Circle Pharma

Circle Pharma is a clinical-stage biopharmaceutical company in South San Francisco, California, developing cell-permeable, orally bioavailable macrocycle therapies for cancer. Founded in 2013 by Matthew P. Jacobson and Scott Lokey out of work on predicting synthetic macrocycle cell permeability, the company applies its proprietary MXMO structure-based design platform to protein-protein interactions that conventional small molecules cannot reach. Its pipeline targets cyclins, the regulators of the cell cycle that drive many cancers: lead program CID-078, a first-in-class oral cyclin A/B RxL inhibitor, is in Phase 1 for advanced solid tumors, followed by a preclinical cyclin D1 RxL inhibitor and undisclosed cyclin programs partnered with Boehringer Ingelheim. Circle Pharma closed a $90M Series D led by The Column Group in 2024 and has an agreement with Eli Lilly to use Lilly TuneLab to strengthen the AI/ML side of the MXMO platform. Circle Pharma runs no developer program and publishes no product API; the only machine-readable surface it exposes is the anonymously readable WordPress REST content API behind circlepharma.com.

Circle Pharma publishes 1 API on the APIs.io network: Content API. Tagged areas include Company, Biotechnology, Pharmaceuticals, Oncology, and Drug Discovery.

Circle Pharma’s developer surface includes engineering blog, support, authentication, and 22 more developer resources.

🌐 Visit website 📡 Source on GitHub

32.9/100 thin ▬ flat Agent 22/100 agent aware Full breakdown ↓
scored 2026-08-25 · rubric v0.14.0

1 APIs

Company Biotechnology Pharmaceuticals Oncology Drug Discovery Macrocycles Clinical Trials Life Sciences content-api

Kin Score

Kin Score How this is scored →
scored 2026-08-25 · rubric v0.14.0

Composite quality — 32.9/100 · thin

Contract Quality 11.7 / 21

Developer Ergonomics 3.5 / 17

Access Clarity 3.6 / 17

Operational Transparency 0.0 / 11

Contract Governance 1.7 / 10

Discoverability 5.8 / 9

Regulatory Posture 4.7 / 15

Agent readiness — 22/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 6 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 9 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 4 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Surface 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. This rating is computed from github.com/api-evangelist/circle-pharma: open an issue to ask a question, or submit a pull request to add artifacts. Want it done for you? Prioritized profiling — $2,500 →

APIs 1

Individual APIs this provider publishes, each with its own machine-readable definition.

Agent Surfaces 3

MCP servers, agent skills, and machine-readable catalogs

WellKnown

WellKnown

LLMsTxt

LLMsTxt

AgentSkill

AgentSkill

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions

Conformance

ErrorCatalog

Lifecycle

DataModel

Access & Security 2

Authentication, authorization, and security posture

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 3

Status, limits, changes, and where to get help

PressReleases

PressReleases

Contact

Contact

Support

Support

Commercial 2

Pricing, plans, and the legal terms of use

TermsOfService

TermsOfService

PrivacyPolicy

PrivacyPolicy

Company 7

The organization behind the API

Website

About

Blog

BlogRSS

Careers

Investors

LinkedIn

Scroll for all 7

Other 3

Properties that don't map to a standard resource type

Publications

Publications

Events

Events

SecondaryMarket

SecondaryMarket

Source (apis.yml)

aid: circle-pharma
name: Circle Pharma
description: 'Circle Pharma is a clinical-stage biopharmaceutical company in South San Francisco, California, developing cell-permeable,
  orally bioavailable macrocycle therapies for cancer. Founded in 2013 by Matthew P. Jacobson and Scott Lokey out of work
  on predicting synthetic macrocycle cell permeability, the company applies its proprietary MXMO structure-based design platform
  to protein-protein interactions that conventional small molecules cannot reach. Its pipeline targets cyclins, the regulators
  of the cell cycle that drive many cancers: lead program CID-078, a first-in-class oral cyclin A/B RxL inhibitor, is in Phase
  1 for advanced solid tumors, followed by a preclinical cyclin D1 RxL inhibitor and undisclosed cyclin programs partnered
  with Boehringer Ingelheim. Circle Pharma closed a $90M Series D led by The Column Group in 2024 and has an agreement with
  Eli Lilly to use Lilly TuneLab to strengthen the AI/ML side of the MXMO platform. Circle Pharma runs no developer program
  and publishes no product API; the only machine-readable surface it exposes is the anonymously readable WordPress REST content
  API behind circlepharma.com.'
image: https://circlepharma.com/wp-content/uploads/2024/01/Asset-2@2x.png
url: https://raw.githubusercontent.com/api-evangelist/circle-pharma/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enriched
specificationVersion: '0.23'
created: '2026-08-01'
modified: '2026-08-01'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Oncology
- Drug Discovery
- Macrocycles
- Clinical Trials
- Life Sciences
- content-api
tags_raw:
- Company
- biotechnology
- pharmaceuticals
- oncology
- drug-discovery
- macrocycles
- clinical-trials
- life-sciences
- content-api
apis:
- aid: circle-pharma:circle-pharma-content-api
  name: Circle Pharma Content API
  description: The anonymously readable WordPress REST API behind circlepharma.com. It exposes Circle Pharma press releases,
    publications and in-the-news items (posts), site pages, the media library, the leadership and board roster (team + member_type
    taxonomy), the events calendar (all_events + event_type taxonomy) and cross-content search. This is not a developer product
    Circle Pharma markets; it is the site's own discovery surface, published at /wp-json/ and verified to return data without
    credentials. The OpenAPI in this repo is derived from that published route index.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://circlepharma.com/wp-json
  tags:
  - Content
  - Press Releases
  - Event
  - WordPress
  tags_raw:
  - content
  - press-releases
  - events
  - wordpress
  properties:
  - type: OpenAPI
    url: openapi/circle-pharma-content-openapi.yml
  - type: Overlay
    url: overlays/circle-pharma-content-overlay.yaml
  - type: Authentication
    url: authentication/circle-pharma-authentication.yml
  - type: ErrorCatalog
    url: errors/circle-pharma-problem-types.yml
  - type: Conventions
    url: conventions/circle-pharma-conventions.yml
  - type: DataModel
    url: data-model/circle-pharma-data-model.yml
  x-contract-provenance: Derived by the API Evangelist enrichment pipeline from the WordPress REST route index the site publishes
    at https://circlepharma.com/wp-json/ and verified against live anonymous responses on 2026-08-01. Circle Pharma publishes
    no developer documentation, no API reference and no support channel for this surface, so no Documentation/APIReference/GettingStarted
    pointers are emitted — the humanURL above is the upstream WordPress REST handbook that describes the wp/v2 contract.
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Website
  url: https://circlepharma.com/
- type: About
  url: https://circlepharma.com/about-us
- type: Blog
  url: https://circlepharma.com/whats-new
- type: BlogRSS
  url: https://circlepharma.com/feed/
- type: PressReleases
  url: https://circlepharma.com/press-releases
- type: Publications
  url: https://circlepharma.com/publications
- type: Events
  url: https://circlepharma.com/upcoming-events
- type: Careers
  url: https://circlepharma.com/work-with-us
- type: Contact
  url: https://circlepharma.com/contact-us
- type: Investors
  url: https://circlepharma.com/investors
- type: Support
  url: https://circlepharma.com/contact-us
- type: TermsOfService
  url: https://circlepharma.com/terms-of-use
- type: PrivacyPolicy
  url: https://circlepharma.com/privacy-policy
- type: LinkedIn
  url: https://www.linkedin.com/company/circle-pharma-inc-/
- type: SecondaryMarket
  url: https://forgeglobal.com/circle-pharma_stock/
- type: Authentication
  url: authentication/circle-pharma-authentication.yml
- type: Conventions
  url: conventions/circle-pharma-conventions.yml
- type: Conformance
  url: conformance/circle-pharma-conformance.yml
- type: ErrorCatalog
  url: errors/circle-pharma-problem-types.yml
- type: Lifecycle
  url: lifecycle/circle-pharma-lifecycle.yml
- type: DataModel
  url: data-model/circle-pharma-data-model.yml
- type: WellKnown
  url: well-known/circle-pharma-well-known.yml
- type: DomainSecurity
  url: security/circle-pharma-domain-security.yml
- type: LLMsTxt
  url: llms/circle-pharma-llms.txt
- type: AgentSkill
  url: skills/_index.yml
x-enrichment:
  date: '2026-08-01'
  status: enriched
  artifacts_added: 15
  pass: local-v1

Work with this as data

Every provider here is available over the APIs.io API and to AI agents over MCP.

MCP server

One button, every client — Claude, Cursor, VS Code and the rest.

https://apis.io/mcp

Tools for providers

9 MCP tools reach this

find_providersBrowse and filter every provider in the catalog.
get_provider_artifactsEvery artifact this provider publishes, grouped by type.
get_provider_operationsEvery operation across all of their OpenAPIs — one call instead of parsing every spec.
get_provider_toolsEvery MCP tool they ship, with the operation each wraps.
get_provider_evidenceHow each part of their score was established. Free — the basis for a claim should not sit behind it.
get_provider_ratingPRO — composite, band, trend and facet scores.
apis_io_searchSTART HERE — APIs, providers and tags for one query, each with its total.
resolveTurn a domain, URL or GitHub org into the provider it belongs to.
find_cohortsEvery scored population of providers in the catalog.

All 92 tools

Call it yourself

curl for this page

This provider

curl "https://apis.io/api/v1/providers/circle-pharma"

All providers

curl "https://apis.io/api/v1/providers?limit=25"

Every operation they expose

curl "https://apis.io/api/v1/providers/circle-pharma/operations?limit=25"

How their score was established

curl "https://apis.io/api/v1/providers/circle-pharma/evidence"

Discovery needs no key. Ratings and market analysis are Pro.

Get an API key

Free tier, no email required.

GitHub Google LinkedIn

A second provider on the same verified email joins the account you already have.

Circle Pharma

Kin Score

APIs 1

Circle Pharma Content API

Open Collections 1

Circle Pharma Content API (WordPress REST API)

Security Posture 2

Circle Pharma Authentication

Circle Pharma Domain Security

Resources