Amicus Medicine

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "$id": "https://api-evangelist.github.io/amicus-therapeutics/json-schema/amicus-medicine-schema.json",
  "title": "Amicus Medicine",
  "description": "A marketed Amicus Therapeutics medicine, including its trade name, generic name, indication, mechanism, and approval status.",
  "type": "object",
  "required": ["medicineId", "brandName", "genericName", "indication"],
  "properties": {
    "medicineId": {
      "type": "string",
      "description": "Stable identifier for the Amicus medicine record"
    },
    "brandName": {
      "type": "string",
      "description": "Registered brand / trade name (e.g., Galafold, Pombiliti, Opfolda)"
    },
    "genericName": {
      "type": "string",
      "description": "International nonproprietary name (e.g., migalastat)"
    },
    "drugClass": {
      "type": "string",
      "enum": [
        "Pharmacological Chaperone",
        "Enzyme Replacement Therapy",
        "Enzyme Stabilizer",
        "Small Molecule",
        "Biologic"
      ],
      "description": "Therapeutic class of the medicine"
    },
    "routeOfAdministration": {
      "type": "string",
      "enum": ["Oral", "Intravenous", "Subcutaneous", "Intramuscular", "Inhaled"],
      "description": "How the medicine is administered to patients"
    },
    "indication": {
      "type": "string",
      "description": "Approved disease indication (e.g., Fabry disease, late-onset Pompe disease)"
    },
    "patientPopulation": {
      "type": "string",
      "description": "Eligible patient population description (e.g., adults with amenable GLA variant)"
    },
    "combinationWith": {
      "type": "array",
      "items": { "type": "string" },
      "description": "Other medicines required as part of the regimen (e.g., Opfolda combined with Pombiliti)"
    },
    "mechanismOfAction": {
      "type": "string",
      "description": "Brief description of how the medicine works"
    },
    "approvals": {
      "type": "array",
      "items": {
        "type": "object",
        "required": ["region", "agency"],
        "properties": {
          "region": {
            "type": "string",
            "description": "Geographic / regulatory region (e.g., EU, US, Japan)"
          },
          "agency": {
            "type": "string",
            "description": "Approving authority (e.g., FDA, EC, EMA, PMDA)"
          },
          "approvalDate": {
            "type": "string",
            "format": "date",
            "description": "Date of approval"
          }
        }
      }
    },
    "productSite": {
      "type": "string",
      "format": "uri",
      "description": "Public product / patient information website"
    }
  },
  "additionalProperties": false
}