UniProt

UniRef REST API

UniRef (UniProt Reference Clusters) groups similar sequences to reduce redundancy. UniRef100 combines identical sequences; UniRef90 clusters sequences sharing 90% identity; UniRef50 clusters at 50%. The REST API allows searching and retrieving clusters with associated member lists.

GitHub

Documentation

📖
Documentation
https://www.uniprot.org/help/uniref

Other Resources

🔗
TermsOfService
https://www.uniprot.org/help/license

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API entry from apis.yml

apis.yml Raw ↑ 
name: UniRef REST API
description: 'UniRef (UniProt Reference Clusters) groups similar sequences to reduce redundancy. UniRef100
  combines identical sequences; UniRef90 clusters sequences sharing 90% identity; UniRef50 clusters at
  50%. The REST API allows searching and retrieving clusters with associated member lists.

  '
image: https://www.uniprot.org/images/logos/uniprot.svg
humanURL: https://www.uniprot.org/help/uniref
baseURL: https://rest.uniprot.org/uniref
version: '2026_01'
tags:
- Proteins
- Sequence Clusters
- Redundancy Reduction
properties:
- type: Documentation
  url: https://www.uniprot.org/help/uniref
- type: TermsOfService
  url: https://www.uniprot.org/help/license
contact:
- FN: UniProt Consortium
  email: help@uniprot.org
  url: https://www.uniprot.org/contact