Exscientia
Exscientia was an Oxford UK-based AI-driven precision medicine and drug design company, founded in 2012 as a spin-out from the University of Dundee. Its platform combined generative chemistry (Centaur Chemist) with patient tissue-based screening (EVE, an automated single-cell platform for testing drug candidates directly against patient-derived tumor samples) to design small-molecule drug candidates faster and at lower cost than conventional pharma R&D. Notable firsts included EXS-21546 (an A2A antagonist developed with Evotec), DSP-1181 (the first AI-designed molecule to enter human clinical trials, with Sumitomo Dainippon Pharma), and DSP-0038 (a dual 5-HT1A/5-HT2A modulator for Alzheimer's psychosis). Exscientia maintained active pharma partnerships with Sanofi, Bristol Myers Squibb, Bayer, Sumitomo, and Merck KGaA. Exscientia was acquired by Recursion Pharmaceuticals (NASDAQ: RXRX) in an all-stock deal that closed in November 2024; the combined company operates under the Recursion brand and the legacy exscientia.ai website now redirects to recursion.com. The Exscientia name persists primarily through its GitHub organization, which continues to host open-source scientific Python packages for molecular predictive modelling (molflux), physics-based ML potentials (physicsml), antibody structure prediction (abodybuilder3), and biomolecular simulation (biosimspace) used by the wider computational chemistry and structural biology community. Exscientia did not expose any public commercial APIs, SDKs, or developer products before or after the merger; platform access was always delivered through collaborative drug-discovery agreements.
Exscientia is profiled on the APIs.io network. Tagged areas include Drug Discovery, Drug Design, AI Drug Design, Precision Medicine, and Biotech.
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