CoRegen

CoRegen, Inc. (CoRegen Science) is a clinical-stage biopharmaceutical company in Houston, Texas developing adoptive cell therapies for aggressive solid tumors. Its platform, licensed exclusively from the O'Malley Lab at Baylor College of Medicine, uses CRISPR gene editing to knock out the SRC-3 steroid receptor coactivator gene in regulatory T (Treg) cells, reprogramming them from immunosuppressors into tumor-killing effectors. The lead program, CRG-150, received FDA IND clearance for a first-in-human Phase 1/2a trial in advanced solid tumors, and the underlying science won the 2023 Cozzarelli Prize. CoRegen is a therapeutics organization, not a software company: it publishes a nine-page marketing and science site (about, the science, preclinical studies, pipeline, publications, leadership, news, careers, contact) and no developer program, API, SDK, or machine-readable specification of any kind.

CoRegen is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Life Sciences, Oncology, and Cell Therapy.

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9.0/100 minimal ▬ flat Agent 0/100 human only Front door AI 1/6 silent Heartbeat 100/100 alive saas Full breakdown ↓
scored 2026-11-06 · rubric v0.27.0 · Show this score on your site →

0 APIs

Company Biotechnology Life Sciences Oncology Cell Therapy Immunotherapy Gene Editing Pharmaceuticals Clinical Stage

Kin Score

Kin Score How this is scored →
scored 2026-11-06 · rubric v0.27.0

Composite quality — 9.0/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.0 / 17

Access Clarity 3.6 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.0 / 10

Discoverability 4.3 / 9

Regulatory Posture 1.6 / 15

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Pagination 5 / 5

Distinct Operations 3 / 3

MCP Tool Quality 6 / 6

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

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Agent readiness — checks not met, largest first (exact, from this profile):

Machine-Readable Contract +18 pts — api_specs includes an OpenAPI document
MCP Server +12 pts — deployment.mode + probe verdict on the mcp/ manifest, not the pointer; an unprobed slug falls back to authorship
Agentic Access Contract +10 pts — agentic_access artifact present (x-agentic-access), graded by author
Machine-Readable Auth +10 pts — a served openid-configuration/oauth-authorization-server carrying `issuer` (served), else the securitySchemes class in the provider OpenAPIs — bound (mutualTLS, DPoP, Signature) > negotiable (oauth2 authorizationCode/clientCredentials, openIdConnect) > bearer (http bearer, apiKey)
Idempotency +9 pts — OpenAPI mutating operations declare an idempotency key — a header, a request-body property, or a named de-duplication token whose own description says so (verified); else common[].type matches /idempoten/i (documented)
Stable Error Semantics +8 pts — OpenAPI $refs a shared error schema across 4xx/5xx responses (verified), else common[].type includes ErrorCatalog / ErrorCodes / DeclineCodes

13 more unmet checks in the Agent Readiness table above.

Kin Score — facets with the most composite points still available (weight × headroom):

Contract Quality scores 0.0 — up to +25.0 composite points
Developer Ergonomics scores 0.0 — up to +20.0 composite points
Access Clarity scores 21.1 — up to +15.8 composite points

Each check links to what satisfies it. Publish the artifact, or tell us where it already lives, and the score moves on the next scoring run.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from the provider profile at artifacts.apis.io/coregen/apis.yml: open an issue on github.com/api-evangelist/coregen to ask a question or point us at an artifact you publish. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Standards implemented 1

Standards this provider implements or carries. De facto ones are profiled and measured by the API Commons; formal ones come from the standards directory and are linked by the provider's own tags. The evidence column says how each claim was established — not that it was made.

Universal Commerce Protocol (UCP)

measured — observed by APIs.io (wix)

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Coregen Domain Security

TLSv1.3 · HSTS

SECURITY

Resources

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

LLMsTxt

LLMsTxt

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Operate 1

Status, limits, changes, and where to get help

Contact

Contact

Commercial 2

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

TermsOfService

TermsOfService

Company 4

The organization behind the API

Website

About

Newsroom

Careers

Other 6

Properties that don't map to a standard resource type

Science

Research

Product

Publications

Team

SecondaryMarket

Source (apis.yml)

aid: coregen
name: CoRegen
description: 'CoRegen, Inc. (CoRegen Science) is a clinical-stage biopharmaceutical company in Houston, Texas developing adoptive
  cell therapies for aggressive solid tumors. Its platform, licensed exclusively from the O''Malley Lab at Baylor College
  of Medicine, uses CRISPR gene editing to knock out the SRC-3 steroid receptor coactivator gene in regulatory T (Treg) cells,
  reprogramming them from immunosuppressors into tumor-killing effectors. The lead program, CRG-150, received FDA IND clearance
  for a first-in-human Phase 1/2a trial in advanced solid tumors, and the underlying science won the 2023 Cozzarelli Prize.
  CoRegen is a therapeutics organization, not a software company: it publishes a nine-page marketing and science site (about,
  the science, preclinical studies, pipeline, publications, leadership, news, careers, contact) and no developer program,
  API, SDK, or machine-readable specification of any kind.'
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: false
  label: Hosted service · you call their endpoint
  confidence: medium
  source:
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  probe_state: none
  source:
  - security
  generated: '2026-11-06'
  method: derived
image: https://static.wixstatic.com/media/6bbba7_0128eda3793342649faba3890102b461~mv2.png
url: https://raw.githubusercontent.com/api-evangelist/coregen/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: harvest
specificationVersion: '0.23'
created: '2026-08-11'
modified: '2026-08-11'
tags:
- Company
- Biotechnology
- Life Sciences
- Oncology
- Cell Therapy
- Immunotherapy
- Gene Editing
- Pharmaceuticals
- Clinical Stage
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: DomainSecurity
  url: security/coregen-domain-security.yml
- type: LLMsTxt
  url: llms/coregen-llms.txt
- type: Website
  url: https://www.coregen.com/
- type: About
  url: https://www.coregen.com/about
- type: Science
  name: The Science
  url: https://www.coregen.com/thescience
- type: Research
  name: Preclinical Studies
  url: https://www.coregen.com/preclinicalstudies
- type: Product
  name: Pipeline
  url: https://www.coregen.com/pipeline
- type: Publications
  url: https://www.coregen.com/publications
- type: Team
  name: Leadership
  url: https://www.coregen.com/leadership
- type: Newsroom
  name: News
  url: https://www.coregen.com/news
- type: Careers
  url: https://www.coregen.com/careers
- type: Contact
  url: https://www.coregen.com/contact
- type: PrivacyPolicy
  url: https://www.coregen.com/privacy-policy
- type: TermsOfService
  url: https://www.coregen.com/terms-and-conditions
- type: SecondaryMarket
  name: Forge Global
  url: https://forgeglobal.com/coregen_stock/
x-enrichment:
  date: '2026-08-11'
  status: minimal
  artifacts_added: 3
  pass: local-v1
x-coverage:
  state: none
  reason: not-a-software-company
  detail: CoRegen is a clinical-stage cancer cell-therapy company, not a software company — coregen.com is a nine-page Wix
    marketing and science site (about, the science, preclinical studies, pipeline, publications, leadership, news, careers,
    contact) where /developers, /docs, /api, /graphql, /mcp, /openapi.json and /llms.txt all return a real 404 (verified against
    a control path that also 404s), every /.well-known/* path returns a hard Wix HTTP 400 error page, and no developer subdomain
    (api./docs./developer./mcp.coregen.com) resolves in DNS.
  evidence:
  - url: https://www.coregen.com/
    status: 200
  - url: https://www.coregen.com/developers
    status: 404
  - url: https://www.coregen.com/openapi.json
    status: 400
  - url: https://www.coregen.com/llms.txt
    status: 404
  - url: https://www.coregen.com/api
    status: 404
  - url: https://www.coregen.com/.well-known/agent-card.json
    status: 400
  - url: https://www.coregen.com/.well-known/security.txt
    status: 400
  - url: https://www.coregen.com/definitely-not-a-real-path-abc123xyz
    status: 404
  checked: '2026-08-11'

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