Arc Institute

Arc Institute is an independent nonprofit biomedical research organization headquartered in Palo Alto, California, co-founded in 2021 by Silvana Konermann (Executive Director), Patrick Hsu (Core Investigator), and Stripe co-founder Patrick Collison. With 300+ staff ("Arconauts") across 9 core laboratories and 5 technology centers, Arc develops AI foundation models for biology that span DNA, RNA, proteins, and single cells. Its flagship releases include Evo (Science, 2024) and Evo 2 (Nature, 2026) — DNA foundation models trained on trillions of nucleotides at single-nucleotide resolution with up to a 1-megabase context; STATE and Stack single-cell foundation models for cellular perturbation and in-context learning; the Arc Virtual Cell Atlas; the SRAgent LLM agents for bioinformatics; and the BINSEQ binary sequencing format. Models are released under Apache 2.0 on GitHub and Hugging Face, with hosted inference for Evo 2 available through NVIDIA BioNeMo and the NVIDIA build.nvidia.com API. Arc is funded by philanthropic donations from Patrick and John Collison, Vitalik Buterin, the Ron Conway family, Dustin Moskovitz, Daniel Gross, Elad Gil, and other technology benefactors; it does not sell APIs, SaaS, or models commercially.

Arc Institute is profiled on the APIs.io network. Tagged areas include Biomedical Research, Computational Biology, Genomics, DNA Foundation Models, and Foundation Models.

Arc Institute’s developer surface includes tooling, product news, YouTube channel, engineering blog, and 17 more developer resources.

🌐 Visit website 📡 Source on GitHub

7.9/100 minimal ▬ flat Agent 0/100 human only Full breakdown ↓
scored 2026-07-27 · rubric v0.5

0 APIs

Biomedical ResearchComputational BiologyGenomicsDNA Foundation ModelsFoundation ModelsSingle CellProtein EngineeringEvoEvo 2BioinformaticsNonprofitOpen SourceMachine LearningAI for Science

Kin Score

Kin Score How this is scored →
scored 2026-07-27 · rubric v0.5

Composite quality — 7.9/100 · minimal

Contract Quality 0.0 / 25

Developer Ergonomics 0.4 / 20

Commercial Clarity 0.0 / 20

Operational Transparency 0.7 / 13

Governance 0.0 / 12

Discoverability 6.8 / 10

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 15

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

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Build 2

SDKs, sample code, and the tooling you integrate with

Tools

Tools

GitHubOrganization

GitHubOrganization

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Learn 1

Tutorials, courses, talks, and written guidance

YouTube

YouTube

Company 7

The organization behind the API

Website

About

News

Careers

LinkedIn

Twitter

Twitter

Blog

Blog

Scroll for all 7

Other 10

Properties that don't map to a standard resource type

Programs

Models

Publications

HuggingFace

Evo

Evo2

HostedAPI

BioNeMo

Paper

Paper

Scroll for all 10

Source (apis.yml)

aid: arc-institute
name: Arc Institute
description: Arc Institute is an independent nonprofit biomedical research organization headquartered in Palo Alto, California,
  co-founded in 2021 by Silvana Konermann (Executive Director), Patrick Hsu (Core Investigator), and Stripe co-founder Patrick
  Collison. With 300+ staff ("Arconauts") across 9 core laboratories and 5 technology centers, Arc develops AI foundation
  models for biology that span DNA, RNA, proteins, and single cells. Its flagship releases include Evo (Science, 2024) and
  Evo 2 (Nature, 2026) — DNA foundation models trained on trillions of nucleotides at single-nucleotide resolution with up
  to a 1-megabase context; STATE and Stack single-cell foundation models for cellular perturbation and in-context learning;
  the Arc Virtual Cell Atlas; the SRAgent LLM agents for bioinformatics; and the BINSEQ binary sequencing format. Models are
  released under Apache 2.0 on GitHub and Hugging Face, with hosted inference for Evo 2 available through NVIDIA BioNeMo and
  the NVIDIA build.nvidia.com API. Arc is funded by philanthropic donations from Patrick and John Collison, Vitalik Buterin,
  the Ron Conway family, Dustin Moskovitz, Daniel Gross, Elad Gil, and other technology benefactors; it does not sell APIs,
  SaaS, or models commercially.
type: Index
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source: []
  generated: '2026-07-22'
  method: derived
position: Provider
access: 3rd-Party
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/arc-institute.png
tags:
- Biomedical Research
- Computational Biology
- Genomics
- DNA Foundation Models
- Foundation Models
- Single Cell
- Protein Engineering
- Evo
- Evo 2
- Bioinformatics
- Nonprofit
- Open Source
- Machine Learning
- AI for Science
url: https://raw.githubusercontent.com/api-evangelist/arc-institute/refs/heads/main/apis.yml
created: '2026-05-24'
modified: '2026-05-24'
specificationVersion: '0.20'
apis: []
common:
- type: DomainSecurity
  url: security/arc-institute-domain-security.yml
- type: Website
  url: https://arcinstitute.org
- type: About
  url: https://arcinstitute.org/about
- type: Programs
  url: https://arcinstitute.org/programs
- type: Tools
  url: https://arcinstitute.org/tools
- type: Models
  url: https://arcinstitute.org/model
- type: News
  url: https://arcinstitute.org/news
- type: Publications
  url: https://arcinstitute.org/publications
- type: Careers
  url: https://arcinstitute.org/jobs
- type: GitHubOrganization
  url: https://github.com/arcinstitute
- type: HuggingFace
  url: https://huggingface.co/arcinstitute
- type: Evo
  url: https://github.com/evo-design/evo
- type: Evo2
  url: https://github.com/arcinstitute/evo2
- type: HostedAPI
  url: https://build.nvidia.com/arc/evo2-40b
- type: BioNeMo
  url: https://docs.nvidia.com/bionemo-framework/latest/models/evo2.html
- type: Paper
  url: https://doi.org/10.1038/s41586-026-10176-5
- type: Paper
  url: https://www.science.org/doi/10.1126/science.ado9336
- type: LinkedIn
  url: https://www.linkedin.com/company/arc-institute
- type: Twitter
  url: https://twitter.com/arcinstitute
- type: YouTube
  url: https://www.youtube.com/@arcinstitute
- type: Blog
  url: https://arcinstitute.org/news
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com