Boltz

Boltz (Boltz PBC) is a public-benefit AI research company building open-source and proprietary foundation models for biomolecular structure prediction, binding-affinity estimation, and generative protein and small-molecule design. Its open-source models (Boltz-1, Boltz-2, BoltzGen, all MIT-licensed) are used by 100,000+ scientists across pharma and biotech, and its commercial platform, Boltz Lab, pairs those models with managed compute and collaborative interfaces. The Boltz Compute API exposes these capabilities as asynchronous jobs - structure & binding prediction, ADME prediction, and small-molecule / protein design and library screening - with official Python, TypeScript, and Go SDKs, a CLI, and an MCP server for agentic drug-discovery workflows. Backed by a $28M seed round led by Amplify Partners, a16z, and Zetta Venture Partners.

Boltz publishes 7 APIs on the APIs.io network, including Admin API, Auth API, CLI API, and 4 more. Tagged areas include Company, Digital Biology, Drug Discovery, Artificial Intelligence, and Machine-Learning.

Boltz’s developer surface includes documentation, API reference, getting-started guide, authentication, CLI, changelog, sandbox, and 23 more developer resources.

🌐 Visit website 📡 Source on GitHub

51.1/100 developing ▬ flat Agent 25/100 agent aware saas Full breakdown ↓
scored 2026-09-06 · rubric v0.19.0

1 APIs 1 MCP Servers

Company Digital Biology Drug Discovery Artificial Intelligence Machine-Learning Protein DesignStructure PredictionLife Sciences Compute

Kin Score

Kin Score How this is scored →
scored 2026-09-06 · rubric v0.19.0

Composite quality — 51.1/100 · developing

Contract Quality 11.3 / 21

Developer Ergonomics 14.6 / 17

Access Clarity 5.4 / 17

Operational Transparency 2.9 / 11

Contract Governance 0.5 / 10

Discoverability 6.5 / 9

Regulatory Posture 5.6 / 15

Agent readiness — 25/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 12 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/boltz: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

APIs 7

Individual APIs this provider publishes, each with its own machine-readable definition.

MCP Servers 1

Model Context Protocol servers that expose these APIs to AI agents.

Get Started 4

Portal, sign-up, and the first successful call

DeveloperPortal

GettingStarted

Sandbox

SignUp

Documentation 3

Reference material describing how the API behaves

Documentation

Documentation

APIReference

APIReference

OpenAPI

OpenAPI

Agent Surfaces 3

MCP servers, agent skills, and machine-readable catalogs

MCPServer

MCPServer

AgentSkill

AgentSkill

LLMsTxt

LLMsTxt

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions

DataModel

ErrorCatalog

Conformance

Lifecycle

Build 4

SDKs, sample code, and the tooling you integrate with

Packages

Packages

SDKs

SDKs

CLI

CLI

GitHubOrganization

GitHubOrganization

Access & Security 2

Authentication, authorization, and security posture

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 3

Status, limits, changes, and where to get help

StatusPage

StatusPage

ChangeLog

ChangeLog

Support

Support

Commercial 3

Pricing, plans, and the legal terms of use

Pricing

Pricing

TermsOfService

TermsOfService

PrivacyPolicy

PrivacyPolicy

Company 2

The organization behind the API

Website

Website

Blog

Blog

Other 1

Properties that don't map to a standard resource type

CapabilityMap

CapabilityMap

Source (apis.yml)

aid: boltz
name: Boltz
description: Boltz (Boltz PBC) is a public-benefit AI research company building open-source and proprietary foundation models
  for biomolecular structure prediction, binding-affinity estimation, and generative protein and small-molecule design. Its
  open-source models (Boltz-1, Boltz-2, BoltzGen, all MIT-licensed) are used by 100,000+ scientists across pharma and biotech,
  and its commercial platform, Boltz Lab, pairs those models with managed compute and collaborative interfaces. The Boltz
  Compute API exposes these capabilities as asynchronous jobs - structure & binding prediction, ADME prediction, and small-molecule
  / protein design and library screening - with official Python, TypeScript, and Go SDKs, a CLI, and an MCP server for agentic
  drug-discovery workflows. Backed by a $28M seed round led by Amplify Partners, a16z, and Zetta Venture Partners.
url: https://raw.githubusercontent.com/api-evangelist/boltz/refs/heads/main/apis.yml
x-type: company
x-source: vc-portfolio
x-backed-by:
- amplify-partners
x-tier: enriched
x-tier-reason: portfolio-lead
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: true
  label: Hosted service · you call their endpoint
  confidence: high
  source:
  - openapi
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - authentication
  - security
  - sandbox
  generated: '2026-09-03'
  method: derived
image: https://boltz.bio/android-chrome-512x512.png
specificationVersion: '0.23'
created: '2026-07-17'
modified: '2026-07-18'
tags:
- Company
- Digital Biology
- Drug Discovery
- Artificial Intelligence
- Machine-Learning
- Protein Design
- Structure Prediction
- Life Sciences
- Compute
tags_raw:
- Company
- Digital Biology
- Drug Discovery
- Artificial Intelligence
- Machine Learning
- Protein Design
- Structure Prediction
- Life Sciences
- Compute
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
apis:
- aid: boltz:boltz-admin-api
  name: Boltz Admin API
  description: The Admin API from Boltz — 7 operation(s) for admin.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Admin
  properties:
  - type: OpenAPI
    url: openapi/boltz-admin-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-auth-api
  name: Boltz Auth API
  description: The Auth API from Boltz — 1 operation(s) for auth.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Authentication
  tags_raw:
  - Auth
  properties:
  - type: OpenAPI
    url: openapi/boltz-auth-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-cli-api
  name: Boltz CLI API
  description: The CLI API from Boltz — 1 operation(s) for cli.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - CLI
  properties:
  - type: OpenAPI
    url: openapi/boltz-cli-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-predictions-api
  name: Boltz Predictions API
  description: The Predictions API from Boltz — 8 operation(s) for predictions.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Predictions
  properties:
  - type: OpenAPI
    url: openapi/boltz-predictions-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-protein-api
  name: Boltz Protein API
  description: The Protein API from Boltz — 15 operation(s) for protein.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Protein
  properties:
  - type: OpenAPI
    url: openapi/boltz-protein-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-share-links-api
  name: Boltz Share Links API
  description: The Share Links API from Boltz — 4 operation(s) for share links.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Share Links
  properties:
  - type: OpenAPI
    url: openapi/boltz-share-links-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-small-molecule-api
  name: Boltz Small Molecule API
  description: The Small Molecule API from Boltz — 14 operation(s) for small molecule.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Small Molecule
  properties:
  - type: OpenAPI
    url: openapi/boltz-small-molecule-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
common:
- type: CapabilityMap
  url: capabilities/boltz-capability-edges.yml
  name: Boltz Business Capability Map
- type: Website
  url: https://boltz.bio
- type: DeveloperPortal
  url: https://docs.boltz.bio
- type: Documentation
  url: https://docs.boltz.bio
- type: APIReference
  url: https://api.boltz.bio/docs
- type: GettingStarted
  url: https://docs.boltz.bio/user-guide/introduction/Quickstart.md
- type: OpenAPI
  url: openapi/_original/boltz-compute.yml
- type: Authentication
  url: authentication/boltz-authentication.yml
- type: Packages
  url: packages/boltz-packages.yml
- type: SDKs
  url: packages/boltz-packages.yml
- type: CLI
  url: cli/boltz-cli.yml
- type: MCPServer
  url: mcp/boltz-mcp.yml
- type: AgentSkill
  url: skills/_index.yml
- type: LLMsTxt
  url: llms/boltz-llms.txt
- type: Conventions
  url: conventions/boltz-conventions.yml
- type: DataModel
  url: data-model/boltz-data-model.yml
- type: ErrorCatalog
  url: errors/boltz-problem-types.yml
- type: Conformance
  url: conformance/boltz-conformance.yml
- type: Lifecycle
  url: lifecycle/boltz-lifecycle.yml
- type: StatusPage
  url: https://status.boltz.bio
- type: ChangeLog
  url: changelog/boltz-changelog.yml
- type: Sandbox
  url: sandbox/boltz-sandbox.yml
- type: DomainSecurity
  url: security/boltz-domain-security.yml
- type: Pricing
  url: https://boltz.bio/pricing
- type: Blog
  url: https://boltz.bio/news
- type: GitHubOrganization
  url: https://github.com/boltz-bio
- type: SignUp
  url: https://lab.boltz.bio
- type: Support
  url: https://boltz.bio/join-slack
- type: TermsOfService
  url: https://docs.boltz.bio/terms-of-service/terms-of-service.md
- type: PrivacyPolicy
  url: https://docs.boltz.bio/privacy-policy/privacy-policy.md
x-enrichment:
  date: '2026-07-19'
  status: backfilled
  pass: local-v1
  note: backfilled from .gitignore signal + verified work evidence

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