Crystalys Therapeutics

Crystalys Therapeutics is a clinical-stage biopharmaceutical company headquartered in San Diego, California, focused on addressing the significant unmet medical needs of people living with gout. Its lead investigational therapy, dotinurad, is a next-generation, highly selective urate transporter 1 (URAT1) inhibitor designed to lower serum uric acid by targeting the renal transport pathways responsible for urate reabsorption. The company was co-founded by its executive team together with Catalys Pacific and Novo Holdings, and is running Phase 2 and Phase 3 clinical trials (AMETHYST, RUBY and TOPAZ) in the U.S. and Europe to evaluate dotinurad as a second-line therapy for hyperuricemia associated with gout.

Crystalys Therapeutics is profiled on the APIs.io network. Tagged areas include Company, Biopharmaceutical, Clinical Stage, Pharmaceuticals, and Drug Development.

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6.4/100 minimal ▲ 5.1 Agent 0/100 human only Full breakdown ↓
scored 2026-11-06 · rubric v0.27.0 · Show this score on your site →

0 APIs

Company Biopharmaceutical Clinical Stage Pharmaceuticals Drug Development TherapeuticsGoutHyperuricemiaDotinuradURAT1 Inhibitor

Kin Score

Kin Score How this is scored →
scored 2026-11-06 · rubric v0.27.0

Composite quality — 6.4/100 · minimal

Contract Quality 0.0 / 21

Developer Ergonomics 0.0 / 17

Access Clarity 1.8 / 17

Operational Transparency 0.0 / 11

Contract Governance 0.0 / 10

Discoverability 4.2 / 9

Regulatory Posture 1.2 / 15

Agent readiness — 0/100 · human only

Machine-Readable Contract 0 / 18

Agentic Access Contract 0 / 10

Documented Reversibility 0 / 6

MCP Server 0 / 12

Machine-Readable Auth 0 / 10

Idempotency 0 / 9

Stable Error Semantics 0 / 8

Request/Response Examples 0 / 7

Rate-Limit Signaling 0 / 7

Typed Event Surface 0 / 6

Agent Skills 0 / 5

Well-Known Catalog 0 / 4

Consent & Bot Identity 0 / 3

A2A Agent Card 0 / 8

Dry-Run / Simulate Mode 0 / 4

Delegated User Identity 0 / 6

Protected Resource Metadata 0 / 5

Registration Without a Human 0 / 6

Agentic Commerce Well-Known Document 0 / 5

Pagination 5 / 5

Distinct Operations 3 / 3

MCP Tool Quality 6 / 6

Regulatory Posture applies to this provider. Its tags matched the Health regime, so Regulatory Posture carries 15 points of the composite. If this regime is wrong for your business, say so on your provider repo — the applicability map is public and we will correct it.

Create-or-Update Ergonomics could not be measured. We hold no machine-readable contract for this provider to read, so there is nothing to measure a write surface against. Excluded rather than scored zero: never-measured and measured-empty are different facts. Publishing an OpenAPI is what makes this facet — and several others — scorable at all.

The six quality facets above are damped to 85 points between them, because the conditional facet above carries the other 15. That is why each facet's contribution is shown against a damped maximum: raising a quality facet moves the composite by 85% of its nominal weight, not 100%. The full arithmetic is at apis.io/rating/.

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Agent readiness — checks not met, largest first (exact, from this profile):

Machine-Readable Contract +18 pts — api_specs includes an OpenAPI document
MCP Server +12 pts — deployment.mode + probe verdict on the mcp/ manifest, not the pointer; an unprobed slug falls back to authorship
Agentic Access Contract +10 pts — agentic_access artifact present (x-agentic-access), graded by author
Machine-Readable Auth +10 pts — a served openid-configuration/oauth-authorization-server carrying `issuer` (served), else the securitySchemes class in the provider OpenAPIs — bound (mutualTLS, DPoP, Signature) > negotiable (oauth2 authorizationCode/clientCredentials, openIdConnect) > bearer (http bearer, apiKey)
Idempotency +9 pts — OpenAPI mutating operations declare an idempotency key — a header, a request-body property, or a named de-duplication token whose own description says so (verified); else common[].type matches /idempoten/i (documented)
Stable Error Semantics +8 pts — OpenAPI $refs a shared error schema across 4xx/5xx responses (verified), else common[].type includes ErrorCatalog / ErrorCodes / DeclineCodes

13 more unmet checks in the Agent Readiness table above.

Kin Score — facets with the most composite points still available (weight × headroom):

Contract Quality scores 0.0 — up to +25.0 composite points
Developer Ergonomics scores 0.0 — up to +20.0 composite points
Access Clarity scores 10.5 — up to +17.9 composite points

Each check links to what satisfies it. Publish the artifact, or tell us where it already lives, and the score moves on the next scoring run.

Improve this rating by publishing the missing artifacts — every area above can be raised, and the full rubric is at apis.io/rating/. Every facet and dimension name above is a link: it opens that measurement's own page — what it means, the exact checks that feed it, how the whole catalog distributes on it, and the providers at the top of it. This rating is computed from the provider profile at artifacts.apis.io/crystalys-therapeutics/apis.yml: open an issue on github.com/api-evangelist/crystalys-therapeutics to ask a question or point us at an artifact you publish. Submit an artifact on GitHub — free → Manage your own listing — the Influence plan, $499/mo →

Security Posture 1

Authentication, domain security, vulnerability disclosure, and trust-center signals.

Crystalys Therapeutics Domain Security

TLSv1.3 · DMARC

SECURITY

Resources

Access & Security 1

Authentication, authorization, and security posture

DomainSecurity

DomainSecurity

Commercial 2

Pricing, plans, and the legal terms of use

PrivacyPolicy

PrivacyPolicy

TermsOfService

TermsOfService

Company 3

The organization behind the API

Website

Website

Newsroom

Newsroom

LinkedIn

Other 3

Properties that don't map to a standard resource type

Hosts

Hosts

Vendors

Vendors

Source (apis.yml)

aid: crystalys-therapeutics
name: Crystalys Therapeutics
description: Crystalys Therapeutics is a clinical-stage biopharmaceutical company headquartered in San Diego, California,
  focused on addressing the significant unmet medical needs of people living with gout. Its lead investigational therapy,
  dotinurad, is a next-generation, highly selective urate transporter 1 (URAT1) inhibitor designed to lower serum uric acid
  by targeting the renal transport pathways responsible for urate reabsorption. The company was co-founded by its executive
  team together with Catalys Pacific and Novo Holdings, and is running Phase 2 and Phase 3 clinical trials (AMETHYST, RUBY
  and TOPAZ) in the U.S. and Europe to evaluate dotinurad as a second-line therapy for hyperuricemia associated with gout.
accessModel:
  pricing: unknown
  onboarding: unknown
  trial: false
  try_now: false
  public: false
  label: Unknown
  confidence: low
  probe_state: none
  source:
  - security
  generated: '2026-11-06'
  method: derived
image: https://crystalystx.com/wp-content/uploads/2024/12/crystalys_wordmark_rgb.svg
url: https://raw.githubusercontent.com/api-evangelist/crystalys-therapeutics/refs/heads/main/apis.yml
x-type: company
x-source: harvest:secondary-market
x-tier: profiled
x-tier-reason: enrichment pass 2026-11-04 (modular-v1; identity re-run after front-door verdict:open)
specificationVersion: '0.20'
created: '2026-10-11'
modified: '2026-11-04'
tags:
- Company
- Biopharmaceutical
- Clinical Stage
- Pharmaceuticals
- Drug Development
- Therapeutics
- Gout
- Hyperuricemia
- Dotinurad
- URAT1 Inhibitor
maintainers:
- FN: Kin Lane
  email: kin@apievangelist.com
- FN: APIs.json
  email: info@apis.io
common:
- type: Website
  url: https://crystalystx.com/
- type: Newsroom
  url: https://crystalystx.com/news/
- type: PrivacyPolicy
  url: https://crystalystx.com/privacy-policy/
- type: TermsOfService
  url: https://crystalystx.com/terms-of-use/
- type: LinkedIn
  url: https://www.linkedin.com/company/crystalys-therapeutics/
- type: X
  url: https://x.com/Crystalys_Tx
- type: Hosts
  url: hosts/crystalys-therapeutics-hosts.yml
- type: Vendors
  url: vendors/crystalys-therapeutics-vendors.yml
- type: DomainSecurity
  url: security/crystalys-therapeutics-domain-security.yml
apis: []
x-coverage:
  state: none
  reason: not-a-software-company
  detail: Crystalys Therapeutics is a clinical-stage biopharmaceutical company; its own site is a WordPress corporate marketing
    site (home, about-us, science, news, investors, contact, legal) with no developer, API, docs or SDK pages, and preflight
    contract discovery against crystalystx.com and api.crystalystx.com returned absent for OpenAPI, AsyncAPI, GraphQL and
    MCP.
  evidence:
  - url: https://crystalystx.com/api
    status: 404
  - url: https://crystalystx.com/developers
    status: 404
  - url: https://crystalystx.com/docs
    status: 404
  - url: https://crystalystx.com/developer
    status: 404
  - url: https://crystalystx.com/sitemap_index.xml
    status: 200
  checked: '2026-11-04'
x-enrichment:
  date: '2026-11-04'
  status: nochange
  artifacts_added: 0
  pass: modular-v1
  engine: identity=anthropic,contract=anthropic,surfaces=anthropic,docs=anthropic,regulatory=anthropic

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