Work with this as data
Every API here is available over the APIs.io API and to AI agents over MCP.
MCP server
One button, every client — Claude, Cursor, VS Code and the rest.
https://apis.io/mcp
Tools for apis
7 MCP tools reach this
find_apisBrowse and filter every API in the catalog.get_api_artifactsOne API's artifacts, grouped by type.get_openapiThe primary OpenAPI for this API.find_similar_apisAPIs that look like this one.apis_io_searchSTART HERE — APIs, providers and tags for one query, each with its total.resolveTurn a domain, URL or GitHub org into the provider it belongs to.find_cohortsEvery scored population of providers in the catalog.
Call it yourself
curl for this page
This API
curl "https://apis.io/api/v1/apis/2s-io:2s-io-bio-api"
All apis
curl "https://apis.io/api/v1/apis?limit=25"Discovery needs no key. Ratings and market analysis are Pro.
Get an API key
Free tier, no form to fill in. Signing in shares your email address with us — we store it to create your key and to recognise you if you sign in with another provider. See our Privacy Policy and Terms.
A second provider on the same verified email joins the account you already have.
OpenAPI Specification
openapi: 3.2.0
info:
title: 2s — the (most) everything Bio API
version: '1'
summary: The (most) everything API.
description: 'The (most) everything API for AI agents: 575+ pay-per-call endpoints on one origin.'
contact:
name: 2s
url: https://2s.io
email: alley@2s.io
x-logo:
url: https://2s.io/icon-512.png
altText: 2s
x-guidance: 'Pay-per-call REST API for AI agents — hundreds of endpoints returning ground-truth data (US public records, company & legal identifiers, finance/SEC, crypto/web3, security & CVEs, medical codes, weather & geocoding, agriculture, energy, maritime, music, and more). Every endpoint is paid per call in USDC via x402 (Base or Solana) — no API key, no signup. Call any endpoint with no auth to get a 402 PaymentRequirements envelope, sign it (EIP-3009 on Base, partial SPL transfer on Solana), and retry with the PAYMENT-SIGNATURE header. Add ?trial=1 for one free real call per endpoint per hour to test before paying. To discover the right endpoint: GET https://2s.io/api/directory for the full catalog, or GET https://2s.io/api/search/endpoints?q=<natural-language task> for a ranked match. Per-call price is on each operation as x-payment-info (from $0.001). Batch up to 50 calls behind one payment via POST https://2s.io/api/batch/run.'
servers:
- url: https://2s.io
tags:
- name: bio
paths:
/api/bio/gene:
get:
tags:
- bio
summary: Look up a gene by its official symbol (e.g
description: 'Look up a gene by its official symbol (e.g. "TP53", "BRCA1", "CFTR") and organism (taxid, default 9606 = human), merging NCBI Gene with UniProt. Returns the gene symbol, NCBI Gene ID, full description, organism, chromosome + cytogenetic map location, alias symbols, and the curated RefSeq function summary; plus the reviewed protein from UniProt — accession, entry id, recommended protein name, length in amino acids, and the curated function description. NCBI + UniProt links. Bioinformatics, clinical-genetics research, education. Public-domain NCBI + CC-BY UniProt data. Common organism taxids: human 9606, mouse 10090, zebrafish 7955, fruit fly 7227, yeast 559292.'
operationId: bio_gene
deprecated: false
security:
- x402Payment: []
responses:
'200':
description: 'Normalized envelope: items = [{ gene }] (one gene; the best-effort UniProt protein sub-block stays inside the item); total = 1; meta.sources lists both NCBI Gene + UniProt attributions (envelope source is the primary, NCBI Gene).'
content:
application/json:
schema:
type: object
required:
- data
- meta
properties:
data:
type: object
properties:
ok:
type: boolean
enum:
- true
items:
type: array
items:
type: object
properties:
gene:
type: object
properties:
symbol:
type: string
nullable: true
ncbiGeneId:
type: string
nullable: true
description:
type: string
nullable: true
organism:
type: object
properties:
scientificName:
type: string
nullable: true
commonName:
type: string
nullable: true
taxid:
type: number
nullable: true
required:
- scientificName
- commonName
- taxid
additionalProperties: false
nullable: true
chromosome:
type: string
nullable: true
mapLocation:
type: string
nullable: true
aliases:
type: array
items:
type: string
summary:
type: string
nullable: true
protein:
type: object
properties:
found:
type: boolean
uniprotAccession:
type: string
nullable: true
uniprotId:
type: string
nullable: true
name:
type: string
nullable: true
lengthAa:
type: number
nullable: true
function:
type: string
nullable: true
required:
- found
- uniprotAccession
- uniprotId
- name
- lengthAa
- function
additionalProperties: false
ncbiUrl:
type: string
nullable: true
uniprotUrl:
type: string
nullable: true
required:
- symbol
- ncbiGeneId
- description
- organism
- chromosome
- mapLocation
- aliases
- summary
- protein
- ncbiUrl
- uniprotUrl
additionalProperties: false
required:
- gene
additionalProperties: false
total:
type: integer
nullable: true
description: Total matching rows upstream; null when unknown.
source:
$ref: '#/components/schemas/Source'
meta:
type: object
properties:
sources:
type: array
items:
$ref: '#/components/schemas/Source'
required:
- sources
additionalProperties: false
required:
- ok
- items
- total
- source
additionalProperties: false
meta:
$ref: '#/components/schemas/CallMeta'
'400':
$ref: '#/components/responses/BadRequest'
'402':
$ref: '#/components/responses/PaymentRequired'
'405':
$ref: '#/components/responses/MethodNotAllowed'
'500':
$ref: '#/components/responses/ServerError'
'502':
$ref: '#/components/responses/UpstreamError'
x-2s-id: bio.gene
x-2s-version: null
x-2s-price:
usd: 0.0048
x-2s-accepts:
- x402
x-2s-response-shape: normalized
x-payment-info:
price:
mode: fixed
currency: USD
amount: '0.004800'
protocols:
- x402: {}
parameters:
- name: symbol
in: query
required: true
description: Symbol.
schema:
type: string
minLength: 1
maxLength: 30
- name: taxid
in: query
required: false
description: Taxid.
schema:
type: integer
minimum: 1
maximum: 9999999
default: 9606
- $ref: '#/components/parameters/TrialMode'
/api/bio/protein:
get:
tags:
- bio
summary: Look up a protein in UniProtKB by accession (e.g
description: 'Look up a protein in UniProtKB by accession (e.g. "P04637", "Q9Y6K9", "P0DTC2"). Returns the entry id, reviewed (Swiss-Prot) flag, recommended + alternative protein names, gene names, organism + taxid, sequence length and molecular weight, the curated function description, subcellular locations, Gene Ontology terms (id + term + aspect: biological_process / molecular_function / cellular_component), PDB structure ids, and keywords. Bioinformatics, structural biology, drug-target research, education. Gene-centric sibling: /api/bio/gene. CC-BY UniProt data.'
operationId: bio_protein
deprecated: false
security:
- x402Payment: []
responses:
'200':
description: 'Normalized envelope: items = [{ protein }] (one UniProtKB entry: names, organism, sequence, function, GO terms, PDB ids); total = 1.'
content:
application/json:
schema:
type: object
required:
- data
- meta
properties:
data:
type: object
properties:
ok:
type: boolean
enum:
- true
items:
type: array
items:
type: object
properties:
protein:
type: object
properties:
accession:
type: string
entryId:
type: string
nullable: true
reviewed:
type: boolean
proteinName:
type: string
nullable: true
alternativeNames:
type: array
items:
type: string
genes:
type: array
items:
type: string
organism:
type: object
properties:
scientificName:
type: string
nullable: true
commonName:
type: string
nullable: true
taxid:
type: number
nullable: true
required:
- scientificName
- commonName
- taxid
additionalProperties: false
nullable: true
lengthAa:
type: number
nullable: true
molecularWeightDa:
type: number
nullable: true
function:
type: string
nullable: true
subcellularLocations:
type: array
items:
type: string
goTerms:
type: array
items:
type: object
properties:
id:
type: string
term:
type: string
aspect:
type: string
nullable: true
required:
- id
- term
- aspect
additionalProperties: false
pdbStructures:
type: array
items:
type: string
keywords:
type: array
items:
type: string
uniprotUrl:
type: string
required:
- accession
- entryId
- reviewed
- proteinName
- alternativeNames
- genes
- organism
- lengthAa
- molecularWeightDa
- function
- subcellularLocations
- goTerms
- pdbStructures
- keywords
- uniprotUrl
additionalProperties: false
required:
- protein
additionalProperties: false
total:
type: integer
nullable: true
description: Total matching rows upstream; null when unknown.
source:
$ref: '#/components/schemas/Source'
required:
- ok
- items
- total
- source
additionalProperties: false
meta:
$ref: '#/components/schemas/CallMeta'
'400':
$ref: '#/components/responses/BadRequest'
'402':
$ref: '#/components/responses/PaymentRequired'
'405':
$ref: '#/components/responses/MethodNotAllowed'
'500':
$ref: '#/components/responses/ServerError'
'502':
$ref: '#/components/responses/UpstreamError'
x-2s-id: bio.protein
x-2s-version: null
x-2s-price:
usd: 0.0036
x-2s-accepts:
- x402
x-2s-response-shape: normalized
x-payment-info:
price:
mode: fixed
currency: USD
amount: '0.003600'
protocols:
- x402: {}
parameters:
- name: accession
in: query
required: true
description: Accession.
schema:
type: string
minLength: 2
maxLength: 20
pattern: ^[A-Za-z0-9]+$
- $ref: '#/components/parameters/TrialMode'
/api/bio/species:
get:
tags:
- bio
summary: Resolve any organism by scientific or common name to the
description: Resolve any organism by scientific or common name to the GBIF taxonomic backbone — the canonical free reference for life on Earth. Returns the accepted scientific name + canonical name, taxonomic rank and status, the match type/confidence, the full classification (kingdom → phylum → class → order → family → genus → species), up to 8 English vernacular (common) names, the count of recorded occurrences worldwide, and the GBIF species URL. Biodiversity, ecology, education, and as a taxonomy normalizer for other pipelines. Fuzzy-matches misspellings. CC-BY GBIF data.
operationId: bio_species
deprecated: false
security:
- x402Payment: []
responses:
'200':
description: 'Normalized envelope: items = [{ species }] (one resolved taxon; classification + vernacular + occurrence sub-blocks stay inside the item, best-effort); total = 1.'
content:
application/json:
schema:
type: object
required:
- data
- meta
properties:
data:
type: object
properties:
ok:
type: boolean
enum:
- true
items:
type: array
items:
type: object
properties:
species:
type: object
properties:
usageKey:
type: number
nullable: true
scientificName:
type: string
nullable: true
canonicalName:
type: string
nullable: true
rank:
type: string
nullable: true
taxonomicStatus:
type: string
nullable: true
matchType:
type: string
nullable: true
matchConfidence:
type: number
nullable: true
classification:
type: object
properties:
kingdom:
type: string
nullable: true
phylum:
type: string
nullable: true
class:
type: string
nullable: true
order:
type: string
nullable: true
family:
type: string
nullable: true
genus:
type: string
nullable: true
species:
type: string
nullable: true
required:
- kingdom
- phylum
- class
- order
- family
- genus
- species
additionalProperties: false
vernacularNames:
type: array
items:
type: string
occurrenceCount:
type: number
nullable: true
gbifUrl:
type: string
nullable: true
required:
- usageKey
- scientificName
- canonicalName
- rank
- taxonomicStatus
- matchType
- matchConfidence
- classification
- vernacularNames
- occurrenceCount
- gbifUrl
additionalProperties: false
required:
- species
additionalProperties: false
total:
type: integer
nullable: true
description: Total matching rows upstream; null when unknown.
source:
$ref: '#/components/schemas/Source'
required:
- ok
- items
- total
- source
additionalProperties: false
meta:
$ref: '#/components/schemas/CallMeta'
'400':
$ref: '#/components/responses/BadRequest'
'402':
$ref: '#/components/responses/PaymentRequired'
'405':
$ref: '#/components/responses/MethodNotAllowed'
'500':
$ref: '#/components/responses/ServerError'
'502':
$ref: '#/components/responses/UpstreamError'
x-2s-id: bio.species
x-2s-version: null
x-2s-price:
usd: 0.0036
x-2s-accepts:
- x402
x-2s-response-shape: normalized
x-payment-info:
price:
mode: fixed
currency: USD
amount: '0.003600'
protocols:
- x402: {}
parameters:
- name: name
in: query
required: true
description: Name to search for.
schema:
type: string
minLength: 2
maxLength: 120
- $ref: '#/components/parameters/TrialMode'
components:
schemas:
Source:
type: object
description: 'Provenance of the data: upstream provider, source URL, and license.'
properties:
provider:
type: string
description: Upstream data provider.
url:
type: string
description: Source URL or documentation link.
license:
type: string
description: License / usage terms for the data.
CallMeta:
type: object
description: Per-call meta envelope — endpoint id, cost, caller kind, settlement details.
X402PaymentRequiredV2:
type: object
description: x402 v2 PaymentRequired envelope. Pick any entry from accepts[], sign for that rail, retry with the PAYMENT-SIGNATURE header.
required:
- x402Version
- accepts
properties:
x402Version:
type: integer
const: 2
error:
type: string
description: Human-readable reason payment is required.
resource:
type: string
description: The resource URL being purchased.
accepts:
type: array
description: Payment requirement options, one per supported network (Base USDC, Solana USDC).
items:
type: object
required:
- scheme
- network
- amount
- asset
- payTo
- maxTimeoutSeconds
properties:
scheme:
type: string
enum:
- exact
network:
type: string
description: CAIP-2 network id, e.g. "eip155:8453" (Base) or "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp".
amount:
type: string
description: Price in atomic asset units (USDC has 6 decimals).
asset:
type: string
description: Asset contract address / mint.
payTo:
type: string
description: Treasury address to pay.
maxTimeoutSeconds:
type: integer
extra:
type: object
description: 'Rail-specific extras (EVM: EIP-712 domain name/version; Solana: feePayer).'
additionalProperties: true
extensions:
type: object
description: Optional discovery metadata (e.g. bazaar input/output schemas).
additionalProperties: true
responses:
PaymentRequired:
description: Payment required. Body contains the x402 PaymentRequirements envelope with a multi-network accepts array; the per-call price is in accepts[].amount (and on the operation as x-2s-price). Sign for whichever rail you hold USDC on (EIP-3009 for Base, partial SPL transfer for Solana) and retry with the PAYMENT-SIGNATURE header (X-PAYMENT also accepted for v1 clients).
content:
application/json:
schema:
$ref: '#/components/schemas/X402PaymentRequiredV2'
UpstreamError:
description: Upstream provider error.
MethodNotAllowed:
description: Method not allowed — see `Allow` header for the supported method.
ServerError:
description: Internal server error.
BadRequest:
description: Bad request — invalid parameters.
parameters:
TrialMode:
name: trial
in: query
required: false
description: 'Try before you buy. Set to 1 for one free real call per endpoint per hour — no wallet or payment needed — to verify the endpoint before paying. Equivalent to sending the "X-2s-Trial: 1" request header. Works on every endpoint.'
schema:
type: integer
enum:
- 1
securitySchemes:
x402Payment:
type: apiKey
in: header
name: PAYMENT-SIGNATURE
description: 'x402 protocol v2: base64-encoded PaymentPayload. Call any paid endpoint without auth to receive a 402 with a multi-network PaymentRequirements envelope. Sign for either rail: EIP-3009 transferWithAuthorization (Base USDC) OR a partial SPL token transfer (Solana USDC). Retry with PAYMENT-SIGNATURE header. X-PAYMENT is also accepted for v1 buyer clients. See https://x402.org.'