# Upstream Bio

**Canonical:** https://apis.io/providers/upstream-bio/  
**Website:** https://upstreambio.com/  
**APIs profiled:** 0

Upstream Bio is a clinical-stage biotechnology company headquartered at 460 Totten Pond Road in Waltham, Massachusetts, founded in 2021 and listed on Nasdaq as UPB since its October 2024 IPO. The company develops treatments for inflammatory disease with an initial focus on severe respiratory disorders, and its strategy is built around a single lead asset: verekitug (UPB-101), described by the company as the only known antagonist in clinical development that targets the receptor for thymic stromal lymphopoietin (TSLP). Verekitug has been advanced into Phase 2 studies in severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic obstructive pulmonary disease (COPD), with a Phase 3 development strategy announced in 2026. Upstream Bio is a therapeutics developer rather than a software vendor: upstreambio.com is a fourteen-page WordPress marketing site, investor material is served from a hosted Q4-style investor-relations subdomain, and the company publishes no developer program, no public API, no SDK and no machine-readable API contract.

## Kin Score — 10.5 / 100 (minimal)

Scored 2026-09-02 under rubric 0.18.0.

| Facet | Score |
|---|---|
| Discoverability | 50.0 |
| Contract Quality | 0.0 |
| Governance | 0.0 |
| Contract Governance | 0.0 |
| Operational Transparency | 0.0 |
| Developer Ergonomics | 7.1 |
| Commercial Clarity | 21.1 |
| Access Clarity | 21.1 |

Regulatory layer — **Health**: 17.5 (matched via tags).

## Agent readiness — 0.0 (human-only)

| Dimension | Value |
|---|---|
| Spec Presence | no |
| Agentic Access | no |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | no |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |
| Delegated Identity | no |
| Protected Resource Metadata | no |
| Dynamic Client Registration | no |
| Agentic Commerce | no |

## Security (1)

- **Upstream Bio Domain Security** — TLSv1.3 · DMARC

## Tags

Company, Biotechnology, Pharmaceuticals, Life Sciences, Healthcare, Immunology, Respiratory, Clinical Trials, Drug Development, Nasdaq

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/upstream-bio/). Scores are computed from the provider's own public artifacts under a published rubric.