Cullgen

Cullgen Inc. is a clinical-stage biopharmaceutical company headquartered in San Diego, California, founded in 2018 and focused on first-in-class targeted protein degradation medicines. Its proprietary uSMITE (ubiquitin-mediated, small molecule-induced target elimination) platform harnesses the body's own ubiquitin-proteasome system to selectively degrade disease-causing intracellular proteins, including targets considered undruggable by conventional small molecules, and the company extends that chemistry into degrader-antibody conjugates (DACs). Its lead TRK degrader program has entered Phase 1 clinical dosing, and the company has partnered with Astellas and taken investment from AstraZeneca. Gyre Therapeutics completed an all-stock acquisition of Cullgen valued at approximately $300 million on 4 May 2026. Cullgen publishes a corporate marketing website only: profiling on 2026-08-04 found no developer portal, documentation, machine-readable API contract, package registry presence, or public code repositories.

Cullgen is profiled on the APIs.io network. Tagged areas include Company, Biotechnology, Pharmaceuticals, Life Sciences, and Drug Discovery.

Cullgen’s developer surface includes engineering blog and 9 more developer resources.

🌐 Visit website 📡 Source on GitHub

3.8/100 minimal ▬ flat Agent 0/100 human only Full breakdown ↓
scored 2026-09-08 · rubric v0.20.0

0 APIs

Company Biotechnology Pharmaceuticals Life Sciences Drug Discovery Targeted Protein Degradation Oncology Clinical Stage

Kin Score

Kin Score How this is scored →
scored 2026-09-08 · rubric v0.20.0

Composite quality — 3.8/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.4 / 17

Access Clarity 0.0 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.0 / 10

Discoverability 4.3 / 9

Regulatory Posture 1.1 / 15

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/cullgen: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Cullgen Domain Security

TLSv1.3 · DMARC

SECURITY

Resources

Agent Surfaces 1

MCP servers, agent skills, and machine-readable catalogs

LLMsTxt

LLMsTxt

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Operate 1

Status, limits, changes, and where to get help

Contact

Contact

Company 6

The organization behind the API

Website

About

Blog

Careers

LinkedIn

Twitter

Twitter

Other 1

Properties that don't map to a standard resource type

SecondaryMarket

SecondaryMarket

Source (apis.yml)

aid: cullgen
name: Cullgen
deliveryModel:
  model: unknown
  open_source: false
  commercial: false
  callable_host: false
  label: Delivery model not determined — needs a product licence on record
  confidence: low
  source:
  - none
  generated: '2026-08-28'
  method: derived
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  source:
  - security
  generated: '2026-09-02'
  method: derived
image: https://images.squarespace-cdn.com/content/64fa49d6dc6a8807524aa6c6/6a0a0ac8-3bf2-40b4-9f81-547d92175843/cullgen+logo+with+drop+shadow+more+blurry.png?format=1500w&content-type=image%2Fpng
description: 'Cullgen Inc. is a clinical-stage biopharmaceutical company headquartered in San Diego, California, founded in
  2018 and focused on first-in-class targeted protein degradation medicines. Its proprietary uSMITE (ubiquitin-mediated, small
  molecule-induced target elimination) platform harnesses the body''s own ubiquitin-proteasome system to selectively degrade
  disease-causing intracellular proteins, including targets considered undruggable by conventional small molecules, and the
  company extends that chemistry into degrader-antibody conjugates (DACs). Its lead TRK degrader program has entered Phase
  1 clinical dosing, and the company has partnered with Astellas and taken investment from AstraZeneca. Gyre Therapeutics
  completed an all-stock acquisition of Cullgen valued at approximately $300 million on 4 May 2026. Cullgen publishes a corporate
  marketing website only: profiling on 2026-08-04 found no developer portal, documentation, machine-readable API contract,
  package registry presence, or public code repositories.'
url: https://raw.githubusercontent.com/api-evangelist/cullgen/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: stub
x-tier-reason: harvest
x-api-surface: none
specificationVersion: '0.23'
created: '2026-08-04'
modified: '2026-08-04'
tags:
- Company
- Biotechnology
- Pharmaceuticals
- Life Sciences
- Drug Discovery
- Targeted Protein Degradation
- Oncology
- Clinical Stage
apis: []
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: DomainSecurity
  url: security/cullgen-domain-security.yml
- type: LLMsTxt
  url: llms/cullgen-llms.txt
- type: Website
  url: https://www.cullgen.com/
- type: About
  url: https://www.cullgen.com/about-us
- type: Blog
  url: https://www.cullgen.com/news-press-releases
- type: Contact
  url: https://www.cullgen.com/contact-us
- type: Careers
  url: https://www.cullgen.com/careers-1
- type: LinkedIn
  url: https://www.linkedin.com/company/cullgen
- type: Twitter
  url: https://twitter.com/CullgenInc
- type: SecondaryMarket
  url: https://forgeglobal.com/cullgen_stock/
x-enrichment:
  date: '2026-08-04'
  status: minimal
  artifacts_added: 2
  pass: local-v1

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