II,
  and a GRIN-NDD natural history study; radiprodil carries FDA Breakthrough Therapy, Orphan Drug and Rare Pediatric Disease
  designations and EMA PRIME and Orphan Drug designations. In May 2025 GRIN Therapeutics entered an exclusive collaboration
  with Angelini Pharma to develop and commercialise radiprodil outside North America. GRIN Therapeutics runs no developer
  program and publishes no product API, no developer portal and no API documentation; the only machine-readable surface reachable
  without credentials is the WordPress REST content API behind grintherapeutics.com, catalogued here.
deliveryModel:
  model: unknown
  open_source: false
  commercial: false
  callable_host: true
  label: Delivery model not determined — needs a product licence on record
  confidence: low
  source:
  - openapi
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - authentication
  - security
  generated: '2026-09-03'
  method: derived
image: https://grintherapeutics.com/wp-content/uploads/2023/11/neurvati_grin_inline_fullcolor_rgb_6in@72ppi.png
url: https://raw.githubusercontent.com/api-evangelist/grin-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enriched
specificationVersion: '0.23'
created: '2026-08-04'
modified: '2026-08-04'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Neuroscience
- Rare Disease
- Precision Medicine
- Clinical Trials
- Pediatrics
- Epilepsy
- Life Sciences
- content-api
tags_raw:
- Company
- biotechnology
- pharmaceuticals
- neuroscience
- rare-disease
- precision-medicine
- clinical-trials
- pediatrics
- epilepsy
- life-sciences
- content-api
apis:
- aid: grin-therapeutics:grintherapeutics-com-website-wordpress-rest
  name: GRIN Therapeutics Website (WordPress REST)
  description: 'The public WordPress REST API (wp-json) of the GRIN Therapeutics website at grintherapeutics.com: the route
    index of the site''s content management system, catalogued as one site surface rather than as separate APIs.'
  baseURL: https://grintherapeutics.com/wp-json
  tags:
  - WordPress
  x-surface: platform-generated
  properties:
  - type: Documentation
    url: https://grintherapeutics.com/wp-json
  x-platform: wordpress
  x-platform-surface: rest
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Overlay
  url: overlays/grin-therapeutics-content-overlay.yaml
- type: Website
  url: https://grintherapeutics.com/
- type: About
  url: https://grintherapeutics.com/about-grin-therapeutics/
- type: Science
  url: https://grintherapeutics.com/our-science/
- type: DiseaseState
  url: https://grintherapeutics.com/disease-state/
- type: PatientResources
  url: https://grintherapeutics.com/resources-for-patients-and-caregivers/
- type: News
  url: https://grintherapeutics.com/news/
- type: BlogRSS
  url: https://grintherapeutics.com/feed/
- type: Careers
  url: https://grintherapeutics.com/careers/
- type: Contact
  url: https://grintherapeutics.com/contact/
- type: Support
  url: https://grintherapeutics.com/contact/
- type: PrivacyPolicy
  url: https://grintherapeutics.com/privacy/
- type: CookiePolicy
  url: https://grintherapeutics.com/cookie-policy/
- type: LinkedIn
  url: https://www.linkedin.com/company/grin-therapeutics-inc
- type: Twitter
  url: https://twitter.com/GRIN_tx
- type: ParentCompany
  url: https://neurvati.com/
- type: SecondaryMarket
  url: https://forgeglobal.com/grin-therapeutics_stock/
- type: Authentication
  url: authentication/grin-therapeutics-authentication.yml
- type: Conventions
  url: conventions/grin-therapeutics-conventions.yml
- type: Conformance
  url: conformance/grin-therapeutics-conformance.yml
- type: ErrorCatalog
  url: errors/grin-therapeutics-problem-types.yml
- type: Lifecycle
  url: lifecycle/grin-therapeutics-lifecycle.yml
- type: DataModel
  url: data-model/grin-therapeutics-data-model.yml
- type: WellKnown
  url: well-known/grin-therapeutics-well-known.yml
- type: DomainSecurity
  url: security/grin-therapeutics-domain-security.yml
- type: LLMsTxt
  url: llms/grin-therapeutics-llms.txt
- type: AgentSkill
  url: skills/_index.yml
x-enrichment:
  date: '2026-08-04'
  status: enriched
  artifacts_added: 15
  pass: local-v1

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