Combinatorx

CombinatoRx, Inc. was a Cambridge/Boston, Massachusetts biopharmaceutical company (SEC CIK 0001135906, SIC 2834 Pharmaceutical Preparations, incorporated in Delaware) that pursued combination drug discovery — screening pairs of approved drugs for synergistic therapeutic effects. It registered with the SEC in 2002 and traded publicly following its 2005 IPO. The company was renamed Zalicus Inc. in September 2010 after its combination with Neuromed Pharmaceuticals, and renamed again to EPIRUS Biopharmaceuticals, Inc. in July 2014 after merging with EPIRUS. EPIRUS was delisted in September 2016 (Form 25-NSE) and its SEC registration was formally revoked on 2024-05-14. The company is defunct: it operated no developer program and published no public API, SDK, or developer documentation, and combinatorx.com is now a parked NameBright listing unrelated to the original company. This profile is retained as a historical record of a Canaan Partners portfolio company and has no API surface to catalog.

Combinatorx is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Drug Discovery, and Life Sciences.

📡 Source on GitHub

0.0/100 minimal Agent 0/100 human only Full breakdown ↓
scored 2026-09-25 · rubric v0.23.0

0 APIs

Company Biotechnology Pharmaceuticals Drug Discovery Life Sciences Healthcare Defunct Venture Backed

Kin Score

Kin Score How this is scored →
scored 2026-09-25 · rubric v0.23.0

Composite quality — 0.0/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.0 / 17

Access Clarity 0.0 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.0 / 10

Discoverability 0.0 / 9

Regulatory Posture 0.0 / 15

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/combinatorx: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Resources

Other 1

Properties that don't map to a standard resource type

SECFilings

SECFilings

Source (apis.yml)

aid: combinatorx
deliveryModel:
  model: unknown
  open_source: false
  commercial: false
  callable_host: false
  label: Delivery model not determined — needs a product licence on record
  confidence: low
  source:
  - none
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source: []
  generated: '2026-07-22'
  method: derived
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/combinatorx.png
name: Combinatorx
description: 'CombinatoRx, Inc. was a Cambridge/Boston, Massachusetts biopharmaceutical company (SEC CIK 0001135906, SIC 2834
  Pharmaceutical Preparations, incorporated in Delaware) that pursued combination drug discovery — screening pairs of approved
  drugs for synergistic therapeutic effects. It registered with the SEC in 2002 and traded publicly following its 2005 IPO.
  The company was renamed Zalicus Inc. in September 2010 after its combination with Neuromed Pharmaceuticals, and renamed
  again to EPIRUS Biopharmaceuticals, Inc. in July 2014 after merging with EPIRUS. EPIRUS was delisted in September 2016 (Form
  25-NSE) and its SEC registration was formally revoked on 2024-05-14. The company is defunct: it operated no developer program
  and published no public API, SDK, or developer documentation, and combinatorx.com is now a parked NameBright listing unrelated
  to the original company. This profile is retained as a historical record of a Canaan Partners portfolio company and has
  no API surface to catalog.'
url: https://raw.githubusercontent.com/api-evangelist/combinatorx/refs/heads/main/apis.yml
x-type: company
x-source: vc-portfolio
x-backed-by:
- canaan-partners
x-tier: stub
x-tier-reason: defunct-no-api-surface
x-status: defunct
x-successor: EPIRUS Biopharmaceuticals, Inc.
x-former-names:
- name: COMBINATORX INC
  from: '2002-09-12'
  to: '2004-02-26'
- name: COMBINATORX, INC
  from: '2004-12-10'
  to: '2010-08-10'
- name: Zalicus Inc.
  from: '2010-09-09'
  to: '2014-07-02'
specificationVersion: '0.23'
created: '2026-07-17'
modified: '2026-07-20'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Drug Discovery
- Life Sciences
- Healthcare
- Defunct
- Venture Backed
apis: []
common:
- type: SECFilings
  name: SEC EDGAR filings (CIK 0001135906)
  url: https://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=0001135906&type=10-K&dateb=&owner=include&count=40
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
x-enrichment:
  date: '2026-07-20'
  status: nochange
  artifacts_added: 0
  pass: local-v1
  notes: 'Company confirmed defunct via SEC EDGAR (CIK 0001135906): CombinatoRx -> Zalicus (2010) -> EPIRUS Biopharmaceuticals
    (2014), delisted 2016-09-26, registration revoked 2024-05-14. No API, SDK, package, GitHub org, or developer surface exists.
    combinatorx.com resolves to a parked NameBright page whose catch-all returns 200 for every path, so the /.well-known/security.txt
    and /llms.txt hits are not real artifacts and were not saved. No artifacts written.'

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