BillionToOne website screenshot

BillionToOne

BillionToOne is a molecular diagnostics company using proprietary single-molecule Quantitative Counting Template (QCT) technology to detect disease at the DNA level from cell-free DNA. Its Unity prenatal screening suite (Unity Complete, Unity Confirm, and Unity fetal antigen tests) delivers non-invasive prenatal testing from maternal blood at nine weeks, and its Northstar oncology line (Northstar Select and Northstar Response) provides liquid-biopsy therapy selection and real-time treatment-response monitoring. BillionToOne integrates with electronic medical records through a collaboration with Epic and delivers results through its provider and patient portals. It was added to the API Evangelist network as a portfolio company of 500 Global, Norwest Venture Partners, and Y Combinator.

BillionToOne is profiled on the APIs.io network. Tagged areas include Company, Molecular Diagnostics, Healthcare, Genomics, and Prenatal Testing.

BillionToOne’s developer surface includes support, engineering blog, and 6 more developer resources.

🌐 Visit website 📡 Source on GitHub
14.5/100 emerging ▬ flat Agent 0/100 human only Full breakdown ↓
scored 2026-08-20 · rubric v0.12.0
0 APIs
CompanyMolecular DiagnosticsHealthcareGenomicsPrenatal TestingOncologyLiquid BiopsyDiagnostics

Kin Score

Kin Score Kin Score How this is scored →
scored 2026-08-20 · rubric v0.12.0
Composite quality — 14.5/100 · emerging
Contract Quality 0.0 / 21
Developer Ergonomics 1.2 / 17
Access Clarity 6.3 / 17
Operational Transparency 0.0 / 11
Contract Governance 0.0 / 10
Discoverability 4.3 / 9
Regulatory Posture 3.6 / 15
Agent readiness — 0/100 · human only
Machine-Readable Contract 0 / 18
Agentic Access Contract 0 / 10
Documented Reversibility 0 / 6
MCP Server 0 / 12
Machine-Readable Auth 0 / 10
Idempotency 0 / 9
Stable Error Semantics 0 / 8
Request/Response Examples 0 / 7
Rate-Limit Signaling 0 / 7
Typed Event Surface 0 / 6
Agent Skills 0 / 5
Well-Known Catalog 0 / 4
Consent & Bot Identity 0 / 3
A2A Agent Card 0 / 8
Dry-Run / Simulate Mode 0 / 4
Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.
The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.
Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. This rating is computed from github.com/api-evangelist/billiontoone: open an issue to ask a question, or submit a pull request to add artifacts. Want it done for you? Prioritized profiling — $2,500 →

Security Posture 2

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Billiontoone Domain Security

TLSv1.3 · DMARC

SECURITY

Billiontoone Trust Center

SOC 2, HIPAA

SECURITY

Resources

Access & Security 3

Authentication, authorization, and security posture

TrustCenter
TrustCenter
 Compliance
Compliance
 DomainSecurity
DomainSecurity

Operate 1

Status, limits, changes, and where to get help

Support
Support

Commercial 2

Pricing, plans, and the legal terms of use

PrivacyPolicy
PrivacyPolicy
 TermsOfService
TermsOfService

Company 2

The organization behind the API

Website
Website
 Blog
Blog

Source (apis.yml)

apis.yml Raw ↑ 
aid: billiontoone
name: BillionToOne
description: BillionToOne is a molecular diagnostics company using proprietary single-molecule Quantitative Counting Template
  (QCT) technology to detect disease at the DNA level from cell-free DNA. Its Unity prenatal screening suite (Unity Complete,
  Unity Confirm, and Unity fetal antigen tests) delivers non-invasive prenatal testing from maternal blood at nine weeks,
  and its Northstar oncology line (Northstar Select and Northstar Response) provides liquid-biopsy therapy selection and real-time
  treatment-response monitoring. BillionToOne integrates with electronic medical records through a collaboration with Epic
  and delivers results through its provider and patient portals. It was added to the API Evangelist network as a portfolio
  company of 500 Global, Norwest Venture Partners, and Y Combinator.
url: https://raw.githubusercontent.com/api-evangelist/billiontoone/refs/heads/main/apis.yml
x-type: company
x-source: vc-portfolio
x-backed-by:
- 500-global
- norwest-venture-partners
- y-combinator
x-tier: stub
x-tier-reason: portfolio-lead
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source: []
  generated: '2026-07-22'
  method: derived
specificationVersion: '0.23'
created: '2026-07-17'
modified: '2026-07-18'
image: https://cdn.prod.website-files.com/6880c9300eb95bb084b75b2e/68f9c805125d5bd39b931a16_bto_logo_new.svg
tags:
- Company
- Molecular Diagnostics
- Healthcare
- Genomics
- Prenatal Testing
- Oncology
- Liquid Biopsy
- Diagnostics
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: TrustCenter
  url: security/billiontoone-trust-center.yml
- type: Compliance
  url: https://trust.billiontoone.com/
- type: DomainSecurity
  url: security/billiontoone-domain-security.yml
- type: Website
  url: https://billiontoone.com
- type: Support
  url: https://billiontoone.com/contact
- type: Blog
  url: https://www.billiontoone.com/news-media
- type: PrivacyPolicy
  url: https://billiontoone.com/privacy-policy
- type: TermsOfService
  url: https://billiontoone.com/terms-of-use
x-enrichment:
  date: '2026-07-19'
  status: backfilled
  pass: local-v1
  note: backfilled from .gitignore signal + verified work evidence