Patsnap Drug Clinical Trial Data API
Drug Clinical Trial Data APIs.
Drug Clinical Trial Data APIs.
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openapi: 3.2.0
info:
title: Patsnap Open Platform AI Translation Drug Clinical Trial Data API
version: 1.0.0
description: OpenAPI specification for Patsnap Open Platform APIs, including patent search, analytics, and Eureka AI capabilities.
servers:
- url: https://connect.patsnap.com
description: Patsnap Open Platform API gateway
tags:
- name: Drug Clinical Trial Data
description: Drug Clinical Trial Data APIs.
paths:
/synapse/clinical-trial/contact:
get:
operationId: b027ClinicalTrialContact
summary: B027 Clinical trial contact
description: Obtain clinical trial contact through clinical trial id or registry number
tags:
- Drug Clinical Trial Data
security:
- bearerAuth: []
responses:
'200':
description: Successful b027 clinical trial contact response.
content:
application/json:
schema:
$ref: '#/components/schemas/B027ClinicalTrialContactResponse'
'401':
description: Unauthorized.
'403':
description: Forbidden.
'404':
description: Not Found.
externalDocs:
description: API Reference documentation
url: https://open.patsnap.com/devportal/api-reference/synapse/clinical-trial/contact
parameters:
- name: clinical_trial_id
in: query
required: false
description: Clinical trial id, obtain this through clinical trial search interface
schema:
type: string
example: 202425a889e52ae802432a8295220e53
description: Clinical trial id, obtain this through clinical trial search interface
- name: register_number
in: query
required: false
description: register number
schema:
type: string
example: NCT06498986
description: register number
/synapse/clinical-trial/description:
get:
operationId: b024ClinicalTrialDescription
summary: B024 Clinical trial description
description: Obtain clinical trial description through clinical trial id or registry number
tags:
- Drug Clinical Trial Data
security:
- bearerAuth: []
responses:
'200':
description: Successful b024 clinical trial description response.
content:
application/json:
schema:
$ref: '#/components/schemas/B024ClinicalTrialDescriptionResponse'
'401':
description: Unauthorized.
'403':
description: Forbidden.
'404':
description: Not Found.
externalDocs:
description: API Reference documentation
url: https://open.patsnap.com/devportal/api-reference/synapse/clinical-trial/description
parameters:
- name: clinical_trial_id
in: query
required: false
description: Clinical trial id, obtain this through clinical trial search interface
schema:
type: string
example: 202425a889e52ae802432a8295220e53
description: Clinical trial id, obtain this through clinical trial search interface
- name: register_number
in: query
required: false
description: register number
schema:
type: string
example: NCT06498986
description: register number
/synapse/clinical-trial/detail:
get:
operationId: b022ClinicalTrialDetail
summary: B022 Clinical trial basic information
description: Obtain clinical trial basic information through clinical trial id or registry number
tags:
- Drug Clinical Trial Data
security:
- bearerAuth: []
responses:
'200':
description: Successful b022 clinical trial basic information response.
content:
application/json:
schema:
$ref: '#/components/schemas/B022ClinicalTrialDetailResponse'
'401':
description: Unauthorized.
'403':
description: Forbidden.
'404':
description: Not Found.
externalDocs:
description: API Reference documentation
url: https://open.patsnap.com/devportal/api-reference/synapse/clinical-trial/detail
parameters:
- name: clinical_trial_id
in: query
required: false
description: Clinical trial id, obtain this through clinical trial search interface
schema:
type: string
example: 202425a889e52ae802432a8295220e53
description: Clinical trial id, obtain this through clinical trial search interface
- name: register_number
in: query
required: false
description: Register number
schema:
type: string
example: NCT06498986
description: Register number
/synapse/clinical-trial/design:
get:
operationId: b026ClinicalTrialDesign
summary: B026 Clinical trial design
description: Obtain clinical trial design through clinical trial id or registry number
tags:
- Drug Clinical Trial Data
security:
- bearerAuth: []
responses:
'200':
description: Successful b026 clinical trial design response.
content:
application/json:
schema:
$ref: '#/components/schemas/B026ClinicalTrialDesignResponse'
'401':
description: Unauthorized.
'403':
description: Forbidden.
'404':
description: Not Found.
externalDocs:
description: API Reference documentation
url: https://open.patsnap.com/devportal/api-reference/synapse/clinical-trial/design
parameters:
- name: clinical_trial_id
in: query
required: false
description: Clinical trial id, obtain this through clinical trial search interface
schema:
type: string
example: 202425a889e52ae802432a8295220e53
description: Clinical trial id, obtain this through clinical trial search interface
- name: register_number
in: query
required: false
description: register number
schema:
type: string
example: NCT06498986
description: register number
/synapse/clinical-trial/eligibility:
get:
operationId: b025ClinicalTrialEligibility
summary: B025 Clinical trial eligibility
description: Obtain clinical trial eligibility through clinical trial id or registry number
tags:
- Drug Clinical Trial Data
security:
- bearerAuth: []
responses:
'200':
description: Successful b025 clinical trial eligibility response.
content:
application/json:
schema:
$ref: '#/components/schemas/B025ClinicalTrialEligibilityResponse'
'401':
description: Unauthorized.
'403':
description: Forbidden.
'404':
description: Not Found.
externalDocs:
description: API Reference documentation
url: https://open.patsnap.com/devportal/api-reference/synapse/clinical-trial/eligibility
parameters:
- name: clinical_trial_id
in: query
required: false
description: Clinical trial id, obtain this through clinical trial search interface
schema:
type: string
example: 202425a889e52ae802432a8295220e53
description: Clinical trial id, obtain this through clinical trial search interface
- name: register_number
in: query
required: false
description: register number
schema:
type: string
example: NCT06498986
description: register number
/synapse/clinical-trial/related-entity:
get:
operationId: b023ClinicalTrialRelatedEntity
summary: B023 Clinical trial related entity
description: Obtain clinical trial related entity through clinical trial id or registry number
tags:
- Drug Clinical Trial Data
security:
- bearerAuth: []
responses:
'200':
description: Successful b023 clinical trial related entity response.
content:
application/json:
schema:
$ref: '#/components/schemas/B023ClinicalTrialRelatedEntityResponse'
'401':
description: Unauthorized.
'403':
description: Forbidden.
'404':
description: Not Found.
externalDocs:
description: API Reference documentation
url: https://open.patsnap.com/devportal/api-reference/synapse/clinical-trial/related-entity
parameters:
- name: clinical_trial_id
in: query
required: false
description: Clinical trial id, obtain this through clinical trial search interface
schema:
type: string
example: 202425a889e52ae802432a8295220e53
description: Clinical trial id, obtain this through clinical trial search interface
- name: register_number
in: query
required: false
description: register number
schema:
type: string
example: NCT06498986
description: register number
/synapse/ct-result/detail:
get:
operationId: b032CtResultDetail
summary: B032 Drug clinical result basic information
description: Obtain clinical result data through clinical result ID
tags:
- Drug Clinical Trial Data
security:
- bearerAuth: []
responses:
'200':
description: Successful b032 drug clinical result basic information response.
content:
application/json:
schema:
$ref: '#/components/schemas/B032CtResultDetailResponse'
'401':
description: Unauthorized.
'403':
description: Forbidden.
'404':
description: Not Found.
externalDocs:
description: API Reference documentation
url: https://open.patsnap.com/devportal/api-reference/synapse/ct-result/detail
parameters:
- name: ct_result_id
in: query
required: false
description: Clinical trial result ID, obtain this through clinical result search interface
schema:
type: string
example: e8ea588d3590e929a8022420da25d555
description: Clinical trial result ID, obtain this through clinical result search interface
/synapse/ct-result/group:
get:
operationId: b048CtResultGroup
summary: B048 Drug clinical result group information
description: Obtain clinical result group data through clinical result ID
tags:
- Drug Clinical Trial Data
security:
- bearerAuth: []
responses:
'200':
description: Successful b048 drug clinical result group information response.
content:
application/json:
schema:
$ref: '#/components/schemas/B048CtResultGroupResponse'
'401':
description: Unauthorized.
'403':
description: Forbidden.
'404':
description: Not Found.
externalDocs:
description: API Reference documentation
url: https://open.patsnap.com/devportal/api-reference/synapse/ct-result/group
parameters:
- name: ct_result_id
in: query
required: false
description: 临床结果ID,通过临床结果检索接口获取
schema:
type: string
example: 5adee5585028aaa5da5982d22a808a99
description: 临床结果ID,通过临床结果检索接口获取
components:
schemas:
B026ClinicalTrialDesign_Outcome:
type: object
properties:
title:
type: string
example: Recommended Phase II Dose (RP2D)
description: Measure
time_frame:
type: string
example: Up to approximately 24 months
description: Time Frame
description:
type: string
example: The RP2D is defined as the dose level chosen by the sponsor (in consultation with the investigators) for phase II study, based on safety, tolerability, efficacy, PK, and PD data collected during the dose escalation study of BL-B01D1.
description: Description
outcome_type:
type: string
example: Primary
description: Outcome Type
B025ClinicalTrialEligibility_Age:
type: object
properties:
age:
type: string
example: 18
description: Age
unit:
type: string
example: Years
description: Unit
B032CtResultDetail_GetClinicalTrialResultResponseDto:
type: object
properties:
drug:
type: array
example:
- drug_id: 2838b95ade834c96b17ac8bcd2b68c27
display_name:
- lang: EN
name: Sotorasib
- lang: CN
name: 索托拉西布
description: Drug
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonDrug'
phase:
$ref: '#/components/schemas/B032CtResultDetail_CommonDictionary'
title:
type: string
example: Matching-Adjusted Indirect Treatment Comparisons (MAIC) of Sotorasib 960mg (soto960) Plus Panitumumab (pani) Vs. Trifluridine/Tipiracil(T/T) Plus Bevacizumab (bev) in Chemorefractory Metastatic Colorectal Cancer (mCRC)
description: title
target:
type: array
example:
- target_id: 8556307199154d34b1f9bc9685f2ec47
short_name:
- lang: EN
name: IL-6RA
display_name:
- lang: EN
name: Interleukin-6 receptor alpha subunit
- lang: CN
name: 白细胞介素-6受体α亚基
description: Target
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonTarget'
biomarker:
type: array
example:
- id: 11acf267a4fc42f392751e023482aac3
display_name:
- lang: EN
name: CTNNB1 Mutation
description: Biomarker Id
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonEntity'
conclusion:
type: string
example: Sotorasib-panitumumab demonstrated acceptable safety with promising efficacy in chemotherapy-refractory KRASG12C-mutated metastatic colorectal cancer.
description: Conclusion
related_id:
type: array
example:
- id_type: study_identifier
id_value: CodeBreaK 300
description: Study code
items:
$ref: '#/components/schemas/B032CtResultDetail_RelatedId'
ct_result_id:
type: string
example: 5400a5a2dee3da90dd52408a3585d805
description: Clinical Trial Result Id
organization:
type: array
example:
- display_name:
- lang: EN
name: Amgen, Inc.
- lang: CN
name: 安进股份有限公司
organization_id: 11ef8a9e8bf5ca80213a1183511cded3
description: Organization master entity id view
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonOrganization'
study_design:
$ref: '#/components/schemas/B032CtResultDetail_StudyDesignDto'
therapy_type:
type: array
example:
- display_name:
- lang: EN
name: Third line
- lang: CN
name: 三线
normalized_id: 62662f0b1d5b3fafabeb571a211e9a31
description: Therapy type view
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonDictionary'
published_time:
type: integer
format: int64
example: 1719446400000
description: Publication Date
register_number:
type: array
example:
- NCT05198934
description: Register number
single_or_multi:
type: string
example: single_drug
description: Single or multi, options:single_drug,multiple_drugs
mechanism_action:
type: array
example:
- short_name:
- lang: EN
name: IL-6RA antagonists
- lang: CN
name: IL-6RA拮抗剂
display_name:
- lang: EN
name: Interleukin-6 receptor alpha subunit antagonists
- lang: CN
name: 白细胞介素-6受体α亚基拮抗剂
mechanism_id: b30a0bdb2e0bd9c03a908a84588c4217
description: Mechanism Action
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonMechanismAction'
therapeutic_area:
type: array
example:
- disease_id: 042cbe45c973477b957717ded29ef7b6
display_name:
- lang: EN
name: Nervous System Diseases
- lang: CN
name: 神经系统疾病
description: Therapeutic Area
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonDisease'
condition_disease:
type: array
example:
- disease_id: e35ce4e9b7a846d49e600ce7ac4a7fd6
display_name:
- lang: EN
name: Metastatic Colorectal Carcinoma
- lang: CN
name: 转移性结直肠癌
description: Condition Disease
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonDisease'
general_evaluation:
$ref: '#/components/schemas/B032CtResultDetail_CommonDictionary'
original_biomarker:
type: array
example:
- name: IL-6
description: Original Biomarker
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonName'
overall_enrollment:
type: integer
format: int32
example: 100
description: Overall enrollment
register_number_map:
type: object
example:
NCT04737187: 5a4a2ad359d8a855d925943e23a58845
description: Register number map
sponsor_organization:
type: array
example:
- display_name:
- lang: EN
name: Amgen, Inc.
- lang: CN
name: 安进股份有限公司
organization_id: 11ef8a9e8bf5ca80213a1183511cded3
description: Sponsor Organization
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonOrganization'
collaborator_organization:
type: array
example:
- display_name:
- lang: EN
name: Amgen, Inc.
- lang: CN
name: 安进股份有限公司
organization_id: 11ef8a9e8bf5ca80213a1183511cded3
description: Collaborator Organization
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonOrganization'
B022ClinicalTrialDetailResponse:
type: object
properties:
data:
$ref: '#/components/schemas/B022ClinicalTrialDetail_GetClinicalTrialBasicInformationResponseDto'
status:
type: boolean
example: 'false'
description: Status
error_msg:
type: string
example: The request parameter format is incorrect!
description: Error Message
error_code:
type: integer
example: '0'
description: Error Code
required:
- status
- error_code
B032CtResultDetail_StudyDesignDto:
type: object
properties:
masking:
type: string
example: XXXX
description: Masking
allocation:
type: string
example: XXXX
description: Allocation
primary_purpose:
type: string
example: XXXX
description: Primary Purpose
intervention_model:
type: string
example: XXXX
description: Intervention Model
allocation_normalized:
$ref: '#/components/schemas/B032CtResultDetail_CommonDictionary'
intervention_model_normalized:
$ref: '#/components/schemas/B032CtResultDetail_CommonDictionary'
B025ClinicalTrialEligibility_GetClinicalTrialEligibilityResponseDto:
type: object
properties:
gender:
type: string
example: All
description: Sexes
max_age:
$ref: '#/components/schemas/B025ClinicalTrialEligibility_Age'
min_age:
$ref: '#/components/schemas/B025ClinicalTrialEligibility_Age'
register_number:
type: string
example: NCT06498986
description: Trial Number
exclude_criteria:
type: string
example: <ul><li>1. Patients with prior systemic therapy;</li><li>2. Previous treatment with EGFR-TKI;</li><li>3. Participants who participated in any other clinical trial within 4 weeks before the trial dose;</li><li>4. Traditional Chinese medicine (TCM) which had received radiotherapy within 4 weeks before the first use of the study drug and had anti-tumor indications within 2 weeks before the first use of the study drug;</li><li>5. Had undergone major surgery within 4 weeks before the first dose;</li><li>6. History of severe heart disease or cerebrovascular disease;</li><li>7. Unstable thrombotic events requiring therapeutic intervention within 6 months before screening; Infusion-related thrombosis was excluded;</li><li>8. QT prolongation, complete left bundle branch block, III degree atrioventricular block, frequent and uncontrollable arrhythmia;</li><li>9. Previous history of interstitial lung disease requiring steroid therapy, or current ILD or grade ≥2 radiation pneumonitis;</li><li>10. Complicated pulmonary diseases leading to clinically severe respiratory function impairment;</li><li>11. Severe systemic infection within 4 weeks before screening;</li><li>12. Patients at risk for active autoimmune disease or with a history of autoimmune disease;</li><li>13. Other malignant tumors within 5 years before the first dose;</li><li>14. HIV antibody positive, active tuberculosis, active hepatitis B virus infection, or hepatitis C virus infection;</li><li>15. Hypertension poorly controlled by two antihypertensive drugs;</li><li>16. Patients with poor glycemic control;</li><li>17. Patients with massive effusions, or effusions with obvious symptoms, or poorly controlled effusions;</li><li>18. Patients with active central nervous system metastases;</li><li>19. Imaging examination showed that the tumor had invaded or enveloped the large blood vessels in the abdomen, chest, neck, and pharynx;</li><li>20. Severe unhealed wound, ulcer, or fracture within 4 weeks before consent signing;</li><li>21. Sign a four weeks before there were clinically significant bleeding or bleeding tendency obviously subjects;</li><li>22. Previous history of allogeneic stem cell, bone marrow or organ transplantation;</li><li>23. Patients with a history of allergy to recombinant humanized antibodies or to any of the excipients of BL-B01D1;</li><li>24. A history of severe neurological or psychiatric illness;</li><li>25. Pregnant or lactating women;</li><li>26. Subjects who were scheduled to receive live vaccine or received live vaccine within 28 days before study randomization;</li><li>27. Other conditions for participation in the trial were not considered appropriate by the investigator.</li>
description: Exclusion Criteria
include_criteria:
type: string
example: '<ul><li>1. Voluntarily sign the informed consent and follow the requirements of the protocol;</li><li>2. No gender limit;</li><li>3. Age ≥18 years old;</li><li>4. Expected survival time ≥3 months;</li><li>5. Patients with histologically and/or cytologically confirmed locally advanced or metastatic non-small cell lung cancer;</li><li>6. Documentation of EGFR sensitive mutations detected from tumor tissue or blood samples;</li><li>7. Consent to provide archived tumor tissue or fresh tissue samples from primary or metastatic sites within 2 years for biomarker testing;</li><li>8. At least one measurable lesion meeting the RECIST v1.1 definition was required;</li><li>9. ECOG ≤1;</li><li>10. Toxicity of previous antineoplastic therapy has returned to ≤ grade 1 defined by NCI-CTCAE v5.0;</li><li>11. No severe cardiac dysfunction, left ventricular ejection fraction ≥50%;</li><li>12. The level of organ function must meet the requirements on the premise that blood transfusion is not allowed within 14 days before the screening period and no cell growth factor drugs are allowed;</li><li>13. Blood coagulation function: international standardization ratio of 1.5 or less, and the part activated clotting time live enzymes acuities were 1.5 x ULN;</li><li>14. Urine protein ≤2+ or ≤1000mg/24h;</li><li>15. Fertile female subjects or male subjects with fertile partners must use highly effective contraception from 7 days before the first dose until 6 months after the dose. Female subjects of childbearing potential had to have a negative serum pregnancy test within 7 days before the first dose.</li>'
description: Inclusion Criteria
clinical_trial_id:
type: string
example: 202425a889e52ae802432a8295220e53
description: Clinical Trial ID
healthy_volunteers:
type: string
example: 'No'
description: 'Accepts Healthy Volunteers, enumeration values: Yes, No'
B025ClinicalTrialEligibilityResponse:
type: object
properties:
data:
$ref: '#/components/schemas/B025ClinicalTrialEligibility_GetClinicalTrialEligibilityResponseDto'
status:
type: boolean
example: 'false'
description: Status
error_msg:
type: string
example: The request parameter format is incorrect!
description: Error Message
error_code:
type: integer
example: '0'
description: Error Code
required:
- status
- error_code
B032CtResultDetail_CommonDisease:
type: object
properties:
disease_id:
type: string
example: 06a9082fe1ec4c97bea31d888b9cfdce
description: Disease ID
display_name:
type: array
example:
- lang: EN
name: Uveitic Macular Edema
- lang: CN
name: 葡萄膜炎黄斑水肿
description: Disease Name, Referencing "CommonName"
items:
$ref: '#/components/schemas/B032CtResultDetail_CommonName'
B026ClinicalTrialDesign_GetClinicalTrialDesignResponseDto:
type: object
properties:
masking:
type: string
example: None (Open Label)
description: Masking
outcome:
type: array
example:
- title: Recommended Phase II Dose (RP2D)
time_frame: Up to approximately 24 months
description: The RP2D is defined as the dose level chosen by the sponsor (in consultation with the investigators) for phase II study, based on safety, tolerability, efficacy, PK, and PD data collected during the dose escalation study of BL-B01D1.
outcome_type: Primary
- title: Objective response rate (ORR)
time_frame: Up to approximately 24 months
description: ORR is defined as the percentage of participants, who has a CR (disappearance of all target lesions) or PR (at least a 30% decrease in the sum of diameters of target lesions). The percentage of participants who experiences a confirmed CR or PR is according to RECIST 1.1.
outcome_type: Primary
description: Outcome Measures
items:
$ref: '#/components/schemas/B026ClinicalTrialDesign_Outcome'
allocation:
type: string
example: N/A
description: Allocation
enrollment:
type: array
example:
- enrollment: '40'
description: Enrollment
items:
$ref: '#/components/schemas/B026ClinicalTrialDesign_Enrollment'
start_date:
$ref: '#/components/schemas/B026ClinicalTrialDesign_DateItem'
study_type:
type: string
example: Interventional
description: 'Study Type, enumeration values: "Prevention", "Expanded Access", "Health Services Research", "Interventional", "Diagnosis", "Cause", "Observational", "Basic Science", "Unknown", "Others"'
completion_date:
$ref: '#/components/schemas/B026ClinicalTrialDesign_DateItem'
primary_purpose:
type: string
example: Treatment
description: Primary Purpose
register_number:
type: string
example: NCT06498986
description: Trial Number
arm_intervention:
type: array
example:
- intervention:
- intervention_name: BL-B01D1
intervention_type: Drug
intervention_description: Administration by intravenous infusion for a cycle of 3 weeks.
- intervention_name: Osimertinib Mesylate Tablets
intervention_type: Drug
intervention_description: Oral administration, 80mg daily for a cycle of 3 weeks.
design_group_type: Experimental
design_group_title: BL-B01D1+Osimertinib Mesylate Tablets
design_group_description: Participants receive BL-B01D1+Osimertinib Mesylate Tablets in the first cycle (3 weeks). Participants with clinical benefit could receive additional treatment for more cycles. The administration will be terminated because of disease progression or intolerable toxicity occurring or other reasons.
description: Arms and Interventions
items:
$ref: '#/components/schemas/B026ClinicalTrialDesign_ArmIntervention'
clinical_trial_id:
type: string
example: 202425a889e52ae802432a8295220e53
description: Clinical Trial ID
first_posted_date:
type: integer
format: int64
example: 1720742400000
description: First Posted Date
intervention_model:
type: string
example: Single Group Assignment
description: Intervention Model
primary_completion_date:
$ref: '#/components/schemas/B026ClinicalTrialDesign_DateItem'
B023ClinicalTrialRelatedEntity_CommonTarget:
type: object
properties:
target_id:
type: string
example: 1c2067e5ab054a8995f73efcfcf56207
description: Target ID
short_name:
type: array
example:
- lang: EN
name: VEGF
description: Target Short Name, Referencing "CommonName"
items:
$ref: '#/components/schemas/B023ClinicalTrialRelatedEntity_CommonName'
display_name:
type: array
example:
- lang: EN
name: Vascular endothelial growth factor
- lang: CN
name: 血管内皮生长因子
description: Target Full Name, Referencing "CommonName"
items:
$ref: '#/components/schemas/B023ClinicalTrialRelatedEntity_CommonName'
B027ClinicalTrialContactResponse:
type: object
properties:
data:
$ref: '#/components/schemas/B027ClinicalTrialContact_GetClinicalTrialContactResponseDto'
status:
type: boolean
example: 'false'
description: Status
error_msg:
type: string
example: The request parameter format is incorrect!
description: Error Message
error_code:
type: integer
example: '0'
description: Error Code
required:
- status
- error_code
B023ClinicalTrialRelatedEntity_CommonOrganization:
type: object
properties:
display_name:
type: array
example:
- lang: EN
name: Roche Holding AG
- lang: CN
name: 罗氏
description: Organization Name, Referencing "CommonName"
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