STRING Annotation API

openapi: 3.2.0
info:
  title: STRING REST Annotation API
  description: 'STRING is a protein-protein interaction network database providing scored associations between proteins across thousands of organisms. The REST API enables programmatic access to interaction scores, network visualizations, functional enrichment analysis, homology data, and protein annotations. STRING integrates data from genomic context, co-expression, text mining, biochemical and genetic experiments, and curated databases.

    '
  version: '12.0'
  contact:
    name: STRING Consortium
    url: https://string-db.org
  license:
    name: Creative Commons Attribution
    url: https://string-db.org/cgi/access?footer_active_subpage=licensing
  termsOfService: https://string-db.org/cgi/info?footer_active_subpage=cookies
servers:
- url: https://string-db.org
  description: STRING Production Server
security: []
tags:
- name: annotation
  description: Functional annotations and term lookup
paths:
  /api/{format}/functional_annotation:
    get:
      operationId: getFunctionalAnnotation
      summary: Functional Annotation
      description: 'Retrieve all functional annotations associated with input proteins. Includes GO terms, KEGG pathways, Pfam/InterPro/SMART domains, tissue expression (COMPARTMENTS), and disease associations.

        '
      tags:
      - annotation
      parameters:
      - $ref: '#/components/parameters/format'
      - name: identifiers
        in: query
        required: true
        description: Protein identifiers, newline-separated (%0d in URL)
        schema:
          type: string
      - $ref: '#/components/parameters/species'
      - name: allow_pubmed
        in: query
        required: false
        description: Include PubMed text mining annotations (1=include)
        schema:
          type: integer
          enum:
          - 0
          - 1
          default: 0
      - $ref: '#/components/parameters/caller_identity'
      responses:
        '200':
          description: Functional annotations for the proteins
          content:
            text/plain:
              schema:
                $ref: '#/components/schemas/TsvResponse'
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/FunctionalAnnotation'
        '400':
          $ref: '#/components/responses/BadRequest'
  /api/{format}/functional_terms:
    get:
      operationId: getFunctionalTerms
      summary: Functional Terms
      description: 'Retrieve proteins and details associated with specific functional terms (GO terms, KEGG pathways, Reactome pathways, Pfam domains, etc.).

        '
      tags:
      - annotation
      parameters:
      - $ref: '#/components/parameters/format'
      - name: identifier
        in: query
        required: true
        description: Functional term identifier (e.g. GO:0008150, hsa00010, PF00069)
        schema:
          type: string
          example: GO:0008150
      - name: category
        in: query
        required: false
        description: Term category to restrict search
        schema:
          type: string
          enum:
          - Process
          - Function
          - Component
          - Keyword
          - KEGG
          - RCTM
          - Pfam
          - InterPro
          - SMART
          - NetworkNeighborAL
          - COMPARTMENTS
          - Tissue
          - Disease
      - $ref: '#/components/parameters/species'
      - $ref: '#/components/parameters/caller_identity'
      responses:
        '200':
          description: Proteins and details associated with the functional term
          content:
            text/plain:
              schema:
                $ref: '#/components/schemas/TsvResponse'
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/FunctionalTermResult'
        '400':
          $ref: '#/components/responses/BadRequest'
  /api/{format}/geneset_description:
    get:
      operationId: getGenesetDescription
      summary: Gene Set Description
      description: 'Retrieve auto-generated textual descriptions for a set of proteins, summarizing the most relevant functional themes in the gene set.

        '
      tags:
      - annotation
      parameters:
      - $ref: '#/components/parameters/format'
      - name: identifiers
        in: query
        required: true
        description: Protein identifiers, newline-separated (%0d in URL)
        schema:
          type: string
      - $ref: '#/components/parameters/species'
      - $ref: '#/components/parameters/caller_identity'
      responses:
        '200':
          description: Textual descriptions for the gene set
          content:
            text/plain:
              schema:
                $ref: '#/components/schemas/TsvResponse'
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/GenesetDescription'
        '400':
          $ref: '#/components/responses/BadRequest'
components:
  responses:
    BadRequest:
      description: Bad request (invalid parameters)
      content:
        application/json:
          schema:
            $ref: '#/components/schemas/Error'
        text/plain:
          schema:
            type: string
  parameters:
    caller_identity:
      name: caller_identity
      in: query
      required: false
      description: 'A string identifying your application or organization. Strongly recommended; helps STRING admins contact you if there are issues.

        '
      schema:
        type: string
        example: my_bioinformatics_pipeline
    format:
      name: format
      in: path
      required: true
      description: Output format
      schema:
        type: string
        enum:
        - tsv
        - tsv-no-header
        - json
        - xml
        example: json
    species:
      name: species
      in: query
      required: false
      description: 'NCBI taxon ID to restrict results to a specific organism. Common values: 9606 (human), 10090 (mouse), 10116 (rat), 7227 (D. melanogaster), 6239 (C. elegans), 4932 (S. cerevisiae), 3702 (A. thaliana), 7955 (zebrafish).

        '
      schema:
        type: integer
        example: 9606
  schemas:
    TsvResponse:
      type: string
      description: Tab-separated values response with header row
    FunctionalAnnotation:
      type: object
      description: Functional annotation for a protein
      properties:
        stringId:
          type: string
          description: STRING protein identifier
        ncbiTaxonId:
          type: integer
          description: NCBI taxon ID
        taxonName:
          type: string
          description: Scientific name of the organism
        preferredName:
          type: string
          description: Preferred gene/protein name
        category:
          type: string
          description: Annotation category
        term:
          type: string
          description: Term identifier
        description:
          type: string
          description: Human-readable term description
    Error:
      type: object
      properties:
        status:
          type: integer
        error:
          type: string
        message:
          type: string
    GenesetDescription:
      type: object
      description: Auto-generated description for a protein gene set
      properties:
        description:
          type: string
          description: Auto-generated functional description of the gene set
        ncbiTaxonId:
          type: integer
          description: NCBI taxon ID
    FunctionalTermResult:
      type: object
      description: Proteins associated with a specific functional term
      properties:
        category:
          type: string
          description: Annotation category
        term:
          type: string
          description: Term identifier
        description:
          type: string
          description: Human-readable term description
        preferredName:
          type: string
          description: Protein preferred name
        stringId:
          type: string
          description: STRING identifier for the protein
  securitySchemes:
    ApiKeyAuth:
      type: apiKey
      in: query
      name: api_key
      description: 'API key required only for Values/Ranks Enrichment endpoints. Obtain via POST /api/json/get_api_key. All other endpoints are publicly accessible without authentication.

        '
externalDocs:
  description: STRING API Documentation
  url: https://string-db.org/help/api/