Chempirical

Chempirical (operated as Nitramine per the submission) publishes free tools for chemists and a free, keyless, read-only JSON API at chempirical.com/api covering compounds (names, formula, SMILES/InChI identifiers, molar mass, density, melting and boiling points, Antoine constants, azeotropes), substructure and similarity search, structure SVGs, reactions with participants and reaction scaling. CORS is open; the docs ask for a few requests per second.

Chempirical is listed with 1 API on the APIs.io network: (Nitramine) API. Tagged areas include Company, Chemistry, Compounds, Reactions, and Science.

The Chempirical catalog on APIs.io includes 1 JSON-LD context and 1 Spectral governance ruleset.

Chempirical’s developer surface includes documentation, engineering blog, and 12 more developer resources.

🌐 Visit website 📡 Source on GitHub

26.2/100 thin Agent 18/100 agent aware Full breakdown ↓
scored 2026-10-09 · rubric v0.23.0

1 API

Company Chemistry Compounds Reactions Science Open DataJSON API

Kin Score

Kin Score How this is scored →
scored 2026-10-09 · rubric v0.23.0

Composite quality — 26.2/100 · thin

Contract Quality 4.6 / 21

Developer Ergonomics 2.0 / 17

Access Clarity 5.8 / 17

Operational Transparency 2.3 / 11

Contract Governance 2.2 / 10

Discoverability 5.6 / 9

Regulatory Posture 1.6 / 15

Agent readiness — 18/100 · agent aware

Machine-Readable Contract 18 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 7 / 7

Rate-Limit Signaling 7 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Regulatory Posture applies to this provider. Its tags matched the Government & Public Sector regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from github.com/api-evangelist/chempirical: open an issue to ask a question, or submit a pull request to add artifacts. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

APIs 1

Individual APIs this provider publishes, each with its own machine-readable definition.

Chempirical (Nitramine) API

Chempirical (Nitramine) API as documented publicly: 6 operations. Contract generated from the documentation by API Evangelist (2026-10-09); not the provider's own document.

Pricing Plans 1

Published pricing tiers and plan structures.

Chempirical Plans Pricing

1 plans

PLANS

Rate Limits 1

Documented rate limits and quota policies.

Chempirical Rate Limits

1 limits

RATE LIMITS

Semantic Vocabularies 1

JSON-LD contexts and semantic vocabularies used across these APIs.

Chempirical Context

7 classes · 9 properties

JSON-LD

Spectral Rules 1

Spectral governance rulesets for linting and validating these APIs.

Chempirical API Rules

11 rules · 9 errors 1 warnings 1 info

SPECTRAL

JSON Schema 6

Standalone JSON Schema definitions for this provider's data models.

GetApiApiidResponse

1 properties

JSON SCHEMA

GetApiMoleculeSvg50782Response

1 properties

JSON SCHEMA

GetApiMoleculesMoleculeidResponse

3 properties

JSON SCHEMA

GetApiReactionsHenryNitroaldolResponse

1 properties

JSON SCHEMA

GetApiReactionsHenryNitroaldolScaleResponse

1 properties

JSON SCHEMA

PostApiMoleculesMoleculeidResponse

3 properties

JSON SCHEMA

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Chempirical Domain Security

TLSv1.3 · HSTS · DMARC

SECURITY

Resources

Get Started 1

Portal, sign-up, and the first successful call

Login

Documentation 1

Reference material describing how the API behaves

Documentation

Documentation

Design & Contract 6

Pagination, idempotency, versioning, errors, and events

Spectral

JSONLD

Vocabulary

DataModel

Conventions

Conformance

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Operate 1

Status, limits, changes, and where to get help

RateLimits

RateLimits

Commercial 1

Pricing, plans, and the legal terms of use

Plans

Plans

Company 2

The organization behind the API

Website

Website

Blog

Blog

Other 1

Properties that don't map to a standard resource type

Hosts

Hosts

Source (apis.yml)

aid: chempirical
name: Chempirical
image: https://chempirical.com/og-image.png
description: Chempirical (operated as Nitramine per the submission) publishes free tools for chemists and a free, keyless,
  read-only JSON API at chempirical.com/api covering compounds (names, formula, SMILES/InChI identifiers, molar mass, density,
  melting and boiling points, Antoine constants, azeotropes), substructure and similarity search, structure SVGs, reactions
  with participants and reaction scaling. CORS is open; the docs ask for a few requests per second.
url: https://raw.githubusercontent.com/api-evangelist/chempirical/refs/heads/main/apis.yml
x-type: company
x-source: harvest:new-submission
x-tier: profiled
x-tier-reason: enrichment pass 2026-10-09 (local-v5; was harvest)
specificationVersion: '0.20'
created: '2026-10-09'
modified: '2026-10-09'
tags:
- Company
- Chemistry
- Compounds
- Reactions
- Science
- Open Data
- JSON API
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: RateLimits
  url: rate-limits/chempirical-rate-limits.yml
- type: Plans
  url: plans/chempirical-plans-pricing.yml
- type: Spectral
  url: rules/chempirical-rules.yml
- type: JSONLD
  url: json-ld/chempirical-context.jsonld
- type: Vocabulary
  url: vocabulary/chempirical-vocabulary.yml
- type: DataModel
  url: data-model/chempirical-data-model.yml
- type: Conventions
  url: conventions/chempirical-conventions.yml
- type: Conformance
  url: conformance/chempirical-conformance.yml
- type: Hosts
  url: hosts/chempirical-hosts.yml
- type: DomainSecurity
  url: security/chempirical-domain-security.yml
- type: Website
  url: https://chempirical.com
- type: Documentation
  url: https://chempirical.com/api/
- type: Blog
  url: https://chempirical.com/blog/
- type: Login
  url: https://chempirical.com/auth/login
apis:
- aid: chempirical:chempirical-api
  name: Chempirical (Nitramine) API
  description: 'Chempirical (Nitramine) API as documented publicly: 6 operations. Contract generated from the documentation
    by API Evangelist (2026-10-09); not the provider''s own document.'
  humanURL: https://chempirical.com/api/
  properties:
  - type: OpenAPI
    url: openapi/_ae-authored/chempirical-openapi-generated.yml
    x-provenance: generated
  - type: JSONSchema
    url: json-schema/chempirical-get-api-molecules-moleculeid-response-schema.json
  - type: JSONSchema
    url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-response-schema.json
  - type: JSONSchema
    url: json-schema/chempirical-get-api-apiid-response-schema.json
  - type: JSONSchema
    url: json-schema/chempirical-get-api-reactions-henry-nitroaldol-scale-response-schema.json
  - type: JSONSchema
    url: json-schema/chempirical-post-api-molecules-moleculeid-response-schema.json
  - type: JSONSchema
    url: json-schema/chempirical-get-api-molecule-svg50782-response-schema.json
  baseURL: https://chempirical.com/api
  tags:
  - Chemistry
  - Compounds
  - Reactions
x-submission-notes: Free keyless chemistry JSON API (compounds, reactions)
x-submission-probe: /api/ 200 HTML docs; /openapi.json and /api/openapi.json 404 (no contract found); invented path 404
x-submitted-by: marty@chempirical.com (apis.io/add, 2026-10-09)
x-coverage:
  state: unreadable
  reason: no-machine-readable-spec
  method: derived
  generated: '2026-10-09'
  generator: derive-coverage.py (pre-flight evidence)
  detail: the company publishes developer documentation but serves no machine-readable contract from it
  evidence:
  - url: https://chempirical.com
    status: 200
x-enrichment:
  date: '2026-10-09'
  status: enriched
  artifacts_added: 14
  pass: local-v5

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