EvolutionaryScale Generation API

openapi: 3.1.0
info:
  title: EvolutionaryScale Forge ESM3 Embeddings Generation API
  description: 'Hosted inference API for the ESM3 multimodal protein language model from EvolutionaryScale. ESM3 reasons jointly across sequence, structure, and function tracks. The Forge API exposes generate, batch_generate, encode, decode, forward_and_sample, and logits operations across small (1.4B), medium (7B), and large (98B) parameter checkpoints. All requests authenticate with a Forge API token obtained from forge.evolutionaryscale.ai. This OpenAPI is reconstructed from the open-source `esm` Python SDK (Biohub/esm) which is the canonical client for the Forge service.

    '
  version: 2024-08-01
  contact:
    name: EvolutionaryScale Forge
    url: https://forge.evolutionaryscale.ai
  license:
    name: Cambrian Inference Clickthrough License Agreement
    url: https://www.evolutionaryscale.ai/policies/cambrian-inference-clickthrough-license-agreement
servers:
- url: https://forge.evolutionaryscale.ai
  description: EvolutionaryScale Forge Production
security:
- BearerAuth: []
tags:
- name: Generation
  description: Generate proteins across sequence, structure, and function tracks.
paths:
  /api/v1/generate:
    post:
      summary: Generate Protein With ESM3
      description: 'Iteratively samples tokens on the requested track of an `ESMProtein` input, filling in masked positions until the track is complete. Wraps encode, iterative sampling, and decode in a single call. Returns a fully populated `ESMProtein`.

        '
      operationId: generate
      tags:
      - Generation
      requestBody:
        required: true
        content:
          application/json:
            schema:
              $ref: '#/components/schemas/GenerateRequest'
            examples:
              SequenceCompletion:
                $ref: '#/components/examples/SequenceCompletionRequest'
      responses:
        '200':
          description: Generated protein with completed track.
          content:
            application/json:
              schema:
                $ref: '#/components/schemas/ESMProtein'
        4XX:
          $ref: '#/components/responses/ErrorResponse'
  /api/v1/batch_generate:
    post:
      summary: Batch Generate Proteins With ESM3
      description: 'Generate multiple proteins concurrently using a list of `ESMProtein` inputs and a parallel list of `GenerationConfig` objects. Returns a list of completed `ESMProtein` results in the same order.

        '
      operationId: batchGenerate
      tags:
      - Generation
      requestBody:
        required: true
        content:
          application/json:
            schema:
              $ref: '#/components/schemas/BatchGenerateRequest'
      responses:
        '200':
          description: List of generated proteins.
          content:
            application/json:
              schema:
                type: array
                items:
                  $ref: '#/components/schemas/ESMProtein'
        4XX:
          $ref: '#/components/responses/ErrorResponse'
components:
  schemas:
    GenerateRequest:
      type: object
      required:
      - model
      - protein
      - config
      properties:
        model:
          type: string
          description: ESM3 model checkpoint identifier.
          example: esm3-medium-2024-08
          enum:
          - esm3-large-2024-03
          - esm3-medium-2024-08
          - esm3-small-2024-08
          - esm3-open
        protein:
          $ref: '#/components/schemas/ESMProtein'
        config:
          $ref: '#/components/schemas/GenerationConfig'
    Error:
      type: object
      properties:
        error:
          type: object
          properties:
            type:
              type: string
            message:
              type: string
            code:
              type: string
    GenerationConfig:
      type: object
      description: Configuration for an ESM3 generate call.
      required:
      - track
      properties:
        track:
          type: string
          description: Which protein track to generate.
          enum:
          - sequence
          - structure
          - secondary_structure
          - sasa
          - function
        num_steps:
          type: integer
          description: Number of iterative sampling steps.
          default: 8
          minimum: 1
        temperature:
          type: number
          description: Sampling temperature.
          default: 1.0
          minimum: 0.0
        top_p:
          type: number
          description: Nucleus sampling cutoff.
          minimum: 0.0
          maximum: 1.0
        schedule:
          type: string
          description: Decoding schedule (e.g. cosine, linear).
          enum:
          - cosine
          - linear
        invalid_ids:
          type: array
          description: Token IDs that the sampler must never emit.
          items:
            type: integer
    BatchGenerateRequest:
      type: object
      required:
      - model
      - proteins
      - configs
      properties:
        model:
          type: string
          example: esm3-medium-2024-08
        proteins:
          type: array
          items:
            $ref: '#/components/schemas/ESMProtein'
        configs:
          type: array
          items:
            $ref: '#/components/schemas/GenerationConfig'
    ESMProtein:
      type: object
      description: Raw protein representation with optional sequence, structure, function, secondary structure, and SASA tracks.
      properties:
        sequence:
          type: string
          description: Amino acid sequence using one-letter codes (A, R, N, ..., V). Underscore `_` marks masked positions.
          example: MKTAYIAKQRQISFVK_____SSERVKKLLVGDIVT
        coordinates:
          type: array
          description: Per-residue atom37 coordinates (list of [37,3] arrays).
          items:
            type: array
            items:
              type: array
              items:
                type: number
        secondary_structure:
          type: string
          description: DSSP-style per-residue secondary structure annotation.
        sasa:
          type: array
          description: Per-residue solvent accessible surface area.
          items:
            type: number
        function_annotations:
          type: array
          description: Optional per-residue function annotations.
          items:
            type: object
        ptm:
          type: number
          description: Predicted TM-score (if available).
        plddt:
          type: array
          description: Per-residue pLDDT confidence (if available).
          items:
            type: number
  responses:
    ErrorResponse:
      description: Error returned by the Forge API.
      content:
        application/json:
          schema:
            $ref: '#/components/schemas/Error'
  examples:
    SequenceCompletionRequest:
      summary: Fill masked positions in a partial sequence
      value:
        model: esm3-medium-2024-08
        protein:
          sequence: MKTAYIAKQRQISFVK_____SSERVKKLLVGDIVT
        config:
          track: sequence
          num_steps: 8
          temperature: 1.0
  securitySchemes:
    BearerAuth:
      type: http
      scheme: bearer
      description: Forge API token issued via forge.evolutionaryscale.ai.