GRIN Therapeutics website screenshot

GRIN Therapeutics

GRIN Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to the research and development of precision therapeutics for pediatric neurodevelopmental disorders caused by NMDA receptor dysfunction. It is an affiliate of Neurvati Neurosciences, a Blackstone Life Sciences portfolio company, and traces its founding to Dr. Pierandrea Muglia's attendance at the 2019 CFERV Conference on GRIN Variants at Emory University. Its lead investigational asset is radiprodil, an orally bioavailable selective negative allosteric modulator of the GluN2B subunit of the NMDA receptor, designed to fine-tune dysregulated receptor activity rather than fully block the channel. Radiprodil is in development for GRIN-related neurodevelopmental disorder (GRIN-NDD) arising from gain-of-function variants in GRIN1, GRIN2A, GRIN2B and GRIN2D, and for tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) type II. The clinical programme comprises the completed Phase 1b/2a Honeycomb trial, the enrolling global Phase 3 Beeline registrational trial, the Phase 1b/2a Astroscape trial in TSC and FCD type II, and a GRIN-NDD natural history study; radiprodil carries FDA Breakthrough Therapy, Orphan Drug and Rare Pediatric Disease designations and EMA PRIME and Orphan Drug designations. In May 2025 GRIN Therapeutics entered an exclusive collaboration with Angelini Pharma to develop and commercialise radiprodil outside North America. GRIN Therapeutics runs no developer program and publishes no product API, no developer portal and no API documentation; the only machine-readable surface reachable without credentials is the WordPress REST content API behind grintherapeutics.com, catalogued here.

GRIN Therapeutics publishes 8 APIs on the APIs.io network, including Discovery API, Media API, Oembed API, and 5 more. Tagged areas include Company, biotechnology, pharmaceuticals, neuroscience, and rare-disease.

GRIN Therapeutics’ developer surface includes product news, support, authentication, and 24 more developer resources.

🌐 Visit website 📡 Source on GitHub
28.2/100 thin ▬ flat Agent 33/100 agent aware Full breakdown ↓
scored 2026-08-12 · rubric v0.11.0
8 APIs
Companybiotechnologypharmaceuticalsneurosciencerare-diseaseprecision-medicineclinical-trialspediatricsepilepsylife-sciencescontent-api

Kin Score

Kin Score Kin Score How this is scored →
scored 2026-08-12 · rubric v0.11.0
Composite quality — 28.2/100 · thin
Contract Quality 11.5 / 21
Developer Ergonomics 2.9 / 17
Commercial Clarity 1.8 / 17
Operational Transparency 0.0 / 11
Governance 1.2 / 10
Discoverability 6.9 / 9
Regulatory Posture 3.9 / 15
Agent readiness — 33/100 · agent aware
Machine-Readable Contract 18 / 18
Agentic Access Contract 0 / 10
MCP Server 0 / 12
Machine-Readable Auth 10 / 10
Idempotency 0 / 9
Stable Error Semantics 8 / 8
Request/Response Examples 7 / 7
Rate-Limit Signaling 0 / 7
Typed Event Surface 0 / 6
Agent Skills 5 / 5
Well-Known Catalog 0 / 4
Consent & Bot Identity 0 / 3
A2A Agent Card 0 / 8
Dry-Run / Simulate Mode 0 / 4
Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.
The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.
Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. This rating is computed from github.com/api-evangelist/grin-therapeutics: open an issue to ask a question, or submit a pull request to add artifacts. Want it done for you? Prioritized profiling — $2,500 →

APIs 8

Individual APIs this provider publishes, each with its own machine-readable definition.

GRIN Therapeutics Discovery API

Route, type, taxonomy and status discovery documents.

GRIN Therapeutics Media API

Media library (174 attachments at harvest time).

GRIN Therapeutics Oembed API

oEmbed 1.0 provider endpoint for grintherapeutics.com URLs.

GRIN Therapeutics Pages API

Corporate and clinical-programme pages (10 published at harvest time).

GRIN Therapeutics Posts API

Blog/news post collection. Registered and reachable, but empty (X-WP-Total 0) — the News page is authored as a WPBakery page, not as posts.

GRIN Therapeutics Search API

Cross-content search across published objects.

GRIN Therapeutics Taxonomy API

Categories and tags. Registered by WordPress core; every term reports count 0 on this deployment.

GRIN Therapeutics Users API

Public author records.

Scroll for all 8

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Grin Therapeutics Authentication

none/http · 3 schemes

SECURITY

Grin Therapeutics Domain Security

TLSv1.3 · HSTS · DMARC

SECURITY

Resources

Agent Surfaces 3

MCP servers, agent skills, and machine-readable catalogs

WellKnown
WellKnown
 LLMsTxt
LLMsTxt
 AgentSkill
AgentSkill

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions
Conventions
 Conformance
Conformance
 ErrorCatalog
ErrorCatalog
 Lifecycle
Lifecycle
 DataModel
DataModel

Access & Security 2

Authentication, authorization, and security posture

Authentication
Authentication
 DomainSecurity
DomainSecurity

Operate 2

Status, limits, changes, and where to get help

Contact
Contact
 Support
Support

Commercial 1

Pricing, plans, and the legal terms of use

PrivacyPolicy
PrivacyPolicy

Company 7

The organization behind the API

Website
Website
 About
About
 News
News
 BlogRSS
BlogRSS
 Careers
Careers
 LinkedIn
LinkedIn
 Twitter
Twitter

Scroll for all 7

Other 7

Properties that don't map to a standard resource type

Overlay
Overlay
 Science
Science
 DiseaseState
DiseaseState
 PatientResources
PatientResources
 CookiePolicy
CookiePolicy
 ParentCompany
ParentCompany
 SecondaryMarket
SecondaryMarket

Scroll for all 7

Source (apis.yml)

apis.yml Raw ↑ 
aid: grin-therapeutics
name: GRIN Therapeutics
description: GRIN Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to the research and development of
  precision therapeutics for pediatric neurodevelopmental disorders caused by NMDA receptor dysfunction. It is an affiliate
  of Neurvati Neurosciences, a Blackstone Life Sciences portfolio company, and traces its founding to Dr. Pierandrea Muglia's
  attendance at the 2019 CFERV Conference on GRIN Variants at Emory University. Its lead investigational asset is radiprodil,
  an orally bioavailable selective negative allosteric modulator of the GluN2B subunit of the NMDA receptor, designed to fine-tune
  dysregulated receptor activity rather than fully block the channel. Radiprodil is in development for GRIN-related neurodevelopmental
  disorder (GRIN-NDD) arising from gain-of-function variants in GRIN1, GRIN2A, GRIN2B and GRIN2D, and for tuberous sclerosis
  complex (TSC) and focal cortical dysplasia (FCD) type II. The clinical programme comprises the completed Phase 1b/2a Honeycomb
  trial, the enrolling global Phase 3 Beeline registrational trial, the Phase 1b/2a Astroscape trial in TSC and FCD type II,
  and a GRIN-NDD natural history study; radiprodil carries FDA Breakthrough Therapy, Orphan Drug and Rare Pediatric Disease
  designations and EMA PRIME and Orphan Drug designations. In May 2025 GRIN Therapeutics entered an exclusive collaboration
  with Angelini Pharma to develop and commercialise radiprodil outside North America. GRIN Therapeutics runs no developer
  program and publishes no product API, no developer portal and no API documentation; the only machine-readable surface reachable
  without credentials is the WordPress REST content API behind grintherapeutics.com, catalogued here.
image: https://grintherapeutics.com/wp-content/uploads/2023/11/neurvati_grin_inline_fullcolor_rgb_6in@72ppi.png
url: https://raw.githubusercontent.com/api-evangelist/grin-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enriched
specificationVersion: '0.20'
created: '2026-08-04'
modified: '2026-08-04'
tags:
- Company
- biotechnology
- pharmaceuticals
- neuroscience
- rare-disease
- precision-medicine
- clinical-trials
- pediatrics
- epilepsy
- life-sciences
- content-api
apis:
- aid: grin-therapeutics:grin-therapeutics-discovery-api
  name: GRIN Therapeutics Discovery API
  description: Route, type, taxonomy and status discovery documents.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://grintherapeutics.com/wp-json
  tags:
  - discovery
  properties:
  - type: OpenAPI
    url: openapi/grin-therapeutics-discovery-api-openapi.yml
  - type: Authentication
    url: authentication/grin-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/grin-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/grin-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/grin-therapeutics-data-model.yml
- aid: grin-therapeutics:grin-therapeutics-media-api
  name: GRIN Therapeutics Media API
  description: Media library (174 attachments at harvest time).
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://grintherapeutics.com/wp-json
  tags:
  - media
  properties:
  - type: OpenAPI
    url: openapi/grin-therapeutics-media-api-openapi.yml
  - type: Authentication
    url: authentication/grin-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/grin-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/grin-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/grin-therapeutics-data-model.yml
- aid: grin-therapeutics:grin-therapeutics-oembed-api
  name: GRIN Therapeutics Oembed API
  description: oEmbed 1.0 provider endpoint for grintherapeutics.com URLs.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://grintherapeutics.com/wp-json
  tags:
  - oembed
  properties:
  - type: OpenAPI
    url: openapi/grin-therapeutics-oembed-api-openapi.yml
  - type: Authentication
    url: authentication/grin-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/grin-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/grin-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/grin-therapeutics-data-model.yml
- aid: grin-therapeutics:grin-therapeutics-pages-api
  name: GRIN Therapeutics Pages API
  description: Corporate and clinical-programme pages (10 published at harvest time).
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://grintherapeutics.com/wp-json
  tags:
  - pages
  properties:
  - type: OpenAPI
    url: openapi/grin-therapeutics-pages-api-openapi.yml
  - type: Authentication
    url: authentication/grin-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/grin-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/grin-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/grin-therapeutics-data-model.yml
- aid: grin-therapeutics:grin-therapeutics-posts-api
  name: GRIN Therapeutics Posts API
  description: Blog/news post collection. Registered and reachable, but empty (X-WP-Total 0) — the News page is authored as
    a WPBakery page, not as posts.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://grintherapeutics.com/wp-json
  tags:
  - posts
  properties:
  - type: OpenAPI
    url: openapi/grin-therapeutics-posts-api-openapi.yml
  - type: Authentication
    url: authentication/grin-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/grin-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/grin-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/grin-therapeutics-data-model.yml
- aid: grin-therapeutics:grin-therapeutics-search-api
  name: GRIN Therapeutics Search API
  description: Cross-content search across published objects.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://grintherapeutics.com/wp-json
  tags:
  - search
  properties:
  - type: OpenAPI
    url: openapi/grin-therapeutics-search-api-openapi.yml
  - type: Authentication
    url: authentication/grin-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/grin-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/grin-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/grin-therapeutics-data-model.yml
- aid: grin-therapeutics:grin-therapeutics-taxonomy-api
  name: GRIN Therapeutics Taxonomy API
  description: Categories and tags. Registered by WordPress core; every term reports count 0 on this deployment.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://grintherapeutics.com/wp-json
  tags:
  - taxonomy
  properties:
  - type: OpenAPI
    url: openapi/grin-therapeutics-taxonomy-api-openapi.yml
  - type: Authentication
    url: authentication/grin-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/grin-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/grin-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/grin-therapeutics-data-model.yml
- aid: grin-therapeutics:grin-therapeutics-users-api
  name: GRIN Therapeutics Users API
  description: Public author records.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://grintherapeutics.com/wp-json
  tags:
  - users
  properties:
  - type: OpenAPI
    url: openapi/grin-therapeutics-users-api-openapi.yml
  - type: Authentication
    url: authentication/grin-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/grin-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/grin-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/grin-therapeutics-data-model.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Overlay
  url: overlays/grin-therapeutics-content-overlay.yaml
- type: Website
  url: https://grintherapeutics.com/
- type: About
  url: https://grintherapeutics.com/about-grin-therapeutics/
- type: Science
  url: https://grintherapeutics.com/our-science/
- type: DiseaseState
  url: https://grintherapeutics.com/disease-state/
- type: PatientResources
  url: https://grintherapeutics.com/resources-for-patients-and-caregivers/
- type: News
  url: https://grintherapeutics.com/news/
- type: BlogRSS
  url: https://grintherapeutics.com/feed/
- type: Careers
  url: https://grintherapeutics.com/careers/
- type: Contact
  url: https://grintherapeutics.com/contact/
- type: Support
  url: https://grintherapeutics.com/contact/
- type: PrivacyPolicy
  url: https://grintherapeutics.com/privacy/
- type: CookiePolicy
  url: https://grintherapeutics.com/cookie-policy/
- type: LinkedIn
  url: https://www.linkedin.com/company/grin-therapeutics-inc
- type: Twitter
  url: https://twitter.com/GRIN_tx
- type: ParentCompany
  url: https://neurvati.com/
- type: SecondaryMarket
  url: https://forgeglobal.com/grin-therapeutics_stock/
- type: Authentication
  url: authentication/grin-therapeutics-authentication.yml
- type: Conventions
  url: conventions/grin-therapeutics-conventions.yml
- type: Conformance
  url: conformance/grin-therapeutics-conformance.yml
- type: ErrorCatalog
  url: errors/grin-therapeutics-problem-types.yml
- type: Lifecycle
  url: lifecycle/grin-therapeutics-lifecycle.yml
- type: DataModel
  url: data-model/grin-therapeutics-data-model.yml
- type: WellKnown
  url: well-known/grin-therapeutics-well-known.yml
- type: DomainSecurity
  url: security/grin-therapeutics-domain-security.yml
- type: LLMsTxt
  url: llms/grin-therapeutics-llms.txt
- type: AgentSkill
  url: skills/_index.yml
x-enrichment:
  date: '2026-08-04'
  status: enriched
  artifacts_added: 15
  pass: local-v1