Boltz

Boltz (Boltz PBC) is a public-benefit AI research company building open-source and proprietary foundation models for biomolecular structure prediction, binding-affinity estimation, and generative protein and small-molecule design. Its open-source models (Boltz-1, Boltz-2, BoltzGen, all MIT-licensed) are used by 100,000+ scientists across pharma and biotech, and its commercial platform, Boltz Lab, pairs those models with managed compute and collaborative interfaces. The Boltz Compute API exposes these capabilities as asynchronous jobs - structure & binding prediction, ADME prediction, and small-molecule / protein design and library screening - with official Python, TypeScript, and Go SDKs, a CLI, and an MCP server for agentic drug-discovery workflows. Backed by a $28M seed round led by Amplify Partners, a16z, and Zetta Venture Partners.

Boltz publishes 7 API contracts indexed on the APIs.io network, including Admin API, Auth API, CLI API, and 4 more. Tagged areas include Company, Digital Biology, Drug Discovery, Artificial Intelligence, and Machine Learning.

The Boltz catalog on APIs.io includes 1 Spectral governance ruleset.

Boltz’s developer surface includes documentation, API reference, getting-started guide, authentication, CLI, changelog, sandbox, and 24 more developer resources.

🌐 Visit website 📡 Profile data on GitHub

56.9/100 strong ▬ flat Agent 25/100 agent aware Front door AI 5/6 prominent Heartbeat 63/100 slowing saas Full breakdown ↓
scored 2026-11-06 · rubric v0.27.0 · Show this score on your site →

AccessFreemiumSelf serve⚡ Free to try

1 published contract 1 MCP Servers

Company Digital Biology Drug Discovery Artificial Intelligence Machine Learning Protein DesignStructure PredictionLife Sciences Compute

What this lets a business do 1

Business capabilities this provider's published APIs can perform, derived from its own contracts. Browse all capabilities →

Drug Discovery Management

BC-1500

PredictionsProteinSmall Molecule

POST /compute/v1/predictions/structure-and-binding GET /compute/v1/predictions/adme POST /compute/v1/protein/design GET /compute/v1/protein/library-screen

Kin Score

Kin Score How this is scored →
scored 2026-11-06 · rubric v0.27.0

Composite quality — 56.9/100 · strong

Contract Quality 9.0 / 19

Developer Ergonomics 12.9 / 15

Access Clarity 10.7 / 15

Operational Transparency 2.6 / 10

Contract Governance 1.6 / 9

Discoverability 5.4 / 8

Regulatory Posture 3.3 / 15

Create-or-Update Ergonomics 0.0 / 10

Agent readiness — 25/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 12 / 12

Machine-Readable Auth 10 / 10

Idempotency 0 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Pagination 5 / 5

Distinct Operations 3 / 3

MCP Tool Quality 6 / 6

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics applies to this provider. This API accepts writes, so it carries 10 points of the composite. It is scored from the published contracts themselves: whether a caller can create-or-update in one call, whether the write accepts a key the caller already holds, and whether the response says which branch ran. Without that, every write needs a search-and-branch in front of it, and the first time that check is skipped a duplicate record is created. Scored against the observed mean rather than raw — a provider at the catalog average is unchanged by this facet, not penalised by it.

The six quality facets above are damped to 75 points between them, because the conditional facet above carries the other 25. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 75% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

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Agent readiness — checks not met, largest first (exact, from this profile):

Agentic Access Contract +10 pts — agentic_access artifact present (x-agentic-access), graded by author
Idempotency +9 pts — OpenAPI mutating operations declare an idempotency key — a header, a request-body property, or a named de-duplication token whose own description says so (verified); else common[].type matches /idempoten/i (documented)
A2A Agent Card +8 pts — a2a/-a2a.yml manifest, graded on conformance.grade against A2A 1.0.0
Rate-Limit Signaling +7 pts — OpenAPI responses document X-RateLimit-* / RateLimit headers (verified), else a rate_limits artifact or RateLimits link (documented)
Request/Response Examples +7 pts — share of operations carrying request/response examples; else an Examples / Code Samples link
Registration Without a Human +6 pts — a `registration_endpoint` in the served RFC 8414 / OIDC discovery document

8 more unmet checks in the Agent Readiness table above.

Kin Score — facets with the most composite points still available (weight × headroom):

Contract Quality scores 47.8 — up to +13.1 composite points
Contract Governance scores 18.2 — up to +9.8 composite points
Operational Transparency scores 26.3 — up to +9.6 composite points

Each check links to what satisfies it. Publish the artifact, or tell us where it already lives, and the score moves on the next scoring run.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from the provider profile at artifacts.apis.io/boltz/apis.yml: open an issue on github.com/api-evangelist/boltz to ask a question or point us at an artifact you publish. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Markets this provider is in provisional

The Kin Score Market layer reads a provider inside its market: its position, and how deep its integrations go. Depth is only comparable within a position. Provisional and unweighted: not part of the Kin Score or agent readiness.

Market	Position	Depth	Registered MCP server	Declares compatibility
Agent Skills (SKILL.md packages)	distribution	28.8	-	1

Registered MCP server and declares compatibility are report only — not weighted. Undeclared means we found nothing we can read, so there is no number: we never infer integrations.

Standards implemented 3

Standards this provider implements or carries. De facto ones are profiled and measured by the API Commons; formal ones come from the standards directory and are linked by the provider's own tags. The evidence column says how each claim was established — not that it was made.

Model Context Protocol (MCP)

measured — observed by APIs.io (documented)

Agent Skills

measured — observed by APIs.io (published)

OpenAPI

measured — observed by APIs.io (published)

APIs 7

Individual APIs this provider publishes, each with its own machine-readable definition.

Boltz Admin API

The Admin API from Boltz — 7 operation(s) for admin.

Boltz Auth API

The Auth API from Boltz — 1 operation(s) for auth.

Boltz CLI API

The CLI API from Boltz — 1 operation(s) for cli.

Boltz Predictions API

The Predictions API from Boltz — 8 operation(s) for predictions.

Boltz Protein API

The Protein API from Boltz — 15 operation(s) for protein.

Boltz Share Links API

The Share Links API from Boltz — 4 operation(s) for share links.

Boltz Small Molecule API

The Small Molecule API from Boltz — 14 operation(s) for small molecule.

Scroll for all 7

Open Collections 7

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

Boltz Compute Admin API

OPEN COLLECTION

Boltz Compute Admin Auth API

OPEN COLLECTION

Boltz Compute Admin CLI API

OPEN COLLECTION

Boltz Compute Admin Predictions API

OPEN COLLECTION

Boltz Compute Admin Protein API

OPEN COLLECTION

Boltz Compute Admin Share Links API

OPEN COLLECTION

Boltz Compute Admin Small Molecule API

OPEN COLLECTION

Scroll for all 7

MCP Servers 1

Model Context Protocol servers that expose these APIs to AI agents.

Boltz MCP Server

Official Boltz MCP server, distributed as an MCP Bundle (.mcpb) named "boltz". Wraps the Boltz Compute API so agents can estimate/run structure & binding predictions, small-mole...

MCP SERVER

Boltz API pricing

Prices published by Boltz, read 2026-10-07 from boltz.com/pricing.

Plan	Price
Professional	$0 subscription Includes: Up to 200 free predictions every month
Enterprise	Custom pricing Includes: Finetuning and customization with private data; single tenant or private cloud deployment; unlimited
Small-molecule pipeline (design + structure + affinity + admet)	$0.025 per molecule
Protein design pipeline 0–256	$0.025
Protein design pipeline 257–512	$0.05
Protein design pipeline 513–1024	$0.10
Protein design pipeline 1025–2048	$0.20
Protein design pipeline 2049+	$0.40

All 13 plans, limits and sources →

Billed by: crop size 0–256 · FinOps profile →

Pricing Plans 1

Published pricing tiers and plan structures.

Boltz Plans Pricing

13 plans

PLANS

Service Levels 1

Uptime the provider promises or reports, as SLA4OAI. Read from its own pages; APIs.io runs no monitors.

Boltz

SLA

FinOps 1

Cost, billing, and metering signals for API financial operations.

Boltz Finops

FINOPS

Spectral Rules 1

Spectral governance rulesets for linting and validating these APIs.

Boltz API Rules

56 rules · 54 errors 1 warnings 1 info

SPECTRAL

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Boltz Authentication

1 scheme

SECURITY

Boltz Domain Security

TLSv1.3 · DMARC

SECURITY

Resources

Get Started 4

Portal, sign-up, and the first successful call

DeveloperPortal

GettingStarted

Sandbox

SignUp

Documentation 3

Reference material describing how the API behaves

Documentation

Documentation

APIReference

APIReference

OpenAPI

OpenAPI

Agent Surfaces 3

MCP servers, agent skills, and machine-readable catalogs

MCPServer

MCPServer

AgentSkill

AgentSkill

LLMsTxt

LLMsTxt

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions

DataModel

ErrorCatalog

Conformance

Lifecycle

Build 4

SDKs, sample code, and the tooling you integrate with

Packages

Packages

SDKs

SDKs

CLI

CLI

GitHubOrganization

GitHubOrganization

Access & Security 2

Authentication, authorization, and security posture

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 3

Status, limits, changes, and where to get help

StatusPage

StatusPage

ChangeLog

ChangeLog

Support

Support

Commercial 4

Pricing, plans, and the legal terms of use

Plans

Pricing

TermsOfService

PrivacyPolicy

Company 2

The organization behind the API

Website

Website

Blog

Blog

Other 1

Properties that don't map to a standard resource type

CapabilityMap

CapabilityMap

Source (apis.yml)

aid: boltz
name: Boltz
description: Boltz (Boltz PBC) is a public-benefit AI research company building open-source and proprietary foundation models
  for biomolecular structure prediction, binding-affinity estimation, and generative protein and small-molecule design. Its
  open-source models (Boltz-1, Boltz-2, BoltzGen, all MIT-licensed) are used by 100,000+ scientists across pharma and biotech,
  and its commercial platform, Boltz Lab, pairs those models with managed compute and collaborative interfaces. The Boltz
  Compute API exposes these capabilities as asynchronous jobs - structure & binding prediction, ADME prediction, and small-molecule
  / protein design and library screening - with official Python, TypeScript, and Go SDKs, a CLI, and an MCP server for agentic
  drug-discovery workflows. Backed by a $28M seed round led by Amplify Partners, a16z, and Zetta Venture Partners.
url: https://raw.githubusercontent.com/api-evangelist/boltz/refs/heads/main/apis.yml
x-type: company
x-source: vc-portfolio
x-backed-by:
- amplify-partners
x-tier: enriched
x-tier-reason: portfolio-lead
deliveryModel:
  model: saas
  open_source: false
  commercial: true
  callable_host: true
  label: Hosted service · you call their endpoint
  confidence: high
  source:
  - openapi
  - pricing
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: freemium
  onboarding: self-serve
  trial: false
  try_now: true
  public: false
  gated: none
  gated_source:
  - onboarding
  label: Freemium · Self-serve signup
  confidence: high
  source:
  - plans
  - authentication
  - security
  - sandbox
  generated: '2026-11-06'
  method: derived
image: https://boltz.bio/android-chrome-512x512.png
specificationVersion: '0.23'
created: '2026-07-17'
modified: '2026-07-18'
x-docs-platform: mintlify
x-docs-platform-confidence: medium
x-docs-platform-checked: 2026-09-20
x-docs-hosting: vercel
tags:
- Company
- Digital Biology
- Drug Discovery
- Artificial Intelligence
- Machine Learning
- Protein Design
- Structure Prediction
- Life Sciences
- Compute
tags_raw:
- Company
- Digital Biology
- Drug Discovery
- Artificial Intelligence
- Machine Learning
- Protein Design
- Structure Prediction
- Life Sciences
- Compute
- Machine-Learning
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
apis:
- aid: boltz:boltz-admin-api
  name: Boltz Admin API
  description: The Admin API from Boltz — 7 operation(s) for admin.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Admin
  properties:
  - type: OpenAPI
    url: openapi/boltz-admin-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-auth-api
  name: Boltz Auth API
  description: The Auth API from Boltz — 1 operation(s) for auth.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Authentication
  tags_raw:
  - Auth
  properties:
  - type: OpenAPI
    url: openapi/boltz-auth-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-cli-api
  name: Boltz CLI API
  description: The CLI API from Boltz — 1 operation(s) for cli.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - CLI
  properties:
  - type: OpenAPI
    url: openapi/boltz-cli-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-predictions-api
  name: Boltz Predictions API
  description: The Predictions API from Boltz — 8 operation(s) for predictions.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Predictions
  properties:
  - type: OpenAPI
    url: openapi/boltz-predictions-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-protein-api
  name: Boltz Protein API
  description: The Protein API from Boltz — 15 operation(s) for protein.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Proteins
  tags_raw:
  - Protein
  properties:
  - type: OpenAPI
    url: openapi/boltz-protein-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-share-links-api
  name: Boltz Share Links API
  description: The Share Links API from Boltz — 4 operation(s) for share links.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Share Links
  properties:
  - type: OpenAPI
    url: openapi/boltz-share-links-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-small-molecule-api
  name: Boltz Small Molecule API
  description: The Small Molecule API from Boltz — 14 operation(s) for small molecule.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Small Molecule
  properties:
  - type: OpenAPI
    url: openapi/boltz-small-molecule-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
common:
- type: Plans
  url: plans/boltz-plans-pricing.yml
- type: CapabilityMap
  url: capabilities/boltz-capability-edges.yml
  name: Boltz Business Capability Map
- type: Website
  url: https://boltz.bio
- type: DeveloperPortal
  url: https://docs.boltz.bio
- type: Documentation
  url: https://docs.boltz.bio
- type: APIReference
  url: https://api.boltz.bio/docs
- type: GettingStarted
  url: https://docs.boltz.bio/user-guide/introduction/Quickstart.md
- type: OpenAPI
  url: openapi/_original/boltz-compute.yml
- type: Authentication
  url: authentication/boltz-authentication.yml
- type: Packages
  url: packages/boltz-packages.yml
- type: SDKs
  url: packages/boltz-packages.yml
- type: CLI
  url: cli/boltz-cli.yml
- type: MCPServer
  url: mcp/boltz-mcp.yml
- type: AgentSkill
  url: skills/_index.yml
- type: LLMsTxt
  url: llms/boltz-llms.txt
- type: Conventions
  url: conventions/boltz-conventions.yml
- type: DataModel
  url: data-model/boltz-data-model.yml
- type: ErrorCatalog
  url: errors/boltz-problem-types.yml
- type: Conformance
  url: conformance/boltz-conformance.yml
- type: Lifecycle
  url: lifecycle/boltz-lifecycle.yml
- type: StatusPage
  url: https://status.boltz.bio
- type: ChangeLog
  url: changelog/boltz-changelog.yml
- type: Sandbox
  url: sandbox/boltz-sandbox.yml
- type: DomainSecurity
  url: security/boltz-domain-security.yml
- type: Pricing
  url: https://boltz.bio/pricing
- type: Blog
  url: https://boltz.bio/news
- type: GitHubOrganization
  url: https://github.com/boltz-bio
- type: SignUp
  url: https://lab.boltz.bio
- type: Support
  url: https://boltz.bio/join-slack
- type: TermsOfService
  url: https://docs.boltz.bio/terms-of-service/terms-of-service.md
- type: PrivacyPolicy
  url: https://docs.boltz.bio/privacy-policy/privacy-policy.md
x-enrichment:
  date: '2026-07-19'
  status: backfilled
  pass: local-v1
  note: backfilled from .gitignore signal + verified work evidence

Boltz API — frequently asked questions

Does Boltz have an API?

Yes. APIs.io lists 7 APIs from Boltz, including Boltz Admin API, Boltz Auth API and Boltz CLI API, and 4 more.

Is there an OpenAPI specification for the Boltz API?

Yes. APIs.io indexes 7 OpenAPI specifications for Boltz, each linked for download from this page.

How do I authenticate with the Boltz API?

Boltz uses bearer-token authentication (1 scheme). The details are profiled on APIs.io as Boltz Authentication.

How much does the Boltz API cost?

Boltz publishes its prices; its Professional plan is $0 subscription as of 2026-10-07. APIs.io lists 13 pricing plans for Boltz, with each plan's price, limits and inclusions under Pricing on this page.

Does Boltz have an MCP server?

Yes. APIs.io lists 1 MCP server for Boltz: Official Boltz MCP server, distributed as an MCP Bundle (.mcpb) named "boltz". Wraps the Boltz Compute API so agents can estimate/run structure & binding predictions, small-molecule and protein design

Is the Boltz API ready for AI agents?

Boltz has a Kin Score of 56.9 out of 100 (strong) and an Agent Readiness score of 24.9 (agent-aware), scored by API Evangelist on 2026-11-06.

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