Acelot

Acelot, Inc. is a clinical-stage biopharmaceutical company headquartered in South San Francisco, California, developing first-in-class small-molecule therapies for neurodegenerative diseases with high unmet need. Its lead candidate, ACE-2223, is designed to target misfolded and aggregated TDP-43 and restore the protein's healthy form and function, addressing pathology central to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Acelot's discovery work is powered by Resolute, an internal integrated drug-discovery platform combining AI-driven computational chemistry with structural and biological insight to drug historically intractable protein targets. Acelot publishes no public API, developer portal, SDK or machine-readable specification; its four public GitHub repositories are forks of third-party cheminformatics tooling.

Acelot is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Drug Discovery, and Life Sciences.

Acelot’s developer surface includes engineering blog and 8 more developer resources.

🌐 Visit website 📡 Profile data on GitHub

4.5/100 minimal ▬ flat Agent 0/100 human only Front door AI 3/6 light Heartbeat 100/100 alive Full breakdown ↓
scored 2026-11-06 · rubric v0.27.0 · Show this score on your site →

0 APIs

Company Biotechnology Pharmaceuticals Drug Discovery Life Sciences Neurodegenerative Disease Artificial Intelligence Computational Chemistry

Kin Score

Kin Score How this is scored →
scored 2026-11-06 · rubric v0.27.0

Composite quality — 4.5/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.4 / 17

Access Clarity 0.0 / 17

Operational Transparency 0.3 / 11

Contract Governance 0.0 / 10

Discoverability 4.1 / 9

Regulatory Posture 0.7 / 15

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Pagination 5 / 5

Distinct Operations 3 / 3

MCP Tool Quality 6 / 6

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

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Agent readiness — checks not met, largest first (exact, from this profile):

Machine-Readable Contract +18 pts — api_specs includes an OpenAPI document
MCP Server +12 pts — deployment.mode + probe verdict on the mcp/ manifest, not the pointer; an unprobed slug falls back to authorship
Agentic Access Contract +10 pts — agentic_access artifact present (x-agentic-access), graded by author
Machine-Readable Auth +10 pts — a served openid-configuration/oauth-authorization-server carrying `issuer` (served), else the securitySchemes class in the provider OpenAPIs — bound (mutualTLS, DPoP, Signature) > negotiable (oauth2 authorizationCode/clientCredentials, openIdConnect) > bearer (http bearer, apiKey)
Idempotency +9 pts — OpenAPI mutating operations declare an idempotency key — a header, a request-body property, or a named de-duplication token whose own description says so (verified); else common[].type matches /idempoten/i (documented)
Stable Error Semantics +8 pts — OpenAPI $refs a shared error schema across 4xx/5xx responses (verified), else common[].type includes ErrorCatalog / ErrorCodes / DeclineCodes

13 more unmet checks in the Agent Readiness table above.

Kin Score — facets with the most composite points still available (weight × headroom):

Contract Quality scores 0.0 — up to +25.0 composite points
Access Clarity scores 0.0 — up to +20.0 composite points
Developer Ergonomics scores 2.4 — up to +19.5 composite points

Each check links to what satisfies it. Publish the artifact, or tell us where it already lives, and the score moves on the next scoring run.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from the provider profile at artifacts.apis.io/acelot-inc/apis.yml: open an issue on github.com/api-evangelist/acelot-inc to ask a question or point us at an artifact you publish. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Acelot Inc Domain Security

TLSv1.3 · HSTS · DMARC

SECURITY

Resources

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

LLMsTxt

LLMsTxt

Build 1

SDKs, sample code, and the tooling you integrate with

GitHubOrganization

GitHubOrganization

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Company 4

The organization behind the API

Website

Website

Blog

Blog

BlogRSS

BlogRSS

LinkedIn

Other 2

Properties that don't map to a standard resource type

x-Publications

x-Publications

x-Team

x-Team

Source (apis.yml)

aid: acelot-inc
name: Acelot
description: Acelot, Inc. is a clinical-stage biopharmaceutical company headquartered in South San Francisco, California,
  developing first-in-class small-molecule therapies for neurodegenerative diseases with high unmet need. Its lead candidate,
  ACE-2223, is designed to target misfolded and aggregated TDP-43 and restore the protein's healthy form and function, addressing
  pathology central to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Acelot's discovery
  work is powered by Resolute, an internal integrated drug-discovery platform combining AI-driven computational chemistry
  with structural and biological insight to drug historically intractable protein targets. Acelot publishes no public API,
  developer portal, SDK or machine-readable specification; its four public GitHub repositories are forks of third-party cheminformatics
  tooling.
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  probe_state: none
  source:
  - security
  generated: '2026-11-06'
  method: derived
image: https://static1.squarespace.com/static/6721bd430e24a6572ea4152a/t/6732691e70799e3f6a4e8b71/1731356958733/Acelot-Website-LogoKnockout-111124-v01.png?format=1500w
url: https://raw.githubusercontent.com/api-evangelist/acelot-inc/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: harvest
specificationVersion: '0.20'
created: '2026-09-06'
modified: '2026-09-06'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Drug Discovery
- Life Sciences
- Neurodegenerative Disease
- Artificial Intelligence
- Computational Chemistry
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Website
  url: https://www.acelot.com/
- type: Blog
  url: https://www.acelot.com/news
- type: BlogRSS
  url: https://www.acelot.com/news?format=rss
- type: GitHubOrganization
  url: https://github.com/acelot-inc
- type: LinkedIn
  url: https://www.linkedin.com/company/acelot-inc./
- type: x-Publications
  url: https://www.acelot.com/publications
- type: x-Team
  url: https://www.acelot.com/our-team
- type: DomainSecurity
  url: security/acelot-inc-domain-security.yml
- type: LLMsTxt
  url: llms/acelot-inc-llms.txt
x-enrichment:
  date: '2026-09-06'
  status: minimal
  artifacts_added: 3
  pass: local-v3
x-coverage:
  state: none
  reason: no-developer-program
  detail: Acelot is a clinical-stage biopharmaceutical company whose product is a small-molecule therapeutic (ACE-2223), and
    its Resolute AI drug-discovery platform is described by the company as employed in-house only — acelot.com is a five-page
    Squarespace marketing site with no developer, docs or API section, and every contract-discovery path returned 404 on both
    acelot.com and www.acelot.com.
  evidence:
  - url: https://www.acelot.com/pipeline-and-platform
    status: 200
  - url: https://www.acelot.com/openapi.json
    status: 404
  - url: https://www.acelot.com/swagger.json
    status: 404
  - url: https://www.acelot.com/api-docs
    status: 404
  - url: https://www.acelot.com/graphql
    status: 404
  - url: https://www.acelot.com/mcp
    status: 404
  - url: https://www.acelot.com/llms.txt
    status: 404
  - url: https://www.acelot.com/.well-known/agent-card.json
    status: 404
  - url: https://www.acelot.com/.well-known/api-catalog
    status: 404
  - url: https://github.com/acelot-inc
    status: 200
  checked: '2026-09-06'
x-legal-name: Acelot, Inc.

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