Drug Target

A biological target for drug development identified through Regeneron's genetics and research programs

PharmaceuticalsBiotechnologyGenomicsBioinformaticsDrug DiscoveryClinical ResearchLife SciencesFortune 500

Properties

Name	Type	Description
targetId	string	Unique target identifier
name	string	Target name (gene symbol or protein name)
targetType	string	Type of biological target
geneSymbol	string	HGNC approved gene symbol
uniprotId	string	UniProt accession number for protein targets
biologicalFunction	string	Description of the target's biological role
diseaseArea	array	Disease areas the target is relevant to
modality	string	Drug modality applicable to this target
geneticValidation	boolean	Whether the target has been validated by human genetics evidence
rgcEvidence	boolean	Whether evidence comes from the Regeneron Genetics Center exome database

View JSON Schema on GitHub

JSON Schema

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "$id": "https://api-evangelist.github.io/regeneron-pharmaceuticals/json-schema/regeneron-drug-target-schema.json",
  "title": "Drug Target",
  "description": "A biological target for drug development identified through Regeneron's genetics and research programs",
  "type": "object",
  "required": ["targetId", "name", "targetType"],
  "properties": {
    "targetId": {
      "type": "string",
      "description": "Unique target identifier"
    },
    "name": {
      "type": "string",
      "description": "Target name (gene symbol or protein name)"
    },
    "targetType": {
      "type": "string",
      "enum": ["Protein", "Gene", "Pathway", "RNA"],
      "description": "Type of biological target"
    },
    "geneSymbol": {
      "type": "string",
      "description": "HGNC approved gene symbol"
    },
    "uniprotId": {
      "type": "string",
      "description": "UniProt accession number for protein targets"
    },
    "biologicalFunction": {
      "type": "string",
      "description": "Description of the target's biological role"
    },
    "diseaseArea": {
      "type": "array",
      "items": { "type": "string" },
      "description": "Disease areas the target is relevant to"
    },
    "modality": {
      "type": "string",
      "enum": ["Antibody", "Small Molecule", "Gene Therapy", "RNA Therapy", "Cell Therapy"],
      "description": "Drug modality applicable to this target"
    },
    "geneticValidation": {
      "type": "boolean",
      "description": "Whether the target has been validated by human genetics evidence"
    },
    "rgcEvidence": {
      "type": "boolean",
      "description": "Whether evidence comes from the Regeneron Genetics Center exome database"
    }
  },
  "additionalProperties": false
}