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OpenAPI Specification

openapi: 3.2.0
info:
  title: Helix Insight - Variant Analysis Service Discordance API
  description: AI-powered variant analysis and interpretation service
  version: 0.1.0
tags:
- name: discordance
paths:
  /sessions/{session_id}/variants/discordance-analysis:
    post:
      tags:
      - discordance
      summary: Run classification discordance analysis
      description: Scans classified variants for internal inconsistencies, ClinVar disagreements, predictor conflicts, criteria anomalies, frequency conflicts, constraint mismatches, and inheritance mode issues. Platform admin only. Read-only.
      operationId: run_discordance_analysis_sessions__session_id__variants_discordance_analysis_post
      security:
      - HTTPBearer: []
      parameters:
      - name: session_id
        in: path
        required: true
        schema:
          type: string
          format: uuid
          title: Session Id
      requestBody:
        content:
          application/json:
            schema:
              $ref: '#/components/schemas/DiscordanceRequest'
              default:
                max_results_per_check: 100
      responses:
        '200':
          description: Successful Response
          content:
            application/json:
              schema:
                $ref: '#/components/schemas/DiscordanceResponse'
        '422':
          description: Validation Error
          content:
            application/json:
              schema:
                $ref: '#/components/schemas/HTTPValidationError'
components:
  schemas:
    DiscordanceVariantResponse:
      properties:
        variant_idx:
          type: integer
          title: Variant Idx
        gene_symbol:
          anyOf:
          - type: string
          - type: 'null'
          title: Gene Symbol
        chromosome:
          anyOf:
          - type: string
          - type: 'null'
          title: Chromosome
        position:
          anyOf:
          - type: integer
          - type: 'null'
          title: Position
        hgvs_protein:
          anyOf:
          - type: string
          - type: 'null'
          title: Hgvs Protein
        transcript_id:
          anyOf:
          - type: string
          - type: 'null'
          title: Transcript Id
        transcript_representations:
          anyOf:
          - additionalProperties: true
            type: object
          - type: 'null'
          title: Transcript Representations
        hgvs_cdna:
          anyOf:
          - type: string
          - type: 'null'
          title: Hgvs Cdna
        acmg_class:
          anyOf:
          - type: string
          - type: 'null'
          title: Acmg Class
        acmg_criteria:
          anyOf:
          - type: string
          - type: 'null'
          title: Acmg Criteria
        severity:
          type: string
          title: Severity
        reason:
          type: string
          title: Reason
        extra:
          additionalProperties: true
          type: object
          title: Extra
      type: object
      required:
      - variant_idx
      - severity
      - reason
      title: DiscordanceVariantResponse
      description: Single discordant variant.
    DiscordanceRequest:
      properties:
        checks:
          anyOf:
          - items:
              type: string
            type: array
          - type: 'null'
          title: Checks
          description: 'Specific checks to run. Default: all checks.'
        max_results_per_check:
          type: integer
          maximum: 500.0
          minimum: 1.0
          title: Max Results Per Check
          description: Max variants per check (per sub-check for criteria anomalies).
          default: 100
      type: object
      title: DiscordanceRequest
      description: Optional request body for discordance analysis.
    HTTPValidationError:
      properties:
        detail:
          items:
            $ref: '#/components/schemas/ValidationError'
          type: array
          title: Detail
      type: object
      title: HTTPValidationError
    DiscordanceResponse:
      properties:
        session_id:
          type: string
          title: Session Id
        classifier_version_current:
          type: string
          title: Classifier Version Current
        classifier_version_data:
          type: string
          title: Classifier Version Data
          default: unknown
        total_variants_analyzed:
          type: integer
          title: Total Variants Analyzed
        total_discordances:
          type: integer
          title: Total Discordances
        summary:
          additionalProperties:
            type: integer
          type: object
          title: Summary
        format_warnings:
          items:
            type: string
          type: array
          title: Format Warnings
        checks:
          additionalProperties:
            $ref: '#/components/schemas/CheckResultResponse'
          type: object
          title: Checks
      type: object
      required:
      - session_id
      - classifier_version_current
      - total_variants_analyzed
      - total_discordances
      title: DiscordanceResponse
      description: Full discordance analysis response.
    CheckResultResponse:
      properties:
        total:
          type: integer
          title: Total
        critical:
          type: integer
          title: Critical
          default: 0
        high:
          type: integer
          title: High
          default: 0
        medium:
          type: integer
          title: Medium
          default: 0
        low:
          type: integer
          title: Low
          default: 0
        variants:
          items:
            $ref: '#/components/schemas/DiscordanceVariantResponse'
          type: array
          title: Variants
        error:
          anyOf:
          - type: string
          - type: 'null'
          title: Error
      type: object
      required:
      - total
      title: CheckResultResponse
      description: Result of one discordance check.
    ValidationError:
      properties:
        loc:
          items:
            anyOf:
            - type: string
            - type: integer
          type: array
          title: Location
        msg:
          type: string
          title: Message
        type:
          type: string
          title: Error Type
        input:
          title: Input
        ctx:
          type: object
          title: Context
      type: object
      required:
      - loc
      - msg
      - type
      title: ValidationError
  securitySchemes:
    HTTPBearer:
      type: http
      scheme: bearer