Circle Pharma

aid: circle-pharma
name: Circle Pharma
description: 'Circle Pharma is a clinical-stage biopharmaceutical company in South San Francisco, California, developing cell-permeable,
  orally bioavailable macrocycle therapies for cancer. Founded in 2013 by Matthew P. Jacobson and Scott Lokey out of work
  on predicting synthetic macrocycle cell permeability, the company applies its proprietary MXMO structure-based design platform
  to protein-protein interactions that conventional small molecules cannot reach. Its pipeline targets cyclins, the regulators
  of the cell cycle that drive many cancers: lead program CID-078, a first-in-class oral cyclin A/B RxL inhibitor, is in Phase
  1 for advanced solid tumors, followed by a preclinical cyclin D1 RxL inhibitor and undisclosed cyclin programs partnered
  with Boehringer Ingelheim. Circle Pharma closed a $90M Series D led by The Column Group in 2024 and has an agreement with
  Eli Lilly to use Lilly TuneLab to strengthen the AI/ML side of the MXMO platform. Circle Pharma runs no developer program
  and publishes no product API; the only machine-readable surface it exposes is the anonymously readable WordPress REST content
  API behind circlepharma.com.'
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: true
  label: Hosted service · you call their endpoint
  confidence: high
  source:
  - openapi
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - authentication
  - security
  generated: '2026-09-03'
  method: derived
image: https://circlepharma.com/wp-content/uploads/2024/01/Asset-2@2x.png
url: https://raw.githubusercontent.com/api-evangelist/circle-pharma/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enriched
specificationVersion: '0.23'
created: '2026-08-01'
modified: '2026-08-01'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Oncology
- Drug Discovery
- Macrocycles
- Clinical Trials
- Life Sciences
- content-api
tags_raw:
- Company
- biotechnology
- pharmaceuticals
- oncology
- drug-discovery
- macrocycles
- clinical-trials
- life-sciences
- content-api
apis:
- aid: circle-pharma:circlepharma-com-website-wordpress-rest
  name: Circle Pharma Website (WordPress REST)
  description: 'The public WordPress REST API (wp-json) of the Circle Pharma website at circlepharma.com: the route index
    of the site''s content management system, catalogued as one site surface rather than as separate APIs.'
  baseURL: https://circlepharma.com/wp-json
  tags:
  - WordPress
  x-surface: platform-generated
  properties:
  - type: Documentation
    url: https://circlepharma.com/wp-json
  x-platform: wordpress
  x-platform-surface: rest
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Overlay
  url: overlays/circle-pharma-content-overlay.yaml
- type: Website
  url: https://circlepharma.com/
- type: About
  url: https://circlepharma.com/about-us
- type: Blog
  url: https://circlepharma.com/whats-new
- type: BlogRSS
  url: https://circlepharma.com/feed/
- type: PressReleases
  url: https://circlepharma.com/press-releases
- type: Publications
  url: https://circlepharma.com/publications
- type: Events
  url: https://circlepharma.com/upcoming-events
- type: Careers
  url: https://circlepharma.com/work-with-us
- type: Contact
  url: https://circlepharma.com/contact-us
- type: Investors
  url: https://circlepharma.com/investors
- type: Support
  url: https://circlepharma.com/contact-us
- type: TermsOfService
  url: https://circlepharma.com/terms-of-use
- type: PrivacyPolicy
  url: https://circlepharma.com/privacy-policy
- type: LinkedIn
  url: https://www.linkedin.com/company/circle-pharma-inc-/
- type: SecondaryMarket
  url: https://forgeglobal.com/circle-pharma_stock/
- type: Authentication
  url: authentication/circle-pharma-authentication.yml
- type: Conventions
  url: conventions/circle-pharma-conventions.yml
- type: Conformance
  url: conformance/circle-pharma-conformance.yml
- type: ErrorCatalog
  url: errors/circle-pharma-problem-types.yml
- type: Lifecycle
  url: lifecycle/circle-pharma-lifecycle.yml
- type: DataModel
  url: data-model/circle-pharma-data-model.yml
- type: WellKnown
  url: well-known/circle-pharma-well-known.yml
- type: DomainSecurity
  url: security/circle-pharma-domain-security.yml
- type: LLMsTxt
  url: llms/circle-pharma-llms.txt
- type: AgentSkill
  url: skills/_index.yml
x-enrichment:
  date: '2026-08-01'
  status: enriched
  artifacts_added: 15
  pass: local-v1