Cadence Design Systems

Orion Molecular Design Platform API

The cloud-native molecular design platform from OpenEye, Cadence Molecular Sciences — the Cadence Design Systems business unit acquired in 2022 (its documentation carries a Cadence Design Systems copyright). Orion runs cube/floe computational workflows, datasets, shard collections, jobs and GPU-backed molecule search. Clients authenticate with an account-issued token; the published interface is the orionclient Python library and the ocli command line interface, and no OpenAPI, GraphQL SDL or AsyncAPI contract is published for it. Base host read from the provider's own documented example ("Url of Orion Stack, ex: orion.eyesopen.com").

GitHub

Documentation

📖
Documentation
https://docs.eyesopen.com/orion-developer/index.html
📖
APIReference
https://docs.eyesopen.com/orion-developer/modules/orion-platform/docs/orionclient/cli.html
📖
GettingStarted
https://docs.eyesopen.com/orion-developer/development/intro.html
📖
Authentication
https://raw.githubusercontent.com/api-evangelist/cadence/refs/heads/main/authentication/cadence-authentication.yml

Other Resources

🔗
CLI
https://raw.githubusercontent.com/api-evangelist/cadence/refs/heads/main/cli/cadence-cli.yml
🔗
Conventions
https://raw.githubusercontent.com/api-evangelist/cadence/refs/heads/main/conventions/cadence-conventions.yml
🔗
ChangeLog
https://docs.eyesopen.com/orion-user-interface/releasenotes/index.html
🔗
SignUp
https://www.eyesopen.com/orion-signup

Work with this as data

Every API here is available over the APIs.io API and to AI agents over MCP.

MCP server

One button, every client — Claude, Cursor, VS Code and the rest.

https://apis.io/mcp

Tools for apis

7 MCP tools reach this
  • find_apisBrowse and filter every API in the catalog.
  • get_api_artifactsOne API's artifacts, grouped by type.
  • get_openapiThe primary OpenAPI for this API.
  • find_similar_apisAPIs that look like this one.
  • apis_io_searchSTART HERE — APIs, providers and tags for one query, each with its total.
  • resolveTurn a domain, URL or GitHub org into the provider it belongs to.
  • find_cohortsEvery scored population of providers in the catalog.
All 92 tools →

Call it yourself

curl for this page
This API 
curl "https://apis.io/api/v1/apis/orion"
All apis 
curl "https://apis.io/api/v1/apis?limit=25"

Discovery needs no key. Ratings and market analysis are Pro.

Get an API key

Free tier, no form to fill in. Signing in shares your email address with us — we store it to create your key and to recognise you if you sign in with another provider. See our Privacy Policy and Terms.

GitHub Google LinkedIn

A second provider on the same verified email joins the account you already have.

API entry from apis.yml

apis.yml Raw ↑ 
aid: cadence:orion
name: Orion Molecular Design Platform API
image: https://kinlane-images.s3.amazonaws.com/shared/apis-json/icons/cadence.png
tags:
- Molecular Design
- Drug Discovery
- Cheminformatics
- Scientific Computing
- Cloud Platform
humanURL: https://www.eyesopen.com/orion/platform
baseURL: https://orion.eyesopen.com
properties:
- type: Documentation
  url: https://docs.eyesopen.com/orion-developer/index.html
- type: APIReference
  url: https://docs.eyesopen.com/orion-developer/modules/orion-platform/docs/orionclient/cli.html
- type: GettingStarted
  url: https://docs.eyesopen.com/orion-developer/development/intro.html
- type: Authentication
  url: authentication/cadence-authentication.yml
- type: CLI
  url: cli/cadence-cli.yml
- type: Conventions
  url: conventions/cadence-conventions.yml
- type: ChangeLog
  url: https://docs.eyesopen.com/orion-user-interface/releasenotes/index.html
- type: SignUp
  url: https://www.eyesopen.com/orion-signup
description: 'The cloud-native molecular design platform from OpenEye, Cadence Molecular Sciences — the
  Cadence Design Systems business unit acquired in 2022 (its documentation carries a Cadence Design Systems
  copyright). Orion runs cube/floe computational workflows, datasets, shard collections, jobs and GPU-backed
  molecule search. Clients authenticate with an account-issued token; the published interface is the orionclient
  Python library and the ocli command line interface, and no OpenAPI, GraphQL SDL or AsyncAPI contract
  is published for it. Base host read from the provider''s own documented example ("Url of Orion Stack,
  ex: orion.eyesopen.com").'