Zetagen Therapeutics

Zetagen Therapeutics is a private, clinical-stage biopharmaceutical company founded in 2015 and based in Syracuse, New York, where it has operated from laboratory space in the Central New York Biotech Accelerator at SUNY Upstate Medical University since 2017. It develops locally administered small-molecule therapies for metastatic and primary cancers to bone and other organs, built on a proprietary "Zeta" platform derived from the company's discovery of a new molecular pathway acting through the Met5-enkephalin / opioid growth factor receptor signalling axis. Its oncology pipeline includes ZetaMet (Zeta-BC-003) for metastatic breast cancer to bone, which received FDA Breakthrough Device Designation in December 2021 and Health Canada authorisation for a Phase 2a study in January 2022 and reported Phase 2a results at ASCO in June 2026; ZetaMet-P (Zeta-PC-004) for prostate cancer; ZetaMAST (Zeta-MBC-005) for metastatic breast cancer in liver; Zeta-BC-007; and ZetaOnc. Its osteologic programme is ZetaFuse, a synthetic osteoinductive bone graft studied in anterior cervical discectomy and fusion. The company reached 64 worldwide patents in 2024, has been funded by NCI and NIAMS grants, a $5.34M Series A, a $9.79M Series B and an oversubscribed Series B1 closed in November 2025, and its shares trade on secondary markets. Zetagen Therapeutics runs no developer program and publishes no product API, developer portal or API documentation. The only machine-readable surface reachable without credentials is the WordPress REST content API behind zetagen.com, catalogued here.

Zetagen Therapeutics publishes 9 APIs on the APIs.io network, including Content API, Discovery API, Downloads API, and 6 more. Tagged areas include Company, biopharmaceuticals, Oncology, Bone Health, and Orthopedics.

Zetagen Therapeutics’ developer surface includes product news, authentication, and 28 more developer resources.

🌐 Visit website 📡 Source on GitHub

22.2/100 emerging ▬ flat Agent 22/100 agent aware Full breakdown ↓
scored 2026-09-03 · rubric v0.18.2

AccessOpen

1 APIs

Company biopharmaceuticals OncologyBone HealthOrthopedics Clinical Trials Life Sciences Drug Development Medical Devices content-api

Kin Score

Kin Score How this is scored →
scored 2026-09-03 · rubric v0.18.2

Composite quality — 22.2/100 · emerging

Contract Quality 2.7 / 21

Developer Ergonomics 2.3 / 17

Access Clarity 4.9 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.5 / 10

Discoverability 6.5 / 9

Regulatory Posture 5.3 / 15

Agent readiness — 22/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 6 / 6

MCP Server 0 / 12

Machine-Readable Auth 10 / 10

Idempotency 9 / 9

Stable Error Semantics 8 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 5 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 4 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Surface 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/zetagen-therapeutics: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

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APIs 9

Individual APIs this provider publishes, each with its own machine-readable definition.

Open Collections 10

Open, tool-agnostic API collections (OpenAPI-derived and Bruno).

Get Started 1

Portal, sign-up, and the first successful call

ClinicalTrials

ClinicalTrials

Agent Surfaces 3

MCP servers, agent skills, and machine-readable catalogs

WellKnown

WellKnown

LLMsTxt

LLMsTxt

AgentSkill

AgentSkill

Design & Contract 5

Pagination, idempotency, versioning, errors, and events

Conventions

Conformance

ErrorCatalog

Lifecycle

DataModel

Access & Security 2

Authentication, authorization, and security posture

Authentication

Authentication

DomainSecurity

DomainSecurity

Operate 3

Status, limits, changes, and where to get help

RegulatoryStatus

RegulatoryStatus

PressReleases

PressReleases

Contact

Contact

Commercial 1

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

Company 5

The organization behind the API

Website

About

News

BlogRSS

LinkedIn

Other 10

Properties that don't map to a standard resource type

Overlay

Science

Oncology

Research

ExpandedAccessPolicy

Publications

PatientResources

CookiePolicy

Disclaimer

SecondaryMarket

Scroll for all 10

Source (apis.yml)

aid: zetagen-therapeutics
name: Zetagen Therapeutics
description: Zetagen Therapeutics is a private, clinical-stage biopharmaceutical company founded in 2015 and based in Syracuse,
  New York, where it has operated from laboratory space in the Central New York Biotech Accelerator at SUNY Upstate Medical
  University since 2017. It develops locally administered small-molecule therapies for metastatic and primary cancers to bone
  and other organs, built on a proprietary "Zeta" platform derived from the company's discovery of a new molecular pathway
  acting through the Met5-enkephalin / opioid growth factor receptor signalling axis. Its oncology pipeline includes ZetaMet
  (Zeta-BC-003) for metastatic breast cancer to bone, which received FDA Breakthrough Device Designation in December 2021
  and Health Canada authorisation for a Phase 2a study in January 2022 and reported Phase 2a results at ASCO in June 2026;
  ZetaMet-P (Zeta-PC-004) for prostate cancer; ZetaMAST (Zeta-MBC-005) for metastatic breast cancer in liver; Zeta-BC-007;
  and ZetaOnc. Its osteologic programme is ZetaFuse, a synthetic osteoinductive bone graft studied in anterior cervical discectomy
  and fusion. The company reached 64 worldwide patents in 2024, has been funded by NCI and NIAMS grants, a $5.34M Series A,
  a $9.79M Series B and an oversubscribed Series B1 closed in November 2025, and its shares trade on secondary markets. Zetagen
  Therapeutics runs no developer program and publishes no product API, developer portal or API documentation. The only machine-readable
  surface reachable without credentials is the WordPress REST content API behind zetagen.com, catalogued here.
deliveryModel:
  model: unknown
  open_source: false
  commercial: false
  callable_host: true
  label: Delivery model not determined — needs a product licence on record
  confidence: low
  source:
  - openapi
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: open
  trial: false
  try_now: false
  public: true
  label: Open access
  confidence: low
  source:
  - authentication
  - security
  generated: '2026-09-02'
  method: derived
image: https://zetagen.com/wp-content/uploads/2021/08/zetagen-logo.png
url: https://raw.githubusercontent.com/api-evangelist/zetagen-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enriched
specificationVersion: '0.23'
created: '2026-08-05'
modified: '2026-08-05'
tags:
- Company
- biopharmaceuticals
- Oncology
- Bone Health
- Orthopedics
- Clinical Trials
- Life Sciences
- Drug Development
- Medical Devices
- content-api
tags_raw:
- Company
- biopharmaceuticals
- oncology
- bone-health
- orthopedics
- clinical-trials
- life-sciences
- drug-development
- medical-devices
- content-api
apis:
- aid: zetagen-therapeutics:zetagen-therapeutics-content-api
  name: Zetagen Therapeutics Content API
  description: Posts, pages and the block library.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://zetagen.com/wp-json
  tags:
  - Content
  tags_raw:
  - content
  properties:
  - type: OpenAPI
    url: openapi/zetagen-therapeutics-content-api-openapi.yml
  - type: Authentication
    url: authentication/zetagen-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/zetagen-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/zetagen-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/zetagen-therapeutics-data-model.yml
- aid: zetagen-therapeutics:zetagen-therapeutics-discovery-api
  name: Zetagen Therapeutics Discovery API
  description: Route index, registered types, taxonomies and statuses.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://zetagen.com/wp-json
  tags:
  - Discovery
  tags_raw:
  - discovery
  properties:
  - type: OpenAPI
    url: openapi/zetagen-therapeutics-discovery-api-openapi.yml
  - type: Authentication
    url: authentication/zetagen-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/zetagen-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/zetagen-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/zetagen-therapeutics-data-model.yml
- aid: zetagen-therapeutics:zetagen-therapeutics-downloads-api
  name: Zetagen Therapeutics Downloads API
  description: WP Download Manager public search.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://zetagen.com/wp-json
  tags:
  - Downloads
  tags_raw:
  - downloads
  properties:
  - type: OpenAPI
    url: openapi/zetagen-therapeutics-downloads-api-openapi.yml
  - type: Authentication
    url: authentication/zetagen-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/zetagen-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/zetagen-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/zetagen-therapeutics-data-model.yml
- aid: zetagen-therapeutics:zetagen-therapeutics-embed-api
  name: Zetagen Therapeutics Embed API
  description: oEmbed 1.0 provider.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://zetagen.com/wp-json
  tags:
  - Embed
  tags_raw:
  - embed
  properties:
  - type: OpenAPI
    url: openapi/zetagen-therapeutics-embed-api-openapi.yml
  - type: Authentication
    url: authentication/zetagen-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/zetagen-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/zetagen-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/zetagen-therapeutics-data-model.yml
- aid: zetagen-therapeutics:zetagen-therapeutics-media-api
  name: Zetagen Therapeutics Media API
  description: The 388-item media library.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://zetagen.com/wp-json
  tags:
  - Media
  tags_raw:
  - media
  properties:
  - type: OpenAPI
    url: openapi/zetagen-therapeutics-media-api-openapi.yml
  - type: Authentication
    url: authentication/zetagen-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/zetagen-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/zetagen-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/zetagen-therapeutics-data-model.yml
- aid: zetagen-therapeutics:zetagen-therapeutics-people-api
  name: Zetagen Therapeutics People API
  description: Author records. Personal data — see x-personal-data. Documented for completeness; deliberately excluded from
    every packaged Agent Skill in this repo.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://zetagen.com/wp-json
  tags:
  - People
  tags_raw:
  - people
  properties:
  - type: OpenAPI
    url: openapi/zetagen-therapeutics-people-api-openapi.yml
  - type: Authentication
    url: authentication/zetagen-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/zetagen-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/zetagen-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/zetagen-therapeutics-data-model.yml
- aid: zetagen-therapeutics:zetagen-therapeutics-search-api
  name: Zetagen Therapeutics Search API
  description: Cross-content search.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://zetagen.com/wp-json
  tags:
  - Search
  tags_raw:
  - search
  properties:
  - type: OpenAPI
    url: openapi/zetagen-therapeutics-search-api-openapi.yml
  - type: Authentication
    url: authentication/zetagen-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/zetagen-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/zetagen-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/zetagen-therapeutics-data-model.yml
- aid: zetagen-therapeutics:zetagen-therapeutics-seo-api
  name: Zetagen Therapeutics Seo API
  description: Yoast SEO head metadata.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://zetagen.com/wp-json
  tags:
  - SEO
  tags_raw:
  - seo
  properties:
  - type: OpenAPI
    url: openapi/zetagen-therapeutics-seo-api-openapi.yml
  - type: Authentication
    url: authentication/zetagen-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/zetagen-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/zetagen-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/zetagen-therapeutics-data-model.yml
- aid: zetagen-therapeutics:zetagen-therapeutics-taxonomy-api
  name: Zetagen Therapeutics Taxonomy API
  description: Categories and tags.
  humanURL: https://developer.wordpress.org/rest-api/
  baseURL: https://zetagen.com/wp-json
  tags:
  - Taxonomy
  tags_raw:
  - taxonomy
  properties:
  - type: OpenAPI
    url: openapi/zetagen-therapeutics-taxonomy-api-openapi.yml
  - type: Authentication
    url: authentication/zetagen-therapeutics-authentication.yml
  - type: ErrorCatalog
    url: errors/zetagen-therapeutics-problem-types.yml
  - type: Conventions
    url: conventions/zetagen-therapeutics-conventions.yml
  - type: DataModel
    url: data-model/zetagen-therapeutics-data-model.yml
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Overlay
  url: overlays/zetagen-therapeutics-content-overlay.yaml
- type: Website
  url: https://zetagen.com/
- type: About
  url: https://zetagen.com/our-company/
- type: Science
  url: https://zetagen.com/the-science/
- type: Oncology
  url: https://zetagen.com/oncology-sector/
- type: Research
  url: https://zetagen.com/research-overview/
- type: RegulatoryStatus
  url: https://zetagen.com/research-overview/regulatory-status/
- type: ClinicalTrials
  url: https://zetagen.com/research-overview/clinical-trials/
- type: ExpandedAccessPolicy
  url: https://zetagen.com/research-overview/expanded-access-policy/
- type: Publications
  url: https://zetagen.com/news/publications/
- type: News
  url: https://zetagen.com/news/
- type: PressReleases
  url: https://zetagen.com/news/press-releases/
- type: BlogRSS
  url: https://zetagen.com/feed/
- type: Contact
  url: https://zetagen.com/contact-us/
- type: PatientResources
  url: https://zetagen.com/walk-with-you/
- type: PrivacyPolicy
  url: https://zetagen.com/privacy-statement-us/
- type: CookiePolicy
  url: https://zetagen.com/cookie-policy-eu/
- type: Disclaimer
  url: https://zetagen.com/disclaimer/
- type: LinkedIn
  url: https://www.linkedin.com/company/zetagen-therapeutics
- type: SecondaryMarket
  url: https://forgeglobal.com/zetagen-therapeutics_stock/
- type: Authentication
  url: authentication/zetagen-therapeutics-authentication.yml
- type: Conventions
  url: conventions/zetagen-therapeutics-conventions.yml
- type: Conformance
  url: conformance/zetagen-therapeutics-conformance.yml
- type: ErrorCatalog
  url: errors/zetagen-therapeutics-problem-types.yml
- type: Lifecycle
  url: lifecycle/zetagen-therapeutics-lifecycle.yml
- type: DataModel
  url: data-model/zetagen-therapeutics-data-model.yml
- type: WellKnown
  url: well-known/zetagen-therapeutics-well-known.yml
- type: DomainSecurity
  url: security/zetagen-therapeutics-domain-security.yml
- type: LLMsTxt
  url: llms/zetagen-therapeutics-llms.txt
- type: AgentSkill
  url: skills/_index.yml
x-enrichment:
  date: '2026-08-05'
  status: enriched
  artifacts_added: 16
  pass: local-v1

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