Drug

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "$id": "https://raw.githubusercontent.com/api-evangelist/life-sciences/refs/heads/main/json-schema/drug-schema.json",
  "title": "Drug",
  "description": "A pharmaceutical product / drug record harmonizing identifiers and attributes from openFDA, RxNorm, DailyMed, and DrugBank.",
  "type": "object",
  "properties": {
    "rxcui": {
      "type": "string",
      "description": "RxNorm Concept Unique Identifier (RxCUI) — the canonical NLM identifier for a clinical drug concept.",
      "pattern": "^[0-9]+$",
      "example": "1191"
    },
    "name": {
      "type": "string",
      "description": "Common or generic name of the drug.",
      "example": "Aspirin"
    },
    "brandNames": {
      "type": "array",
      "description": "Branded names under which the drug is marketed.",
      "items": { "type": "string" },
      "example": ["Bayer", "Bufferin"]
    },
    "ingredients": {
      "type": "array",
      "description": "Active ingredients with their strength.",
      "items": {
        "type": "object",
        "properties": {
          "name": { "type": "string" },
          "strength": { "type": "string", "example": "81 mg" },
          "unii": {
            "type": "string",
            "description": "FDA Unique Ingredient Identifier (UNII).",
            "example": "R16CO5Y76E"
          }
        },
        "required": ["name"]
      }
    },
    "dosageForm": {
      "type": "string",
      "description": "Dosage form (Tablet, Capsule, Solution, Injection, etc.).",
      "example": "Tablet"
    },
    "routeOfAdministration": {
      "type": "array",
      "items": { "type": "string" },
      "example": ["Oral"]
    },
    "ndc": {
      "type": "array",
      "description": "National Drug Code identifiers assigned by the FDA, in any of 4-4-2, 5-3-2, 5-4-1, or 5-4-2 segment formats.",
      "items": {
        "type": "string",
        "example": "0573-0142-40"
      }
    },
    "atcCodes": {
      "type": "array",
      "description": "WHO Anatomical Therapeutic Chemical classification codes.",
      "items": {
        "type": "string",
        "pattern": "^[A-V][0-9]{2}([A-Z]([A-Z]([0-9]{2})?)?)?$",
        "example": "B01AC06"
      }
    },
    "manufacturer": {
      "type": "string",
      "description": "Manufacturer or labeller name as registered with the FDA."
    },
    "fdaApprovalDate": {
      "type": "string",
      "format": "date",
      "description": "Date of first FDA approval for the drug product."
    },
    "marketingStatus": {
      "type": "string",
      "enum": [
        "Prescription",
        "Over-the-counter",
        "Discontinued",
        "Withdrawn",
        "Unapproved",
        "Investigational"
      ]
    },
    "indications": {
      "type": "array",
      "description": "Therapeutic indications and approved usage statements.",
      "items": { "type": "string" }
    },
    "interactions": {
      "type": "array",
      "description": "Known drug-drug or drug-substance interactions.",
      "items": {
        "type": "object",
        "properties": {
          "interactingDrug": { "type": "string" },
          "severity": {
            "type": "string",
            "enum": ["High", "Moderate", "Low", "Unknown"]
          },
          "description": { "type": "string" }
        },
        "required": ["interactingDrug"]
      }
    },
    "blackBoxWarning": {
      "type": "boolean",
      "description": "Whether the FDA has applied a boxed warning to this product."
    },
    "drugbankId": {
      "type": "string",
      "description": "DrugBank accession (DB followed by 5 digits).",
      "pattern": "^DB[0-9]{5}$",
      "example": "DB00945"
    },
    "splSetId": {
      "type": "string",
      "description": "Structured Product Labeling SET ID assigned by DailyMed.",
      "format": "uuid"
    },
    "labelUrl": {
      "type": "string",
      "format": "uri",
      "description": "Canonical URL to the SPL prescribing-information document."
    }
  },
  "required": ["rxcui", "name"]
}