# UniProt

**Canonical:** https://apis.io/providers/uniprot/  
**Website:** https://www.uniprot.org/  
**APIs profiled:** 7

UniProt is the world's leading high-quality, comprehensive, and freely accessible resource for protein sequence and functional annotation data. Maintained by the UniProt Consortium (EMBL-EBI, SIB, and PIR), it integrates information from experimental literature and computational analysis to provide a single authoritative source on protein function, taxonomy, sequences, cross-references, and disease associations. UniProt exposes a REST API at rest.uniprot.org for searching and retrieving entries from UniProtKB, UniRef, UniParc, Proteomes, and supporting services such as ID mapping. All data is freely available under Creative Commons Attribution 4.0.

## Kin Score — 21.4 / 100 (emerging)

Scored 2026-08-25 under rubric 0.14.0. Trend: flat (+0.0 from 21.4).

| Facet | Score |
|---|---|
| Discoverability | 81.5 |
| Contract Quality | 33.3 |
| Governance | 0.0 |
| Contract Governance | 0.0 |
| Operational Transparency | 31.6 |
| Developer Ergonomics | 0.0 |
| Commercial Clarity | 7.9 |
| Access Clarity | 7.9 |

Regulatory layer — **Health**: 13.8 (matched via tags).

## Agent readiness — 15.5 (agent-aware)

| Dimension | Value |
|---|---|
| Spec Presence | yes |
| Agentic Access | no |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | no |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | documented |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |
| Delegated Identity | no |
| Protected Resource Metadata | no |
| Dynamic Client Registration | no |
| Agentic Commerce | no |

## Access

Unknown — onboarding: unknown, pricing: unknown, trial: no (confidence: low).

## APIs (7)

- **UniProtKB REST API** — Search and retrieve protein entries from UniProtKB, which integrates Swiss-Prot (manually reviewed) and TrEMBL (computationally annotated) databases. Supports full-text and fiel...
- **UniRef REST API** — UniRef (UniProt Reference Clusters) groups similar sequences to reduce redundancy. UniRef100 combines identical sequences; UniRef90 clusters sequences sharing 90% identity; UniR...
- **UniParc REST API** — UniParc (UniProt Archive) is a comprehensive non-redundant database of publicly available protein sequences. Each unique sequence appears once with a stable UniParc identifier a...
- **Proteomes REST API** — Provides access to UniProt proteomes — the complete or near-complete sets of proteins from fully sequenced organisms. Supports retrieval of reference proteomes and gene-centric ...
- **ID Mapping REST API** — Maps identifiers between UniProt accessions and over 150 external database identifiers (e.g., RefSeq, Ensembl, PDB, ChEMBL, KEGG, OMIM). Asynchronous job-based service: submit a...
- **UniProt SPARQL Endpoint** — A standards-compliant SPARQL 1.1 endpoint exposing the full UniProt knowledge graph as RDF. The current release contains approximately 232 billion triples across 21 named graphs...
- **EBI Proteins REST API** — The EMBL-EBI Proteins API provides integrated access to UniProt protein annotations alongside large-scale study data including variation data from 1000 Genomes, ClinVar, ExAC, C...

## Security (1)

- **Uniprot Domain Security** — TLSv1.3 · HSTS · DMARC

## Plans (1)

- **Free**

## Tags

Proteins, Bioinformatics, Genomics, Life Sciences, Open Data

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/uniprot/). Scores are computed from the provider's own public artifacts under a published rubric.