# Surescripts **Canonical:** https://apis.io/providers/surescripts/ **Website:** https://surescripts.com **APIs profiled:** 8 Surescripts operates the largest health information network in the United States, connecting prescribers, pharmacies, pharmacy benefit managers (PBMs), health plans, and health systems for e-prescribing, medication history, benefit and eligibility verification, electronic prior authorization, and clinical interoperability. Transaction services run over NCPDP SCRIPT (NewRx, RxRenewal, RxChange, RxTransfer, RxFill, CancelRx), NCPDP Real-Time Prescription Benefit, NCPDP Formulary and Benefit, X12 (270/271 eligibility, 278 prior authorization), the Direct Standard, and - since the Surescripts Developer Portal launched at docs.surescripts.com on 2026-08-06 - two publicly documented HTTP APIs - a Medication History for Populations API implemented in HL7 FHIR R4, and a four-endpoint Formulary Download REST API. Both authenticate the calling organization with a Surescripts-issued client certificate over mutual TLS plus a Participant ID header; Surescripts runs its own Certificate Authority. There is still no OpenAPI, no self-serve sign-up, no published pricing and no free API keys - production access requires Surescripts certification (conformance testing against current NCPDP standards, Certification Review Board contract approval, and a DEA third-party audit for EPCS) or integration through a certified middleware/EHR partner. ## Kin Score — 41.1 / 100 (developing) Scored 2026-08-25 under rubric 0.14.0. Trend: flat (+0.0 from 41.1). | Facet | Score | |---|---| | Discoverability | 72.2 | | Contract Quality | 0.0 | | Governance | 18.2 | | Contract Governance | 18.2 | | Operational Transparency | 47.4 | | Developer Ergonomics | 64.3 | | Commercial Clarity | 43.4 | | Access Clarity | 43.4 | Regulatory layer — **Health**: 45.0 (matched via tags). ## Agent readiness — 7.9 (agent-aware) | Dimension | Value | |---|---| | Spec Presence | no | | Agentic Access | no | | Reversibility Documented | no | | MCP Server | no | | Auth Clarity | bearer | | Idempotency | no | | Error Semantics | documented | | OpenAPI Examples | no | | Rate Limit Signal | documented | | Event Surface Described | no | | Agent Skills | no | | Well Known Catalog | no | | Consent Identity | no | | Agent Card | no | | Dry Run Mode | no | | Delegated Identity | no | | Protected Resource Metadata | no | | Dynamic Client Registration | no | | Agentic Commerce | no | ## Access Unknown — onboarding: unknown, pricing: unknown, trial: no (confidence: low). ## APIs (8) - **Surescripts Medication History for Populations FHIR API** — Publicly documented HL7 FHIR Release 4 API for retrieving medication history panels and near-real-time Prescription Notifications for enrolled patient populations. Panels and no... - **Surescripts Formulary Download API** — Four documented REST endpoints that let a technology vendor locate and download NCPDP Formulary and Benefit lists - GET /formulary/pbms, GET /formulary/listTypes, GET /formulary... - **Surescripts E-Prescribing** — Routes electronic prescriptions between prescribers and pharmacies over the NCPDP SCRIPT standard (version 2023011), supporting NewRx, RxRenewalRequest/Response, RxChangeRequest... - **Surescripts Eligibility and Formulary** — Verifies patient pharmacy benefit eligibility and returns formulary and benefit coverage details so prescribers see coverage and coverage alternatives in workflow. Eligibility r... - **Surescripts Real-Time Prescription Benefit** — Returns patient-specific, real-time out-of-pocket drug cost, coverage status, and therapeutic alternatives at the point of prescribing, as a synchronous RTPBRequest/RTPBResponse... - **Surescripts Electronic Prior Authorization** — Automates electronic prior authorization (ePA) between prescribers and PBMs/payers using the NCPDP SCRIPT ePA transaction set (PAInitiationRequest, PARequest, PAResponse, and re... - **Surescripts Clinical Direct Messaging** — Provides secure, HIPAA-compliant clinical message exchange (Direct Secure Messaging) for care coordination between providers, including transitions of care and referrals. Delive... - **Surescripts Record Locator and Exchange** — Locates where a patient has clinical records across the network and enables retrieval of relevant clinical documents to inform care decisions. Delivered to certified participant... ## Security (3) - **Surescripts Authentication** — mutualTLS/apiKey · 4 schemes - **Surescripts Domain Security** — TLSv1.3 · HSTS · DNSSEC · DMARC - **Surescripts Trust Center** — HITRUST r2, SOC 2 Type II, EHNAC, DirectTrust, WebTrust for Certification Authorities, HIPAA ## Plans (1) - **Surescripts Plans Pricing** ## Tags Healthcare, e-Prescribing, Health Information Network, NCPDP SCRIPT, Medication History, Prior Authorization, Interoperability, FHIR, Formulary, Eligibility, Real-Time Prescription Benefit, Mutual TLS, Gated --- Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/surescripts/). Scores are computed from the provider's own public artifacts under a published rubric.