Boltz website screenshot

Boltz

Boltz (Boltz PBC) is a public-benefit AI research company building open-source and proprietary foundation models for biomolecular structure prediction, binding-affinity estimation, and generative protein and small-molecule design. Its open-source models (Boltz-1, Boltz-2, BoltzGen, all MIT-licensed) are used by 100,000+ scientists across pharma and biotech, and its commercial platform, Boltz Lab, pairs those models with managed compute and collaborative interfaces. The Boltz Compute API exposes these capabilities as asynchronous jobs - structure & binding prediction, ADME prediction, and small-molecule / protein design and library screening - with official Python, TypeScript, and Go SDKs, a CLI, and an MCP server for agentic drug-discovery workflows. Backed by a $28M seed round led by Amplify Partners, a16z, and Zetta Venture Partners.

Boltz publishes 7 APIs on the APIs.io network, including Admin API, Auth API, CLI API, and 4 more. Tagged areas include Company, Digital Biology, Drug Discovery, Artificial Intelligence, and Machine Learning.

Boltz’s developer surface includes documentation, API reference, getting-started guide, authentication, CLI, changelog, sandbox, and 22 more developer resources.

🌐 Visit website 📡 Source on GitHub
54.8/100 developing ▬ flat Agent 51/100 agent ready Full breakdown ↓
scored 2026-07-27 · rubric v0.5
AccessSelf serve
7 APIs 1 MCP Servers
CompanyDigital BiologyDrug DiscoveryArtificial IntelligenceMachine LearningProtein DesignStructure PredictionLife SciencesCompute

Kin Score

Kin Score Kin Score How this is scored →
scored 2026-07-27 · rubric v0.5
Composite quality — 54.8/100 · developing
Contract Quality 13.7 / 25
Developer Ergonomics 17.4 / 20
Commercial Clarity 8.9 / 20
Operational Transparency 4.8 / 13
Governance 0.0 / 12
Discoverability 10.0 / 10
Agent readiness — 51/100 · agent ready
Machine-Readable Contract 18 / 18
Agentic Access Contract 0 / 15
MCP Server 12 / 12
Machine-Readable Auth 10 / 10
Idempotency 0 / 9
Stable Error Semantics 8 / 8
Request/Response Examples 0 / 7
Rate-Limit Signaling 0 / 7
Typed Event Surface 0 / 6
Agent Skills 5 / 5
Well-Known Catalog 0 / 4
Consent & Bot Identity 0 / 3
Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. This rating is computed from github.com/api-evangelist/boltz: open an issue to ask a question, or submit a pull request to add artifacts. Want it done for you? Prioritized profiling — $2,500 →

APIs 7

Individual APIs this provider publishes, each with its own machine-readable definition.

Boltz Admin API

The Admin API from Boltz — 7 operation(s) for admin.

Boltz Auth API

The Auth API from Boltz — 1 operation(s) for auth.

Boltz CLI API

The CLI API from Boltz — 1 operation(s) for cli.

Boltz Predictions API

The Predictions API from Boltz — 8 operation(s) for predictions.

Boltz Protein API

The Protein API from Boltz — 15 operation(s) for protein.

Boltz Share Links API

The Share Links API from Boltz — 4 operation(s) for share links.

Boltz Small Molecule API

The Small Molecule API from Boltz — 14 operation(s) for small molecule.

Scroll for all 7

MCP Servers 1

Model Context Protocol servers that expose these APIs to AI agents.

boltz-mcp.yml

MCP SERVER

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Boltz Authentication

1 scheme

SECURITY

Boltz Domain Security

TLSv1.3 · DMARC

SECURITY

Resources

Get Started 4

Portal, sign-up, and the first successful call

DeveloperPortal
DeveloperPortal
 GettingStarted
GettingStarted
 Sandbox
Sandbox
 SignUp
SignUp

Documentation 3

Reference material describing how the API behaves

Documentation
Documentation
 APIReference
APIReference
 OpenAPI
OpenAPI

Agent Surfaces 3

MCP servers, agent skills, and machine-readable catalogs

MCPServer
MCPServer
 AgentSkill
AgentSkill
 LLMsTxt
LLMsTxt

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions
Conventions
 DataModel
DataModel
 ErrorCatalog
ErrorCatalog
 Conformance
Conformance
 Lifecycle
Lifecycle

Build 4

SDKs, sample code, and the tooling you integrate with

Packages
Packages
 SDKs
SDKs
 CLI
CLI
 GitHubOrganization
GitHubOrganization

Access & Security 2

Authentication, authorization, and security posture

Authentication
Authentication
 DomainSecurity
DomainSecurity

Operate 3

Status, limits, changes, and where to get help

StatusPage
StatusPage
 ChangeLog
ChangeLog
 Support
Support

Commercial 3

Pricing, plans, and the legal terms of use

Pricing
Pricing
 TermsOfService
TermsOfService
 PrivacyPolicy
PrivacyPolicy

Company 2

The organization behind the API

Website
Website
 Blog
Blog

Source (apis.yml)

apis.yml Raw ↑ 
aid: boltz
name: Boltz
description: Boltz (Boltz PBC) is a public-benefit AI research company building open-source and proprietary foundation models
  for biomolecular structure prediction, binding-affinity estimation, and generative protein and small-molecule design. Its
  open-source models (Boltz-1, Boltz-2, BoltzGen, all MIT-licensed) are used by 100,000+ scientists across pharma and biotech,
  and its commercial platform, Boltz Lab, pairs those models with managed compute and collaborative interfaces. The Boltz
  Compute API exposes these capabilities as asynchronous jobs - structure & binding prediction, ADME prediction, and small-molecule
  / protein design and library screening - with official Python, TypeScript, and Go SDKs, a CLI, and an MCP server for agentic
  drug-discovery workflows. Backed by a $28M seed round led by Amplify Partners, a16z, and Zetta Venture Partners.
url: https://raw.githubusercontent.com/api-evangelist/boltz/refs/heads/main/apis.yml
x-type: company
x-source: vc-portfolio
x-backed-by:
- amplify-partners
x-tier: enriched
x-tier-reason: portfolio-lead
accessModel:
  pricing: unknown
  onboarding: self-serve
  trial: false
  try_now: false
  public: false
  label: Self-serve signup
  confidence: medium
  source:
  - authentication
  generated: '2026-07-22'
  method: derived
image: https://boltz.bio/android-chrome-512x512.png
specificationVersion: '0.20'
created: '2026-07-17'
modified: '2026-07-18'
tags:
- Company
- Digital Biology
- Drug Discovery
- Artificial Intelligence
- Machine Learning
- Protein Design
- Structure Prediction
- Life Sciences
- Compute
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
apis:
- aid: boltz:boltz-admin-api
  name: Boltz Admin API
  description: The Admin API from Boltz — 7 operation(s) for admin.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Admin
  properties:
  - type: OpenAPI
    url: openapi/boltz-admin-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-auth-api
  name: Boltz Auth API
  description: The Auth API from Boltz — 1 operation(s) for auth.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Auth
  properties:
  - type: OpenAPI
    url: openapi/boltz-auth-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-cli-api
  name: Boltz CLI API
  description: The CLI API from Boltz — 1 operation(s) for cli.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - CLI
  properties:
  - type: OpenAPI
    url: openapi/boltz-cli-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-predictions-api
  name: Boltz Predictions API
  description: The Predictions API from Boltz — 8 operation(s) for predictions.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Predictions
  properties:
  - type: OpenAPI
    url: openapi/boltz-predictions-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-protein-api
  name: Boltz Protein API
  description: The Protein API from Boltz — 15 operation(s) for protein.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Protein
  properties:
  - type: OpenAPI
    url: openapi/boltz-protein-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-share-links-api
  name: Boltz Share Links API
  description: The Share Links API from Boltz — 4 operation(s) for share links.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Share Links
  properties:
  - type: OpenAPI
    url: openapi/boltz-share-links-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
- aid: boltz:boltz-small-molecule-api
  name: Boltz Small Molecule API
  description: The Small Molecule API from Boltz — 14 operation(s) for small molecule.
  humanURL: https://api.boltz.bio/docs
  baseURL: https://api.boltz.bio
  tags:
  - Small Molecule
  properties:
  - type: OpenAPI
    url: openapi/boltz-small-molecule-api-openapi.yml
  - type: APIReference
    url: https://api.boltz.bio/docs
  - type: Documentation
    url: https://docs.boltz.bio
  - type: Authentication
    url: authentication/boltz-authentication.yml
common:
- type: Website
  url: https://boltz.bio
- type: DeveloperPortal
  url: https://docs.boltz.bio
- type: Documentation
  url: https://docs.boltz.bio
- type: APIReference
  url: https://api.boltz.bio/docs
- type: GettingStarted
  url: https://docs.boltz.bio/user-guide/introduction/Quickstart.md
- type: OpenAPI
  url: openapi/boltz-compute.yml
- type: Authentication
  url: authentication/boltz-authentication.yml
- type: Packages
  url: packages/boltz-packages.yml
- type: SDKs
  url: packages/boltz-packages.yml
- type: CLI
  url: cli/boltz-cli.yml
- type: MCPServer
  url: mcp/boltz-mcp.yml
- type: AgentSkill
  url: skills/_index.yml
- type: LLMsTxt
  url: llms/boltz-llms.txt
- type: Conventions
  url: conventions/boltz-conventions.yml
- type: DataModel
  url: data-model/boltz-data-model.yml
- type: ErrorCatalog
  url: errors/boltz-problem-types.yml
- type: Conformance
  url: conformance/boltz-conformance.yml
- type: Lifecycle
  url: lifecycle/boltz-lifecycle.yml
- type: StatusPage
  url: https://status.boltz.bio
- type: ChangeLog
  url: changelog/boltz-changelog.yml
- type: Sandbox
  url: sandbox/boltz-sandbox.yml
- type: DomainSecurity
  url: security/boltz-domain-security.yml
- type: Pricing
  url: https://boltz.bio/pricing
- type: Blog
  url: https://boltz.bio/news
- type: GitHubOrganization
  url: https://github.com/boltz-bio
- type: SignUp
  url: https://lab.boltz.bio
- type: Support
  url: https://boltz.bio/join-slack
- type: TermsOfService
  url: https://docs.boltz.bio/terms-of-service/terms-of-service.md
- type: PrivacyPolicy
  url: https://docs.boltz.bio/privacy-policy/privacy-policy.md
x-enrichment:
  date: '2026-07-19'
  status: backfilled
  pass: local-v1
  note: backfilled from .gitignore signal + verified work evidence